Jianpeng Xue
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View article: The role of medicinal Cu<sup>2+</sup> salts in expanding the multi-pathway application of tigecycline against drug-resistant bacteria
The role of medicinal Cu<sup>2+</sup> salts in expanding the multi-pathway application of tigecycline against drug-resistant bacteria Open
Tetracyclines are highly susceptible to photolysis, causing pollution in water, land and other ecosystems, as well as posing threats to human health. In this study, we found that only tigecycline and minocycline reduce the antibacterial ac…
View article: Molecular mechanism of crisaborole combined with erythromycin against methicillin-resistant Staphylococcus aureus in vivo and in vitro
Molecular mechanism of crisaborole combined with erythromycin against methicillin-resistant Staphylococcus aureus in vivo and in vitro Open
The widespread presence of methicillin-resistant Staphylococcus aureus (MRSA) severely threatens convenient therapeutic options in the postantibiotic era. The use of combinations of existing drugs at this stage may be a viable strategy for…
View article: Tunicamycin and β-Lactams with Five Membered Ring Structures Have Stronger Synergistic Effects Against Gram-Positive Bacteria
Tunicamycin and β-Lactams with Five Membered Ring Structures Have Stronger Synergistic Effects Against Gram-Positive Bacteria Open
Objective: The prevalence of antimicrobial resistance is increasing among gram-positive bacteria, particularly the resistance of methicillin-resistant Staphylococcus aureus (MRSA) to β-lactam antibiotics. Methods: Checkerboard minimum inhi…
View article: Efficient Immune Shield: Biomimetic Nanovaccine of Acinetobacter Baumannii Recombinant Outer Membrane Protein W
Efficient Immune Shield: Biomimetic Nanovaccine of Acinetobacter Baumannii Recombinant Outer Membrane Protein W Open
Background The development of vaccines is an effective and safe strategy to combat multidrug-resistant (MDR) Acinetobacter baumannii (A. baumannii) infections. This study aimed to prepare a DC-targeting multiepitope peptide biomimetic nano…
View article: A Multiepitope Peptide, rOmp22, Encapsulated in Chitosan-PLGA Nanoparticles as a Candidate Vaccine Against Acinetobacter baumannii Infection
A Multiepitope Peptide, rOmp22, Encapsulated in Chitosan-PLGA Nanoparticles as a Candidate Vaccine Against Acinetobacter baumannii Infection Open
CS-PLGA-rOmp22 NPs elicited specific IgG antibodies, Th1 cellular immunity and protection against acute lethal intratracheal A. baumannii challenge. Our results indicate that this nanovaccine is a desirable candidate for preventing …
View article: Identifying metastatic ability of prostate cancer cell lines using native fluorescence spectroscopy and machine learning methods
Identifying metastatic ability of prostate cancer cell lines using native fluorescence spectroscopy and machine learning methods Open
View article: A Multi-epitope Peptide rOmp22 Encapsulated in Chitosan-PLGA Nanoparticles as Vaccine Candidate Against Acinetobacter baumannii Infection
A Multi-epitope Peptide rOmp22 Encapsulated in Chitosan-PLGA Nanoparticles as Vaccine Candidate Against Acinetobacter baumannii Infection Open
Background: Development of vaccine is a promising and cost-effective strategy to prevent emerging multi-drug resistant (MDR) Acinetobacter baumannii infections. The purpose of this study was to prepare a multi-epitope peptide nanovaccine a…
View article: <p>Combined administration of PTX and S-HM-3 in TPGS/Solutol micelle system for oncotarget therapy</p>
Combined administration of PTX and S-HM-3 in TPGS/Solutol micelle system for oncotarget therapy Open
TPGS and Solutol micelles hold promising potential to resolve the conundrum of combined therapy of cytotoxic drug and angiogenesis inhibitor with different physicochemical property and anticancer mechanism in clinical use.
View article: Recombination of a dual-CAR-modified T lymphocyte to accurately eliminate pancreatic malignancy
Recombination of a dual-CAR-modified T lymphocyte to accurately eliminate pancreatic malignancy Open
A novel type of CAR-T cells, termed dCAR-T, was designed with specific activities, that is, significant cytotoxicity for two antigen-positive tumor cells yet no cytotoxicity for single antigen-positive tumor cells. Dual-targeted CAR-T cell…
View article: Accurate control of dual-receptor-engineered T cell activity through a bifunctional anti-angiogenic peptide
Accurate control of dual-receptor-engineered T cell activity through a bifunctional anti-angiogenic peptide Open
View article: Gold nanoparticle-based beacon to detect STAT5b mRNA expression in living cells: a case optimized by bioinformatics screen
Gold nanoparticle-based beacon to detect STAT5b mRNA expression in living cells: a case optimized by bioinformatics screen Open
Messenger RNA (mRNA), a single-strand ribonucleic acid with functional gene information is usually abnormally expressed in cancer cells and has become a promising biomarker for the study of tumor progress. Hairpin DNA-coated gold nanoparti…
View article: Tunable Ultrasmall Visible-to-Extended Near-Infrared Emitting Silver Sulfide Quantum Dots for Integrin-Targeted Cancer Imaging
Tunable Ultrasmall Visible-to-Extended Near-Infrared Emitting Silver Sulfide Quantum Dots for Integrin-Targeted Cancer Imaging Open
The large size of many near-infrared (NIR) fluorescent nanoparticles prevents rapid extravasation from blood vessels and subsequent diffusion to tumors. This confines in vivo uptake to the peritumoral space and results in high liver retent…