Jianji Pan
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View article: Integrated Multi-Omics Analysis Identifies SRI as a Critical Target Promoting Gastric Cancer Progression and Associated with Poor Prognosis
Integrated Multi-Omics Analysis Identifies SRI as a Critical Target Promoting Gastric Cancer Progression and Associated with Poor Prognosis Open
Background: We aimed to identify key molecular drivers of gastric cancer progression and poor prognosis by integrating multi-omics analyses with experimental validation. Methods: Single-cell RNA-seq data were clustered to delineate major c…
View article: MRI and 18F-BPA PET-guided targeting in boron neutron capture therapy
MRI and 18F-BPA PET-guided targeting in boron neutron capture therapy Open
In modern Boron neutron capture therapy (BNCT) treatment planning, 18F-BPA (18F-boronophenylalanine) PET (positron emission tomography) imaging is used to assess boron uptake and guide accurate dose delivery. This stu…
View article: Burden of laryngeal cancer attributable to occupational asbestos exposure in China: A comprehensive analysis from 1990 to 2021
Burden of laryngeal cancer attributable to occupational asbestos exposure in China: A comprehensive analysis from 1990 to 2021 Open
Background Laryngeal cancer attributable to occupational asbestos exposure remains a significant public health concern, particularly in industrialized regions. This study analyzes the burden, trends, and contributing factors of laryngeal c…
View article: L‑type amino acid transporter 1 in enhancing boron neutron capture therapy: Mechanisms, challenges and future directions (Review)
L‑type amino acid transporter 1 in enhancing boron neutron capture therapy: Mechanisms, challenges and future directions (Review) Open
L‑type amino acid transporter 1 (LAT1) has emerged as a critical molecular target for advancing boron neutron capture therapy (BNCT), a promising treatment that leverages selective boron accumulation and neutron irradiation to eradicate ca…
View article: Application of a proven treatment planning system for accelerator-based boron neutron capture therapy
Application of a proven treatment planning system for accelerator-based boron neutron capture therapy Open
This study introduces NeuMANTA (Multifunctional Arithmetic for Neutron Transportation Analysis), a dedicated treatment planning system (TPS) developed for accelerator-based boron neutron capture therapy (AB-BNCT). NeuMANTA integrates Monte…
View article: L-shape association between serum chloride and 365-day mortality in critically ill patients with sepsis based on the MIMIC-IV database
L-shape association between serum chloride and 365-day mortality in critically ill patients with sepsis based on the MIMIC-IV database Open
View article: Genomic Landscape and Clinical Relevance in Chinese Patients With Upper Tract Urothelial Carcinoma
Genomic Landscape and Clinical Relevance in Chinese Patients With Upper Tract Urothelial Carcinoma Open
PURPOSE Upper tract urothelial carcinoma (UTUC) is one of the common urothelial cancers. Although large cohorts have illustrated spectrum of germline mutations, landscape of somatic alterations has not been revealed in Chinese patients wit…
View article: Deep learning-based quantification of tumor-infiltrating lymphocytes as a prognostic indicator in nasopharyngeal carcinoma: multicohort findings
Deep learning-based quantification of tumor-infiltrating lymphocytes as a prognostic indicator in nasopharyngeal carcinoma: multicohort findings Open
The TILDL percentage derived from H&E-stained WSIs effectively stratifies risk in nonmetastatic NPC and may serve as a biomarker in metastatic NPC treated with ICB, aiding in patient selection for individualized treatment.
