Jianglong Lu
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View article: Necroptotic Signaling Orchestrates GBM Malignancy and Potentiates Temozolomide Response
Necroptotic Signaling Orchestrates GBM Malignancy and Potentiates Temozolomide Response Open
Glioblastoma (GBM), a highly aggressive form of glioma, poses serious harm to patients due to its extremely poor prognosis and severe resistance to chemotherapeutic agents. Although programmed necrosis (necroptosis) has been implicated in …
View article: Multimodal Model for Non-Invasive Detection of DRD2, SSTR2 and ESR1 Receptor Profiling in Pituitary Neuroendocrine Tumors: A Retrospective Study
Multimodal Model for Non-Invasive Detection of DRD2, SSTR2 and ESR1 Receptor Profiling in Pituitary Neuroendocrine Tumors: A Retrospective Study Open
Introduction : The dopamine receptor D2 (DRD2), somatostatin receptor 2 (SSTR2), and oestrogen receptor 1 (ESR1) have been demonstrated to play a critical role in determining treatment response in pituitary neuroendocrine tumors (PitNETs).…
View article: Extracellular Vesicles From Bone Marrow‐Derived Macrophages Enriched in ARG1 Enhance Microglial Phagocytosis and Haematoma Clearance Following Intracerebral Haemorrhage
Extracellular Vesicles From Bone Marrow‐Derived Macrophages Enriched in ARG1 Enhance Microglial Phagocytosis and Haematoma Clearance Following Intracerebral Haemorrhage Open
Microglial phagocytosis of haematomas is crucial for neural functional recovery following intracerebral haemorrhage (ICH), a process regulated by various factors from within and outside the central nervous system (CNS). Extracellular vesic…
View article: Exploring causal correlations of inflammatory biomarkers in idiopathic normal-pressure hydrocephalus: insights from bidirectional Mendelian randomization analysis
Exploring causal correlations of inflammatory biomarkers in idiopathic normal-pressure hydrocephalus: insights from bidirectional Mendelian randomization analysis Open
Background and objective Neuroinflammatory processes have been identified as playing a crucial role in the pathophysiology of various neurodegenerative diseases, including idiopathic normal-pressure hydrocephalus (iNPH). iNPH, defined as a…
View article: Mechanism of action of paclitaxel for treating glioblastoma based on single-cell RNA sequencing data and network pharmacology
Mechanism of action of paclitaxel for treating glioblastoma based on single-cell RNA sequencing data and network pharmacology Open
Paclitaxel is an herbal active ingredient used in clinical practice that shows anti-tumor effects. However, its biological activity, mechanism, and cancer cell-killing effects remain unknown. Information on the chemical gene interactions o…
View article: Construction and validation of a glioblastoma prognostic model based on immune-related genes
Construction and validation of a glioblastoma prognostic model based on immune-related genes Open
Background Glioblastoma multiforme (GBM) is a common malignant brain tumor with high mortality. It is urgently necessary to develop a new treatment because traditional approaches have plateaued. Purpose Here, we identified an immune-relate…
View article: Systematic Analysis of Chemokines Reveals CCL18 is a Prognostic Biomarker in Glioblastoma
Systematic Analysis of Chemokines Reveals CCL18 is a Prognostic Biomarker in Glioblastoma Open
Our study reveals comprehensive and comparable roles of chemokine members in glioblastoma, and identified CCL18 as a critical driver of GBM malignant behaviors, therefore providing a potential target for developing prognosis and therapy in…
View article: A Multielement Prognostic Nomogram Based on a Peripheral Blood Test, Conventional MRI and Clinical Factors for Glioblastoma
A Multielement Prognostic Nomogram Based on a Peripheral Blood Test, Conventional MRI and Clinical Factors for Glioblastoma Open
Background Glioblastoma (GBM) is one of the most malignant types of tumors in the central nervous system, and the 5-year survival remains low. Several studies have shown that preoperative peripheral blood tests and preoperative conventiona…
View article: A Six-Immune-Related Genes Prognostic Signature for Glioblastoma
A Six-Immune-Related Genes Prognostic Signature for Glioblastoma Open
Background: Glioblastoma (GBM) multiforme is a common malignant brain tumor with high mortality. It is urgently necessary to develop a new treatment because traditional approaches have reached a bottleneck. Purpose : Here we created an imm…
View article: Surgery and Medical Treatment in Microprolactinoma: A Systematic Review and Meta-Analysis
Surgery and Medical Treatment in Microprolactinoma: A Systematic Review and Meta-Analysis Open
