Jinhua Li
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View article: Study on the Positive Regulation of Drought Tolerance by Pdmyb2r032 in Populus Deltoides Based on R2r3-Myb Gene Family Analysis
Study on the Positive Regulation of Drought Tolerance by Pdmyb2r032 in Populus Deltoides Based on R2r3-Myb Gene Family Analysis Open
View article: Erzhi pill for diabetic nephropathy: validation of integrated network pharmacology, molecular docking, proteomics, and transcriptomics
Erzhi pill for diabetic nephropathy: validation of integrated network pharmacology, molecular docking, proteomics, and transcriptomics Open
OBJECTIVE: The study aimed to investigate the mechanism of Erzhi Pill in treating diabetic nephropathy (DN) using network pharmacology and molecular docking, with animal experiments providing additional validation. METHODS: Initially, the …
View article: Mining and expression analysis of color related genes in Bougainvillea glabra bracts based on transcriptome sequencing
Mining and expression analysis of color related genes in Bougainvillea glabra bracts based on transcriptome sequencing Open
Bract coloration is one of the key ornamental traits in Bougainvillea, yet research has predominantly focused on phenotypic color traits and pigment composition, with limited understanding of the molecular mechanisms underlying color forma…
View article: The secreted micropeptide C4orf48 enhances renal fibrosis via an RNA-binding mechanism
The secreted micropeptide C4orf48 enhances renal fibrosis via an RNA-binding mechanism Open
Renal interstitial fibrosis is an important mechanism in the progression of chronic kidney disease (CKD) to end-stage kidney disease. However, we lack specific treatments to slow or halt renal fibrosis. Ribosome profiling identified upregu…
View article: Effects of low‐frequency pulsed electrical stimulation at the common peroneal nerve on chronic refractory wounds of the lower limb: A randomized controlled trial
Effects of low‐frequency pulsed electrical stimulation at the common peroneal nerve on chronic refractory wounds of the lower limb: A randomized controlled trial Open
Background and aims Electrical stimulation (ES) has been shown to substantially enhance the quality of life by alleviating pain in patients with chronic wounds. This study aimed to observe the effects of low‐frequency pulsed wearable ES at…
View article: The secreted micropeptide C4orf48 enhances renal fibrosis via an RNA-binding mechanism
The secreted micropeptide C4orf48 enhances renal fibrosis via an RNA-binding mechanism Open
Renal interstitial fibrosis is an important mechanism in the progression of chronic kidney disease (CKD) to end-stage kidney disease. However, we lack specific treatments to slow or halt renal fibrosis. Ribosome profiling identified upregu…
View article: Discovery of novel, potent and orally available benzoazipinone derivatives that elicit MKLP2-inhibitory phenotypes
Discovery of novel, potent and orally available benzoazipinone derivatives that elicit MKLP2-inhibitory phenotypes Open
Mitotic kinesin-like protein 2 (MKLP2/KIF20A) is a key mitotic regulator frequently overexpressed in human malignancies and its abundance is positively correlated with poor outcomes of the disease. Despite extensive research on MKLP2 as a …
View article: Pharmacokinetics, Tissue Distribution, and Formulation Study of a Small-molecule Inhibitor of MKLP2, LG157
Pharmacokinetics, Tissue Distribution, and Formulation Study of a Small-molecule Inhibitor of MKLP2, LG157 Open
LG157 is a recently identified small-molecule inhibitor of mitotic kinesin-like protein 2 (MKLP2), an overlooked oncology target. This study aims to explore the drug developability of LG157, by assessing its druglike properties, determinin…
View article: Left Ventricular Reverse Remodeling After Revascularization and Its Predictive Role for Survival
Left Ventricular Reverse Remodeling After Revascularization and Its Predictive Role for Survival Open
Aims For patients with ischemic heart failure who underwent revascularization, ejection fraction (EF) improvement is a major predictor of survival benefit. However, the association between left ventricular (LV) remodeling and outcomes has …
View article: Site U1580
