Explanipedia

Biomaterials‐driven stem cell therapy for tissue repair and functional rehabilitation after ischemic stroke Open

Mengjie Wang, Yuanyuan Ran, Jianshen Liang, Fanglei Li, Ning Li , et al. · 2025

Ischemic stroke is a serious cerebrovascular disease with limited effective treatments. While stem cell therapy shows promise, ensuring cell survival and integration into neural networks remains a challenge. Recent research shows tissue en…

High frequency chest wall oscillation vs. oscillation and lung expansion on lung recruitment in hypersecretive mechanically ventilated patients: a randomized crossover study Open

Hao Wang, Yi Li, Guangyu Niu, Jianing Xi, Hongying Jiang · 2024

Oscillation and lung expansion (OLE) is a pneumatic noninvasive physiotherapy technique that delivers aerosolized medication with continuous positive expiratory pressure and continuous high-frequency oscillation in a cyclic manner. A recen…

Corrigendum: PI-YOLO: dynamic sparse attention and lightweight convolutional based YOLO for vessel detection in pathological images Open

Cong Li, Shuanlong Che, Haotian Gong, Youde Ding, Yizhou Luo , et al. · 2024

[This corrects the article DOI: 10.3389/fonc.2024.1347123.].

Corrigendum: PI-YOLO: dynamic sparse attention and lightweight convolutional based YOLO for vessel detection in pathological images Open

Cong Li, Shuanlong Che, Haotian Gong, Youde Ding, Yizhou Luo , et al. · 2024

[This corrects the article DOI: 10.3389/fonc.2024.1347123.].

Curcumin loaded hydrogel with double ROS-scavenging effect regulates microglia polarization to promote poststroke rehabilitation Open

Shulei Zhang, Yuanyuan Ran, Yerasel Tuolhen, Yufei Wang, Guiqin Tian , et al. · 2024

Cyclodextrins are used to include curcumin to form complex, which is subsequently loaded into a reactive oxygen species (ROS) responsive hydrogel (Cur gel). This gel exhibits a dual ROS scavenging effect. The gel can neutralize extracellul…

PI-YOLO: dynamic sparse attention and lightweight convolutional based YOLO for vessel detection in pathological images Open

Cong Li, Shuanlong Che, Haotian Gong, Youde Ding, Yizhou Luo , et al. · 2024

Vessel density within tumor tissues strongly correlates with tumor proliferation and serves as a critical marker for tumor grading. Recognition of vessel density by pathologists is subject to a strong inter-rater bias, thus limiting its pr…

Prefrontal activation in response to a plantar contact task under open and closed eye conditions in patients with cerebral infarction Open

Zhiquan Yang, Meng-Fan Wei, Jianing Xi · 2023

Objective This study investigates the effect of a bilateral (paralyzed side, healthy side) plantar contact task on dorsolateral prefrontal activation in patients recovering from cerebral infarction under open and closed eye conditions. Met…

Tannic acid as building block constructing injectable hydrogel and regulating microglial phenotype to enhance neuroplasticity for post-stroke rehabilitation Open

Zongjian Liu, Shulei Zhang, Yuanyuan Ran, Huimin Geng, Fuhai Gao , et al. · 2023

Background Stroke is the second leading cause of mortality and disability in the world. Post-stroke rehabilitation is still unsatisfactory in clinics, which brings giant pains and economic burdens to stroke patients. In this study, an inje…

Scientometric and Visualized Analysis of Intravoxel Incoherent Motion Magnetic Resonance Imaging: 1988-2021 Open

Youwei Li, Yuan‐Fang Zhang, Honglin Shang, Qiang Gao, Qiping Wen , et al. · 2023

BACKGROUND Despite an increasing number of published articles on intravoxel incoherent motion (IVIM) in the past decade, almost all have focused on the technique and clinical applications of IVIM, with little attention to the collective kn…

Nanoarchitectonics of tannic acid based injectable hydrogel regulate the microglial phenotype to enhance neuroplasticity for poststroke rehabilitation Open

