Explanipedia

Internal jugular vein obstruction induced by double-lumen CVC dislodgement Open

Junming Huang · 2025

N6-methyladenosine-induced hsa_circ_0011536 acts as a microRNA-576-5p sponge to promote ferroptosis of non-small cell lung cancer cells via transferrin receptor Open

Junming Huang, Caijiu Deng, Hanhan Zhu, Xiaofeng Chen, Peixi Chen , et al. · 2025

Lung cancer is the leading cause of death and the most diagnosed cancer worldwide. Non-small cell lung cancer (NSCLC) is the most common type of lung cancer; 85% of lung cancer patients are diagnosed with NSCLC. Though numerous treatments …

Targeting the SYVN1-EGFR axis: a breakthrough strategy for TKI-resistant NSCLC Open

Xinsheng Xie, Weilai Tong, Yue Xie, Huinan Jiang, Alan Jiang , et al. · 2025

Non-small cell lung cancer (NSCLC) is the leading cause of cancer-related death. Currently, molecular targeted therapy remains a crucial approach to the treatment of NSCLC. However, the development of acquired drug resistance poses signifi…

Targeting spermine metabolism to overcome immunotherapy resistance in pancreatic cancer Open

Hanshen Yang, Xiaozhen Zhang, Sirui Zhang, Yanqing Yang, Yan Chen , et al. · 2025

While dysregulation of polyamine metabolism is frequently observed in cancer, it is unknown how polyamines alter the tumor microenvironment (TME) and contribute to therapeutic resistance. Analysis of polyamines in the plasma of pancreatic …

CD142-positive synovial fibroblasts drive meniscus destruction in rheumatoid arthritis Open

Hao Sun, Xiaobin Lin, Fangzhou Liu, Yingbin Zhang, Jian‐Da Ma , et al. · 2025

Global Burden of Lip and Oral Cavity Cancer From 1990 to 2021 and Projection to 2040: Findings From the 2021 Global Burden of Disease Study Open

Mingxing Chen, Jingshu Li, Wei Su, Junming Huang, Chuanzhen Yang , et al. · 2025

Background The aim of this study was to estimate the global burden of lip and oral cavity cancer (LOC) and its trends in different genders, age groups, regions, and countries globally. Methods Data were sourced from the Global Burden of Di…

Intrahepatic cholangiocarcinoma patient with epidermal growth factor receptor exon 19 deletion unresponsive to Afatinib monotherapy: a case report Open

Caijiu Deng, Junming Huang, Qian Yu, Jianjun Han, Yuanxue Jiang , et al. · 2025

In this report, the CCA patient with EGFR exon 19 deletion was unresponsive to afatinib treatment. However, genetic testing may be still worthwhile for CCA to increase the possible treatment options.

Multi-View Semi-Supervised Ordinal Regression Open

Yanshan Xiao, Junming Huang, Bo Liu · 2025

SOST/Sclerostin impairs the osteogenesis and angiogesis in glucocorticoid-associated osteonecrosis of femoral head Open

Junming Huang, Tianle Ma, Chenzhong Wang, Zhe Wang, Xinyuan Wang , et al. · 2024

Unraveling the genetic association between knee osteoarthritis and hallux deformities Open

Zheng‐tao Lv, Mingchao Lin, Jiaming Zhang, KuoYang Sun, Zunwen Lin , et al. · 2024

In this study, the genetic causality between KOA and increased risk of hallux deformities (HV and HR) is established, which can provide evidence-based recommendations for reducing the incidence of hallux deformities in KOA patients. Furthe…

CD142+ synovial fibroblast drives meniscus destruction in rheumatoid arthritis Open

Ruofan Ma, Hao Sun, Xiaobin Lin, Fangzhou Liu, Yingbin Zhang , et al. · 2024

Rheumatoid arthritis (RA) induced destruction of knee joints is a common cause of total knee arthroplasty (TKA). Although previous evidence suggests that bone and cartilage damage is the main pathogenesis of RA joint destruction, the menis…

