Jianqing Gao
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View article: A biomimetic microneedle platform using neutrophil membrane for synergistic immune-antibacterial therapy of MRSA infection
A biomimetic microneedle platform using neutrophil membrane for synergistic immune-antibacterial therapy of MRSA infection Open
View article: The cytoskeletal protein smoothelin maintains homologous recombination repair by stabilizing RAD51 in an HUWE1-dependent manner in colorectal cancer
The cytoskeletal protein smoothelin maintains homologous recombination repair by stabilizing RAD51 in an HUWE1-dependent manner in colorectal cancer Open
View article: From stem cell transplantation to stem cell-based drug delivery systems targeting hematological malignancies: recent advances and clinical considerations
From stem cell transplantation to stem cell-based drug delivery systems targeting hematological malignancies: recent advances and clinical considerations Open
While stem cell therapies hold promise, issues include the heterogeneity of stem cell sources, complexity of the cultivation process, and long-term safety issues. Future research should focus on large-scale technologies, stem cell engineer…
View article: Mesenchymal stem cell membrane functionalized vesicles for Baicalein targeted delivery in Alzheimer’s disease
Mesenchymal stem cell membrane functionalized vesicles for Baicalein targeted delivery in Alzheimer’s disease Open
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline and memory impairment. The lack of effective therapeutic strategies underscores the urgent need for disease-modifying therapies. Baical…
View article: SSEGLip:Self-supervised Speaker Embedding Generation for Speaker-independent Hearing-impaired Lip Reading
SSEGLip:Self-supervised Speaker Embedding Generation for Speaker-independent Hearing-impaired Lip Reading Open
View article: p62/SQSTM1 impairs immunotherapy in lung adenocarcinoma by suppressing immune infiltration and peripheral immune response
p62/SQSTM1 impairs immunotherapy in lung adenocarcinoma by suppressing immune infiltration and peripheral immune response Open
View article: Small molecular chelator for comprehensive regulation of tumor lactate levels in synergy with photodynamic therapy for cancer treatment
Small molecular chelator for comprehensive regulation of tumor lactate levels in synergy with photodynamic therapy for cancer treatment Open
View article: An engineering-reinforced extracellular vesicle–integrated hydrogel with an ROS-responsive release pattern mitigates spinal cord injury
An engineering-reinforced extracellular vesicle–integrated hydrogel with an ROS-responsive release pattern mitigates spinal cord injury Open
The local delivery of mesenchymal stem cell–derived extracellular vesicles (EVs) via hydrogel has emerged as an effective approach for spinal cord injury (SCI) treatment. However, achieving on-demand release of EVs from hydrogel to address…
View article: Curcumin Is Primarily Distributed in Lung, Spleen and Liver, Metabolized to Glucuronide and Sulfate, and Excreted through Bile and Urine by Using an Amorphous Curcumin Formulation with High Absorbability
Curcumin Is Primarily Distributed in Lung, Spleen and Liver, Metabolized to Glucuronide and Sulfate, and Excreted through Bile and Urine by Using an Amorphous Curcumin Formulation with High Absorbability Open
Curcumin (CUR), a polyphenol, is a promising compound for use in functional foods owing to various biological properties. However, the kinetics of CUR remains unclear because CUR has extremely low water solubility and absorbability. Here, …
View article: Nomogram to predict periprosthetic joint infection after total hip arthroplasty using laboratory tests
Nomogram to predict periprosthetic joint infection after total hip arthroplasty using laboratory tests Open
View article: The CONDOR Observatory: A Gamma-Ray Observatory with a 100 GeV Threshold at 5300 Meters Above Sea Level
The CONDOR Observatory: A Gamma-Ray Observatory with a 100 GeV Threshold at 5300 Meters Above Sea Level Open
We present the design of the Compact Network of Detectors with Orbital Range (CONDOR), a proposed high-altitude gamma-ray and cosmic-ray (CR) observatory set to become the highest of its kind. Planned for installation at Cerro Toco in the …
View article: Nanoparticles Designed Based on the Blood‐Brain Barrier for the Treatment of Cerebral Ischemia‐Reperfusion Injury
Nanoparticles Designed Based on the Blood‐Brain Barrier for the Treatment of Cerebral Ischemia‐Reperfusion Injury Open
Cerebral ischemia‐reperfusion injury (CI/RI) is currently considered a significant factor affecting the prognosis of ischemic stroke. The blood‐brain barrier (BBB) plays multiple roles in the treatment ofCI/RI. BBB leakage allows bloodborn…
View article: Drug Delivery Systems Based on Dendritic-Cell-Derived Exosomes
Drug Delivery Systems Based on Dendritic-Cell-Derived Exosomes Open
Exosomes, spherical lipid-bilayered particles secreted by cells, have recently emerged as a novel and highly promising drug delivery system, attracting extensive attention in the field of biomedical research. Dendritic-cell-derived exosome…
View article: Audio-Visual Representation Learning via Knowledge Distillation from Speech Foundation Models
Audio-Visual Representation Learning via Knowledge Distillation from Speech Foundation Models Open
Audio-visual representation learning is crucial for advancing multimodal speech processing tasks, such as lipreading and audio-visual speech recognition. Recently, speech foundation models (SFMs) have shown remarkable generalization capabi…
View article: Bistratal Conjunctival Microneedle for Long-Acting Dual Treatment of Dry Eye Disease via Efficient Ocular Drug Delivery
Bistratal Conjunctival Microneedle for Long-Acting Dual Treatment of Dry Eye Disease via Efficient Ocular Drug Delivery Open
View article: Comprehensive Mass Spectral Libraries of Human Thyroid Tissues and Cells
