Jianping Zuo
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View article: Discovery of a Novel Non‐Nucleoside Inhibitor of RNA‐Dependent RNA Polymerase Against Dengue Virus
Discovery of a Novel Non‐Nucleoside Inhibitor of RNA‐Dependent RNA Polymerase Against Dengue Virus Open
Dengue virus (DENV) is an acute infectious pathogen worldwide, for which no effective therapeutics are available. The RNA‐dependent RNA polymerase (RdRp) displays an important role during DENV replication and is therefore a promising targe…
View article: A novel coupled progressive corrosion–water hammer inrush model for deep coal seam floors
A novel coupled progressive corrosion–water hammer inrush model for deep coal seam floors Open
View article: Modeling and Dynamic Simulation of a Hybrid Wind-Wave System on a Hexagonal Semi-Submersible Platform
Modeling and Dynamic Simulation of a Hybrid Wind-Wave System on a Hexagonal Semi-Submersible Platform Open
Offshore renewable energy systems offer promising solutions for sustainable power generation, yet most existing platforms harvest either wind or wave energy in isolation. This study presents a hybrid floating offshore platform that integra…
View article: A nitrogen-containing diphyllin derivative C156-P1 exhibited broad-spectrum antiviral activity against <i>Flaviviridae</i> viruses by preventing endosomal acidification
A nitrogen-containing diphyllin derivative C156-P1 exhibited broad-spectrum antiviral activity against <i>Flaviviridae</i> viruses by preventing endosomal acidification Open
Dengue virus (DENV) represents a significant public health threat, with its four serotypes estimated to account for approximately 96 million symptomatic infections annually. Currently, there are no antiviral agents available for the preven…
View article: Effects of pores and inclusions on the elastoplastic behaviors of heterogeneous rock-like materials at same scale
Effects of pores and inclusions on the elastoplastic behaviors of heterogeneous rock-like materials at same scale Open
View article: Permeability of granite from a shallow buried mountain pipe gallery tunnel under unloading confining pressure
Permeability of granite from a shallow buried mountain pipe gallery tunnel under unloading confining pressure Open
The rock mass within mountain tunnels undergoes complex changes in permeability, strength, and deformation during tunneling excavation. The comprehensive pipe gallery tunnel for the 2022 Winter Olympics buried in Haituo Mountain experience…
View article: Sources spatial localization algorithm and applications of rock failure acoustic emission
Sources spatial localization algorithm and applications of rock failure acoustic emission Open
View article: ComplexVCoder: An LLM-Driven Framework for Systematic Generation of Complex Verilog Code
ComplexVCoder: An LLM-Driven Framework for Systematic Generation of Complex Verilog Code Open
Recent advances have demonstrated the promising capabilities of large language models (LLMs) in generating register-transfer level (RTL) code, such as Verilog. However, existing LLM-based frameworks still face significant challenges in acc…
View article: Investigation on Mechanical Response and Fracture Behavior of Initially Damaged Shale Based on Multi-Level Pb-Gbm Method
Investigation on Mechanical Response and Fracture Behavior of Initially Damaged Shale Based on Multi-Level Pb-Gbm Method Open
View article: Structural Optimization of Phthalazine Derivatives for Anti-Hbv Activities to Improve Oral Bioavailability
Structural Optimization of Phthalazine Derivatives for Anti-Hbv Activities to Improve Oral Bioavailability Open
View article: Reinforcement learning-based maintenance scheduling for a stochastic deteriorating fuel cell considering stack-to-stack heterogeneity
Reinforcement learning-based maintenance scheduling for a stochastic deteriorating fuel cell considering stack-to-stack heterogeneity Open
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View article: Failure mechanisms of roadways with non-coplanar axial direction and stress space: True triaxial test and mechanical analysis
Failure mechanisms of roadways with non-coplanar axial direction and stress space: True triaxial test and mechanical analysis Open
The axial direction of a roadway often forms a certain spatial angle with the in-situ stress field. Variations in the spatial angles can lead to differences in the stress environment in which the roadway is exposed. Different forms of fail…
View article: Fractional creep damage constitutive model of weakly cemented soft rock under unloading confining pressure
Fractional creep damage constitutive model of weakly cemented soft rock under unloading confining pressure Open
View article: Microstructure effect of mechanical and cracking behaviors on brittle rocks using image-based fast Fourier transform method
Microstructure effect of mechanical and cracking behaviors on brittle rocks using image-based fast Fourier transform method Open
The internal microstructures of rock materials, including mineral heterogeneity and intrinsic microdefects, exert a significant influence on their nonlinear mechanical and cracking behaviors. It is of great significance to accurately chara…
View article: Enhancing mechanical performance and crack morphology of engineered cementitious composites through tailoring coral sand
Enhancing mechanical performance and crack morphology of engineered cementitious composites through tailoring coral sand Open
Seawater coral aggregate concrete (SCAC) development has effectively addressed the issues of raw material shortage and construction period delay in the construction of remote islands and reefs. In the present study, seawater coral sand eng…
