Jiani Li
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View article: Study on Translating Subjectless Sentences in the China’s Energy Transition White Paper
Study on Translating Subjectless Sentences in the China’s Energy Transition White Paper Open
Subjectless sentences, a notable feature of Chinese, are prevalent in political texts but pose challenges in English translation due to a reliance on explicit subjects, potentially impeding cross-cultural communication. This study aims to …
View article: Advancing virulence factor prediction using protein language models
Advancing virulence factor prediction using protein language models Open
View article: Teropavimab and zinlirvimab sensitivity in people living with multidrug-resistant HIV-1: data from the PRESTIGIO Registry
Teropavimab and zinlirvimab sensitivity in people living with multidrug-resistant HIV-1: data from the PRESTIGIO Registry Open
We characterized sensitivity to teropavimab (TAB) and zinlirvimab (ZAB) in people living with four-class drug-resistant HIV (4DR-PWH). This was a multicenter, observational study using plasma or peripheral blood mononuclear cells collected…
View article: Adaptive Compound Eye Imaging Device Based on Electrowetting Liquid Aperture with Adjustable Shape
Adaptive Compound Eye Imaging Device Based on Electrowetting Liquid Aperture with Adjustable Shape Open
Artificial compound eye technology has been a research hotspot due to its advantages, including a large field of view (FOV). However, the lack of adjustability limits its applications. Here, an adaptive compound eye (ACE) imaging device ba…
View article: Prostaglandin F2α exacerbated dry eye by promoting lacrimal gland fibrosis progression through the activation of the RhoA/ROCKs signaling pathway
Prostaglandin F2α exacerbated dry eye by promoting lacrimal gland fibrosis progression through the activation of the RhoA/ROCKs signaling pathway Open
PGF2α exacerbated DE by promoting lacrimal gland fibrosis progression via the RhoA/ROCKs signaling pathway. Inhibiting PGF2α receptors effectively suppressed the progression of dry eye and lacrimal gland fibrosis, which may offer a promisi…
View article: Umbilical Cord‐Mesenchymal Stromal Cell‐Derived Extracellular Vesicles Target the Liver to Improve Neurovascular Health in Type 2 Diabetes With Non‐Alcoholic Fatty Liver Disease
Umbilical Cord‐Mesenchymal Stromal Cell‐Derived Extracellular Vesicles Target the Liver to Improve Neurovascular Health in Type 2 Diabetes With Non‐Alcoholic Fatty Liver Disease Open
Type 2 diabetes mellitus (T2DM) combined with non‐alcoholic fatty liver disease (NAFLD) exacerbates metabolic dysregulation and neurovascular complications, presenting significant therapeutic challenges. We demonstrate, using SPECT/CT imag…
View article: Astrocytic modulation of GABA transmission in the VTA limits progression of anxiety- and depression-like behaviors in adult mice
Astrocytic modulation of GABA transmission in the VTA limits progression of anxiety- and depression-like behaviors in adult mice Open
Stressors can induce anxiety and depression by altering dopaminergic neuronal activity in the ventral tegmental area (VTA). However, the precise modulation of dopaminergic neurons in response to stressors remains largely unclear. Here, we …
View article: Case Report: Kyrieleis plaques in an unusual Behcet's disease uveitis
Case Report: Kyrieleis plaques in an unusual Behcet's disease uveitis Open
Kyrieleis plaques are a rare retinal manifestation that has rarely been reported in Behcet's disease uveitis. We report the case of a 41-year-old man who presented with Behçet's disease uveitis combined with central serous chorioretinopath…
View article: Advances in recombinant Bacillus Calmette–Guérin therapy for bladder cancer from 2015 to 2024: Innovations and challenges
Advances in recombinant Bacillus Calmette–Guérin therapy for bladder cancer from 2015 to 2024: Innovations and challenges Open
Background: Non-muscle invasive bladder cancer is commonly treated by Bacillus Calmette–Guérin (BCG) therapy, but its efficacy is limited. Research into recombinant BCG (rBCG) aims to enhance its effectiveness and minimize sid…
View article: Multi-omics insights into growth and fruiting body development in the entomopathogenic fungus Cordyceps blackwelliae
Multi-omics insights into growth and fruiting body development in the entomopathogenic fungus Cordyceps blackwelliae Open
Cordyceps blackwelliae is an entomopathogenic fungus with significant potential for research and development due to its ease of cultivation. However, the lack of omics-based studies has limited our understanding of the molecular mechanisms…
