Jianing Yan
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View article: Biological roles and potential clinical value of tRNA-derived small RNAs in gastrointestinal malignancies
Biological roles and potential clinical value of tRNA-derived small RNAs in gastrointestinal malignancies Open
tRNA-derived small RNAs (tsRNAs) are small RNA fragments generated from tRNA molecules or their precursors through cleavage by enzymes such as Dicer. As noncoding small RNAs, tsRNAs have important biological functions, including regulating…
View article: Case Report: Novel endoscopic characteristics of early-stage autoimmune gastritis from two cases: the fog is lifting
Case Report: Novel endoscopic characteristics of early-stage autoimmune gastritis from two cases: the fog is lifting Open
With the development of research, the clinical characteristics of autoimmune gastritis (AIG) have become much clearer. However, due to its occult endoscopic appearance, it remains difficult to diagnose early, including ultra-early AIG. Mor…
View article: Biological roles and potential clinical values of snoRNAs in Cancer
Biological roles and potential clinical values of snoRNAs in Cancer Open
Small nucleolar RNAs (snoRNAs), a class of intron-derived non-coding RNAs, primarily localize within the nucleolus and Cajal bodies. Based on conserved structural motifs and associated RNA modification functions, snoRNAs are classified int…
View article: Small non-coding RNAs: key regulatory factors and potential therapeutic targets in tumor immunity
Small non-coding RNAs: key regulatory factors and potential therapeutic targets in tumor immunity Open
Tumor immunity has emerged as a focal point for cancer research. Although tumor immunotherapy represents a promising approach to cancer treatment, its effectiveness is often hindered by the heterogeneity of the tumor microenvironment (TME)…
View article: Comprehensive analysis of Mendelian randomization and scRNA-seq identify key prognostic genes and relevant functional roles in colorectal cancer
Comprehensive analysis of Mendelian randomization and scRNA-seq identify key prognostic genes and relevant functional roles in colorectal cancer Open
The prognosis of advanced CRC is poor, and identifying key genes related to CRC is vital for improving CRC prognosis. Our research used univariate Cox analysis and Mendelian randomization (MR) analysis to identify key prognostic genes in C…
View article: Dynamic Evolution of Hyperplastic Polyps in the Setting of Autoimmune Gastritis: An In-Depth Interpretation of Gastrin-Driven Patho-mechanisms in a Case
Dynamic Evolution of Hyperplastic Polyps in the Setting of Autoimmune Gastritis: An In-Depth Interpretation of Gastrin-Driven Patho-mechanisms in a Case Open
Through longitudinal clinical follow-up of a 75-year-old male with autoimmune gastritis (AIG) complicated by gastric hyperplastic polyps (GHPs), this study systematically investigated the critical regulatory role of gastrin signaling netwo…
View article: Comprehensive analysis of scRNA-seq and bulk RNA-seq data via machine learning and bioinformatics reveals the role of lysine metabolism-related genes in gastric carcinogenesis
Comprehensive analysis of scRNA-seq and bulk RNA-seq data via machine learning and bioinformatics reveals the role of lysine metabolism-related genes in gastric carcinogenesis Open
View article: Comprehensive pan-cancer analysis indicates key gene of p53-independent apoptosis is a novel biomarker for clinical application and chemotherapy in colorectal cancer
Comprehensive pan-cancer analysis indicates key gene of p53-independent apoptosis is a novel biomarker for clinical application and chemotherapy in colorectal cancer Open
Background Schlafen11 (SLFN11) is a key gene in p53-independent apoptosis through ribosome stalling; however, systematic research has been conducted on its role in the tumor immune microenvironment, clinical application, and immunotherapy …
View article: Downregulated STAT3 and STAT5B are prognostic biomarkers for colorectal cancer and are associated with immune infiltration
Downregulated STAT3 and STAT5B are prognostic biomarkers for colorectal cancer and are associated with immune infiltration Open
View article: Weighted Gene Coexpression Network Analysis Identifies Neutrophil-Related Molecular Subtypes and Their Clinical Significance in Gastric Cancer
Weighted Gene Coexpression Network Analysis Identifies Neutrophil-Related Molecular Subtypes and Their Clinical Significance in Gastric Cancer Open
We identified two neutrophil-related molecular GC subtypes with different prognostic outcomes and clinical significance. VIM, RBMS1 and RGS2 were identified as potential prognostic markers and therapeutic targets for GC. These findings pro…
View article: Molecular subtype of gastric cancer based on apoptosis-related genes reveals differential immune microenvironment and intratumoral microorganisms distribution
Molecular subtype of gastric cancer based on apoptosis-related genes reveals differential immune microenvironment and intratumoral microorganisms distribution Open
Our study conducted a comprehensive analysis of the molecular characteristics of ARGs in GC, revealed their association with the tumor immune microenvironment and intratumoral microorganisms. These findings provide new ideas for the molecu…
View article: Biological functions and molecular mechanisms of exosome-derived circular RNAs and their clinical implications in digestive malignancies: the vintage in the bottle
Biological functions and molecular mechanisms of exosome-derived circular RNAs and their clinical implications in digestive malignancies: the vintage in the bottle Open
We summarize the update of digestive malignancies associated exo-circRNAs in biogenesis, biological functions, molecular mechanisms, clinical implications, potential applications and experimental technique in order to effectively promote t…