Comprehensive Mass Spectral Libraries of Human Thyroid Tissues and Cells Open
View article: Effects and mechanisms of Apelin in treating central nervous system diseases
Effects and mechanisms of Apelin in treating central nervous system diseases Open
Apelin, an endogenous ligand of G protein-coupled receptor APJ, is widely distributed in the central nervous system (CNS). It can be divided into such subtypes as Apelin-13, Apelin-17, and Apelin-36 as they have different amino acid struct…
View article: Engineering the Functional Expansion of Microneedles
Engineering the Functional Expansion of Microneedles Open
Microneedles (MNs), composed of an array of micro‐sized needles and a supporting base, have transcended their initial use to replace hypodermic needles in drug delivery and fluid collection, advancing toward multifunctional platforms. In t…
View article: Deep CLAS: Deep Contextual Listen, Attend and Spell
Deep CLAS: Deep Contextual Listen, Attend and Spell Open
Contextual-LAS (CLAS) has been shown effective in improving Automatic Speech Recognition (ASR) of rare words. It relies on phrase-level contextual modeling and attention-based relevance scoring without explicit contextual constraint which …
View article: Chemically programmed metabolism drives a superior cell fitness for cartilage regeneration
Chemically programmed metabolism drives a superior cell fitness for cartilage regeneration Open
The rapid advancement of cell therapies underscores the importance of understanding fundamental cellular attributes. Among these, cell fitness—how transplanted cells adapt to new microenvironments and maintain functional stability in vivo—…
View article: Extracellular vesicles for delivering therapeutic agents in ischemia/reperfusion injury
Extracellular vesicles for delivering therapeutic agents in ischemia/reperfusion injury Open
Ischemia/reperfusion (I/R) injury is marked by the restriction and subsequent restoration of blood supply to an organ. This process can exacerbate the initial tissue damage, leading to further disorders, disability, and even death. Extrace…
View article: The USTC-NERCSLIP Systems for the CHiME-8 NOTSOFAR-1 Challenge
The USTC-NERCSLIP Systems for the CHiME-8 NOTSOFAR-1 Challenge Open
This technical report outlines our submission system for the CHiME-8 NOTSOFAR-1 Challenge. The primary difficulty of this challenge is the dataset recorded across various conference rooms, which captures real-world complexities such as hig…
View article: From mesenchymal stem cells to their extracellular vesicles: Progress and prospects for asthma therapy
From mesenchymal stem cells to their extracellular vesicles: Progress and prospects for asthma therapy Open
View article: Hematopoietic stem and progenitor cell membrane-coated vesicles for bone marrow-targeted leukaemia drug delivery
Hematopoietic stem and progenitor cell membrane-coated vesicles for bone marrow-targeted leukaemia drug delivery Open
Leukemia is a kind of hematological malignancy originating from bone marrow, which provides essential signals for initiation, progression, and recurrence of leukemia. However, how to specifically deliver drugs to the bone marrow remains el…
View article: Targeting cancer-associated fibroblast autophagy renders pancreatic cancer eradicable with immunochemotherapy by inhibiting adaptive immune resistance
Targeting cancer-associated fibroblast autophagy renders pancreatic cancer eradicable with immunochemotherapy by inhibiting adaptive immune resistance Open
Accumulating evidence suggests that cancer-associated fibroblast (CAF) macroautophagy/autophagy is crucial in tumor development and may be a therapeutic target for pancreatic ductal adenocarcinoma (PDAC). However, the role of CAF autophagy…
View article: Exosome-like nanoparticles derived from fruits, vegetables, and herbs: innovative strategies of therapeutic and drug delivery
Exosome-like nanoparticles derived from fruits, vegetables, and herbs: innovative strategies of therapeutic and drug delivery Open
Over the past ten years, significant advancements have been made in exploring plant-derived exosome-like nanoparticles (PELNs) for disease therapeutics and drug delivery. PELNs, as inherent nanoscale particles comprised of proteins, lipids…
View article: Targeting cancer-associated fibroblast autophagy renders pancreatic cancer eradicable with immunochemotherapy by inhibiting adaptive immune resistance
Targeting cancer-associated fibroblast autophagy renders pancreatic cancer eradicable with immunochemotherapy by inhibiting adaptive immune resistance Open
Accumulating evidence suggests that cancer-associated fibroblast (CAF) macroautophagy/autophagy is crucial in tumor development and may be a therapeutic target for pancreatic ductal adenocarcinoma (PDAC). However, the role of CAF autophagy…
View article: Initial IL-10 production dominates the therapy of mesenchymal stem cell scaffold in spinal cord injury
Initial IL-10 production dominates the therapy of mesenchymal stem cell scaffold in spinal cord injury Open
Rationale: Spinal cord injury (SCI) is an acute damage to the central nervous system that results in severe morbidity and permanent disability. Locally implanted scaffold systems with immobilized mesenchymal stem cells (MSCs) have b…
View article: Risk of deep vein thrombosis (DVT) in lower extremity after total knee arthroplasty (TKA) in patients over 60 years old
Risk of deep vein thrombosis (DVT) in lower extremity after total knee arthroplasty (TKA) in patients over 60 years old Open
Purpose There is a significant risk of DVT after TKA. We aim to evaluate the potential risk factors for postoperative DVT in the lower extremities in TKA patients over 60 years of age and provide a reference for the effective prevention of…
View article: Stem cell-based ischemic stroke therapy: Novel modifications and clinical challenges
Stem cell-based ischemic stroke therapy: Novel modifications and clinical challenges Open