Jianxia Wei
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View article: NSUN2 Negatively Regulates TP53 mRNA Stability to Promote the Malignant Progression of Nasopharyngeal Carcinoma
NSUN2 Negatively Regulates TP53 mRNA Stability to Promote the Malignant Progression of Nasopharyngeal Carcinoma Open
Background: Nasopharyngeal carcinoma (NPC) is a prevalent malignancy in China, often diagnosed at advanced stages. The 5-methylcytosine (m5C) RNA modification plays a crucial role in tumorigenesis, influencing cell proliferation, different…
View article: TRIM25 degrades BRD7 protein stability through the ubiquitin proteasome pathway to promote breast cancer progression and paclitaxel resistance by activating YB1/Bcl-2 transcription axis
TRIM25 degrades BRD7 protein stability through the ubiquitin proteasome pathway to promote breast cancer progression and paclitaxel resistance by activating YB1/Bcl-2 transcription axis Open
Paclitaxel (PTX) is one of the most common chemotherapeutic drugs for treating breast cancer (BC), but resistance to PTX chemotherapy remains the major cause of treatment failure in BC patients. Our previous studies demonstrated that BRD7 …
View article: The associations between skeletal muscle mass to visceral fat area ratio (SVR) with bone mineral density (BMD) and 10-year probability of fracture risk in Chinese patients with type 2 diabetes mellitus (T2DM): a cross-sectional study
The associations between skeletal muscle mass to visceral fat area ratio (SVR) with bone mineral density (BMD) and 10-year probability of fracture risk in Chinese patients with type 2 diabetes mellitus (T2DM): a cross-sectional study Open
Our study provided a novel viewpoint on the relationship between SVR and BMD/fracture risk. Relatively high SVR is a protective factor for bone in T2DM patients, but the osteoprotective effect of SVR was mediated by age and gender, and it …
View article: BRD7 enhances the radiosensitivity of nasopharyngeal carcinoma cells by negatively regulating USP5/METTL3 axis-mediated homologous recombination repair
BRD7 enhances the radiosensitivity of nasopharyngeal carcinoma cells by negatively regulating USP5/METTL3 axis-mediated homologous recombination repair Open
An important reason for the poor prognosis of nasopharyngeal carcinoma (NPC) patients is radioresistance. Our previous studies demonstrated that BRD7 is expressed at low levels in NPC and functions as a tumor suppressor to inhibit NPC prog…
View article: TRIM28 promotes tumor growth and metastasis in breast cancer by targeting the BRD7 protein for ubiquitination and degradation
TRIM28 promotes tumor growth and metastasis in breast cancer by targeting the BRD7 protein for ubiquitination and degradation Open
Purpose: BRD7 is downregulated and functions as a tumor suppressor in many types of cancers including breast cancer, and the dysregulation of BRD7 expression is closely related to the development and progression of breast cancer. Whereas l…
View article: Validation of Core Ingredients and Molecular Mechanism of Cinobufotalin Injection Against Liver Cancer
Validation of Core Ingredients and Molecular Mechanism of Cinobufotalin Injection Against Liver Cancer Open
Cinobufotalin injection was confirmed to includes eight core ingredients, and they play therapeutic effects in liver cancer by blocking cell cycle-related pathways, which provides important insights for the mechanism of cinobufotalin injec…
View article: Changes in blood lipid levels during various stages of pregnancy in women with type 2 diabetes and their effects on the incidence of large-for-gestational-age newborns
Changes in blood lipid levels during various stages of pregnancy in women with type 2 diabetes and their effects on the incidence of large-for-gestational-age newborns Open
Aims: To study the effect of blood lipid changes on the incidence of large-for-gestational-age (LGA) fetuses in pregnant women with type 2 diabetes Methods: We selected pregnant women with type 2 diabetes who delivered at our hospital betw…
View article: <scp>CircBRD7</scp> attenuates tumor growth and metastasis in nasopharyngeal carcinoma via epigenetic activation of its host gene
<span>CircBRD7</span> attenuates tumor growth and metastasis in nasopharyngeal carcinoma via epigenetic activation of its host gene Open
BRD7 was identified as a tumor suppressor in nasopharyngeal carcinoma (NPC). Circular RNAs (CircRNAs) are involved in the occurrence and development of NPC as oncogenes or tumor suppressors. However, the function and mechanism of the circu…
View article: NOP2/Sun RNA methyltransferase 2 is a potential pan-cancer prognostic biomarker and is related to immunity
NOP2/Sun RNA methyltransferase 2 is a potential pan-cancer prognostic biomarker and is related to immunity Open
Background NOP2/Sun RNA methyltransferase 2 (NSUN2), an important methyltransferase of m5C, has been poorly studied in cancers, and the relationship between NSUN2 and immunity remains largely unclear. Therefore, the purpose of this study w…
View article: Changes in blood lipid levels during different stages of pregnancy with normal BMI and its impact on the incidence of larger-than-gestational-age infants
Changes in blood lipid levels during different stages of pregnancy with normal BMI and its impact on the incidence of larger-than-gestational-age infants Open
Background To study the impact of changes in blood lipids during pregnancy on the delivery of larger-than-gestational-age infants in pregnant women with normal BMI and reasonable blood glucose control during pregnancy. Methods This study s…
View article: Exploration of Serum lipid levels during twin pregnancy
Exploration of Serum lipid levels during twin pregnancy Open
Objective: This study aims to characterize changes in serum lipid levels throughout twin pregnancies and explore the relationship between lipid levels and gestational diabetes mellitus (GDM) and hypertensive disorders complicating p…
View article: Understanding the roles and regulation patterns of circRNA on its host gene in tumorigenesis and tumor progression
Understanding the roles and regulation patterns of circRNA on its host gene in tumorigenesis and tumor progression Open
View article: Dissecting the roles and clinical potential of YY1 in the tumor microenvironment
Dissecting the roles and clinical potential of YY1 in the tumor microenvironment Open
Yin-Yang 1 (YY1) is a member of the GLI-Kruppel family of zinc finger proteins and plays a vital dual biological role in cancer as an oncogene or a tumor suppressor during tumorigenesis and tumor progression. The tumor microenvironment (TM…
View article: BRD7 inhibits enhancer activity and expression of BIRC2 to suppress tumor growth and metastasis in nasopharyngeal carcinoma
BRD7 inhibits enhancer activity and expression of BIRC2 to suppress tumor growth and metastasis in nasopharyngeal carcinoma Open
BRD7 functions as a crucial tumor suppressor in numerous malignancies including nasopharyngeal carcinoma (NPC). However, its function and exact mechanisms involved in tumor progression are not well understood. Here, we found that the B7BS …
View article: Deciphering the vital roles and mechanism of m5C modification on RNA in cancers.
