Jianzhi Zhao
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View article: Auricularia heimuer Ameliorates Oxidative Stress and Inflammation to Inhibit Atherosclerosis Development in ApoE−/− Mice
Auricularia heimuer Ameliorates Oxidative Stress and Inflammation to Inhibit Atherosclerosis Development in ApoE−/− Mice Open
Background: Atherosclerosis is a chronic vascular disease triggered by lipid accumulation. Auricularia heimuer is rich in various bioactive compounds that have anti-inflammatory, antioxidant, and hypolipidemic properties. The specific bene…
View article: Tremella fuciformis Berk Alleviated Atherosclerosis Symptoms via Nuclear Factor-Kappa B-Mediated Inflammatory Response in ApoE−/− Mice
Tremella fuciformis Berk Alleviated Atherosclerosis Symptoms via Nuclear Factor-Kappa B-Mediated Inflammatory Response in ApoE−/− Mice Open
Background: Atherosclerosis, a persistent inflammatory disease marked by the presence of atherosclerotic plaques or fibrous plaques, is a significant contributor to the onset of the development of cardiovascular disease. Tremella fuciformi…
View article: Widely Targeted Metabolomics Revealed the Metabolic Basis of Physiological Function and Flavor of Natto
Widely Targeted Metabolomics Revealed the Metabolic Basis of Physiological Function and Flavor of Natto Open
Background: Natto is a fermented product derived from soybeans through the action of Bacillus subtilis natto, possessing various pharmacological and health-promoting properties. However, due to the absence of large-scale and systematic inv…
View article: Genetic association of type 2 diabetes and antidiabetic drug target with skin cancer
Genetic association of type 2 diabetes and antidiabetic drug target with skin cancer Open
Background Several observational studies have suggested that type 2 diabetes (T2D) is a risk factor for skin cancer, and antidiabetic drugs may reduce skin cancer risk. Nevertheless, the findings remain ambiguous. This Mendelian randomizat…
View article: Engineering transcriptional regulatory networks for improving second-generation fuel ethanol production in Saccharomyces cerevisiae
Engineering transcriptional regulatory networks for improving second-generation fuel ethanol production in Saccharomyces cerevisiae Open
View article: Development of a Robust Saccharomyces cerevisiae Strain for Efficient Co-Fermentation of Mixed Sugars and Enhanced Inhibitor Tolerance through Protoplast Fusion
Development of a Robust Saccharomyces cerevisiae Strain for Efficient Co-Fermentation of Mixed Sugars and Enhanced Inhibitor Tolerance through Protoplast Fusion Open
The economical and efficient commercial production of second-generation bioethanol requires fermentation microorganisms capable of entirely and rapidly utilizing all sugars in lignocellulosic hydrolysates. In this study, we developed a rec…
View article: Highly Efficient Production of Cellulosic Ethanol from Poplar Using an Optimal C6/C5 Co-Fermentation Strain of Saccharomyces cerevisiae
Highly Efficient Production of Cellulosic Ethanol from Poplar Using an Optimal C6/C5 Co-Fermentation Strain of Saccharomyces cerevisiae Open
Cellulosic ethanol is the key technology to alleviate the pressure of energy supply and climate change. However, the ethanol production process, which is close to industrial production and has a high saccharification rate and ethanol yield…
View article: Disease Burden of Atopic Dermatitis in China and Globally: An Analysis Based on the Global Burden of Disease Study of 2021
Disease Burden of Atopic Dermatitis in China and Globally: An Analysis Based on the Global Burden of Disease Study of 2021 Open
View article: A Predictive Model for Progression to Overt Primary Myelofibrosis in Prefibrotic Primary Myelofibrosis Patients
A Predictive Model for Progression to Overt Primary Myelofibrosis in Prefibrotic Primary Myelofibrosis Patients Open
View article: Engineering Saccharomyces cerevisiae for efficient production of recombinant proteins
Engineering Saccharomyces cerevisiae for efficient production of recombinant proteins Open
Saccharomyces cerevisiae is an excellent microbial cell factory for producing valuable recombinant proteins because of its fast growth rate, robustness, biosafety, ease of operability via mature genomic modification technologies, an…
View article: Co-Fermentation of Glucose–Xylose–Cellobiose–XOS Mixtures Using a Synthetic Consortium of Recombinant Saccharomyces cerevisiae Strains
Co-Fermentation of Glucose–Xylose–Cellobiose–XOS Mixtures Using a Synthetic Consortium of Recombinant Saccharomyces cerevisiae Strains Open
The efficient conversion of cellulosic sugars is vital for the economically viable production of biofuels/biochemicals from lignocellulosic biomass hydrolysates. Based on comprehensive screening, Saccharomyces cerevisiae RC212 was chosen a…
View article: High-Efficient Production of Cellulosic Ethanol from Corn Fiber Based on the Suitable C5/C6 Co-Fermentation Saccharomyces cerevisiae Strain
High-Efficient Production of Cellulosic Ethanol from Corn Fiber Based on the Suitable C5/C6 Co-Fermentation Saccharomyces cerevisiae Strain Open
As a potential alternative to fossil-based fuels, cellulosic ethanol has attracted much attention due to its great benefit to energy sustainability and environmental friendliness. However, at present, the industrial competitiveness of cell…
View article: Reaction-passivation mechanism driven materials separation for recycling of spent lithium-ion batteries
Reaction-passivation mechanism driven materials separation for recycling of spent lithium-ion batteries Open
View article: The impacts of nicotinamide and inositol on the available cells and product performance of industrial baker's yeasts
