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View article: The impact of STAiR18 on multiple myeloma survival rates
The impact of STAiR18 on multiple myeloma survival rates Open
The study revealed that STAiR18 competed with endogenous miR-451a, and formed a novel positive-feedback loop of IL-6R/STAT3/JAK2 to promote proliferation of MM. These findings suggest that STAiR18 represents a promising novel therapeutic s…
View article: XGBoost machine learning algorithm for predicting unplanned readmission in elderly patients with coronary heart disease
XGBoost machine learning algorithm for predicting unplanned readmission in elderly patients with coronary heart disease Open
XGBoost can predict 1-year unplanned readmissions in elderly patients with CHD and identify the risk factors.
View article: Inverse relationship between serum carotenoid levels and obesity prevalence in children and adolescents: a nationwide cross-sectional analysis
Inverse relationship between serum carotenoid levels and obesity prevalence in children and adolescents: a nationwide cross-sectional analysis Open
Our study provides evidence that serum carotenoids, in particular β-carotene, may be associated with a lower prevalence of obesity in children and adolescents.
View article: Deguelin’s Anticancer Bioactivity: Challenges and Opportunities in Medicinal Chemistry
Deguelin’s Anticancer Bioactivity: Challenges and Opportunities in Medicinal Chemistry Open
Deguelin is a natural isoflavone derived from the rotenone family, commonly found in plants belonging to the Derris and Grifola genera. Comprehensive research has underscored its considerable promise in oncological treatment. Deguelin demo…
View article: Associations between body fat anthropometric indices and mortality among individuals with metabolic syndrome
Associations between body fat anthropometric indices and mortality among individuals with metabolic syndrome Open
Background The distribution of body fat and metabolic health may contribute to the onset of metabolic syndrome (MetS), but the associations between body fat anthropometric indices (AIs) and mortality in individuals with MetS remain unclear…
View article: Recent advancements in the small-molecule drugs for hepatocellular carcinoma (HCC): Structure-activity relationships, pharmacological activities, and the clinical trials
Recent advancements in the small-molecule drugs for hepatocellular carcinoma (HCC): Structure-activity relationships, pharmacological activities, and the clinical trials Open
By revealing their structure-activity relationships, pharmacological actions, and clinical trials, small-molecule drugs can offer broad prospects for the development of new medications.
View article: Progress of ATM inhibitors: Opportunities and challenges
Progress of ATM inhibitors: Opportunities and challenges Open
Ataxia-telangiectasia mutated (ATM) was first discovered in patients with AT (ataxia telangiectasia), which is characteristic with cerebellar degeneration, immunodeficiency, being susceptible to malignant tumors and sensitive to radiation.…
View article: Bacteroides ovatus alleviates high-fat and high-cholesterol -induced nonalcoholic fatty liver disease via gut-liver axis
Bacteroides ovatus alleviates high-fat and high-cholesterol -induced nonalcoholic fatty liver disease via gut-liver axis Open
Gut microbiota acts as a critical regulator in the development of nonalcoholic fatty liver disease (NAFLD), making probiotics a promise therapeutic strategy. Studies are needed to identify beneficial Bacteroides strains against NAFLD. Bact…
View article: Progress in the development of modulators targeting Frizzleds
Progress in the development of modulators targeting Frizzleds Open
The Frizzleds (FZDs) receptors on the cell surface belong to the class F of G protein-coupled receptors (GPCRs) which are the major receptors of WNT protein that mediates the classical WNT signaling pathway and other non-classical pathways…
View article: Discovery of Novel Proteolysis-Targeting Chimera Molecules as Degraders of Programmed Cell Death-Ligand 1 for Breast Cancer Therapy
Discovery of Novel Proteolysis-Targeting Chimera Molecules as Degraders of Programmed Cell Death-Ligand 1 for Breast Cancer Therapy Open
