Jianwen Jin
YOU?
Author Swipe
View article: Front Cover: UVA LED Light Promoted Cross‐Coupling of Tertiary <i>α</i>‐Silylamines with 1‐Iodoalkynes (Asian J. Org. Chem. 11/2023)
Front Cover: UVA LED Light Promoted Cross‐Coupling of Tertiary <i>α</i>‐Silylamines with 1‐Iodoalkynes (Asian J. Org. Chem. 11/2023) Open
Electron donor-acceptor (EDA) complexes formed between two or more substrates in the presence of a light source provide an invaluable mode of reactivity in chemical synthesis. The cover art demonstrates the EDA complex formed between a ter…
View article: Chiral Brønsted Acid Catalysed Kinetic Resolution of Secondary and Tertiary 3‐Amido Allylic Alcohols
Chiral Brønsted Acid Catalysed Kinetic Resolution of Secondary and Tertiary 3‐Amido Allylic Alcohols Open
A synthetic method to prepare enantioenriched secondary and tertiary 3‐amido allylic alcohols efficiently that relies on their stereoablative enantioselective kinetic resolution (KR) catalysed by a chiral Brønsted acid is described. Achiev…
View article: Chiral counteranion controlled chemoselectivity in gold catalysed hydroamination/enantioselective formal 1,3-allylic alcohol isomerisation of β-amino-1,4-enynols
Chiral counteranion controlled chemoselectivity in gold catalysed hydroamination/enantioselective formal 1,3-allylic alcohol isomerisation of β-amino-1,4-enynols Open
A synthetic method for the preparation of 1,8-dihydroindeno[2,1-b]pyrroles and pyrrol-2-yl methanols in an enantioselective manner that relies on the chiral gold(I)-catalysed reactions of β-amino-1,4-enynols is described. A divergence in p…
View article: Chiral Counteranion-Controlled Chemoselectivity in Gold-Catalysed Hydroamination/Enantioselective Formal 1,3-Allylic Alcohol Isomerisation of -Amino-1,4-enynols
Chiral Counteranion-Controlled Chemoselectivity in Gold-Catalysed Hydroamination/Enantioselective Formal 1,3-Allylic Alcohol Isomerisation of -Amino-1,4-enynols Open
A synthetic method for the preparation of 1,8-dihydroindeno[2,1-b]pyrroles and pyrrol-2-yl methanols in an enantioselective manner that relies on the chiral gold(I)-catalysed reactions of -amino-1,4-enynols is described. A divergence in p…
View article: Development of 1,2,4-Oxadiazole Antimicrobial Agents to Treat Enteric Pathogens within the Gastrointestinal Tract
Development of 1,2,4-Oxadiazole Antimicrobial Agents to Treat Enteric Pathogens within the Gastrointestinal Tract Open
Colonization of the gastrointestinal (GI) tract with pathogenic bacteria is an important risk factor for the development of certain potentially severe and life-threatening healthcare-associated infections, yet efforts to develop effective …
View article: A robust photoluminescence screening assay identifies uracil-DNA glycosylase inhibitors against prostate cancer
A robust photoluminescence screening assay identifies uracil-DNA glycosylase inhibitors against prostate cancer Open
The discovery of UDG inhibitors against prostate cancer by using a robust photoluminescence screening assay that can avoid false negatives arising from the background fluorescence.
View article: Copper catalyzed<i>N</i>-formylation of α-silyl-substituted tertiary<i>N</i>-alkylamines by air
Copper catalyzed<i>N</i>-formylation of α-silyl-substituted tertiary<i>N</i>-alkylamines by air Open
A site-selective synthetic method to prepareN-formyl amines efficiently from copper(i)-catalyzed oxidation of α-silylamines by air at room temperature is presented.
