Jianping Zhao
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View article: Quantitative Computed Tomographic Clusters in C‐BIOPRED Asthma Cohort: Association with Sputum Proteomics
Quantitative Computed Tomographic Clusters in C‐BIOPRED Asthma Cohort: Association with Sputum Proteomics Open
Severe asthma exhibits heterogeneity in airflow obstruction, driven by airway remodeling and air trapping, which can be noninvasively assessed via quantitative computed tomography (qCT). This study aimed to identify asthma phenotypes by cl…
View article: Ribonucleotide reductase M1 regulates the cell cycle via minichromosome maintenance proteins
Ribonucleotide reductase M1 regulates the cell cycle via minichromosome maintenance proteins Open
View article: Physics-informed machine learning-based real-time long-horizon temperature fields prediction in metallic additive manufacturing
Physics-informed machine learning-based real-time long-horizon temperature fields prediction in metallic additive manufacturing Open
Real-time long-horizon temperature prediction in wire arc additive manufacturing is critical for process control and quality assurance. However, finite element methods are computationally expensive, and the existing data-driven models suff…
View article: A Marfan-Associated FBN1 Nonsense Mutation Mouse Model Reveals Adventitial Inflammation During Aneurysm Progression
A Marfan-Associated FBN1 Nonsense Mutation Mouse Model Reveals Adventitial Inflammation During Aneurysm Progression Open
Marfan syndrome (MFS) is a genetic disorder caused by mutations in fibrillin-1(FBN1) , which encodes FBN1, a key structural component of the extracellular matrix. Mutations in FBN1 influence the severity of aortic disease and therapeutic r…
View article: Six1 promotes alveolar epithelium senescence in pulmonary fibrosis through regulating Tp53
Six1 promotes alveolar epithelium senescence in pulmonary fibrosis through regulating Tp53 Open
Idiopathic pulmonary fibrosis (IPF) is a deadly respiratory condition distinguished by gradual fibrotic restructuring and diminishing pulmonary capacity, with cellular senescence serving as a critical factor in its pathogenesis. This study…
View article: ISG15 deficiency in hepatic stellate cells promotes TGFβ2-induced liver fibrosis by counteracting CREB1 ISGylation
ISG15 deficiency in hepatic stellate cells promotes TGFβ2-induced liver fibrosis by counteracting CREB1 ISGylation Open
Background Interferon (IFN)-stimulated gene 15 (ISG15) is a downstream molecule of the IFN pathways central to many cellular processes. ISG15 mainly exerts its function through a post-translational modification process known as ISGylation.…
View article: Exploring the gut microbiota associated with peripheral nerve invasion in colorectal cancer patients and constructing predictive models
Exploring the gut microbiota associated with peripheral nerve invasion in colorectal cancer patients and constructing predictive models Open
In the PNI and NPNI groups, 35 gut microbiota species exhibited significant variations in abundance. The differential intestinal microbiota associated with PNI in colorectal cancer may modulate the neuroinvasion process via a variety of po…
View article: The MFGE8/integrin β3 axis mitigates experimental neutrophilic asthma by suppressing NLRP3-Caspase-1 pathway-mediated NETosis
The MFGE8/integrin β3 axis mitigates experimental neutrophilic asthma by suppressing NLRP3-Caspase-1 pathway-mediated NETosis Open
Not applicable.
View article: Upregulated Hexokinase-2 in Airway Epithelium Regulates Apoptosis and Drives Inflammation in Asthma via Peptidylprolyl Isomerase F
Upregulated Hexokinase-2 in Airway Epithelium Regulates Apoptosis and Drives Inflammation in Asthma via Peptidylprolyl Isomerase F Open
Hexokinase catalyzes the first rate-limiting step glycolysis. However, the roles of hexokinase 2 (HK2) in asthma remain incompletely understood. This study aimed to investigate metabolic alterations in asthma, focusing on the expression, f…
View article: Comparative Evaluation of Spray-Drying Versus Freeze-Drying Techniques on the Encapsulation Efficiency and Biofunctional Performance of Chenpi Extract Microcapsules
Comparative Evaluation of Spray-Drying Versus Freeze-Drying Techniques on the Encapsulation Efficiency and Biofunctional Performance of Chenpi Extract Microcapsules Open
Chenpi extracts (CPEs) are highly valued for their rich bioactive compounds and distinctive aromatic properties, but their environmental sensitivity poses stability challenges in food applications. In this study, CPE microcapsules were fab…
View article: Oxytocin improves maternal licking behavior deficits in autism-associated Shank3 mutant dogs
Oxytocin improves maternal licking behavior deficits in autism-associated Shank3 mutant dogs Open
View article: From ‘buzz’ to ‘re’nao’: atmospheric encounters and sensory landscapes in urban night markets
From ‘buzz’ to ‘re’nao’: atmospheric encounters and sensory landscapes in urban night markets Open
View article: Effect of Oral estrogen on overactive bladder in women: A research based on NHANES and network pharmacology
Effect of Oral estrogen on overactive bladder in women: A research based on NHANES and network pharmacology Open
Overactive Bladder (OAB), characterized by urinary urgency with frequency and nocturia, affects approximately 12 % of the adult female population's quality of life. Estrogen, known for its role in modulating lower urinary tract function, i…
View article: Uncovering dark mass in population proteomics: Pan-analysis of single amino acid polymorphism relevant to cognition and aging
Uncovering dark mass in population proteomics: Pan-analysis of single amino acid polymorphism relevant to cognition and aging Open