View article: Mechanisms and Therapeutic Implications of EZH2 in Nasal Diseases
Mechanisms and Therapeutic Implications of EZH2 in Nasal Diseases Open
Enhancer of zeste homolog 2 (EZH2), a protein encoded by the EZH2 gene, is a crucial subunit in polycomb repressive complex 2. EZH2 controls the transcription of genes critical for cell proliferation, differentiation, amplification, and fu…
View article: Advances in the study of Ophiopogon japonicus polysaccharides: structural characterization, bioactivity and gut microbiota modulation regulation
Advances in the study of Ophiopogon japonicus polysaccharides: structural characterization, bioactivity and gut microbiota modulation regulation Open
Ophiopogon japonicus polysaccharides (OJPS), the principal bioactive constituents isolated from Ophiopogon japonicus, demonstrate substantial physiological efficacy. OJPS is characterized by a high molecular weight, typically ranging from …
View article: Mechanistic Advances in Hypoglycemic Effects of Natural Polysaccharides: Multi-Target Regulation of Glycometabolism and Gut Microbiota Crosstalk
Mechanistic Advances in Hypoglycemic Effects of Natural Polysaccharides: Multi-Target Regulation of Glycometabolism and Gut Microbiota Crosstalk Open
Natural polysaccharides (NPs), as a class of bioactive macromolecules with multitarget synergistic regulatory potential, exhibit significant advantages in diabetes intervention. This review systematically summarizes the core hypoglycemic m…
View article: Chromosome-level genome assembly of the threatened ornamental plant Hibiscus yunnanensis
Chromosome-level genome assembly of the threatened ornamental plant Hibiscus yunnanensis Open
Hibiscus yunnanensis S.Y. Hu is an endangered species of the genus Hibiscus (Malvaceae), which has high potential economic value. However, the absence of a high-quality reference genome impedes the study of the ecology and molecular biolog…
View article: Evaluation of Nano-Niclosamide in Killing Demodex folliculorum In Vitro and the Potential Application in Ocular Surface
Evaluation of Nano-Niclosamide in Killing Demodex folliculorum In Vitro and the Potential Application in Ocular Surface Open
Background/Objectives: Blepharitis is a condition often caused by Demodex folliculorum infestations, resulting in significant ocular discomfort and surface damage. Current treatments offer only temporary relief and fail to eliminate mites …
View article: Genetic Variation in a Crossing Population of Camellia oleifera Based on ddRAD Sequencing and Analysis of Association with Fruit Traits
Genetic Variation in a Crossing Population of Camellia oleifera Based on ddRAD Sequencing and Analysis of Association with Fruit Traits Open
Tea oil is an important high-quality edible oil derived from woody plants. Camellia oleifera is the largest and most widely planted oil-producing plant in the Camellia genus in China, and its seeds are the most important source for obtaini…
View article: P-2030. Remdesivir and Obeldesivir Retain Potent Activity Against SARS-CoV-2 Omicron Variants
P-2030. Remdesivir and Obeldesivir Retain Potent Activity Against SARS-CoV-2 Omicron Variants Open
Background Remdesivir (RDV), a nucleotide analog prodrug that targets the viral RNA-dependent RNA polymerase, Nsp12, is approved to treat COVID-19 in hospitalized and nonhospitalized patients. Obeldesivir (ODV), an oral mono-5’-isobutyryl …
View article: P-2025. Resistance Analyses from the Remdesivir Phase 2/3 CARAVAN Study in Pediatric and Neonatal Participants Hospitalized with COVID-19
P-2025. Resistance Analyses from the Remdesivir Phase 2/3 CARAVAN Study in Pediatric and Neonatal Participants Hospitalized with COVID-19 Open
Background Remdesivir (RDV) is a nucleotide analog prodrug approved for treatment of COVID-19. Here we present comprehensive SARS-CoV-2 resistance analyses from all cohorts of the Phase 2/3 CARAVAN study, which demonstrated the safety of R…
View article: Remdesivir and Obeldesivir Retain Potent Antiviral Activity Against SARS-CoV-2 Omicron Variants
Remdesivir and Obeldesivir Retain Potent Antiviral Activity Against SARS-CoV-2 Omicron Variants Open
As new SARS-CoV-2 variants continue to emerge, it is important to evaluate the potency of antiviral drugs to support their continued use. Remdesivir (RDV; VEKLURY®) an approved antiviral treatment for COVID-19, and obeldesivir (ODV) are in…
View article: Effects of dietary Trollius chinensis Bunge residue on performance, meat quality, antioxidant capacity, intestinal health, and cecal microbiota in weaned rabbits
Effects of dietary Trollius chinensis Bunge residue on performance, meat quality, antioxidant capacity, intestinal health, and cecal microbiota in weaned rabbits Open