Deciphering the vital roles and mechanism of m5C modification on RNA in cancers. Open
5-methylcytosine (m5C modification) plays an essential role in tumors, which affects different types of RNA, the expression of downstream target genes, and downstream pathways, thus participating in the tumor process. However, the effect o…
View article: Yin Yang 1 suppresses tumor invasion and metastasis in nasopharyngeal carcinoma by negatively regulating eIF4E transcriptional activity and expression.
Yin Yang 1 suppresses tumor invasion and metastasis in nasopharyngeal carcinoma by negatively regulating eIF4E transcriptional activity and expression. Open
Tumor metastasis is a leading cause of death in nasopharyngeal carcinoma (NPC) patients. Previous research has identified that transcription factor Yin Yang 1 (YY1) acts as a tumor suppressor that inhibits cell proliferation and tumor grow…
View article: The Emerging Roles and Clinical Potential of circSMARCA5 in Cancer
The Emerging Roles and Clinical Potential of circSMARCA5 in Cancer Open
Circular RNAs (circRNAs) are a type of endogenous non-coding RNA and a critical epigenetic regulation way that have a closed-loop structure and are highly stable, conserved, and tissue-specific, and they play an important role in the devel…
View article: CircBRD7 inhibits tumor growth and metastasis in nasopharyngeal carcinoma via forming a positive feedback regulation loop with its host gene
CircBRD7 inhibits tumor growth and metastasis in nasopharyngeal carcinoma via forming a positive feedback regulation loop with its host gene Open
Background: BRD7 was identified as a tumor suppressor in nasopharyngeal carcinoma (NPC). Circular RNA (CircRNAs) are involved in the occurrence and development of NPC as oncogenes or tumor suppressors. However, the function and mechanism o…
View article: BRD7 inhibits enhancer activity and expression of BIRC2 to suppress tumor growth and metastasis in nasopharyngeal carcinoma
BRD7 inhibits enhancer activity and expression of BIRC2 to suppress tumor growth and metastasis in nasopharyngeal carcinoma Open
BRD7 functions as a crucial tumor suppressor in numerous malignancies including nasopharyngeal carcinoma (NPC). However, its function and exact mechanisms involved in tumor progression are not well understood. Here, we found that the B7BS …
View article: Trends in the Beijing cesarean section rate and reasons for the fluctuations
Trends in the Beijing cesarean section rate and reasons for the fluctuations Open
To the Editor: Cesarean section (CS) resolves dystocia and serious pregnancy-related complications but also has adverse outcomes such as long recovery time, uterine rupture, and dangerous placenta previa in future pregnancies. The increase…
View article: Understanding the Dual Roles of CircHIPK3 in Tumorigenesis and Tumor Progression
Understanding the Dual Roles of CircHIPK3 in Tumorigenesis and Tumor Progression Open
CircHIPK3 is a type of endogenous circular RNA, which contains a covalently closed circular structure and cannot encode protein or polypeptide. CircHIPK3 is unusually expressed in varieties of tumors and plays dual roles of tumor promotion…
View article: Identification of Core Prognosis‐Related Candidate Genes in Cervical Cancer via Integrated Bioinformatical Analysis
Identification of Core Prognosis‐Related Candidate Genes in Cervical Cancer via Integrated Bioinformatical Analysis Open
Purposes . Cervical cancer (CC) is one of the highest frequently occurred malignant gynecological tumors with high rates of morbidity and mortality. Here, we aimed to identify significant genes associated with poor outcome. Materials and m…
View article: The biogenesis and roles of extrachromosomal oncogene involved in carcinogenesis and evolution.
The biogenesis and roles of extrachromosomal oncogene involved in carcinogenesis and evolution. Open
More and more extrachromosomal DNA (ecDNA) was found in human tumor cells in recent years, which has a high copy number in tumors and changes the expression of oncogenes, thus different from normal chromosomal DNA. These circular structure…
View article: Application of an Infection Control Protocol (ICP) Reduced Cardiac Device Infection (CDI) in Low-Volume Centers
Application of an Infection Control Protocol (ICP) Reduced Cardiac Device Infection (CDI) in Low-Volume Centers Open
BACKGROUND Cardiac device infection (CDI) is a serious complication of cardiovascular implantable electronic device (CIED) implantations. Many risk factors have been identified, but several are still uncertain. This study aimed to identify…