Jianxun Song
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View article: Redefining multiple sclerosis therapy through microbial immunomodulation and epigenetic control
Redefining multiple sclerosis therapy through microbial immunomodulation and epigenetic control Open
Multiple sclerosis (MS) is a chronic autoimmune disorder marked by immune-driven demyelination and neurodegeneration in the central nervous system. This Review explores the immunological, molecular, and epigenetic underpinnings of MS, emph…
View article: Intracranial Dural Extramedullary Hematopoiesis in Myelofibrosis: MRI and CT Imaging Features from a Rare Case Report
Intracranial Dural Extramedullary Hematopoiesis in Myelofibrosis: MRI and CT Imaging Features from a Rare Case Report Open
Intracranial extramedullary hematopoiesis (EMH) is a rare clinical condition. This article reports a case of a 54-year-old male patient with a 6-year history of myelofibrosis, who had been relying on blood transfusion support therapy and c…
View article: Modular Platform for Efficient Assembly of Multifunctional Antibodies Using Orthogonal Protein–Protein Interactions
Modular Platform for Efficient Assembly of Multifunctional Antibodies Using Orthogonal Protein–Protein Interactions Open
Multifunctional antibodies, capable of simultaneously engaging multiple targets, are a unique class of antibodies that have sparked growing interest. Current approaches for making multifunctional antibodies, including chemical conjugation …
View article: Metabolic fitness of NAC1-deficient Tregs in the tumor microenvironment fuels tumor growth
Metabolic fitness of NAC1-deficient Tregs in the tumor microenvironment fuels tumor growth Open
The nucleus accumbens-associated protein 1 (NAC1) has recently emerged as a pivotal factor in oncogenesis by promoting glycolysis. Deletion of NAC1 in regulatory T cells (Tregs) has been shown to enhance FoxP3 stability, a suppressor of gl…
View article: eEF-2K Deficiency Boosts the Virus-Specific Effector CD8+ T Cell Responses During Viral Infection
eEF-2K Deficiency Boosts the Virus-Specific Effector CD8+ T Cell Responses During Viral Infection Open
In this study, we revealed a critical role of eukaryotic elongation factor-2 kinase (eEF-2K), a negative regulator of protein synthesis, in regulating T cells during vaccinia virus (VACV) infection. We found that eEF-2K-deficient (eEF-2K⁻/…
View article: Harnessing Bacterial Agents to Modulate the Tumor Microenvironment and Enhance Cancer Immunotherapy
Harnessing Bacterial Agents to Modulate the Tumor Microenvironment and Enhance Cancer Immunotherapy Open
Cancer immunotherapy has revolutionized cancer treatment by leveraging the immune system to attack tumors. However, its effectiveness is often hindered by the immunosuppressive tumor microenvironment (TME), where a complex interplay of tum…
View article: Correction: Nac1 promotes stemness and regulates myeloid‑derived cell status in triple‑negative breast cancer
Correction: Nac1 promotes stemness and regulates myeloid‑derived cell status in triple‑negative breast cancer Open
View article: NAC1 promotes stemness and regulates myeloid-derived cell status in triple-negative breast cancer
NAC1 promotes stemness and regulates myeloid-derived cell status in triple-negative breast cancer Open
View article: P/D-Serve: Serving Disaggregated Large Language Model at Scale
P/D-Serve: Serving Disaggregated Large Language Model at Scale Open
Serving disaggregated large language models (LLMs) over tens of thousands of xPU devices (GPUs or NPUs) with reliable performance faces multiple challenges. 1) Ignoring the diversity (various prefixes and tidal requests), treating all the …
View article: NAC1 Promotes Stemness and Regulates Myeloid-derived Cell Status in Triple-Negative Breast Cancer
NAC1 Promotes Stemness and Regulates Myeloid-derived Cell Status in Triple-Negative Breast Cancer Open
Triple negative breast cancer (TNBC) is a particularly lethal breast cancer (BC) subtype driven by cancer stem cells (CSCs) and an immunosuppressive microenvironment. Our study reveals that nucleus accumbens associated protein 1 (NAC1), a …
View article: Enhanced NK cell activation via eEF2K-mediated potentiation of the cGAS–STING pathway in hepatocellular carcinoma
Enhanced NK cell activation via eEF2K-mediated potentiation of the cGAS–STING pathway in hepatocellular carcinoma Open
Targeted eEF2K blockade may result in cGAS-STING pathway activation, leading to enhanced infiltration and activity of NK cells within HCC tumors. The synergistic effect achieved by combining an eEF2K inhibitor with PD-1 antibody therapy re…
View article: Role of T Cells in Microbial Pathogenesis
Role of T Cells in Microbial Pathogenesis Open
The immune system functions as a sophisticated defense mechanism, shielding the body from harmful pathogenic invaders [...]