Site U1580 Open
View article: Site U1579
Site U1579 Open
On 10 February, the pilot boarded at 0942 h.The vessel began the transit to the first site (U1579) with the first line away at 1024 h.The pilot was away at 1045 h, and the start of the sea passage was recorded as 1048 h.Within minutes of t…
View article: Site U1582
Site U1582 Open
Remarks on Taxonomy 2 3 The Biostratigraphical and Biochronological Significance of the Abundance Patterns 23 4.1.Calcidiscus formosus and Reticulofenestra umbilicus 23 4.2.Isthmolithus recurvus 25 4.3.Ericsonia obruta 2 8 4.4.Bramletteius…
View article: Site U1581
Site U1581 Open
View article: Orally Bioavailable 4-Phenoxy-quinoline Compound as a Potent Aurora Kinase B Relocation Blocker for Cancer Treatment
Orally Bioavailable 4-Phenoxy-quinoline Compound as a Potent Aurora Kinase B Relocation Blocker for Cancer Treatment Open
We investigated a novel 4-phenoxy-quinoline-based scaffold that mislocalizes the essential mitotic kinase, Aurora kinase B (AURKB). Here, we evaluated the impact of halogen substitutions (F, Cl, Br, and I) on this scaffold with respect to …
View article: ApoE4-mediated blood-brain barrier damage in Alzheimer's disease: Progress and prospects
ApoE4-mediated blood-brain barrier damage in Alzheimer's disease: Progress and prospects Open
Late-onset Alzheimer's disease (AD), a neurodegenerative disease, is expected in the elderly population and adversely affects families and society. The extensive debate on the deposition of amyloid (Aβ), abnormal phosphorylation of Tau pro…
View article: A Survey: Network Feature Measurement Based on Machine Learning
A Survey: Network Feature Measurement Based on Machine Learning Open
In network management, network measuring is crucial. Accurate network measurements can increase network utilization, network management, and the ability to find network problems promptly. With extensive technological advancements, the diff…
View article: An orally bioavailable 4-phenoxy-quinoline compound as a potent AURKB relocation blocker for cancer treatment
An orally bioavailable 4-phenoxy-quinoline compound as a potent AURKB relocation blocker for cancer treatment Open
We investigated a novel 4-phenoxy-quinoline-based scaffold that mislocalizes the essential mitotic kinase, AURKB. Here, we evaluated the impact of halogen substitutions (F, Cl, Br, I) on this scaffold with respect to various drug parameter…
View article: Medicinal fungus Phellinus igniarius alleviates gout in vitro by modulating TLR4/NF-kB/NLRP3 signaling
Medicinal fungus Phellinus igniarius alleviates gout in vitro by modulating TLR4/NF-kB/NLRP3 signaling Open
Background: Phellinus igniarius ( P. igniarius ) is a valuable medicinal and edible fungus with various biological activities such as anti-inflammation, antioxidation, and immune regulation. In this study, we explored the effects of P. ign…
View article: Development and validation of a prognostic nomogram for predicting cancer-specific survival in patients with metastatic clear cell renal carcinoma: A study based on SEER database
Development and validation of a prognostic nomogram for predicting cancer-specific survival in patients with metastatic clear cell renal carcinoma: A study based on SEER database Open
Objectives Clear cell renal cell carcinoma (ccRCC) is highly prevalent, prone to metastasis, and has a poor prognosis after metastasis. Therefore, this study aimed to develop a prognostic model to predict the individualized prognosis of pa…
View article: Developing and validating clinical features-based machine learning algorithms to predict influenza infection in influenza-like illness patients
Developing and validating clinical features-based machine learning algorithms to predict influenza infection in influenza-like illness patients Open
View article: Application of machine learning algorithms in predicting HIV infection among men who have sex with men: Model development and validation
Application of machine learning algorithms in predicting HIV infection among men who have sex with men: Model development and validation Open
Background Continuously growing of HIV incidence among men who have sex with men (MSM), as well as the low rate of HIV testing of MSM in China, demonstrates a need for innovative strategies to improve the implementation of HIV prevention. …