View article: Inhibition of Mettl3 alleviates low-dose cisplatin-induced renal fibrosis and enhances the chemotherapeutic efficacy in mouse models of cancer
Inhibition of Mettl3 alleviates low-dose cisplatin-induced renal fibrosis and enhances the chemotherapeutic efficacy in mouse models of cancer Open
Cisplatin (CDDP), a commonly utilized anti-tumor drug, leads to acute kidney injury (AKI) and chronic kidney disease (CKD). The mechanisms and therapeutic approaches for injury in AKI have been extensively studied, but the mechanisms resul…
View article: Numerical Simulation of Ship Wave Characteristics Under Different Navigation Conditions in the Restricted Waterway of the Pinglu Canal
Numerical Simulation of Ship Wave Characteristics Under Different Navigation Conditions in the Restricted Waterway of the Pinglu Canal Open
The Pinglu Canal is a strategic inland restricted waterway under construction in southwest China. Its ship wave superposition characteristics under conditions of high-density shipping and large ships may threaten navigation safety, but lit…
View article: A preliminary exploration of a predictive model and nomogram for the efficacy of compound digestive enzyme therapy based on serum (PGI, PGII, VIP, and PRDX1) in patients with functional dyspepsia
A preliminary exploration of a predictive model and nomogram for the efficacy of compound digestive enzyme therapy based on serum (PGI, PGII, VIP, and PRDX1) in patients with functional dyspepsia Open
The therapeutic effect prediction model of compound digestive enzyme base on serum PGI, PGII, VIP, PRDX1 in patients with FD has some clinical value, but it still need to be further verified by large sample size and multi-center study.
View article: International Consensus Guideline on Delineation of the Clinical Target Volumes at Different Dose Levels for Nasopharyngeal Carcinoma (2024 Version)
International Consensus Guideline on Delineation of the Clinical Target Volumes at Different Dose Levels for Nasopharyngeal Carcinoma (2024 Version) Open
Amidst the challenges of diverging practices, a comprehensive consensus guideline has been devised based on updated evidence and collective agreement among international experts. This serves as a practical reference for optimal target cove…
View article: Preliminary Survey of Graded Diagnosis and Treatment of Rehabilitation Outpatients and Influencing Factors for Downward Referral in Haikou Area
Preliminary Survey of Graded Diagnosis and Treatment of Rehabilitation Outpatients and Influencing Factors for Downward Referral in Haikou Area Open
View article: Genetic association analysis of lipid-lowering drug target genes in chronic kidney disease
Genetic association analysis of lipid-lowering drug target genes in chronic kidney disease Open
Objective The impact of lipid-lowering medications on chronic kidney disease (CKD) remains a subject of debate. This Mendelian randomization (MR) study aims to elucidate the potential effects of lipid-lowering drug targets on CKD developme…
View article: Efficacy analysis of prophylactic hyperthermic intraperitoneal chemotherapy in patients with locally advanced gastric cancer: a retrospective study
Efficacy analysis of prophylactic hyperthermic intraperitoneal chemotherapy in patients with locally advanced gastric cancer: a retrospective study Open
Purpose This study aims to evaluate the effectiveness and safety of prophylactic hyperthermic intraperitoneal chemotherapy (P-HIPEC) in patients with locally advanced gastric cancer (AGC) after laparoscopic radical gastrectomy. Additionall…
View article: Involvement of USP7 in aggravating Kawasaki disease by promoting TGFβ2 signaling mediated endothelial-mesenchymal transition and coronary artery remodeling
Involvement of USP7 in aggravating Kawasaki disease by promoting TGFβ2 signaling mediated endothelial-mesenchymal transition and coronary artery remodeling Open
View article: Automatic knee osteoarthritis severity grading based on X-ray images using a hierarchical classification method
Automatic knee osteoarthritis severity grading based on X-ray images using a hierarchical classification method Open
View article: The impact of Prophylactic cranial irradiation on the prognosis of patients with limited-stage small cell lung cancer in the MRI era
The impact of Prophylactic cranial irradiation on the prognosis of patients with limited-stage small cell lung cancer in the MRI era Open
In this study, PCI significantly reduced the incidence of BM in patients with limited-stage SCLC who were evaluated as CR and PR after CRT, but it has no significantly positive impact on overall survival in CR patients. Further prospective…
View article: Long-term trends and future projections of larynx cancer burden in China: a comprehensive analysis from 1990 to 2030 using GBD data