View article: Control of CD4+ T cells to restrain inflammatory diseases via eukaryotic elongation factor 2 kinase
Control of CD4+ T cells to restrain inflammatory diseases via eukaryotic elongation factor 2 kinase Open
View article: Investigating chimeric antigen receptor T cell therapy and the potential for cancer immunotherapy (Review)
Investigating chimeric antigen receptor T cell therapy and the potential for cancer immunotherapy (Review) Open
Immunotherapy has emerged as a crucial treatment option, particularly for types of cancer that display resistance to conventional therapies. A remarkable breakthrough in this field is the development of chimeric antigen receptor (CAR) T ce…
View article: Co-Targeting Nucleus Accumbens Associate 1 and NF-κB Signaling Synergistically Inhibits Melanoma Growth
Co-Targeting Nucleus Accumbens Associate 1 and NF-κB Signaling Synergistically Inhibits Melanoma Growth Open
Nucleus-accumbens-associated protein-1 (NAC1) is a cancer-related transcriptional factor encoded by the NACC1 gene, which is amplified and overexpressed in various human cancers and has been appreciated as one of the top potential cancer d…
View article: NAC1 confines virus‐specific memory formation of CD4<sup>+</sup> T cells through the ROCK1‐mediated pathway
NAC1 confines virus‐specific memory formation of CD4<sup>+</sup> T cells through the ROCK1‐mediated pathway Open
Nucleus accumbens‐associated protein 1 (NAC1), a transcriptional cofactor, has been found to play important roles in regulating regulatory T cells, CD8 + T cells, and antitumor immunity, but little is known about its effects on T‐cell memo…
View article: Regulation of CD4 T-cell immunity by eukaryotic Elongation Factor 2 Kinase
Regulation of CD4 T-cell immunity by eukaryotic Elongation Factor 2 Kinase Open
CD4 T cells are a major source of inflammatory cytokines to manage the immune responses, and there is evidence showing that IL-17-secreting helper CD4 T cells (Th17 cells), play a critical role in autoimmune diseases. Eukaryotic Elongation…
View article: Engineered live attenuated bacteria producing 5-hydroxyindole remodels heterogeneous tumor microenvironment and promotes antitumor immunity
Engineered live attenuated bacteria producing 5-hydroxyindole remodels heterogeneous tumor microenvironment and promotes antitumor immunity Open
The highly immunosuppressive tumor microenvironment (TME) stimulates cancer cells resistance to immunotherapy. We have previously shown that a live-attenuated Brucella melitensis Δ vjbR(BmΔ vjbR) bacterial strain, breaks cancer cell resist…
View article: NAC1 constrains CD4+ T cell memory formation through the ROCK1-mediated pathway
NAC1 constrains CD4+ T cell memory formation through the ROCK1-mediated pathway Open
Nucleus accumbens-associated protein 1 (NAC1) is a transcriptional co-factor that has been extensively investigated in cancer biology. Our recent studies indicate that NAC1 can modulate the functional activity of regulatory T cells and tum…
View article: Identification of a NACC1-Regulated Gene Signature Implicated in the Features of Triple-Negative Breast Cancer
Identification of a NACC1-Regulated Gene Signature Implicated in the Features of Triple-Negative Breast Cancer Open
Triple-negative breast cancer (TNBC), characterized by a deficiency in estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor2 (HER2), is among the most lethal subtypes of breast cancer (BC). Neverth…
View article: T Cells in Pathogenic Infections
T Cells in Pathogenic Infections Open
T cells are essential to cell-mediated immunity during bacterial, viral, and fungal infections, and immune-related diseases [...]
