Jing Sun
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View article: Survival analysis of time to reimbursement of novel medicines in five Eurasian countries
Survival analysis of time to reimbursement of novel medicines in five Eurasian countries Open
Background Access to novel medications matters quality-adjusted life years and the opportunity cost associated with productivity lost. Gaps in patient access to novel medicines exist due to insufficient public funding reimbursement in emer…
View article: Precise staging of severe fever with thrombocytopenia syndrome: Integrating the extent of organ damage for prognostic and therapeutic applications
Precise staging of severe fever with thrombocytopenia syndrome: Integrating the extent of organ damage for prognostic and therapeutic applications Open
Objectives This study aimed to develop an accurate staging system for SFTS (Severe Fever with Thrombocytopenia Syndrome) based on the dynamic assessment of organ damage. This staging is intended to improve prognostication and guide treatme…
View article: Increased EBV infection and relapse following haploidentical hematopoietic cell transplantation in the era of letermovir for cytomegalovirus prophylaxis: a propensity score matching analysis
Increased EBV infection and relapse following haploidentical hematopoietic cell transplantation in the era of letermovir for cytomegalovirus prophylaxis: a propensity score matching analysis Open
Background Letermovir (LTV) is an effective strategy for cytomegalovirus (CMV) reactivation prophylaxis and is increasingly used for allogeneic hematopoietic stem cell transplantation. However, it carries the risk of delayed immune reconst…
View article: From exposure to pathogenesis: A critical review of SCCPs-induced toxicity and potential molecular mechanisms
From exposure to pathogenesis: A critical review of SCCPs-induced toxicity and potential molecular mechanisms Open
Short-chained chlorinated paraffins (SCCPs) are a class of polychlorinated n-alkanes containing 10-13 carbon atoms, which are widely used in several industrial sectors due to their excellent thermal and chemical stability. However, their p…
View article: Are there differences in efficacy and safety between local and imported direct-acting antiviral agents for hepatitis C in China?
Are there differences in efficacy and safety between local and imported direct-acting antiviral agents for hepatitis C in China? Open
Background Despite price advantages, local direct-acting antiviral agents (DAAs) for hepatitis C (hep C) have not been widely used in China compared with the imported ones. There is no evidence on their relative efficacy and safety, nor wh…
View article: Targeting <i>Mettl14</i> Using an RNA‐Targeting Clustered Regularly Interspaced Short Palindromic Repeat‐ <i>High‐Fidelity</i> Cas13x System Attenuates Doxorubicin‐Induced Cardiotoxicity
Targeting <i>Mettl14</i> Using an RNA‐Targeting Clustered Regularly Interspaced Short Palindromic Repeat‐ <i>High‐Fidelity</i> Cas13x System Attenuates Doxorubicin‐Induced Cardiotoxicity Open
Background Doxorubicin is an effective chemotherapy drug used to treat various types of cancer. However, doxorubicin treatment is associated with cardiotoxicity, which limits its clinical use. Exercise can benefit both cancer and cardiovas…
View article: Establishment and application of a grading diagnostic model for early detection of severe fever with thrombocytopenia syndrome
Establishment and application of a grading diagnostic model for early detection of severe fever with thrombocytopenia syndrome Open
The present study integrated fever presentation, WBC count, PLT levels and biochemical markers to establish a method for early detection and grading diagnosis of SFTS. This study devised a direct and practical approach to diagnose and bett…
View article: Strategies, Barriers, and Facilitators for Healthcare Professionals to Recommend HPV Vaccination: A Systematic Review
Strategies, Barriers, and Facilitators for Healthcare Professionals to Recommend HPV Vaccination: A Systematic Review Open
Background/Objectives: The HPV vaccine has demonstrated efficacy in preventing approximately 90% of HPV infection-associated cancers. However, the global HPV vaccination coverage rate remains low. Healthcare professionals are trusted sourc…
View article: Characteristics of Cardiac Injury in Patients Diagnosed with Severe Fever with Thrombocytopenia Syndrome
Characteristics of Cardiac Injury in Patients Diagnosed with Severe Fever with Thrombocytopenia Syndrome Open