Zongjian Liu, Shulei Zhang, Yuanyuan Ran, Huimin Geng, Fuhai Gao , et al. · 2023

Background Stroke is the second leading cause of mortality and disability worldwide. Poststroke rehabilitation is still unsatisfactory in clinics, which brings great pain and economic burdens to stroke patients. In this study, an injectabl…

Chest physiotherapy guided by electrical impedance tomography in high-dependency unit patients with pulmonary diseases: an introduction of methodology and feasibility Open

Qing Li, Yi Li, Guangyu Niu, Mingna Li, Jia Deng , et al. · 2023

Predictive Value of Exercise Blood Pressure Changes for Orthostatic Hypotension in Patients With Parkinson’s Disease Open

Yi Qin, Zhaohui Jin, Zhen-ying Zhang, Ke-ke Chen, Xin Yu , et al. · 2023

This study has identified predictive factors for OH development in patients with PD. CPET could be used as a complementary examination to identify patients at a high risk of OH.

Lacunes may worsen cognition but not motor function in Parkinson's disease Open

Keke Chen, Zhaohui Jin, Jinping Fang, Qi Lin, Cui Liu , et al. · 2022

Background As one of the imaging markers of cerebral small vessel disease, lacunes has received little attention. The objective of this study was to investigate the associations of lacunes, cognition and motor function in patients with Par…

Circular RNAs in Parkinson’s Disease: Reliable Biological markers and targets for Rehabilitation Open

Yinan Duan, Yixuan Wang, Yonghong Liu, Zhaohui Jin, Cui Liu , et al. · 2022

In clinical practice, the underlying pathogenesis of Parkinson’s disease (PD) remains unknown. Circular RNAs (circRNAs) have good biological properties and can be used as biological marker. Rehabilitation as a third treatment alongside dru…

Research progress in the application of motor-cognitive dual-task training in rehabilitation of walking function in stroke patients Open

Zhiquan Yang, Meng-Fan Wei, Lin Chen, Jianing Xi · 2022

Restoration of walking ability in stroke patients is the basis for their return to their families and society. Motor-cognitive dual-task training (MCDTT) can effectively strengthen the functional network connection between motor and cognit…

Impact of Exercise Training at Different Intensity Levels on Cardiac Function and Exercise Capacity in Patients with Chronic Heart Failure: A Prospective Cohort Study Open

Zhenying Zhang, Lizhong Wang, Jianing Xi, Xiaojing Sun, Xing‐Guo Sun · 2022

Objective: To investigate training at different intensity levels on cardiac function, exercise capacity, and health-related quality of life in patients with chronic heart failure.Methods: This prospective cohort study enrolled patients wit…

Research trends and hotspot analysis of age-related hearing loss from a bibliographic perspective Open

Qingjia Cui, Na Chen, Cheng Wen, Jianing Xi, Lihui Huang · 2022

Background Up-to-date information about the trends of age-related hearing loss (ARHL) and how this varies between countries is essential to plan for an adequate health-system response. Therefore, this study aimed to assess the research hot…

Effect of multimodal strategy on patients with cervical vertigo: A retrospective study Open

Lihua Zhang, Huaqing Yang, Li-Xin Mi, Jianing Xi · 2022

Extracellular Vesicles-Encapsulated miR-153-3p Potentiate the Survival and Invasion of Lung Adenocarcinoma Open

Hongli Cao, Ping Zhang, Hong Yu, Jianing Xi · 2022

Abnormal Pulmonary Function in Early Parkinson’s Disease: A Preliminary Prospective Observational Study Open

Chenxi Zhang, Jia Deng, Yi Li, Guangyu Niu, Mingna Li , et al. · 2022

Quality of life predicts rehabilitation prognosis in Parkinson's disease patients Open

Detao Meng, Zhaohui Jin, Keke Chen, Xin Yu, Yixuan Wang , et al. · 2022

Background Rehabilitation has been reported to improve the quality of life (QoL) of patients with Parkinson's disease (PD). Nevertheless, not all patients are satisfied with rehabilitation outcomes and could achieve a significant improveme…