View article: Membrane RRM2-positive cells represent a malignant population with cancer stem cell features in intrahepatic cholangiocarcinoma
Membrane RRM2-positive cells represent a malignant population with cancer stem cell features in intrahepatic cholangiocarcinoma Open
View article: Machine learning to establish three sphingolipid metabolism genes signature to characterize the immune landscape and prognosis of patients with gastric cancer
Machine learning to establish three sphingolipid metabolism genes signature to characterize the immune landscape and prognosis of patients with gastric cancer Open
View article: Analysis of Helicobacter pylori resistance in patients with different gastric diseases
Analysis of Helicobacter pylori resistance in patients with different gastric diseases Open
View article: Clinical Significance of Disulfidptosis-related Genes and Functional Analysis in Gastric Cancer
Clinical Significance of Disulfidptosis-related Genes and Functional Analysis in Gastric Cancer Open
Background: Worldwide, gastric cancer (GC) remains intractable due to its poor prognosis and high morbidity and mortality. Disulfidptosis is a novel kind of cell death mediated by abnormal accumulation of intracellular disulphides. …
View article: Clinical significance and potential application of cuproptosis-related genes in gastric cancer
Clinical significance and potential application of cuproptosis-related genes in gastric cancer Open
Esophageal cancer (EC) is one of the most common digestive system malignancies in the world. The combined modality treatment of EC is usually surgery and radiation therapy, however, its clinical efficacy for advanced patients is relatively…
View article: Identification of novel prognostic circRNA biomarkers in circRNA-miRNA-mRNA regulatory network in gastric cancer and immune infiltration analysis
Identification of novel prognostic circRNA biomarkers in circRNA-miRNA-mRNA regulatory network in gastric cancer and immune infiltration analysis Open
View article: Antibiotic resistance in <i>Helicobacter pylori</i>: From potential biomolecular mechanisms to clinical practice
Antibiotic resistance in <i>Helicobacter pylori</i>: From potential biomolecular mechanisms to clinical practice Open
Increasing rates of Helicobacter pylori resistance are associated with multiple clinical challenges. Bacterial factors linked to H. pylori resistance are mutations, efflux pumps, and biofilms. Gene mutations such as nucleic acid synthesis‐…
View article: Identification of novel prognostic biomarkers in the TF-enhancer-target regulatory network in hepatocellular carcinoma and immune infiltration analysis
Identification of novel prognostic biomarkers in the TF-enhancer-target regulatory network in hepatocellular carcinoma and immune infiltration analysis Open
Background: Hepatocellular carcinoma (HCC) remains notorious for its high malignancy, poor prognosis and high mortality. The exploration of novel therapeutic agents for HCC has remained challenging due to its complex aetiology. Therefore, …
View article: Clinical significance and potential application of cuproptosis-related genes in gastric cancer
Clinical significance and potential application of cuproptosis-related genes in gastric cancer Open
Worldwide, gastric cancer (GC) is a common lethal solid malignancy with a poor prognosis. Cuproptosis is a novel kind of cell death mediated by protein lipoylation and the relationship between cuprotosis and GC prognosis. We estimated the …
View article: Research Progress of Machine Learning and Deep Learning in Intelligent Diagnosis of the Coronary Atherosclerotic Heart Disease
Research Progress of Machine Learning and Deep Learning in Intelligent Diagnosis of the Coronary Atherosclerotic Heart Disease Open
The coronary atherosclerotic heart disease is a common cardiovascular disease with high morbidity, disability, and societal burden. Early, precise, and comprehensive diagnosis of the coronary atherosclerotic heart disease is of great signi…
View article: Biological and clinical implications of hsa_circ_0086720 in gastric cancer and its clinical application
Biological and clinical implications of hsa_circ_0086720 in gastric cancer and its clinical application Open
Background Circular RNAs (circRNAs) are thought to be vital participants in carcinogenesis and have the characteristics of being stable, specific, and well conserved. However, their clinical significance and application value in gastric ca…
View article: High expression of the ferroptosis‐associated MGST1 gene in relation to poor outcome and maladjusted immune cell infiltration in uterine corpus endometrial carcinoma
High expression of the ferroptosis‐associated MGST1 gene in relation to poor outcome and maladjusted immune cell infiltration in uterine corpus endometrial carcinoma Open
Background Uterine corpus endometrial carcinoma (UCEC) tightly correlates with dysregulated iron homeostasis. MGST1 (microsomal glutathione S‐transferase 1) involves in the regulation of oxidative stress and plays a key role in inhibiting …
View article: Signet ring cell carcinoma hidden beneath large pedunculated colorectal polyp: A case report
Signet ring cell carcinoma hidden beneath large pedunculated colorectal polyp: A case report Open
This case highlights the importance of paying attention to the malignancy of large pedunculated polyps. Polyps or adenomas removed via endoscopy must be evaluated histologically. Even if adenomas may be fragile, endoscopy doctors sh…
View article: Biological roles and potential clinical values of circular RNAs in gastrointestinal malignancies
Biological roles and potential clinical values of circular RNAs in gastrointestinal malignancies Open
Circular RNAs (circRNAs), a class of endogenous RNA molecules, are produced by alternative splicing of precursor RNA and are covalently linked at the 5' and 3' ends. Recent studies have revealed that dysregulated circRNAs are closely relat…