This study aimed to characterize cardiac injury in individuals diagnosed with severe fever with thrombocytopenia syndrome (SFTS) and to ascertain its relationship with prognosis. A retrospective analysis of data from 324 patients, diagnose…
View article: Research on the Reform of Hybrid Teaching Content in Transportation Engineering Courses under the Background of Smart Transportation
Research on the Reform of Hybrid Teaching Content in Transportation Engineering Courses under the Background of Smart Transportation Open
Smart transportation is a key direction and trend in the development of China’s public transportation sector. Under this background, new opportunities for the development of transportation engineering education have emerged, necessitating …
View article: Dual Functional Radioactive Gel‐Microspheres for Combinatorial Radioembolization and Photothermal Therapy of Hepatocellular Carcinoma
Dual Functional Radioactive Gel‐Microspheres for Combinatorial Radioembolization and Photothermal Therapy of Hepatocellular Carcinoma Open
Transarterial radioembolization (TARE) is an established clinical therapy for treating patients with intermediate to advanced hepatocellular carcinoma (HCC) or those who cannot undergo radical treatment. However, the delivery of a high rad…
View article: Efficacy of Different Acupuncture Techniques for Pain and Dysfunction in Patients with Knee Osteoarthritis: A Randomized Controlled Trial
Efficacy of Different Acupuncture Techniques for Pain and Dysfunction in Patients with Knee Osteoarthritis: A Randomized Controlled Trial Open
View article: Integrating Radiosensitivity Index and Radiation Resistance Related Index Improves Prostate Cancer Outcome Prediction
Integrating Radiosensitivity Index and Radiation Resistance Related Index Improves Prostate Cancer Outcome Prediction Open
This study successfully established a radiosensitivity-related nomogram, which had excellent performance in predicting recurrence in patients with PCa. For patients who received radiation therapy, the 20Genes and RRRI models can be used to…
View article: Multidisciplinary Interventions in Children and Adolescents with Overweight or Obesity: A Systematic Review and Meta-Analysis
Multidisciplinary Interventions in Children and Adolescents with Overweight or Obesity: A Systematic Review and Meta-Analysis Open
View article: Practical Exploration of the Innovative Design of the Yuan Yang Xi Shui Auspicious Pattern
Practical Exploration of the Innovative Design of the Yuan Yang Xi Shui Auspicious Pattern Open
View article: Effect of Health Literacy on Antiviral Treatment of Hepatitis B: Instrumental Variable Analysis
Effect of Health Literacy on Antiviral Treatment of Hepatitis B: Instrumental Variable Analysis Open
Background China is a country with a high burden of hepatitis B (Hep B) but a low treatment rate. One of the key reasons for the low treatment rate is the inadequate health literacy (HL) of the people, which may affect the awareness and kn…
View article: Study protocol for a randomized trial comparing two electroacupuncture waveforms for different severity groups of Bell palsy
Study protocol for a randomized trial comparing two electroacupuncture waveforms for different severity groups of Bell palsy Open
Background Bell palsy (BP) is the most common cause of acute peripheral facial palsy which leads to functional and esthetic disturbances in patients and has a negative influence on daily living. Electroacupuncture (EA) has been considered …
View article: Research and development investment of Chinese chemical pharmaceutical companies under the national pooled procurement: a retrospective panel data analysis, 2013–2022
Research and development investment of Chinese chemical pharmaceutical companies under the national pooled procurement: a retrospective panel data analysis, 2013–2022 Open
Objective To generate evidence about changes in the research and development (R&D) investment of Chinese chemical pharmaceutical companies before and after the implementation of the national pooled procurement, to respond to the concerns t…
View article: Uptake of biosimilars in China: a retrospective analysis of the case of trastuzumab from 2018 to 2023
Uptake of biosimilars in China: a retrospective analysis of the case of trastuzumab from 2018 to 2023 Open
Background The Chinese biosimilar industry has demonstrated rapid growth in recent years. Limited evidence is available about biosimilar uptake at the national level. This study aimed to assess biosimilar uptake in the case of trastuzumab …
View article: Developing a framework for identifying risk factors and estimating direct economic disease burden attributable to healthcare-associated infections: a case study of a Chinese Tuberculosis hospital
