Jiani Wang
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View article: Multidimensional structural-functional coupling uncovers network dysregulation and predicts binge-eating severity in bulimia nervosa
Multidimensional structural-functional coupling uncovers network dysregulation and predicts binge-eating severity in bulimia nervosa Open
View article: Lysine Acetyltransferase 6 in Health and Disease
Lysine Acetyltransferase 6 in Health and Disease Open
Lysine acetyltransferase 6 (KAT6) consists of KAT6A and its paralog KAT6B, which represent crucial regulators for epigenetic modifications. By acylating histone H3 and nonhistone proteins, KAT6 enzymes play predominant roles in transcripti…
View article: Identification and Posture Evaluation of Effective Tea Buds Based on Improved YOLOv8n
Identification and Posture Evaluation of Effective Tea Buds Based on Improved YOLOv8n Open
Aiming at the low qualification rate and high damage caused by the lack of identification, localization, and posture estimation of tea buds in the mechanical harvesting process of famous tea, a framework of lightweight detection + PCA-skel…
View article: The impact of PANoptosis-related genes on immune profiles and subtype classification in ischemic stroke
The impact of PANoptosis-related genes on immune profiles and subtype classification in ischemic stroke Open
View article: Global average socio-economic farm size may triple by 2100
Global average socio-economic farm size may triple by 2100 Open
View article: Associations between dynamic hematological indicators and outcomes in HR-positive, HER2-negative metastatic breast cancer treated with bireociclib or placebo plus fulvestrant: Findings from the BRIGHT-2 trial
Associations between dynamic hematological indicators and outcomes in HR-positive, HER2-negative metastatic breast cancer treated with bireociclib or placebo plus fulvestrant: Findings from the BRIGHT-2 trial Open
View article: Expert Consensus on Tiered Diagnosis and Treatment of Breast Cancer as a Single‐Disease Management Model in China (2025 Edition)
Expert Consensus on Tiered Diagnosis and Treatment of Breast Cancer as a Single‐Disease Management Model in China (2025 Edition) Open
Breast cancer is the most prevalent female malignancy worldwide. In 2022, China recorded approximately 357,000 new breast cancer cases and 75,000 deaths, posing a serious threat to female health. Given the “inverted pyramid” structure of C…
View article: PGC1A Restores Mitochondrial Health to Attenuate EMT During Lens Epithelial Fibrosis via Regulating TFAM
PGC1A Restores Mitochondrial Health to Attenuate EMT During Lens Epithelial Fibrosis via Regulating TFAM Open
PGC1A safeguards LECs against EMT by restoring TFAM-mediated mitochondrial energy metabolism under TGFβ2 stress, offering potential targets for the treatment of lens epithelial fibrosis.
View article: Vitamin B12, Methylmalonic Acid, and Mortality Risk in Stroke Survivors: A Prospective Cohort Study
Vitamin B12, Methylmalonic Acid, and Mortality Risk in Stroke Survivors: A Prospective Cohort Study Open
Purpose This study aims to explore the relationship between serum vitamin B12, methylmalonic acid (MMA, a marker of B12 deficiency), and mortality among stroke survivors. Methods Utilizing data from NHANES, this prospective cohort study in…
View article: Reversing the “cold” tumor microenvironment: the role of neoantigen vaccines in prostate cancer
Reversing the “cold” tumor microenvironment: the role of neoantigen vaccines in prostate cancer Open
This study contributed to an unmet therapeutic need for PCa, particularly its potential mechanisms for reversing "cold" TME, which lays the foundation for future application of neoantigen vaccine immunotherapy in prostate cancer.
