Jianping Tong
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View article: Spatiotemporal Immune Dynamics in Experimental Retinal Ganglion Cell Injury Models
Spatiotemporal Immune Dynamics in Experimental Retinal Ganglion Cell Injury Models Open
Background The damage and regeneration of retinal ganglion cells (RGCs) have been extensively studied. Among them, immune cells in different parts of the visual pathway play an important role in injury, regeneration and repair, but a compr…
View article: Macular epiretinal membrane in high myopia: timing and prognosis of pars plana vitrectomy surgery
Macular epiretinal membrane in high myopia: timing and prognosis of pars plana vitrectomy surgery Open
AIM: To investigate the outcomes and prognosis of macular epiretinal membrane (ERM) after pars plana vitrectomy (PPV) in patients with high myopia (HM), focusing on the optimal timing of surgery and its impact on prognosis. METHODS: The cl…
View article: Efficacy and Safety of Efdamrofusp Alfa with Personalized Dosing Intervals in Neovascular Age-Related Macular Degeneration: A Phase II Trial
Efficacy and Safety of Efdamrofusp Alfa with Personalized Dosing Intervals in Neovascular Age-Related Macular Degeneration: A Phase II Trial Open
Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.
View article: The correlation between intraocular pressure and choroidal microcirculation in patients with high myopia
The correlation between intraocular pressure and choroidal microcirculation in patients with high myopia Open
Background: High myopia (HM) is a leading cause of visual impairment worldwide and the choroid plays a key role in HM progression. Intraocular pressure (IOP) may also be involved in HM development, while the relationship between IOP…
View article: The ROS/AKT/S6K axis induces corneal epithelial dysfunctions under LED blue light exposure
The ROS/AKT/S6K axis induces corneal epithelial dysfunctions under LED blue light exposure Open
In recent years, concerns have escalated regarding eye health problems arising from Light-emitting diode (LED), which emits high-energy blue light (BL), potentially causing corneal epithelial dysfunctions (CEpD). Nevertheless, the mechanis…
View article: Uncovering the role of ferroptosis in Bietti crystalline dystrophy and potential therapeutic strategies
Uncovering the role of ferroptosis in Bietti crystalline dystrophy and potential therapeutic strategies Open
View article: Establishment of in-hospital nutrition support program for middle-aged and elderly patients with acute decompendated heart failure
Establishment of in-hospital nutrition support program for middle-aged and elderly patients with acute decompendated heart failure Open
View article: Methylation in cornea and corneal diseases: a systematic review
Methylation in cornea and corneal diseases: a systematic review Open
View article: Characterization of Retinal VIP-Amacrine Cell Development During the Critical Period
Characterization of Retinal VIP-Amacrine Cell Development During the Critical Period Open
Retinal vasoactive intestinal peptide amacrine cells (VIP-ACs) play an important role in various retinal light-mediated pathological processes related to different developmental ocular diseases and even mental disorders. It is important to…
View article: Metabolomics in Myopia Implies: Amino Acid Metabolism is a New Research Direction
Metabolomics in Myopia Implies: Amino Acid Metabolism is a New Research Direction Open
View article: Mechanistic insights into the alterations and regulation of the AKT signaling pathway in diabetic retinopathy
Mechanistic insights into the alterations and regulation of the AKT signaling pathway in diabetic retinopathy Open
In the early stages of diabetic retinopathy (DR), diabetes-related hyperglycemia directly inhibits the AKT signaling pathway by increasing oxidative stress or inhibiting growth factor expression, which leads to retinal cell apoptosis, nerv…
View article: Blue light impairs cornea and corneal wound healing by downregulating VCAM1 partly
Blue light impairs cornea and corneal wound healing by downregulating VCAM1 partly Open
View article: Retinal Microstructure Based on Optical Coherence Tomography Predicts Visual Prognosis in Diabetic Macular Edema with Extended Intraretinal Cysts and Subretinal Fluid.
Retinal Microstructure Based on Optical Coherence Tomography Predicts Visual Prognosis in Diabetic Macular Edema with Extended Intraretinal Cysts and Subretinal Fluid. Open
Purpose We investigated the association between the retinal microstructure on optical coherence tomography (OCT) and the visual outcomes of diabetic macular edema (DME) with extended intraretinal cysts (IRCs) (maximum diameter ≥ 200 μm) an…
View article: Correlation analysis of aqueous humor metabolomics with myopic axial length and choroidal parameters
Correlation analysis of aqueous humor metabolomics with myopic axial length and choroidal parameters Open
Background To explore differential metabolites in the aqueous humor of patients with different axial lengths and their correlations with axial length and choroidal parameters. Methods In this study, we included 12 patients with axial lengt…
View article: Blue light exposure promotes reactive oxygen stress, apoptosis and suppresses viability, migration and wound healing of cornea via inhibiting PI3K/AKT signaling pathway in corneal epithelial cells.