Attenuating bone loss in osteoporosis: the potential of corylin (CL) as a therapeutic agent Open

Song Zhou, Junming Huang, Kun Chen, Qixuan Wang, Zheng Liu , et al. · 2024

The global prevalence of osteoporosis is being exacerbated by the increasing number of aging societies and longer life expectancies. In response, numerous drugs have been developed in recent years to mitigate bone resorption and enhance bo…

Distance effect of single atoms on stability of cobalt oxide catalysts for acidic oxygen evolution Open

Zhirong Zhang, Chuanyi Jia, Peiyu Ma, Feng Chen, Yang Jin , et al. · 2024

Identifying causal relationships between gastroesophageal reflux and extraesophageal diseases: A Mendelian randomization study Open

Peishan Yao, Xiaomin Liao, Junming Huang, Yi Dang, Haixing Jiang · 2024

Traditional observational and in vivo studies have suggested an etiological link between gastroesophageal reflux disease (GERD) and the development of extraesophageal diseases (EEDs), such as noncardiac chest pain. However, evidence demons…

Deciphering the molecular classification of pediatric sepsis: integrating WGCNA and machine learning-based classification with immune signatures for the development of an advanced diagnostic model Open

Junming Huang, Jinji Chen, Chengbang Wang, Lichuan Lai, Hua Mi , et al. · 2024

Introduction: Pediatric sepsis (PS) is a life-threatening infection associated with high mortality rates, necessitating a deeper understanding of its underlying pathological mechanisms. Recently discovered programmed cell death induced by …

Integrative analysis of gene expression profiles of substantia nigra identifies potential diagnosis biomarkers in Parkinson's disease Open

Junming Huang, Bowen Li, Huangwei Wei, Chengxin Li, Chao Liu , et al. · 2024

Parkinson's disease (PD) is a progressive neurodegenerative disease whose etiology is attributed to development of Lewy bodies and degeneration of dopaminergic neurons in the substantia nigra (SN). Currently, there are no definitive diagno…

Micheliolide prevents estrogen deficiency-induced bone loss via inhibiting osteoclast bone resorption Open

Ziyang Gan, Junming Huang, Mingyou Xu, Xingshi Yuan, Xifu Shang , et al. · 2023

Osteoporosis is one of the major health problems characterized by decreased bone density and increased risk of fractures. Nowadays, the treating strategies against osteoporosis are efficient, but still have some drawbacks. Micheliolide, a …

Icaritin ameliorates RANKL-mediated osteoclastogenesis and ovariectomy-induced osteoporosis Open

Junming Huang, Zhe Wang, Guobin Qi, Qi Lai, A-lan Jiang , et al. · 2023

A rapidly aging society and longer life expectancy are causing osteoporosis to become a global epidemic. Over the last five decades, a number of drugs aimed at reducing bone resorption or restoring bone mass have been developed, but their …

CircFam190a: a critical positive regulator of osteoclast differentiation via enhancement of the AKT1/HSP90β complex Open

Kun Chen, Xi Chen, Chuandong Lang, Xingshi Yuan, Junming Huang , et al. · 2023

Deciphering the molecular Classification of pediatric sepsis: Integrating WGCNA and Machine learning-based classification with immune signatures for the development of an advanced diagnostic model Open

Junming Huang, Jinji Chen, Chengbang Wang, Shaohua Chen, Hua Mi , et al. · 2023

Background Pediatric sepsis (PS) is a life-threatening infection associated with high mortality rates, necessitating a deeper understanding of its underlying pathological mechanisms. Recently discovered programmed cell death induced by cop…

Integrative Analysis of Gene Expression Profiles of Substantia Nigra Identifies Potential Diagnosis Biomarkers in Parkinson's disease Open

