Explanipedia

Hypothermic oxygenated machine perfusion in non-transplant liver surgery: a polled, comparative and quantitative study — correspondence Open

Jianyun Liu, Xiaoyan Liang, Lei Wei · 2025

AKT is a unique downstream mediator of TLR signaling in human mesenchymal stem cells 2927 Open

Jianyun Liu, Chelsea Hunter, S. Joseph, Jasmine Lee, John Brokaw , et al. · 2025

Description Mesenchymal stem cells (MSCs) are being extensively studied in clinical trials for different medical conditions. Understanding the mechanism of MSC therapy is valuable for its clinical application. Activation of TLR signaling p…

Mesenchymal Stromal Cell Therapy Restores Intestinal Integrity and Attentuates Inflammation in a Preterm Piglet Model of Necrotizing Enterocolitis Open

Jasmine Lee, S. Joseph, Krishna Manohar, Fikir Mesfin, Chelsea Hunter , et al. · 2025

Genome-wide association studies with prolapsed gland of the third eyelid in dogs Open

Yu Zeng, Chao Feng, Zishang Jiang, Weian Du, Shan He , et al. · 2025

Cherry eye, the common name for the prolapse of the third eyelid gland in dogs, is a widespread ophthalmic disease affecting dogs of various breeds. This condition severely affects the quality of life of affected dogs, and its underlying c…

Use of a Near Infrared Probe to Assess Intracellular Hydrogen Sulfide Production Open

Jianyun Liu, Fikir M. Mesfin, Li‐Fan Zeng, Krishna Manohar, Chelsea Hunter , et al. · 2025

Nano-confined MnFe2O4/Sepiolite composite for selective and energy-efficient Pb2+ removal via capacitive deionization Open

Boshuang zhang, Yiwen Wang, Meng Li, Zheng Wei, Jianmao Yang , et al. · 2025

Role of innate T cells in necrotizing enterocolitis Open

Jianyun Liu, S. Joseph, Krishna Manohar, Jasmine Lee, John P. Brokaw , et al. · 2024

Necrotizing enterocolitis (NEC) is a destructive gastrointestinal disease primarily affecting preterm babies. Despite advancements in neonatal care, NEC remains a significant cause of morbidity and mortality in neonatal intensive care unit…

LOC646762 Is Involved in Adipogenic Differentiation of Bone Marrow-Derived Mesenchymal Stem Cells Open

Yifan Shao, Minqi Xiong, Jianyun Liu, Zhiping Gu, Zhaoping Wu , et al. · 2024

Long noncoding RNA (lncRNA) has been shown to participate in adipogenic differentiation of bone marrow-derived mesenchymal stem cells (BMSCs). In this study, we aimed to investigate the role of lncRNA-LOC646762 in adipogenic differentiatio…

Tunable Ca Doping in Mgfemno4 Electrode for Enhanced Hardness Removal Selectivity Open

Yue Zhu, Pengfei Nie, Jianan Sun, Boshuang zhang, Jianmao Yang , et al. · 2024

La-Doped Ceo2/Rgo Hybrid  with High Oxygen Vacancy to Enhance Phosphorus Adsorption by Capacitive Deionization Open

Hengfeng Qian, Boshuang zhang, Xiangju Song, Heqing Jiang, Jianmao Yang , et al. · 2024

CD1d-dependent neuroinflammation impairs tissue repair and functional recovery following a spinal cord injury Open

Xiangbing Wu, Jianyun Liu, Wei Li, Mohammad Faizan Khan, Heqiao Dai , et al. · 2023

Tissue damage resulting from a spinal cord injury (SCI) is primarily driven by a robust neuroimmune/neuroinflammatory response. This intricate process is mainly governed by a multitude of cytokines and cell surface proteins in the central …

Genomic selection analysis of morphological and adaptation traits in Chinese indigenous dog breeds Open

Yangfeng Li, Min Huang, Zhenjie Wang, Xueyuan Liu, Shan He , et al. · 2023

The significant morphological differences and abundant germplasm resources of Chinese indigenous dog breeds can be attributed to the diverse geographical environment, including plateaus, mountains, and a long history of raising dogs. The c…

Chondroitin sulfate supplementation improves clinical outcomes in a murine model of necrotizing enterocolitis Open

Krishna Manohar, Brian D. Hosfield, Fikir M. Mesfin, Cameron L. Colgate, W. Christopher Shelley , et al. · 2023

Necrotizing enterocolitis (NEC) continues to be a devastating disease in preterm neonates and has a paucity of medical management options. Chondroitin sulfate (CS) is a naturally occurring glycosaminoglycan (GAG) in human breast milk (HM) …

TMT-based quantitative proteomic analysis revealed that FBLN2 and NPR3 are involved in the early osteogenic differentiation of mesenchymal stem cells (MSCs) Open

Jianyun Liu, Shan He, Baicheng Ma, Xingnuan Li, Yaqin Wang , et al. · 2023

The delicate equilibrium between osteoblast and adipocyte differentiation of MSCs is highly regulated. We screened for early-stage osteogenesis- or adipogenesis-based MSCs protein expression profiles using TMT-based quantitative proteomic …

A sodium-ion-conducted asymmetric electrolyzer to lower the operation voltage for direct seawater electrolysis Open

Hao Shi, Tanyuan Wang, Jianyun Liu, Weiwei Chen, Shenzhou Li , et al. · 2023

Stem cells as a therapeutic avenue for active and long-term complications of Necrotizing Enterocolitis Open