Long-term trends and future projections of larynx cancer burden in China: a comprehensive analysis from 1990 to 2030 using GBD data Open
View article: P111 Interlesional response heterogeneity on paired PSMA and FDG PET strongly associated with conventional progression-free survival in metastatic castration resistant prostate cancer treated with abiraterone: A prospective study
P111 Interlesional response heterogeneity on paired PSMA and FDG PET strongly associated with conventional progression-free survival in metastatic castration resistant prostate cancer treated with abiraterone: A prospective study Open
View article: Feasibility of mNGS in joint replacement patients exhibiting elevated ESR and CRP levels without an underlying diagnosis
Feasibility of mNGS in joint replacement patients exhibiting elevated ESR and CRP levels without an underlying diagnosis Open
View article: The impact of prophylactic cranial irradiation on the prognosis of patients with limited-stage small cell lung cancer in the MRI era
The impact of prophylactic cranial irradiation on the prognosis of patients with limited-stage small cell lung cancer in the MRI era Open
Purposes: To evaluate the impact of Prophylactic cranial irradiation (PCI) on the prognosis of patients with limited-stage small cell lung cancer (SCLC) in the era of MRI surveillance. Methods: Limited-stage SCLC patients recruited in a pr…
View article: Ninth Version of the AJCC and UICC Nasopharyngeal Cancer TNM Staging Classification
Ninth Version of the AJCC and UICC Nasopharyngeal Cancer TNM Staging Classification Open
Importance Accurate staging is a fundamental step in treating patients with nasopharyngeal carcinoma (NPC) worldwide; this is crucial not only for prognostication, but also for guiding treatment decisions. The American Joint Committee on C…
View article: International Recommendations on Postoperative Management for Potentially Resectable Locally Recurrent Nasopharyngeal Carcinoma
International Recommendations on Postoperative Management for Potentially Resectable Locally Recurrent Nasopharyngeal Carcinoma Open
View article: Plasma Epstein-Barr virus microRNA BART8-3p as a potential biomarker for detection and prognostic prediction in early nasopharyngeal carcinoma
Plasma Epstein-Barr virus microRNA BART8-3p as a potential biomarker for detection and prognostic prediction in early nasopharyngeal carcinoma Open
View article: Risk-adapted locoregional radiotherapy strategies based on a prognostic nomogram for de novo metastatic nasopharyngeal carcinoma patients treated with chemoimmunotherapy
Risk-adapted locoregional radiotherapy strategies based on a prognostic nomogram for de novo metastatic nasopharyngeal carcinoma patients treated with chemoimmunotherapy Open
View article: Development of the Ninth Version of the Nasopharyngeal Cancer TNM Staging System by the American Joint Committee on Cancer and Union for International Cancer Control (AJCC/UICC): Recommendations Based on a Multicenter Validation Study and Clinical Considerations
Development of the Ninth Version of the Nasopharyngeal Cancer TNM Staging System by the American Joint Committee on Cancer and Union for International Cancer Control (AJCC/UICC): Recommendations Based on a Multicenter Validation Study and Clinical Considerations Open
View article: STING Agonist‐Loaded Nanoparticles Promotes Positive Regulation of Type I Interferon‐Dependent Radioimmunotherapy in Rectal Cancer
STING Agonist‐Loaded Nanoparticles Promotes Positive Regulation of Type I Interferon‐Dependent Radioimmunotherapy in Rectal Cancer Open
Hypoxia‐associated radioresistance in rectal cancer (RC) has severely hampered the response to radioimmunotherapy (iRT), necessitating innovative strategies to enhance RC radiosensitivity and improve iRT efficacy. Here, a catalytic radiose…
View article: Toripalimab Plus Chemotherapy for Recurrent or Metastatic Nasopharyngeal Carcinoma
Toripalimab Plus Chemotherapy for Recurrent or Metastatic Nasopharyngeal Carcinoma Open
Importance There are currently no therapies approved by the US Food and Drug Administration for nasopharyngeal carcinoma (NPC). Gemcitabine-cisplatin is the current standard of care for the first-line treatment of recurrent or metastatic N…
View article: Methylglyoxal from gut microbes boosts radiosensitivity and radioimmunotherapy in rectal cancer by triggering endoplasmic reticulum stress and cGAS-STING activation
Methylglyoxal from gut microbes boosts radiosensitivity and radioimmunotherapy in rectal cancer by triggering endoplasmic reticulum stress and cGAS-STING activation Open
Background Preoperative radiation therapy (preRT) is a fundamental aspect of neoadjuvant treatment for rectal cancer (RC), but the response to this treatment remains unsatisfactory. The combination of radiation therapy (RT) and immunothera…