Junming Huang, Bowen Li, Huangwei Wei, Chengxin Li, Chao Liu , et al. · 2023

Background Parkinson's disease (PD) is a progressive neurodegenerative disease whose etiology is attributed to development of Lewy bodies and degeneration of dopaminergic neurons in the substantia nigra (SN). Currently, there are no defini…

Knee valgus deformity and lateral bone defects affect the function of superficial medial collateral ligament: A finite element analysis Open

Junming Huang, Hao Sun, Deng Li, Yimin Wang, Jie Xu , et al. · 2023

The Analysis and Prospect of China’s Aid Influence on Nigeria from the Perspective of Structural Power Open

Yangzong Dawa, Junming Huang, Xueyu Zhang · 2023

International aids to the under developed countries have long been an essential part of international cooperation and global governance. As the representative African country, Nigeria has been aided by the United States, the EU, the UN as …

Research on Tesla's Pricing Strategy in China Based on Bertrand Game and SWOT Analysis Open

Junming Huang, Xin Jiang, Yi‐Ting Wang · 2023

With the advent of the post-subsidy era, new energy vehicles are the future development direction of China’s automobile industry, the Chinese government has established a number of New-Energy Vehicle (NEV) market stimulus programs. As a fo…

HOXB13 induced LncRNA CYTOR aggravates spinal cord injury induced neuropathic pain via upregulating TJP1 Open

Junming Huang, Yannan Bi, Xiaoming Liu, Fatai Liu, Haodong Zhu , et al. · 2023

Neuropathic pain (NP) is characterized as a pain disorder results from a lesion or disease of the nervous system. Due to the NP is related to multiple disease development including Shingles, stroke, cancer, trauma, and orthopedics, the pre…

An Ionic Liquid Ablation Agent for Local Ablation and Immune Activation in Pancreatic Cancer Open

Junming Huang, Meng Wang, Fu Zhang, Shiyi Shao, Zhuo Yao , et al. · 2023

Pancreatic ductal adenocarcinoma rapidly acquires resistance to chemotherapy, remaining a fatal disease. Immunotherapy is one of the breakthroughs in cancer treatment, which includes immune checkpoint inhibitors, chimeric antigen receptor …

Titanium-coated PEEK Versus Uncoated PEEK Cages in Lumbar Interbody Fusion Open

Zheng‐tao Lv, Yong Xu, Bin Cao, Jun Dai, Siyuan Zhang , et al. · 2022

Study Design: Systematic review and meta-analysis. Objective: This study was performed to compare the fusion and subsidence rate of titanium-coated polyetheretherketone (Ti-PEEK) versus polyetheretherketone (PEEK) cages after lumbar fusion…

Baohuoside I Inhibits Osteoclastogenesis and Protects Against Ovariectomy-Induced Bone Loss Open

M Ma, Aoyuan Fan, Zheng Liu, Liqing Yang, Junming Huang , et al. · 2022

Bone-resorbing osteoclasts are essential for skeletal remodelling, and the hyperactive formation and function of osteoclasts are common in bone metabolic diseases, especially postmenopausal osteoporosis. Therefore, regulating the osteoclas…

Origin of the frequency-sensitive super-collimation phenomenon from the geometry of band dispersion surface for two-dimensional photonic crystals Open

Meng Zhang, Junming Huang, Xunya Jiang · 2022

Frequency-sensitive super-collimation (FSSC) is a novel dispersion phenomenon of photonic crystals (PhCs) that can realize the beam collimating propagation with very high frequency sensitivity. In order to deeply investigate the origin and…

Oncolytic peptide LTX-315 induces anti-pancreatic cancer immunity by targeting the ATP11B-PD-L1 axis Open

Tianyu Tang, Xing Huang, Gang Zhang, Minghao Lu, Zhengtao Hong , et al. · 2022

Background LTX-315 is an oncolytic peptide deriving from bovine lactoferrin, with the ability to induce cancer immunogenic cell death. However, the mechanism used by LTX-315 to trigger the antitumor immune response is still poorly understo…

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