Fikir M. Mesfin, Krishna Manohar, W. Christopher Shelley, John P. Brokaw, Jianyun Liu , et al. · 2023

MR1-deficiency in neonatal mice renders protection from necrotizing enterocolitis Open

Jianyun Liu, Chelsea Hunter, Krishna Manohar, Fikir Mesfin, W. Christopher Shelley , et al. · 2023

Necrotizing enterocolitis (NEC) is a life-threatening disease that affects ~ 7% of premature neonates. NEC maintains high morbidity/mortality and there are long term sequelae including short bowel syndrome. The risk factors of developing N…

Stem cell derived therapies to preserve and repair the developing intestine Open

Fikir M. Mesfin, Krishna Manohar, Chelsea Hunter, W. Christopher Shelley, John P. Brokaw , et al. · 2023

Gut-Brain cross talk: The pathogenesis of neurodevelopmental impairment in necrotizing enterocolitis Open

Krishna Manohar, Fikir M. Mesfin, Jianyun Liu, W. Christopher Shelley, John P. Brokaw , et al. · 2023

Necrotizing enterocolitis (NEC) is a devastating condition of multi-factorial origin that affects the intestine of premature infants and results in high morbidity and mortality. Infants that survive contend with several long-term sequelae …

Upregulation of MTHFD2 is associated with PD‑L1 activation in bladder cancer via the PI3K/AKT pathway Open

Xinxi Deng, Xiaoqiang Liu, Bing Hu, Jianyun Liu, Bin Fu , et al. · 2022

Methylenetetrahydrofolate dehydrogenase 2 (MTHFD2) has been implicated in the etiology of various human malignant tumors; however, its exact role in bladder cancer (BC) remains to be explored. Through reverse transcription‑quantitative PCR…

The downstream PPARγ target LRRC1 participates in early stage adipocytic differentiation Open

Xinping Wang, Jianyun Liu, Ting Wang, Baicheng Ma, Ping Wu , et al. · 2022

The downstream PPARγ target LRRC1 participates in early-stage adipocytic differentiation Open

Xinping Wang, Jianyun Liu, Ting Wang, Baicheng Ma, Ping Wu , et al. · 2022

LRRC1 is a regulator of cellular polarity that is expressed at high levels in a range of tumor tissue types. Here, we conducted an analysis of the previously unexplored role of LRRC1 as a component of the adipogenic differentiation network…

Greasing wheels of cell-free therapies for cardiovascular diseases: Integrated devices of exosomes/exosome-like nanovectors with bioinspired materials Open

Xuerui Chen, Liyun Zhu, Jianyun Liu, Yi Lu, Longlu Pan , et al. · 2022

Mortality and morbidity of cardiovascular diseases (CVDs) including ischemic heart disease (IHD) and heart failure (HF) are arising worldwide. Once cardiomyocyte is impaired, it is challenging to regenerate which is largely limited by the …

Editorial: Insights in General Cardiovascular Medicine: 2021 Open

Lijun Wang, Jianyun Liu, Yi Lu, Maurizio Acampa, Pier Leopoldo Capecchi , et al. · 2022

Genetic mutation is the major cause of congenital heart defects (CHDs). This study identified miRNAs-mediated regulating on single-nucleotide variants from 3'-UTR of CHD-associated genes. This study suggests that miRNA-related gene regulat…

Candidate genes responsible for lipid droplets formation during adipogenesis simultaneously affect osteoblastogenesis Open

Yi Xia, Ping Wu, Ying Gong, Jianyun Liu, Jianjun Xiong , et al. · 2022

The establishment of the gene transcriptional profiling of lipid droplets formation would provide the molecular switches of hMSCs cell fate determination and the study targets for fat metabolic diseases.

Alterations in chromatin accessibility during osteoblast and adipocyte differentiation in human mesenchymal stem cells Open

Jianyun Liu, Lijun Gan, Baichen Ma, Shan He, Ping Wu , et al. · 2022

Analysis of Risk Factors Related to Acute Kidney Injury After Liver Transplantation in Children Open

Kun Dong, Jianyun Liu, Cheng Zhang, Junze Chen, Chunqiang Dong · 2022

Objective: To identify risk factors related to the development of acute kidney injury (AKI) in children who underwent liver transplantation. Methods: We retrospectively analyzed data of pediatric patients who underwent liver transplantatio…

Downregulation of MTHFD2 Inhibits the Progression of Bladder Cancer Through PI3K/AKT Signaling Pathways Open

Xinxi Deng, Xiaoqiang Liu, Bing Hu, Jianyun Liu, Wensheng Zhang , et al. · 2022

Background: Methylenetetrahydrofolate dehydrogenase 2 (MTHFD2) is related to the pathogenesis of many human malignant tumors, but its role in bladder cancer remains poorly understood. We aimed to determine the effect of downregulation of M…

Efficient Transient Thermal Analysis of Chiplet Heterogeneous Integration Open

Chuanjun Nie, Qin‐Zhi Xu, Chenghan Wang, He Cao, Jianyun Liu , et al. · 2022

Case Report: Exome Sequencing Identified Variants in Three Candidate Genes From Two Families With Hearing Loss, Onychodystrophy, and Epilepsy Open

Yuan Li, Jianjun Xiong, Yi Zhang, Lin Xu, Jianyun Liu , et al. · 2021

A cohort of 542 individuals in 166 families with congenital hearing loss was recruited for whole-exome sequencing analysis. Here, we report the identification of three variants in five affected individuals in two unrelated families. In fam…

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