Human proteome data across populations have been analyzed extensively to reveal protein quantitative associations with physiological or pathological states, while the single amino acid polymorphism (SAP) has been rarely investigated. In th…
View article: Short-term starvation boosts anti-PD-L1 therapy by reshaping tumor-associated macrophages in hepatocellular carcinoma
Short-term starvation boosts anti-PD-L1 therapy by reshaping tumor-associated macrophages in hepatocellular carcinoma Open
Background and Aims: Immune checkpoint inhibitors have revolutionized systemic HCC treatment. Nevertheless, numerous patients are refractory to immune checkpoint inhibitor therapy. It is currently unknown whether diet therapies such as sho…
View article: Synthesis of Butyrolactam and Ε-Caprolactone Copolymer by Anionic Ring-Opening Polymerization with Melting Processability and Bio-Degradation
Synthesis of Butyrolactam and Ε-Caprolactone Copolymer by Anionic Ring-Opening Polymerization with Melting Processability and Bio-Degradation Open
View article: Novel Study for Energy-saving Strategy of BTMS using Transient Simulation under Extreme Condition
Novel Study for Energy-saving Strategy of BTMS using Transient Simulation under Extreme Condition Open
View article: Synthesis of Butyrolactam and Ε-Caprolactone Copolymer by Anionic Ring-Opening Polymerization with Melting Processability and Bio-Degradation
Synthesis of Butyrolactam and Ε-Caprolactone Copolymer by Anionic Ring-Opening Polymerization with Melting Processability and Bio-Degradation Open
View article: Molecular Profile of Micropapillary Urothelial Carcinoma of the Urinary Bladder: An Analysis of 99 Cases by Next-Generation Sequencing
Molecular Profile of Micropapillary Urothelial Carcinoma of the Urinary Bladder: An Analysis of 99 Cases by Next-Generation Sequencing Open
View article: The Effect of WC Particle Contents on Strengthening Mechanism and Properties of Fe/Al-Based Composites by Plasma Cladding
The Effect of WC Particle Contents on Strengthening Mechanism and Properties of Fe/Al-Based Composites by Plasma Cladding Open
View article: Impact of Housing Characteristics and Indoor Environmental Factors on Chronic Obstructive Pulmonary Disease: Findings from the China Pulmonary Health (Cph) Study
Impact of Housing Characteristics and Indoor Environmental Factors on Chronic Obstructive Pulmonary Disease: Findings from the China Pulmonary Health (Cph) Study Open
View article: The Effect of Wc Particle Contents on Strengthening Mechanism and Properties of Fe/Al-Based Composites by Plasma Cladding
The Effect of Wc Particle Contents on Strengthening Mechanism and Properties of Fe/Al-Based Composites by Plasma Cladding Open
View article: Knowledge, attitude, and practice toward oral health management among orthodontic patients: a cross-sectional study
Knowledge, attitude, and practice toward oral health management among orthodontic patients: a cross-sectional study Open
The majority of orthodontic patients demonstrated adequate knowledge, positive attitudes, and proactive practices toward oral health management. Nonetheless, continuous education is still essential for certain groups, such as recently fitt…
View article: The impact of dexamethasone on short- and long-term mortality in hospitalized COVID-19 patients: a retrospective study
The impact of dexamethasone on short- and long-term mortality in hospitalized COVID-19 patients: a retrospective study Open
View article: Impact of systemic therapy on clinical T1 small-cell neuroendocrine carcinoma of the bladder
Impact of systemic therapy on clinical T1 small-cell neuroendocrine carcinoma of the bladder Open
View article: High-quality genome of black wolfberry (<i>Lycium ruthenicum</i> Murr.) provides insights into the genetics of anthocyanin biosynthesis regulation
High-quality genome of black wolfberry (<i>Lycium ruthenicum</i> Murr.) provides insights into the genetics of anthocyanin biosynthesis regulation Open
Black wolfberry (Lycium ruthenicum Murr.) is an important plant for ecological preservation. In addition, its fruits are rich in anthocyanins and have important edible and medicinal value. However, a high-quality chromosome-level genome fo…
View article: Novel insights into the role of immunomodulatory extracellular vesicles in the pathogenesis of liver fibrosis
Novel insights into the role of immunomodulatory extracellular vesicles in the pathogenesis of liver fibrosis Open
View article: CREB3 suppresses hepatocellular carcinoma progression by depressing AKT signaling through competitively binding with insulin receptor and transcriptionally activating RNA‐binding motif protein 38
CREB3 suppresses hepatocellular carcinoma progression by depressing AKT signaling through competitively binding with insulin receptor and transcriptionally activating RNA‐binding motif protein 38 Open
cAMP responsive element binding protein 3 (CREB3), belonging to bZIP family, was reported to play multiple roles in various cancers, but its role in hepatocellular carcinoma (HCC) is still unclear. cAMP responsive element binding protein 3…
View article: Defining Global Benchmarks for Laparoscopic Right Posterior Sectionectomy/H67
Defining Global Benchmarks for Laparoscopic Right Posterior Sectionectomy/H67 Open
Objective: We aimed to establish global benchmark outcomes indicators for L-RPS/H67. Background: Minimally invasive liver resections has seen an increase in uptake in recent years. Over time, challenging procedures as laparoscopic right po…
View article: Kynurenine acts as a signaling molecule to attenuate pulmonary fibrosis by enhancing the AHR-PTEN axis
Kynurenine acts as a signaling molecule to attenuate pulmonary fibrosis by enhancing the AHR-PTEN axis Open
Our studies not only highlighted a critical role of Trp metabolism in PF pathogenesis, but also provided compelling evidence suggesting that Kyn could serve as a promising metabolite against PF.