View article: Linear fractal evolution characteristics of rock crack distributions during loading process
Linear fractal evolution characteristics of rock crack distributions during loading process Open
View article: Asymmetric analogous hyperbola model of overburden movement and its verification
Asymmetric analogous hyperbola model of overburden movement and its verification Open
The extraction of underground coal resources induces the fracture and movement of overlying strata, leading to geological hazards such as surface deformation, cracks, and even subsidence. Utilizing the analogous hyperbola model of overlyin…
View article: Mechanism of principal stress rotation and deformation failure behavior induced by excavation in roadways
Mechanism of principal stress rotation and deformation failure behavior induced by excavation in roadways Open
The failure modes of rock after roadway excavation are diverse and complex. A comprehensive investigation of the internal stress field and the rotation behavior of the stress axis in roadways is essential for elucidating the mechanism of r…
View article: A novel concrete-filled flange steel tubular composite supports for tunnels: A numerical perspective
A novel concrete-filled flange steel tubular composite supports for tunnels: A numerical perspective Open
In this study, a new type of concrete-filled flange steel tubular composite support (referred to as a concrete-filled flange steel composite support) was designed to address the inadequate bending load-bearing performance of concrete-fille…
View article: Flexural Capacity of the Normal Sections of Concrete Beams Strengthened with Corrugated Steel Plates
Flexural Capacity of the Normal Sections of Concrete Beams Strengthened with Corrugated Steel Plates Open
To explore the law of load-carrying performance enhancement of concrete beams reinforced with corrugated steel plates (CSPs), three groups of controlled bending tests were conducted on five beam specimens. The load-bearing capacity of conc…
View article: Oseltamivir (Tamiflu), a Commonly Prescribed Antiviral Drug, Mitigates Hearing Loss in Mice
Oseltamivir (Tamiflu), a Commonly Prescribed Antiviral Drug, Mitigates Hearing Loss in Mice Open
Hearing loss affects up to 10% of all people worldwide, but currently there is only one FDA-approved drug for its prevention in a subgroup of cisplatin-treated pediatric patients. Here, we performed an unbiased screen of 1,300 FDA-approved…
View article: A new layered rock constitutive model incorporating confining pressure and bedding angle weights based on orthogonal matrix analysis
A new layered rock constitutive model incorporating confining pressure and bedding angle weights based on orthogonal matrix analysis Open
Under the combined influences of confining pressure, lithology and bedding, the deformation and failure characteristics of layered rocks become more complex posing a significant challenge in safe underground excavations. In this study, two…
View article: Effects of Normal Stress on Shear Properties and Acoustic Emission Characteristics of Bonded Rock-Concrete Interfaces
Effects of Normal Stress on Shear Properties and Acoustic Emission Characteristics of Bonded Rock-Concrete Interfaces Open
Laboratory direct shear and acoustic emission tests are conducted on standard cylinder specimens with varying levels of normal stress. The aim is to gain a better understanding of shear behavior and failure mechanisms of the bonded interfa…
View article: Physical Mechanism of Selective Healing of Nanopores in Condensed Matter under the Influence of Laser Irradiation and Plasma
Physical Mechanism of Selective Healing of Nanopores in Condensed Matter under the Influence of Laser Irradiation and Plasma Open
The investigation of the features of laser control over the state of nanoscale objects in solid materials is an urgent task of condensed matter physics. We experimentally established the potential for the simultaneous enhancement of hardne…
View article: Discovery of Novel Ebola Entry Inhibitors with 1,2,3,4-Tetrahydroisoquinoline-3-Carboxamide Based on (3s,4as,8as)-2-(3-Amino-2-Hydroxypropyl) Decahydroisoquinoline-3-Carboxamide Scaffold
Discovery of Novel Ebola Entry Inhibitors with 1,2,3,4-Tetrahydroisoquinoline-3-Carboxamide Based on (3s,4as,8as)-2-(3-Amino-2-Hydroxypropyl) Decahydroisoquinoline-3-Carboxamide Scaffold Open
View article: (5R)-5-Hydroxytriptolide Alleviate Inflammatory Muscle Injury in a Murine Experimental Autoimmune Myositis
(5R)-5-Hydroxytriptolide Alleviate Inflammatory Muscle Injury in a Murine Experimental Autoimmune Myositis Open
View article: Influence of Inherent Initial Damage on Failure Behavior of Geomaterial Based on Multi-Level Pb-Gbm Model
Influence of Inherent Initial Damage on Failure Behavior of Geomaterial Based on Multi-Level Pb-Gbm Model Open
View article: Mechanism of Eddy Flow Occurrence in Rough Rock Fractures and a Microscopic Model for Nonlinear Flow
Mechanism of Eddy Flow Occurrence in Rough Rock Fractures and a Microscopic Model for Nonlinear Flow Open
View article: Discovery of Heinsiagenin a as a Potent Immunosuppressant and Triterpenoid Saponins from <i>Mussaenda Densiflora</i>
Discovery of Heinsiagenin a as a Potent Immunosuppressant and Triterpenoid Saponins from <i>Mussaenda Densiflora</i> Open
View article: Highly modified cephalotane-type diterpenoids from Cephalotaxus fortunei var. alpina and C. sinensis
Highly modified cephalotane-type diterpenoids from Cephalotaxus fortunei var. alpina and C. sinensis Open
Six undescribed cephalotane-type diterpenoids and/or norditerpenoids, ceforloids A–F (1–6), were isolated from Cephalotaxus fortunei var. alpina and C. sinensis. Their structures were elucidated by comprehensive analysis of spectroscopic d…