Jiangwei Lin
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View article: Generation of maternally semi-cloned mice
Generation of maternally semi-cloned mice Open
Semi-cloning technology has made a series of advances in studying gene function and building disease models. Maternally semi-cloned mice ( MSCM ) have completely identical maternal genome. MSCM are typically produced by injecting sperm int…
View article: Integrative Omics Reveals Rapidly Evolving Regulatory Sequences Driving Primate Brain Evolution
Integrative Omics Reveals Rapidly Evolving Regulatory Sequences Driving Primate Brain Evolution Open
Although the continual expansion of the brain during primate evolution accounts for our enhanced cognitive capabilities, the drivers of brain evolution have scarcely been explored in these ancestral nodes. Here, we performed large-scale co…
View article: Lineage-specific accelerated sequences underlying primate evolution
Lineage-specific accelerated sequences underlying primate evolution Open
Understanding the mechanisms underlying phenotypic innovation is a key goal of comparative genomic studies. Here, we investigated the evolutionary landscape of lineage-specific accelerated regions (LinARs) across 49 primate species. Genomi…
View article: DNA replication fork speed underlies cell fate changes and promotes reprogramming
DNA replication fork speed underlies cell fate changes and promotes reprogramming Open
Totipotency emerges in early embryogenesis, but its molecular underpinnings remain poorly characterized. In the present study, we employed DNA fiber analysis to investigate how pluripotent stem cells are reprogrammed into totipotent-like 2…
View article: SOX17 Is Not Required for the Derivation and Maintenance of Mouse Extraembryonic Endoderm Stem Cell Lines
SOX17 Is Not Required for the Derivation and Maintenance of Mouse Extraembryonic Endoderm Stem Cell Lines Open
SUMMARY Extraembryonic endoderm stem (XEN) cell lines can be derived and maintained in vitro and reflect the primitive endoderm cell lineage. SOX17 is thought to be required for the derivation and maintenance of mouse XEN cell lines. Here …
View article: The origin of mouse extraembryonic endoderm stem cell lines
The origin of mouse extraembryonic endoderm stem cell lines Open
Mouse extraembryonic endoderm stem (XEN) cell lines can be derived from preimplantation embryos (pre-XEN) and postimplantation embryos (post-XEN). XEN cells share a gene expression profile and cell lineage potential with primitive endoderm…
View article: PDGFRA Is Not Essential for the Derivation and Maintenance of Mouse Extraembryonic Endoderm Stem Cell Lines
PDGFRA Is Not Essential for the Derivation and Maintenance of Mouse Extraembryonic Endoderm Stem Cell Lines Open
Extraembryonic endoderm stem (XEN) cell lines can be derived and maintained in vitro and reflect the primitive endoderm lineage. Platelet-derived growth factor receptor alpha (PDGFRA) is thought to be essential for the derivation and maint…
View article: Exclusive transmission of the embryonic stem cell‐derived genome through the mouse germline
Exclusive transmission of the embryonic stem cell‐derived genome through the mouse germline Open
Summary Gene targeting in embryonic stem (ES) cells remains best practice for introducing complex mutations into the mouse germline. One aspect in this multistep process that has not been streamlined with regard to the logistics and ethics…