The immune checkpoint blockade represents a pivotal strategy for tumor immunotherapy. At present, various programmed cell death-1 (PD-1)/programmed cell death-ligand 1 (PD-L1) monoclonal antibodies have been successfully applied to tumor t…
View article: Correction to “Unleashing the Potential of Camptothecin: Exploring Innovative Strategies for Structural Modification and Therapeutic Advancements”
Correction to “Unleashing the Potential of Camptothecin: Exploring Innovative Strategies for Structural Modification and Therapeutic Advancements” Open
ADVERTISEMENT RETURN TO ARTICLES ASAPPREVAddition/CorrectionNEXTORIGINAL ARTICLEThis notice is a correctionCorrection to "Unleashing the Potential of Camptothecin: Exploring Innovative Strategies for Structural Modification and Therapeutic…
View article: Unleashing the Potential of Camptothecin: Exploring Innovative Strategies for Structural Modification and Therapeutic Advancements
Unleashing the Potential of Camptothecin: Exploring Innovative Strategies for Structural Modification and Therapeutic Advancements Open
Camptothecin (CPT) is a potent anti-cancer agent targeting topoisomerase I (TOP1). However, CPT has poor pharmacokinetic properties, causes toxicities, and leads to drug resistance, which limit its clinical use. In this paper, to review th…
View article: AAA237, an SKP2 inhibitor, suppresses glioblastoma by inducing BNIP3-dependent autophagy through the mTOR pathway
AAA237, an SKP2 inhibitor, suppresses glioblastoma by inducing BNIP3-dependent autophagy through the mTOR pathway Open
Background Glioblastoma (GBM) is the most common brain tumor with the worst prognosis. Temozolomide is the only first-line drug for GBM. Unfortunately, the resistance issue is a classic problem. Therefore, it is essential to develop new dr…
View article: The role of inflammation in autoimmune disease: a therapeutic target
The role of inflammation in autoimmune disease: a therapeutic target Open
Autoimmune diseases (AIDs) are immune disorders whose incidence and prevalence are increasing year by year. AIDs are produced by the immune system’s misidentification of self-antigens, seemingly caused by excessive immune function, but in …
View article: Probiotics and liver fibrosis: An evidence-based review of the latest research
Probiotics and liver fibrosis: An evidence-based review of the latest research Open
Liver fibrosis is one of the most common chronic liver diseases in the world, which can gradually develop into cirrhosis or even liver cancer, posing a serious threat to human health. The causes of liver fibrosis are multiple, including ch…
View article: Corrigendum: Research advances in drug therapy of endometriosis
Corrigendum: Research advances in drug therapy of endometriosis Open
[This corrects the article DOI: 10.3389/fphar.2023.1199010.].
View article: Advances of the small molecule drugs regulating fibroblast-like synovial proliferation for rheumatoid arthritis
Advances of the small molecule drugs regulating fibroblast-like synovial proliferation for rheumatoid arthritis Open
Rheumatoid arthritis (RA) is a type of chronic autoimmune and inflammatory disease. In the pathological process of RA, the alteration of fibroblast-like synoviocyte (FLS) and its related factors is the main influence in the clinic and fund…
View article: [MiR-30e-5p overexpression promotes proliferation and migration of colorectal cancer cells by activating the CXCL12 axis <i>via</i> downregulating PTEN].
[MiR-30e-5p overexpression promotes proliferation and migration of colorectal cancer cells by activating the CXCL12 axis <i>via</i> downregulating PTEN]. Open
Overexpression of miR-30e-5p promotes the malignant behaviors of colorectal cancer cells by downregulating PTEN to activate the CXCL12 axis.
View article: Corrigendum: Research advances in drug therapy of endometriosis
Corrigendum: Research advances in drug therapy of endometriosis Open
[This corrects the article DOI: 10.3389/fphar.2023.1199010.].
View article: Research advances in drug therapy of endometriosis
Research advances in drug therapy of endometriosis Open
Endometriosis is one of the most common benign gynecological disorders in reproductive-aged women. The major symptoms are chronic pelvic pain and infertility. Despite its profound impact on women’s health and quality of life, its pathogene…