View article: Association between red blood cell folate and accelerated aging in American adults: a cross-sectional study from the national health and nutrition examination survey
Association between red blood cell folate and accelerated aging in American adults: a cross-sectional study from the national health and nutrition examination survey Open
Objective The study aims to explore the relationship between red blood cell (RBC) folate concentrations and accelerated aging. Methods Data were derived from the National Health and Nutrition Examination Survey (NHANES) cycles of 2007–2010…
View article: Case Report: Hepatic sarcoidosis-like reaction from neoadjuvant pembrolizumab in early-stage triple-negative breast cancer
Case Report: Hepatic sarcoidosis-like reaction from neoadjuvant pembrolizumab in early-stage triple-negative breast cancer Open
Drug-induced sarcoidosis-like reaction (DISR) is a rare adverse event associated with immunotherapy. Currently, there is no standardized treatment protocol for DISR linked to immune checkpoint inhibitors (ICIs). This study presents a case …
View article: Clinicopathological Features and Prognostic Implications of HER2-Low in Early-Stage Male Breast Cancer: A Retrospective Analysis
Clinicopathological Features and Prognostic Implications of HER2-Low in Early-Stage Male Breast Cancer: A Retrospective Analysis Open
Background: The clinicopathological and prognostic features of HER2-low female breast cancer (BC) patients have been widely studied. Current knowledge suggests that low HER2 expression could be identified as a special entity for treatment.…
View article: Effectiveness of virtual reality assisted active limb movement exercises for patients in the respiratory intensive care unit: a randomized pilot study
Effectiveness of virtual reality assisted active limb movement exercises for patients in the respiratory intensive care unit: a randomized pilot study Open
Objective: The primary aim of this study is to compare the effectiveness of early active limb movement facilitated by virtual reality technologies with conventional exercise therapy in enhancing patient recovery in the Respiratory Intensiv…
View article: Causal relationship between bulimia nervosa and microstructural white matter: evidence from Mendelian randomization
Causal relationship between bulimia nervosa and microstructural white matter: evidence from Mendelian randomization Open
Purpose Observational studies suggest white matter (WM) microstructural anomalies are linked to bulimia nervosa (BN), but a direct causal relationship remains unestablished. This study aimed to investigate the causal impact of BN on WM mic…
View article: Theoretical Framework for Absolute Quantification in Digital Immunoassays and Advancements in Microfluidic-Free Droplet-Based Digital Immunoassay Methodologies
Theoretical Framework for Absolute Quantification in Digital Immunoassays and Advancements in Microfluidic-Free Droplet-Based Digital Immunoassay Methodologies Open
Conventional single-molecule immunoassay models, which model on a single discrete Poisson distribution, are inadequate for achieving theoretical absolute quantification of target proteins. We present a new method that models the capture of…
View article: The ideal strategies of antibody‒drug conjugate sequential treatment in HER2-expressing metastatic breast cancer: A multi-center real-world study
The ideal strategies of antibody‒drug conjugate sequential treatment in HER2-expressing metastatic breast cancer: A multi-center real-world study Open
View article: Integrated bulk and single-cell transcriptomic analysis unveiled a novel cuproptosis-related lipid metabolism gene molecular pattern and a risk index for predicting prognosis and antitumor drug sensitivity in breast cancer
Integrated bulk and single-cell transcriptomic analysis unveiled a novel cuproptosis-related lipid metabolism gene molecular pattern and a risk index for predicting prognosis and antitumor drug sensitivity in breast cancer Open
Breast cancer is the second most prevalent malignant tumor worldwide and is highly heterogeneous. Cuproptosis, a newly identified form of cell death, is intimately connected to lipid metabolism. This study investigated breast cancer hetero…
View article: Associations of Vitamin B12 and Methylmalonic Acid Levels with Mortality Risk in Patients with Preexisting Stroke: A Prospective Cohort Study
Associations of Vitamin B12 and Methylmalonic Acid Levels with Mortality Risk in Patients with Preexisting Stroke: A Prospective Cohort Study Open
Purpose: The relationship between vitamin B12, methylmalonic acid (MMA, a marker of B12 deficiency), and mortality among stroke survivors remains unclear. This study investigates the association between serum vitamin B12 and MMA levels wit…
View article: PRR13 expression as a prognostic biomarker in breast cancer: correlations with immune infiltration and clinical outcomes