View article: Gold Catalyzed Cyclopropanation/[5+3] Cycloaddition of 1,4,9‐ and 1,4,10‐Allenenynes to Bicyclo[3.3.1]nonane Derivatives
Gold Catalyzed Cyclopropanation/[5+3] Cycloaddition of 1,4,9‐ and 1,4,10‐Allenenynes to Bicyclo[3.3.1]nonane Derivatives Open
A synthetic method to prepare cycloalkyl‐ and (hetero)aryl‐fused bicyclo[3.3.1]nonane derivatives from gold(I)‐catalyzed cyclopropanation/[5+3] cycloaddition of 1,4,9‐ and 1,4,10‐allenenynes is described. The suggested double cycloisomeriz…
View article: Brønsted Acid‐Catalyzed Cyclization of <i>β</i>‐Amino‐1,4‐enols to Oxazol‐2(3<i>H</i>)‐ones and 5‐Alkenyloxazolidin‐2‐ones
Brønsted Acid‐Catalyzed Cyclization of <i>β</i>‐Amino‐1,4‐enols to Oxazol‐2(3<i>H</i>)‐ones and 5‐Alkenyloxazolidin‐2‐ones Open
A synthetic method to prepare oxazol‐2(3 H )‐ones and 5‐alkenyloxazolidin‐2‐ones efficiently that relies on a Brønsted acid‐catalyzed cyclization of the respective secondary and tertiary β ‐amino‐1,4‐enols in ethanol is described. The reac…
View article: Front Cover Picture: Gold Catalyzed Photoredox C1‐Alkynylation of <i>N</i>‐Alkyl‐1,2,3,4‐tetrahydroisoquinolines by 1‐Bromoalkynes with UVA LED Light (Adv. Synth. Catal. 6/2019)
Front Cover Picture: Gold Catalyzed Photoredox C1‐Alkynylation of <i>N</i>‐Alkyl‐1,2,3,4‐tetrahydroisoquinolines by 1‐Bromoalkynes with UVA LED Light (Adv. Synth. Catal. 6/2019) Open
Reactivity at the flick of a light switch. The front cover picture, provided by Chan and co-workers, illustrates how [Au2(μ-dppm)2]Cl2 [dppm = bis(diphenylphosphanyl)methane] becomes a highly efficient photosensitizer on exposure to UVA LE…
View article: Chiral Brønsted Acid and Gold Catalyzed Enantioselective Synthesis of 1,8‐Dihydroindeno[2,1‐<i>b</i>]pyrroles
Chiral Brønsted Acid and Gold Catalyzed Enantioselective Synthesis of 1,8‐Dihydroindeno[2,1‐<i>b</i>]pyrroles Open
An enantioselective synthetic method for the preparation of 1,8‐dihydroindeno[2,1‐ b ]pyrroles that relies on the chiral Brønsted acid‐ and gold(I)‐catalyzed dehydrative Nazarov‐type electrocyclization (DNE)/hydroamination of electron‐rich…
View article: Gold Catalyzed Photoredox C1‐Alkynylation of <i>N</i>‐Alkyl‐1,2,3,4‐tetrahydroisoquinolines by 1‐Bromoalkynes with UVA LED Light
Gold Catalyzed Photoredox C1‐Alkynylation of <i>N</i>‐Alkyl‐1,2,3,4‐tetrahydroisoquinolines by 1‐Bromoalkynes with UVA LED Light Open
A synthetic method that combines [Au 2 (μ‐dppm) 2 ]Cl 2 (dppm=bis(diphenylphosphanyl)methane) and UVA LED (LED=light emitting diode) light (365 nm) to catalyze the regioselective C1‐alkynylation of N ‐alkyl‐1,2,3,4‐tetrahydroisoquinolines …
View article: Chiral Brønsted Acid Catalyzed Enantioselective Dehydrative Nazarov-Type Electrocyclization of Aryl and 2-Thienyl Vinyl Alcohols
Chiral Brønsted Acid Catalyzed Enantioselective Dehydrative Nazarov-Type Electrocyclization of Aryl and 2-Thienyl Vinyl Alcohols Open
An efficient chiral Brønsted acid-catalyzed enantioselective dehydrative Nazarov-type electrocyclization (DNE) of electron-rich aryl- and 2-thienyl-β-amino-2-en-1-ols is described. The 4π conrotatory electrocyclization reaction affords acc…
View article: Organocatalytic-Based Strategies for Complex Molecule Synthesis
Organocatalytic-Based Strategies for Complex Molecule Synthesis Open
This thesis describes new chiral Brønsted acid catalyzed asymmetric reactions of alcohol pro-electrophiles as novel synthetic strategies for construction of complex molecule. The findings in this thesis not only offer new synthetic methods…
View article: CCDC 1839656: Experimental Crystal Structure Determination
CCDC 1839656: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1839655: Experimental Crystal Structure Determination
CCDC 1839655: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1839654: Experimental Crystal Structure Determination
CCDC 1839654: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Silver-Catalyzed 1,3-Acyloxy Migration/Diels–Alder Reaction of 1,9-Dien-4-yne Esters to Partially Hydrogenated Isoquinolines
Silver-Catalyzed 1,3-Acyloxy Migration/Diels–Alder Reaction of 1,9-Dien-4-yne Esters to Partially Hydrogenated Isoquinolines Open
A synthetic method to prepare partially hydrogenated isoquinolines efficiently from silver-mediated [3,3]-sigmatropic rearrangement/Diels-Alder reaction of 1,9-dien-4-yne esters is described. The reactions were shown to be robust with a wi…