Blue light exposure promotes reactive oxygen stress, apoptosis and suppresses viability, migration and wound healing of cornea via inhibiting PI3K/AKT signaling pathway in corneal epithelial cells. Open
Background Blue light (400 nm -480 nm), is a main source of eye damage emitted by light-emitting diodes (LEDs). Excessive blue light exposure has been shown to cause damage in cornea. This study aimed to investigate the effects of blue lig…
View article: Long-term blue light exposure impairs mitochondrial dynamics in the retina in light-induced retinal degeneration in vivo and in vitro
Long-term blue light exposure impairs mitochondrial dynamics in the retina in light-induced retinal degeneration in vivo and in vitro Open
Long-term light exposure, especially in the spectrum of blue light, frequently causes excessive oxidative stress in dry age-related macular degeneration (AMD). Here, to gain insight into the underlying mechanism, we focused on mitochondria…
View article: Blue light attenuates TGF-β2-induced epithelial-mesenchymal transition in human lens epithelial cells via autophagy impairment
Blue light attenuates TGF-β2-induced epithelial-mesenchymal transition in human lens epithelial cells via autophagy impairment Open
Background Pathogenesis of posterior capsular opacification (PCO) was related to pathological epithelial-mesenchymal transition (EMT) of lens epithelial cells (LECs). It has been reported that blue light could have an effect on EMT. This s…
View article: Functions of retinal astrocytes and Müller cells in mammalian myopia
Functions of retinal astrocytes and Müller cells in mammalian myopia Open
Background Changes in the retina and choroid blood vessels are regularly observed in myopia. However, if the retinal glial cells, which directly contact blood vessels, play a role in mammalian myopia is unknown. We aimed to explore the pot…
View article: Blue light attenuates TGF-β2-induced epithelial-mesenchymal transition in human lens epithelial cells via autophagy impairment
Blue light attenuates TGF-β2-induced epithelial-mesenchymal transition in human lens epithelial cells via autophagy impairment Open
Background: Pathogenesis of posterior capsular opacification (PCO) was related to pathological epithelial-mesenchymal transition (EMT) of lens epithelial cells (LECs). It has been reported that blue light could have an effect on EMT. This …
View article: A Review of Intraocular Pressure (IOP) and Axial Myopia
A Review of Intraocular Pressure (IOP) and Axial Myopia Open
The pathogenesis of myopia is driven by genetic and environmental risk factors. Accommodation not only alters the curvature and shape of the lens but also involves contraction of the ciliary and extraocular muscles, which influences intrao…
View article: The role of the PI3K/AKT signalling pathway in the corneal epithelium: recent updates
The role of the PI3K/AKT signalling pathway in the corneal epithelium: recent updates Open
View article: Long-Term Blue Light Exposure Impairs the Mitochondrial Dynamics of Retina in the Age-Related Macular Degeneration in Vivo and in Vitro
Long-Term Blue Light Exposure Impairs the Mitochondrial Dynamics of Retina in the Age-Related Macular Degeneration in Vivo and in Vitro Open
View article: MicroRNA-Expression Profiling in Myopia: A Meta-Analysis and Systematic Review
MicroRNA-Expression Profiling in Myopia: A Meta-Analysis and Systematic Review Open
Background: Myopia (nearsightedness) is currently the most common human eye disorder, worldwide. In the recent years, several studies have addressed the role of microRNAs (miRNAs) in the pathogenesis of myopia. Objectiv…
View article: The effects of colour and temporal frequency of flickering light on variability of the accommodation response in emmetropes and myopes
The effects of colour and temporal frequency of flickering light on variability of the accommodation response in emmetropes and myopes Open
View article: Retinal glial cells under hypoxia possibly function in mammalian myopia by responding to mechanical stimuli, affecting hormone metabolism and peptide secretion
Retinal glial cells under hypoxia possibly function in mammalian myopia by responding to mechanical stimuli, affecting hormone metabolism and peptide secretion Open
Purpose Changes in the retina and the choroid blood vessels are regularly observed in myopia. The aim of this study is to test if the retinal glial cells, which directly contact blood vessels, play a role in mammalian myopia. Method We ada…
View article: Investigating a downstream gene of <i>Gpnmb</i> using the systems genetics method.
Investigating a downstream gene of <i>Gpnmb</i> using the systems genetics method. Open
These results suggest that Stc1 may be a downstream candidate of Gpnmb, and that both genes interact with other genes in a network to develop glaucoma pathogenesis through mechanisms such as apoptosis and oxidative stress.
View article: A review of combined phacoemulsification and endoscopic cyclophotocoagulation: efficacy and safety
A review of combined phacoemulsification and endoscopic cyclophotocoagulation: efficacy and safety Open
As cataract occurs frequently in patients with glaucoma, combining phacoemulsification and endoscopic cyclophotocoagulation has been gaining attention recently due to its minimally invasive nature. A variety of studies had evaluated the ef…
View article: Pembrolizumab in patients with advanced/metastatic acral lentiginous melanoma
Pembrolizumab in patients with advanced/metastatic acral lentiginous melanoma Open
View article: Posterior chamber collagen copolymer phakic intraocular lens with a central hole for moderate-to-high myopia
Posterior chamber collagen copolymer phakic intraocular lens with a central hole for moderate-to-high myopia Open
The purpose of this article is to evaluate the clinical outcomes of a posterior chamber phakic intraocular lens (pIOL) (Visian Implantable Collamer Lens V4c) for the correction of moderate to high myopia in Chinese eyes.The article is desi…
View article: Association of the polymorphism Y402H in the <scp>CFH</scp> gene with response to anti‐<scp>VEGF</scp> treatment in age‐related macular degeneration: a systematic review and meta‐analysis
Association of the polymorphism Y402H in the <span>CFH</span> gene with response to anti‐<span>VEGF</span> treatment in age‐related macular degeneration: a systematic review and meta‐analysis Open
To explore whether the complement factor H ( CFH ) polymorphism rs1061170/Y402H is associated with responsiveness to antivascular endothelial growth factor ( VEGF ) agents in age‐related macular degeneration ( AMD ). We reviewed the Englis…