The present study aimed to investigate the effects of Trollius chinensis Bunge residues (TCBR) on growth, meat quality, antioxidant capacity, intestinal healthy and cecal microbiota in weaned rabbits. In total, 48 30-day-old rabbits were r…
View article: Central Recruitment mechanism of Itch and Pain Through the Paraventricular Thalamic Nucleus in a Pathway- and Intensity-Dependent Manner
Central Recruitment mechanism of Itch and Pain Through the Paraventricular Thalamic Nucleus in a Pathway- and Intensity-Dependent Manner Open
The brain is capable of differentiating itch and pain sensations. However, how does the largely overlapped list of nuclei in itch- and pain-matrixes differentially respond to pruriceptive and nociceptive inputs remains unclear. The present…
View article: PiERF1 regulates cold tolerance in Plumbago indica L. through ethylene signalling
PiERF1 regulates cold tolerance in Plumbago indica L. through ethylene signalling Open
Ethylene is a signalling factor that plays a key role in the response of plants to abiotic stresses, such as cold stress. Recent studies have shown that the exogenous application of 1-aminocyclopropane-1-carboxylate (ACC), an ethylene prom…
View article: Epidemiological characteristics of acute viral and mycoplasma respiratory infections in Yongzhou, China: a retrospective descriptive study.
Epidemiological characteristics of acute viral and mycoplasma respiratory infections in Yongzhou, China: a retrospective descriptive study. Open
This study revealed distinct age-dependent and seasonal distribution patterns of respiratory pathogens in Yongzhou, China. The significant changes in pathogen circulation dynamics before, during, and after the COVID-19 pandemic highlight t…
View article: Phase sensitivity plasmon resonance enhanced nonlinear diffraction in a hybrid artificial molecule
Phase sensitivity plasmon resonance enhanced nonlinear diffraction in a hybrid artificial molecule Open
View article: SARS-CoV-2 resistance analyses from the Phase 3 PINETREE study of remdesivir treatment in nonhospitalized participants
SARS-CoV-2 resistance analyses from the Phase 3 PINETREE study of remdesivir treatment in nonhospitalized participants Open
Remdesivir inhibits the SARS-CoV-2 RNA-dependent RNA polymerase (RdRp; Nsp12). Here, we conducted viral resistance analyses from the Phase 3 PINETREE trial of remdesivir in nonhospitalized participants at risk of severe COVID-19. Nasophary…
View article: PiERF1 undergoes ethylene signalling and regulates cold tolerance in Plumbago indica L.
PiERF1 undergoes ethylene signalling and regulates cold tolerance in Plumbago indica L. Open
Ethylene is an essential regulatory factor in the signalling pathways involved in plant responses to abiotic stress, including cold stress, and plays a regulatory role in the cold response. Recent studies have shown that the exogenous appl…
View article: Mechanism of Astragalus polysaccharides (APS) improving myelosuppression and exerting anti-tumor effects during radiotherapy and chemotherapy
Mechanism of Astragalus polysaccharides (APS) improving myelosuppression and exerting anti-tumor effects during radiotherapy and chemotherapy Open
Chemoradiotherapy, as a routine method of anti-tumor treatment, is accompanied by severe adverse reactions such as myelosuppression. It not only hinders the treatment process but also reduces the quality of life of patients. Therefore, eff…
View article: The role and mechanism of extracellular traps in chronic rhinosinusitis
The role and mechanism of extracellular traps in chronic rhinosinusitis Open
Chronic rhinosinusitis (CRS) is a common inflammatory disease of the nose that affects millions of individuals worldwide. Recent research has introduced the concept of an immunologic endotype based on the pathological characteristics of CR…
View article: Targeting Mitochondria: Influence of Metabolites on Mitochondrial Heterogeneity
Targeting Mitochondria: Influence of Metabolites on Mitochondrial Heterogeneity Open
Mitochondria are vital organelles that provide energy for the metabolic processes of cells. These include regulating cellular metabolism, autophagy, apoptosis, calcium ions, and signaling processes. Despite their varying functions, mitocho…
View article: Psychometric validation of the Chinese version of the dry eye-related quality-of-life score questionnaire
Psychometric validation of the Chinese version of the dry eye-related quality-of-life score questionnaire Open
AIM: To psychometrically validate the Chinese version of the dry eye-related quality-of-life score questionnaire (DEQS-CHN) among Chinese patients with dry eye. METHODS: This study involved 231 participants, including 191 with dry eye dise…