Objective. Dopamine agonists (DAs) are recommended as the first-line treatment for prolactinomas; however, tumour recurrence after drug withdrawal remains a clinical problem. Recent studies have reported high remission rates via surgery in…
View article: Ciclopirox and bortezomib synergistically inhibits glioblastoma multiforme growth via simultaneously enhancing JNK/p38 MAPK and NF-κB signaling
Ciclopirox and bortezomib synergistically inhibits glioblastoma multiforme growth via simultaneously enhancing JNK/p38 MAPK and NF-κB signaling Open
Ciclopirox (CPX) is an antifungal drug that has recently been reported to act as a potential anticancer drug. However, the effects and underlying molecular mechanisms of CPX on glioblastoma multiforme (GBM) remain unknown. Bortezomib (BTZ)…
View article: Brusatol Inhibits Tumor Growth and Increases the Efficacy of Cabergoline against Pituitary Adenomas
Brusatol Inhibits Tumor Growth and Increases the Efficacy of Cabergoline against Pituitary Adenomas Open
Cabergoline (CAB) is the first choice for treatment of prolactinoma and the most common subtype of pituitary adenoma. However, drug resistance and lack of effectiveness in other pituitary tumor types remain clinical challenges to this trea…
View article: A Quantified Risk-Scoring System for the Recurrence of Meningiomas: Results From a Retrospective Study of 392 Patients
A Quantified Risk-Scoring System for the Recurrence of Meningiomas: Results From a Retrospective Study of 392 Patients Open
Aim: This study aimed to identify the independent risk factors of recurrence in patients undergoing primary resection of meningioma and construct a scoring system for the prediction of the risk of postoperative recurrence. Materials and Me…
View article: miR‑34a derived from mesenchymal stem cells stimulates senescence in glioma cells by inducing DNA damage
miR‑34a derived from mesenchymal stem cells stimulates senescence in glioma cells by inducing DNA damage Open
Insights into the roles of microRNAs (miRNAs/miRs) in development and disease, particularly in cancer, have made miRNAs attractive tools and targets for novel therapeutic approaches in the treatment of glioma. miR‑34a, as a well‑known tumo…
View article: MicroRNA-93 mediates cabergoline resistance by targeting ATG7 in prolactinoma
MicroRNA-93 mediates cabergoline resistance by targeting ATG7 in prolactinoma Open
To date, the management of dopamine agonist (DA)-resistant prolactinomas remains a major clinical problem. Previously, we determined that miRNA-93 expression increases in DA-resistant prolactinomas; however, the role of miRNA-93 in the DA …
View article: CTRP9 ameliorates cellular senescence via PGC‑1α/AMPK signaling in mesenchymal stem cells
CTRP9 ameliorates cellular senescence via PGC‑1α/AMPK signaling in mesenchymal stem cells Open
Stroke is the second most common cause of death worldwide, and thus, it imposes great financial burdens on both individuals and society. Mesenchymal stem cell (MSC) therapy is a promising approach for ischemic brain injury. However, MSC tr…
View article: Classification of Pathogenic Bacteria in Cerebrospinal Fluid of Patients with Intracranial Infection After Neurosurgery and Selective Use of Antibacterial Agents
Classification of Pathogenic Bacteria in Cerebrospinal Fluid of Patients with Intracranial Infection After Neurosurgery and Selective Use of Antibacterial Agents Open
Background: Anti-infective treatment has become troublesome owing to aggravated resistance to antibacterial agents. Objectives: This study aimed at investigating the distribution characteristics and drug resistance changes of pathogenic ba…
View article: Expression of Stem Cell Markers and Dopamine D2 Receptors in Human and Rat Prolactinomas
Expression of Stem Cell Markers and Dopamine D2 Receptors in Human and Rat Prolactinomas Open
BACKGROUND Dopamine agonists (DAs) are the first-line treatment for prolactinomas. DAs primarily target the dopamine D2 receptor (D2R). Tumor stem-like cells (TSLCs) are associated with the tolerance to radiotherapy and chemotherapy. TSLCs…
View article: HSP47 is associated with the prognosis of laryngeal squamous cell carcinoma by inhibiting cell viability and invasion and promoting apoptosis
HSP47 is associated with the prognosis of laryngeal squamous cell carcinoma by inhibiting cell viability and invasion and promoting apoptosis Open
Heat shock protein 47 (HSP47) is a 47 kDa collagen binding protein that has a close relationship with the development and progression of tumours. However, little is known concerning the expression profile of HSP47 in laryngeal squamous cel…