View article: Identification of a NACC1-Regulated Gene Signature Impli-Cated in the Features of Triple-Negative Breast Cancer
Identification of a NACC1-Regulated Gene Signature Impli-Cated in the Features of Triple-Negative Breast Cancer Open
Triple-negative breast cancer (TNBC), characterized by deficiency in estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor2 (HER2), is among the most lethal subtypes of breast cancer (BC). Neverthel…
View article: T Cell Response to SARS-CoV-2 Coinfection and Comorbidities
T Cell Response to SARS-CoV-2 Coinfection and Comorbidities Open
For the past three years, COVID-19 has become an increasing global health issue. Adaptive immune cells, especially T cells, have been extensively investigated in regard to SARS-CoV-2 infection. However, human health and T cell responses ar…
View article: Reference ranges of myocardial T1 and T2 mapping in healthy Chinese adults: a multicenter 3T cardiovascular magnetic resonance study
Reference ranges of myocardial T1 and T2 mapping in healthy Chinese adults: a multicenter 3T cardiovascular magnetic resonance study Open
View article: Engineering live attenuated vaccines: Old dogs learning new tricks
Engineering live attenuated vaccines: Old dogs learning new tricks Open
Autoimmune diseases such as rheumatoid arthritis and type 1 diabetes are increasingly common global problems. Concerns about increases in the prevalence of such diseases and the limited efficacy of conventional treatment regimens necessita…
View article: A metabolically engineered bacterium controls autoimmunity and inflammation by remodeling the pro-inflammatory microenvironment
A metabolically engineered bacterium controls autoimmunity and inflammation by remodeling the pro-inflammatory microenvironment Open
Immunotherapy has led to impressive advances in the treatment of autoimmune and pro-inflammatory disorders; yet, its clinical outcomes remain limited by a variety of factors including the pro-inflammatory microenvironment (IME). Discoverin…
View article: Tumorous expression of NAC1 restrains antitumor immunity through the LDHA-mediated immune evasion
Tumorous expression of NAC1 restrains antitumor immunity through the LDHA-mediated immune evasion Open
Background T cell-mediated antitumor immunity has a vital role in cancer prevention and treatment; however, the immune-suppressive tumor microenvironment (TME) constitutes a significant contributor to immune evasion that weakens antitumor …
View article: Chicken‐derived <scp>CD20</scp> antibodies with potent B‐cell depletion activity
Chicken‐derived <span>CD20</span> antibodies with potent B‐cell depletion activity Open
Summary We report four novel anti‐human CD20 (hCD20) monoclonal antibodies (mAbs) discovered from a phylogenetically distant species—chickens. The chicken–human chimaeric antibodies exhibit at least 10‐fold enhanced antibody‐dependent cell…
View article: Expression of NAC1 Restrains the Memory Formation of CD8+ T Cells during Viral Infection
Expression of NAC1 Restrains the Memory Formation of CD8+ T Cells during Viral Infection Open
Nucleus accumbens-associated protein 1 (NAC1) is a transcription co-factor that has been shown to possess multiple roles in stem cell and cancer biology. However, little is known about its roles in regulation of the immune system. In the c…
View article: NAC1 modulates autoimmunity by suppressing regulatory T cell–mediated tolerance
NAC1 modulates autoimmunity by suppressing regulatory T cell–mediated tolerance Open
We report here that nucleus accumbens–associated protein-1 (NAC1), a nuclear factor of the Broad-complex, Tramtrack, Bric-a-brac/poxvirus and zinc finger (BTB/POZ) gene family, is a negative regulator of FoxP3 in regulatory T cells (T regs…