Developing a framework for identifying risk factors and estimating direct economic disease burden attributable to healthcare-associated infections: a case study of a Chinese Tuberculosis hospital Open
View article: Developing a framework for identifying risk factors and estimating direct economic disease burden attributable to healthcare-associated infections: case study of a Chinese Tuberculosis hospital
Developing a framework for identifying risk factors and estimating direct economic disease burden attributable to healthcare-associated infections: case study of a Chinese Tuberculosis hospital Open
Healthcare-associated infections (HAIs) represent a major global health burden, necessitating effective frameworks to identify potential risk factors and estimate direct economic disease burden. We proposed a framework designed to address …
View article: Electroacupuncture and carbamazepine for patients with trigeminal neuralgia: a randomized, controlled, 2 × 2 factorial trial
Electroacupuncture and carbamazepine for patients with trigeminal neuralgia: a randomized, controlled, 2 × 2 factorial trial Open
View article: Refocusing the World Health Organization’s Model List of Essential Medicines on the needs of low and middle income countries
Refocusing the World Health Organization’s Model List of Essential Medicines on the needs of low and middle income countries Open
In the wake of escalating medicine prices worldwide, Veronika Wirtz and colleagues argue for refocusing the WHO Model List of Essential Medicines on the needs of low and middle income countries, while retaining its global relevance …
View article: Case report: One case of refractory membranous nephropathy with hypokalemia after rituximab infusion was switched to obinutuzumab without recurrence of hypokalemia
Case report: One case of refractory membranous nephropathy with hypokalemia after rituximab infusion was switched to obinutuzumab without recurrence of hypokalemia Open
Rituximab (RTX) is a monoclonal antibody commonly used to treat PLA2R-associated membranous nephropathy (MN). This report presents a case of refractory MN in a patient who experienced severe hypokalemia, a rare but clinically significant c…
View article: Refusal of treatment among HER2-positive breast cancer patients in China: a retrospective analysis
Refusal of treatment among HER2-positive breast cancer patients in China: a retrospective analysis Open
Background There is a need to update the understanding of treatment refusal among cancer patients in China, taking into account recent developments. This study investigated how public insurance coverage of the first breast cancer targeted …
View article: Impacts of Operating Room Refined Nursing on Orthopedic Surgery Patients
Impacts of Operating Room Refined Nursing on Orthopedic Surgery Patients Open
Objective: To explore the impacts of operating room refined nursing on orthopedic surgery patients. Methods:A sample of 62 orthopedic surgery patients admitted from March 2022 to March 2023 were randomly divided into two groups, with 31 pa…
View article: Analysis of Soundproof Technology of Assembled Steel Structure Houses
Analysis of Soundproof Technology of Assembled Steel Structure Houses Open
The problem of noise has always been highlighted in assembled steel structure houses. Therefore, it is necessary to use effective soundproof measures where steel beams intersect with the reserved line pipe openings, doors, windows, elevato…
View article: Butorphanol Nasal Spray Relieves Pain and Distress in Women Under Epidural Labor Analgesia: A Randomized Controlled Trial
Butorphanol Nasal Spray Relieves Pain and Distress in Women Under Epidural Labor Analgesia: A Randomized Controlled Trial Open
Background Epidural block is currently the most widely used, safe, and effective method of labor analgesia. Poor maternal anesthesia cooperation not only influences the effect of the anesthesia but also causes serious adverse consequences,…
View article: Evaluation Mechanism of Political Discourse: A Holistic Approach
Evaluation Mechanism of Political Discourse: A Holistic Approach Open
Taking the economic issue of Trump’s First State of the Union Address (SUA) as original data, the present study examined the evaluation features of political speeches by adopting a holistic approach, which includes both macro and micro dim…
View article: Uptake of hepatitis C direct-acting antiviral treatment in China: a retrospective study from 2017 to 2021
Uptake of hepatitis C direct-acting antiviral treatment in China: a retrospective study from 2017 to 2021 Open