Jiangminghao Zhao
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View article: Targeting MT‐tsRNA IDDMT with Nanoparticles to Annulus Fibrosus: A Novel Therapeutic Approach for Intervertebral Disc Degeneration
Targeting MT‐tsRNA IDDMT with Nanoparticles to Annulus Fibrosus: A Novel Therapeutic Approach for Intervertebral Disc Degeneration Open
Annulus fibrosus (AF) injury is a significant cause of NP protrusion and intervertebral disc degeneration (IDD). Currently, the molecular mechanisms of IDD remain unclear, and there is a lack of methods for early diagnosis and targeted dru…
View article: Photothermal-triggered NO-releasing nanofiber membrane mitigates intervertebral disc degeneration via inflammation inhibition and matrix stabilization
Photothermal-triggered NO-releasing nanofiber membrane mitigates intervertebral disc degeneration via inflammation inhibition and matrix stabilization Open
Intervertebral disc-related low back pain represents a major source of chronic pain. Due to the inflammatory microenvironment and impaired extracellular matrix (ECM) synthesis in intervertebral disc degeneration (IVDD), annulus fibrosus (A…
View article: Deliver CEBPE via cartilage targeting Lipid nanoparticle to block CEBPE-LTF-STAT3 positive feedback loop for efficient treatment of cartilage endplate degeneration
Deliver CEBPE via cartilage targeting Lipid nanoparticle to block CEBPE-LTF-STAT3 positive feedback loop for efficient treatment of cartilage endplate degeneration Open
View article: Downregulation of ferroptosis-related Genes can regulate the invasion and migration of osteosarcoma cells
Downregulation of ferroptosis-related Genes can regulate the invasion and migration of osteosarcoma cells Open
View article: Harnessing engineered exosomes as METTL3 carriers: Enhancing osteogenesis and suppressing lipogenesis in bone marrow mesenchymal stem cells for postmenopausal osteoporosis treatment
Harnessing engineered exosomes as METTL3 carriers: Enhancing osteogenesis and suppressing lipogenesis in bone marrow mesenchymal stem cells for postmenopausal osteoporosis treatment Open
Postmenopausal osteoporosis (PMOP), a prevalent skeletal disorder among women post-menopause, has emerged as a pressing global public health concern. Exosomes derived from serum have exhibited encouraging therapeutic potential in addressin…
View article: Development and validation of a novel endoplasmic reticulum stress-related lncRNAs signature in osteosarcoma
Development and validation of a novel endoplasmic reticulum stress-related lncRNAs signature in osteosarcoma Open
Osteosarcoma (OS) is a cancerous tumor, and its development is greatly influenced by long non-coding RNA (lncRNA). Endoplasmic reticulum stress (ERS) is an essential biological defense process in cells and contributes to the progression of…
View article: “Dictionary of immune responses” reveals the critical role of monocytes and the core target IRF7 in intervertebral disc degeneration
“Dictionary of immune responses” reveals the critical role of monocytes and the core target IRF7 in intervertebral disc degeneration Open
Background Intervertebral disc degeneration (IDD) is widely regarded as the primary contributor to low back pain(LBP). As an immune-privileged organ, upon the onset of IDD, various components of the nucleus pulposus (NP) are exposed to the…
View article: LTF ameliorates cartilage endplate degeneration by suppressing calcification, senescence and matrix degradation through the JAK2/STAT3 pathway
LTF ameliorates cartilage endplate degeneration by suppressing calcification, senescence and matrix degradation through the JAK2/STAT3 pathway Open
Intervertebral disc degeneration (IDD)‐induced cervical and lumbar herniations are debilitating diseases. The function of intervertebral disc (IVD) mainly depends on the cartilage endplate (CEP), which provides support and waste removal. T…
View article: Identification of a novel mitophagy-related signature for predicting clinical prognosis and immunotherapy of osteosarcoma
Identification of a novel mitophagy-related signature for predicting clinical prognosis and immunotherapy of osteosarcoma Open
Background Osteosarcoma (OS) is a highly aggressive malignancy characterized by a poor prognosis. Mitochondrial autophagy (mitophagy) has been implicated in tumor initiation, progression, and response to therapy, highlighting it a potentia…
View article: PMAIP1, a novel diagnostic and potential therapeutic biomarker in osteoporosis
PMAIP1, a novel diagnostic and potential therapeutic biomarker in osteoporosis Open
All of these outcomes showed a new theoretical basis for further research in the treatment of osteoporosis, and PMAIP1 was identified as a potential biomarker for osteoporosis diagnosis and treatment.