Design and Fabrication of Polymeric Hydrogel Carrier for Nerve Repair Open

Xiaoyu Ma, Mengjie Wang, Yuanyuan Ran, Yusi Wu, Jin Wang , et al. · 2022

Nerve regeneration and repair still remain a huge challenge for both central nervous and peripheral nervous system. Although some therapeutic substances, including neuroprotective agents, clinical drugs and stem cells, as well as various g…

The Role of the Diaphragm in Postural Stability and Visceral Function in Parkinson’s Disease Open

Xin Yu, Hongying Jiang, Chenxi Zhang, Zhaohui Jin, Lei Gao , et al. · 2021

Background: In normal subjects, the diaphragm plays a key functional role in postural stability, articulation, respiration, defecation, and urination. Objectives: The aim of this study was to investigate the role of the diaphragm in postur…

New Insights Into the Roles of Microglial Regulation in Brain Plasticity-Dependent Stroke Recovery Open

Fang Yu, Tingting Huang, Yuanyuan Ran, Da Li, Lin Ye , et al. · 2021

Stroke remains the leading cause of long-term disability worldwide with significant long-term sequelae. However, there is no highly effective treatment to enhance post-stroke recovery despite extensive efforts in exploring rehabilitative t…

C-Gait for Detecting Freezing of Gait in the Early to Middle Stages of Parkinson’s Disease: A Model Prediction Study Open

Ziyan Chen, Hongjiao Yan, Qi Lin, Qiaoxia Zhen, Cui Liu , et al. · 2021

Graphical Abstract Patients with early- to middle-stage PD (Hoehn and Yahr stages 1–3) were enrolled for C-Gait assessment and traditional walking ability assessments. The correlation of C-Gait assessment and traditional walking tests were…

Curcumin Ameliorates White Matter Injury after Ischemic Stroke by Inhibiting Microglia/Macrophage Pyroptosis through NF‐<i>κ</i>B Suppression and NLRP3 Inflammasome Inhibition Open

Yuanyuan Ran, Wei Su, Fuhai Gao, Zitong Ding, Shui-Qing Yang , et al. · 2021

NLRP3 inflammasome‐mediated pyroptosis is a proinflammatory programmed cell death pathway, which plays a vital role in functional outcomes after stroke. We previously described the beneficial effects of curcumin against stroke‐induced neur…

Ultralight hybrid silica aerogels derived from supramolecular hydrogels self-assembled from insoluble nano building blocks Open

Zongjian Liu, Ling Liu, Zheng-Gen Zhong, Yuanyuan Ran, Jianing Xi , et al. · 2021

Physical hydrogels self-assembled from GO and SiO₂–NH₂ nanoparticles are observed, and they could be transferred into corresponding ultralow density aerogels.

Melatonin Protects Against Ischemic Brain Injury by Modulating PI3K/AKT Signaling Pathway via Suppression of PTEN Activity Open

Yuanyuan Ran, Lin Ye, Zitong Ding, Fuhai Gao, Shui-Qing Yang , et al. · 2021

Stroke is one of the leading causes of death and disability worldwide with limited therapeutic options. Melatonin can attenuate ischemic brain damage with improved functional outcomes. However, the cellular mechanisms of melatonin-driven n…

Biomechanical Evaluation of Preoperative Rehabilitation in Patients of Anterior Cruciate Ligament Injury Open

Wei Li, Zhongli Li, Shuyan Qie, Ji Li, Jianing Xi , et al. · 2020

Objectives To investigate the biomechanical characteristics of patients with anterior cruciate ligament (ACL) injury by gait analysis, surface electromyography (SEMG), and proprioception test, and provide rehabilitation suggestions accordi…

Candesartan modulates microglia activation and polarization via NF-κB signaling pathway Open

Shuyan Qie, Yuanyuan Ran, Xiaosheng Lu, Wei Su, Wei Li , et al. · 2020

Microglia are diverse cells that acquire different functional phenotypes in response to microenvironment in which they reside. Several transcriptional regulators have been identified that regulate different microglia phenotypes. They are m…

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