Xuebiao Yao
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View article: Targeting TFAP2β condensation suppresses the development of esophageal squamous cell carcinoma
Targeting TFAP2β condensation suppresses the development of esophageal squamous cell carcinoma Open
Exploring targeted therapies for esophageal squamous cell carcinoma (ESCC) remains challenging. Although investigating the roles and therapeutic applications of liquid-liquid phase separation (LLPS) is increasingly of interest, its relatio…
View article: G2c-Lineage Dominance and S1 Epitope-Glycan Drift of Porcine Epidemic Diarrhea Virus in Guangdong Province, China, 2022–2024
G2c-Lineage Dominance and S1 Epitope-Glycan Drift of Porcine Epidemic Diarrhea Virus in Guangdong Province, China, 2022–2024 Open
Porcine epidemic diarrhea (PED), a severe and highly contagious disease induced by porcine epidemic diarrhea virus (PEDV), impacts pigs across all age groups but has a particularly high lethality in neonatal piglets, with mortality rates r…
View article: Crossover patterning through condensation and coarsening of pro-crossover factors
Crossover patterning through condensation and coarsening of pro-crossover factors Open
Meiotic recombination mixes genetic information from parental genomes, creating unique combinations of alleles. During meiotic prophase, each homologue pair must undergo at least one crossover to segregate faithfully. Only a few recombinat…
View article: Digital reconstruction of full embryos during early mouse organogenesis
Digital reconstruction of full embryos during early mouse organogenesis Open
Early organogenesis is a crucial stage in embryonic development, characterized by extensive cell fate specification to initiate organ formation but also by a high susceptibility to developmental defects. Here, we profiled 285 serial sectio…
View article: Condensation-dependent multivalent interactions of EB1 and CENP-R regulate chromosome oscillations in mitosis
Condensation-dependent multivalent interactions of EB1 and CENP-R regulate chromosome oscillations in mitosis Open
Mitotic chromosomes oscillate between the spindle poles upon the establishment of bi-orientation, which is essential for chromosome alignment and subsequent synchronous segregation. However, the molecular mechanisms underlying the oscillat…
View article: Aurora B maintains spherical shape of mitotic cells via simultaneously stabilizing myosin II and vimentin
Aurora B maintains spherical shape of mitotic cells via simultaneously stabilizing myosin II and vimentin Open
Cells round up when they enter mitosis and maintain this rounded morphology until they pass the spindle assembly checkpoint during anaphase. However, the mechanisms that regulate and maintain this transient spherical state remain unclear. …
View article: Akt-elicited phosphorylation of Acapin steers cell migration
Akt-elicited phosphorylation of Acapin steers cell migration Open
Cell migration requires the generation of branched actin networks and recruitment of vesicular membrane that power the protrusion of the plasma membrane in lamellipodia. However, the molecular mechanisms underlying dynamic recruitment of v…
View article: Triple combination exposure to MPs, Pb2+ and As3+ induces ferroptosis at environmentally relevant concentrations in early development of zebrafish
Triple combination exposure to MPs, Pb2+ and As3+ induces ferroptosis at environmentally relevant concentrations in early development of zebrafish Open
There remains a substantial knowledge gap in understanding the coexistence effects of Microplastics (MPs), lead (Pb) and arsenic (As), which are ubiquitous environmental contaminants. Here, zebrafish (Danio rerio) embryos were used to inve…
View article: Standard: Human gastric organoids
Standard: Human gastric organoids Open
Organoid technology provides a transformative approach to understand human physiology and pathology, offering valuable insights for scientific research and therapeutic development. Human gastric organoids, in particular, have gained signif…
View article: Klp2-mediated Rsp1-Mto1 colocalization inhibits microtubule-dependent microtubule assembly in fission yeast
Klp2-mediated Rsp1-Mto1 colocalization inhibits microtubule-dependent microtubule assembly in fission yeast Open
Microtubule assembly takes place at the centrosome and noncentrosomal microtubule–organizing centers (MTOCs). However, the mechanisms controlling the activity of noncentrosomal MTOCs are poorly understood. Here, using the fission yeast Sch…
View article: Multivalent interactions of Septin 6 promote the establishment of epithelial cell polarity
Multivalent interactions of Septin 6 promote the establishment of epithelial cell polarity Open
Septins, components of the fourth cytoskeleton, play an indispensable role in establishing and maintaining epithelial cell polarity. However, the molecular mechanisms underlying the dynamic assembly of higher-order septin structures and th…
View article: Standard: Human gastric cancer organoids
Standard: Human gastric cancer organoids Open
Gastric cancer is one of the most common malignancies with poor prognosis. The use of organoids to simulate gastric cancer has rapidly developed over the past several years. Patient-derived gastric cancer organoids serve as in vitro models…
View article: Integrative analysis of the transcriptome, proteomics and metabolomics reveals key genes involved in the regulation of breast muscle metabolites in capons
Integrative analysis of the transcriptome, proteomics and metabolomics reveals key genes involved in the regulation of breast muscle metabolites in capons Open
Castration is widely used in poultry and livestock to enhance fat metabolism and improve the flavor, tenderness and juiciness of meat. However, the genetic regulatory mechanism underlying castration consequences have not been clarified. To…
View article: Kupffer Cell-derived IL6 Promotes Hepatocellular Carcinoma Metastasis Via the JAK1-ACAP4 Pathway
Kupffer Cell-derived IL6 Promotes Hepatocellular Carcinoma Metastasis Via the JAK1-ACAP4 Pathway Open
Tumor-associated macrophages (TAMs), which differentiate from tissue-resident macrophages, are recognized for their ability to influence cancer progression and metastasis. However, the specific role of Kupffer cells (KCs), the intrinsic ma…
View article: Machine Learning-Based Prediction Model for Depression Tendency in Chinese Elderly
Machine Learning-Based Prediction Model for Depression Tendency in Chinese Elderly Open
As global aging accelerates, the incidence of depression among the elderly has risen significantly, posing a serious threat not only to their quality of life but also to their overall physical health and well-being. While timely identifica…
View article: Phosphorylation of Lamin A/C regulates the structural integrity of the nuclear envelope
Phosphorylation of Lamin A/C regulates the structural integrity of the nuclear envelope Open
Dynamic disassembly and reconstruction of the nuclear lamina during entry and exit of mitosis, respectively, are pivotal steps in the proliferation of higher eukaryotic cells. Although numerous post-translational modifications of lamin pro…