PRR13 expression as a prognostic biomarker in breast cancer: correlations with immune infiltration and clinical outcomes Open
Introduction Breast cancer continues to be a primary cause of cancer-related mortality among women globally. Identifying novel biomarkers is essential for enhancing patient prognosis and informing therapeutic decisions. The PRR13 gene, ass…
View article: Fibrotic scar formation after cerebral ischemic stroke: Targeting the Sonic hedgehog signaling pathway for scar reduction
Fibrotic scar formation after cerebral ischemic stroke: Targeting the Sonic hedgehog signaling pathway for scar reduction Open
JOURNAL/nrgr/04.03/01300535-202602000-00044/figure1/v/2025-05-17T081902Z/r/image-tiff Recent studies have shown that fibrotic scar formation following cerebral ischemic injury has varying effects depending on the microenvironment. However,…
View article: Associations between sleep disturbance, treatment-related adverse events, and psychological distress in patients with breast cancer: a prospective cohort study
Associations between sleep disturbance, treatment-related adverse events, and psychological distress in patients with breast cancer: a prospective cohort study Open
Background: This study aimed to explore the relationship between sleep disturbance, treatment-related adverse events, and psychological distress in Chinese patients with breast cancer. Methods: This prospective cohort study reported on 300…
View article: Dynamic Hematological Indicators Predict the Efficacy of Cdk4/6 Inhibitors in Hr-Positive, Her2-Negative Metastatic Breast Cancer: An Exploratory Analysis of the Bright-2 Trial
Dynamic Hematological Indicators Predict the Efficacy of Cdk4/6 Inhibitors in Hr-Positive, Her2-Negative Metastatic Breast Cancer: An Exploratory Analysis of the Bright-2 Trial Open
View article: Response of Maturity, Humification, and Gaseous Emissions to Initial Moisture Content in Collaborative Composting of Multiple Organic Solid Wastes
Response of Maturity, Humification, and Gaseous Emissions to Initial Moisture Content in Collaborative Composting of Multiple Organic Solid Wastes Open
View article: Association of quality of life in older patients with breast cancer: a cross-sectional study from China
Association of quality of life in older patients with breast cancer: a cross-sectional study from China Open
Objectives The purpose of this study was to investigate the quality of life (QoL) of older Chinese patients with breast cancer and to explore further the associations of functions, symptoms, financial burdens and comorbidities with global …
View article: Spatiotemporal Distribution and Influence Mechanisms of Antimony Species in Atmospheric and Soil Media of Eastern China's Coastal Urban Areas
Spatiotemporal Distribution and Influence Mechanisms of Antimony Species in Atmospheric and Soil Media of Eastern China's Coastal Urban Areas Open
View article: Enhancing early enamel lesion management: Effects of silver-strontium co-doped mesoporous bioactive glass on remineralization and antibacterial activity
Enhancing early enamel lesion management: Effects of silver-strontium co-doped mesoporous bioactive glass on remineralization and antibacterial activity Open
View article: A Theoretical Framework for Absolute Quantification in Digital Immunoassays and the Advancements in Droplet-Based Digital Immunoassay Methodologies
A Theoretical Framework for Absolute Quantification in Digital Immunoassays and the Advancements in Droplet-Based Digital Immunoassay Methodologies Open
Conventional single-molecule immunoassay models, which model on a single discrete Poisson distribution, are inadequate for achieving theoretical absolute quantification of target proteins. We introduce a novel approach that models the capt…
View article: Spatial and Single-Cell Analyses Reveal the Pro-Invasiveness Role of NUAK1 in Breast Cancer through EMT Regulation
Spatial and Single-Cell Analyses Reveal the Pro-Invasiveness Role of NUAK1 in Breast Cancer through EMT Regulation Open
Objective Breast carcinoma is a leading malignancy in women, and the role of Novel (nua) kinase family 1 (NUAK1) in its progression is not well-defined. This study aimed to investigate the biological significance of NUAK1 in breast cancer …
View article: Development of Absolute Quantification Methods for Digital Immunoassays: Theoretical Framework and Establishment of Droplet-Based Digital Immunoassay Techniques
Development of Absolute Quantification Methods for Digital Immunoassays: Theoretical Framework and Establishment of Droplet-Based Digital Immunoassay Techniques Open
This paper analyzes the current digital Immunoassays techniques and their theoretical foundations. Traditional single-molecule immunoassay models based on a single discrete Poisson distribution cannot explain or achieve absolute quantifica…