The impacts of nicotinamide and inositol on the available cells and product performance of industrial baker's yeasts Open
View article: Engineering Cell Polarization Improves Protein Production in Saccharomyces cerevisiae
Engineering Cell Polarization Improves Protein Production in Saccharomyces cerevisiae Open
Saccharomyces cerevisiae has been widely used as a microbial cell factory to produce recombinant proteins. Therefore, enhancing the protein production efficiency of yeast cell factories to expand the market demand for protein products is n…
View article: Integrated analysis of tRNA-derived small RNAs in proliferative human aortic smooth muscle cells
Integrated analysis of tRNA-derived small RNAs in proliferative human aortic smooth muscle cells Open
View article: Biosensor-Coupled <i>In Vivo</i> Mutagenesis and Omics Analysis Reveals Reduced Lysine and Arginine Synthesis To Improve Malonyl-Coenzyme A Flux in <i>Saccharomyces cerevisiae</i>
Biosensor-Coupled <i>In Vivo</i> Mutagenesis and Omics Analysis Reveals Reduced Lysine and Arginine Synthesis To Improve Malonyl-Coenzyme A Flux in <i>Saccharomyces cerevisiae</i> Open
Malonyl-CoA is a key precursor for the production a variety of value-added chemicals. Although rational engineering has been performed to improve the synthesis of malonyl-CoA in S. cerevisiae , due to the complexity of the metabolism there…
View article: Early Death and Survival of Patients With Acute Promyelocytic Leukemia in ATRA Plus Arsenic Era: A Population-Based Study
Early Death and Survival of Patients With Acute Promyelocytic Leukemia in ATRA Plus Arsenic Era: A Population-Based Study Open
Most randomized trials for acute promyelocytic leukemia (APL) have investigated highly selected patients under idealized conditions, and the findings need to be validated in the real world. We conducted a population-based study of all APL …
View article: miR-320 accelerates chronic heart failure with cardiac fibrosis through activation of the IL6/STAT3 axis
miR-320 accelerates chronic heart failure with cardiac fibrosis through activation of the IL6/STAT3 axis Open
Cardiac fibrosis could induce abnormal cardiac function and become a novel target for cardiac hypertrophy and chronic heart failure. MiRNA-320 is a crucial miRNA in cardiovascular disease, but it is poorly understood whether it plays a rol…
View article: Mitochondrial UPR negatively regulates wounding-induced innate immune response in <i>C. elegans</i> epidermis
Mitochondrial UPR negatively regulates wounding-induced innate immune response in <i>C. elegans</i> epidermis Open
Tissue damage elicits a rapid innate immune response that is essential for efficient wound healing and survival of metazoans. It is well known that p38 MAPK kinase, TGF-β, and hemidesmosome signaling pathways have been involved in wounding…
View article: Integrated Analysis of tRNA-Derived Small RNAs in Proliferative Human Aortic Smooth Muscle Cells
Integrated Analysis of tRNA-Derived Small RNAs in Proliferative Human Aortic Smooth Muscle Cells Open
Background Abnormal proliferation of vascular smooth muscle cells (VSMCs) contributes to vascular remodeling diseases. Recently, it has been discovered that tRNA-derived small RNAs (tsRNAs), a new type of non-coding RNAs, are related to th…
View article: A C6/C5 co‐fermenting<i>Saccharomyces cerevisiae</i>strain with the alleviation of antagonism between xylose utilization and robustness
A C6/C5 co‐fermenting<i>Saccharomyces cerevisiae</i>strain with the alleviation of antagonism between xylose utilization and robustness Open
During second‐generation bioethanol production from lignocellulosic biomass, the desired traits for fermenting microorganisms, such as Saccharomyces cerevisiae , are high xylose utilization and high robustness to inhibitors in lignocellulo…
View article: CAG regimen for refractory or relapsed adult T‐cell acute lymphoblastic leukemia: A retrospective, multicenter, cohort study
CAG regimen for refractory or relapsed adult T‐cell acute lymphoblastic leukemia: A retrospective, multicenter, cohort study Open
Adult patients with relapsed or refractory T‐cell acute lymphoblastic leukemia (R/R‐T‐ALL) have extremely poor prognosis, representing an urgent unmet medical need. Finding an optimal salvage regimen to bridge transplantation is a priority…
View article: Screening and functional prediction of differentially expressed circRNAs in proliferative human aortic smooth muscle cells
Screening and functional prediction of differentially expressed circRNAs in proliferative human aortic smooth muscle cells Open
Vascular smooth muscle cell (VSMC) proliferation is the pathological base of vascular remodelling diseases. Circular RNAs (circRNAs) are important regulators involved in various biological processes. However, the function of circRNAs in VS…
View article: Dynamic control of ERG20 expression combined with minimized endogenous downstream metabolism contributes to the improvement of geraniol production in Saccharomyces cerevisiae
Dynamic control of ERG20 expression combined with minimized endogenous downstream metabolism contributes to the improvement of geraniol production in Saccharomyces cerevisiae Open
View article: Coutilization of D-Glucose, D-Xylose, and L-Arabinose in<i> Saccharomyces cerevisiae</i> by Coexpressing the Metabolic Pathways and Evolutionary Engineering
Coutilization of D-Glucose, D-Xylose, and L-Arabinose in<i> Saccharomyces cerevisiae</i> by Coexpressing the Metabolic Pathways and Evolutionary Engineering Open
Efficient and cost-effective fuel ethanol production from lignocellulosic materials requires simultaneous cofermentation of all hydrolyzed sugars, mainly including D-glucose, D-xylose, and L-arabinose. Saccharomyces cerevisiae is a traditi…