View article: Discovery and Optimization of Seven-Membered Lactam-Based Compounds to Phenocopy the Inhibition of the Aurora Kinase B
Discovery and Optimization of Seven-Membered Lactam-Based Compounds to Phenocopy the Inhibition of the Aurora Kinase B Open
We used mechanism-informed phenotypic screening to identify and optimize compounds that phenocopy the genetic depletion of the mitotic aurora kinase B (AURKB) kinase. After assaying nine aryl fused seven-membered lactam compounds, we ident…
View article: A Case of Postoperative Multiple Organ Metastases from Renal Ewing Sarcoma and Review of the Literature
A Case of Postoperative Multiple Organ Metastases from Renal Ewing Sarcoma and Review of the Literature Open
The incidence of extra-osseous Ewing sarcoma is low, and extra-osseous Ewing sarcoma of renal origin is even less frequently reported. The clinical manifestation of Ewing sarcoma is non-specific and early diagnosis is difficult, and the di…
View article: Repurposing Riociguat to Target a Novel Paracrine Nitric Oxide-TRPC6 Pathway to Prevent Podocyte Injury
Repurposing Riociguat to Target a Novel Paracrine Nitric Oxide-TRPC6 Pathway to Prevent Podocyte Injury Open
Increased expression and activity of the Ca2+ channel transient receptor potential channel 6 (TRPC6) is associated with focal segmental glomerulosclerosis, but therapeutic strategies to target TRPC6 are currently lacking. Nitric oxide (NO)…
View article: Danlou Tablets Inhibit Atherosclerosis in Apolipoprotein E-Deficient Mice by Inducing Macrophage Autophagy: The Role of the PI3K-Akt-mTOR Pathway
Danlou Tablets Inhibit Atherosclerosis in Apolipoprotein E-Deficient Mice by Inducing Macrophage Autophagy: The Role of the PI3K-Akt-mTOR Pathway Open
Atherosclerosis (AS) is a type of chronic vascular disease, and its etiology is not yet fully understood. AS is characterized by lipid deposition, atherosclerotic plaque formation, vascular stenosis or even complete blockage of the blood v…
View article: Clinical effects of high-intensity laser therapy on patients with chronic refractory wounds: a randomised controlled trial
Clinical effects of high-intensity laser therapy on patients with chronic refractory wounds: a randomised controlled trial Open
Objective To investigate the effectiveness of high-intensity laser therapy (HILT) on chronic refractory wounds. Design Randomised controlled trial. Setting The outpatient wound care department of the Affiliated Jiangsu Shengze Hospital of …
View article: Nicotinamide riboside attenuates age-associated metabolic and functional changes in hematopoietic stem cells
Nicotinamide riboside attenuates age-associated metabolic and functional changes in hematopoietic stem cells Open
With age, hematopoietic stem cells (HSC) undergo changes in function, including reduced regenerative potential and loss of quiescence, which is accompanied by a significant expansion of the stem cell pool that can lead to haematological di…
View article: Long-Term Outcome of Secondary Steroid-Resistant Nephrotic Syndrome in Chinese Children
Long-Term Outcome of Secondary Steroid-Resistant Nephrotic Syndrome in Chinese Children Open
View article: Combination Effect of Three Main Constituents From Sarcandra glabra Inhibits Oxidative Stress in the Mice Following Acute Lung Injury: A Role of MAPK-NF-κB Pathway
Combination Effect of Three Main Constituents From Sarcandra glabra Inhibits Oxidative Stress in the Mice Following Acute Lung Injury: A Role of MAPK-NF-κB Pathway Open
Caffeoylquinic acids, coumarins and dicaffeoyl derivatives are considered to be three kinds of the most abundant bioactive components in Sarcandra glabra , an anti-inflammatory herb mainly found in Southern Asia. The combined anti-inflamma…
View article: Decreased expression of endothelial cell specific molecule-1 in lung tissue in emphysematous mice and stable COPD patients.
Decreased expression of endothelial cell specific molecule-1 in lung tissue in emphysematous mice and stable COPD patients. Open
ESM-1 expression decreased and AI increased in emphysematous mice and stable COPD patients. Findings suggested that ESM-1 may be involved in anti-apoptotic therapy of COPD.