Jian Zhang
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View article: Prognostic Value of Baseline and Soluble ST2 Change in Patients With Light Chain Cardiac Amyloidosis
Prognostic Value of Baseline and Soluble ST2 Change in Patients With Light Chain Cardiac Amyloidosis Open
Background The prognostic significance of dynamic changes in soluble suppression of tumorigenicity‐2 (sST2) in patients with light chain cardiac amyloidosis (AL‐CA) remains unclear. We aimed to evaluate the prognostic significance of both …
View article: Introduction of Heart Failure: An Increasing Public Health Concern
Introduction of Heart Failure: An Increasing Public Health Concern Open
Heart failure (HF) is a complex clinical syndrome caused by a range of diseases and has multiple comorbidities. As the final stage of many cardiovascular diseases, HF has become a significant global public health issue, marked by high prev…
View article: Causal relationships of serum iron metabolites with sepsis and cardiomyopathy: a Mendelian randomization analysis
Causal relationships of serum iron metabolites with sepsis and cardiomyopathy: a Mendelian randomization analysis Open
Objective: The study aims to investigate the causal relationships of serum iron (SI) metabolites with sepsis and cardiomyopathy as two distinct outcomes. Methods: Genome-wide association studies (GWAS) data for SI, serum ferritin (SF), ser…
View article: Global, regional, and national burden of heart failure in young adults aged 15-49 years, 1990-2021: results from the global burden of disease study 2021
Global, regional, and national burden of heart failure in young adults aged 15-49 years, 1990-2021: results from the global burden of disease study 2021 Open
Background Heart failure (HF) represents a growing global health challenge, with its burden escalating worldwide. While HF has traditionally been associated with older adults, recent years have witnessed a concerning rise in diagnoses amon…
View article: The global, regional, and national burden of early, middle, and late-onset esophageal cancer and trends from 1990 to 2021: a systematic analysis of the Global Burden of Disease Study 2021
The global, regional, and national burden of early, middle, and late-onset esophageal cancer and trends from 1990 to 2021: a systematic analysis of the Global Burden of Disease Study 2021 Open
Our findings highlighted the need for targeted cancer control strategies that address population-specific needs, particularly with respect to age, gender, and sociodemographic disparities.
View article: Efficacy of Trastuzumab Deruxtecan in HER2-Positive and HER2-Low Metastatic Breast Cancer: A Real-World Retrospective Cohort Study in China
Efficacy of Trastuzumab Deruxtecan in HER2-Positive and HER2-Low Metastatic Breast Cancer: A Real-World Retrospective Cohort Study in China Open
In this real-world analysis, T-DXd demonstrated robust clinical activity in both HER2-positive and HER2-low MBC, consistent with the findings from the DESTINY-Breast clinical trials. Notably, we identified several clinically relevant progn…
View article: Out-of-Office Blood Pressure Measurements in Patients with Heart Failure Registry Study (OOBPM-HF study) in China: study protocol, rationale and design
Out-of-Office Blood Pressure Measurements in Patients with Heart Failure Registry Study (OOBPM-HF study) in China: study protocol, rationale and design Open
Background The optimal blood pressure (BP) target for patients with heart failure (HF) remains a topic of debate. The relationship between out-of-office BP measurements and the prognosis of HF patients is still unclear. However, there is a…
View article: Non-linear associations of triglyceride glucose index with all-cause and cardiovascular mortality in patients with heart failure
Non-linear associations of triglyceride glucose index with all-cause and cardiovascular mortality in patients with heart failure Open
View article: Epigenetic dysregulation-induced metabolic reprogramming fuels tumor progression in bladder cancer
Epigenetic dysregulation-induced metabolic reprogramming fuels tumor progression in bladder cancer Open
Background Bladder cancer remains a significant global health challenge with a high mortality rate despite advancements in treatment modalities. Metabolic alterations serve as crucial contributors to cancer progression, particularly influe…
View article: Unraveling the causal nexus of cathepsins and rheumatoid arthritis: Insights from a two-sample Mendelian randomization framework
Unraveling the causal nexus of cathepsins and rheumatoid arthritis: Insights from a two-sample Mendelian randomization framework Open
Rheumatoid arthritis (RA) is an autoimmune disease attacking joints throughout the body. Cathepsins (CTSs) are essential intracellular proteases participating in immune regulation, bone remodeling, and cartilage degradation. Though the obs…
View article: Case Report: A rare case of male breast synovial sarcoma
Case Report: A rare case of male breast synovial sarcoma Open
Synovial sarcoma (SS) is a rare and aggressive malignancy that primarily affects young people and usually occurs in the extremities. Breast involvement is uncommon, and males with breast SS are even rarer. We present a rare case of a 17-ye…
View article: Global Trends and Regional Differences in the Burden of Infective Endocarditis, 1990–2021: An Analysis of the Global Burden of Disease Study 2021
Global Trends and Regional Differences in the Burden of Infective Endocarditis, 1990–2021: An Analysis of the Global Burden of Disease Study 2021 Open
View article: Splicing Defects and Cell Death Cause <i>SF3B2</i> -Linked Craniofacial Microsomia
Splicing Defects and Cell Death Cause <i>SF3B2</i> -Linked Craniofacial Microsomia Open
Craniofacial microsomia (CFM) is a genetically and phenotypically heterogeneous disorder characterized by hypoplasia of facial tissue that is often asymmetric. Affected tissues typically include the ears (external and internal), mandible, …
View article: Integrated seminal plasma metabolomics and lipidomics profiling highlight distinctive signature of varicocele patients with male infertility
Integrated seminal plasma metabolomics and lipidomics profiling highlight distinctive signature of varicocele patients with male infertility Open
Varicocele (VC) is a common cause of male infertility, yet there is a lack of molecular information for VC-associated male infertility. This study investigated alterations in the seminal plasma metabolomic and lipidomic profiles of inferti…
View article: Comparison of predicting value of triglyceride‑glucose indices family in cardiovascular disease risk over time: Insights from a 9-year nationwide prospective cohort study
Comparison of predicting value of triglyceride‑glucose indices family in cardiovascular disease risk over time: Insights from a 9-year nationwide prospective cohort study Open
View article: Interventional Treatment Strategies for Carotid Blowout Syndrome After Radiotherapy for Nasopharyngeal Carcinoma
Interventional Treatment Strategies for Carotid Blowout Syndrome After Radiotherapy for Nasopharyngeal Carcinoma Open
Endovascular interventions, including coil embolization and stent grafting, are effective in managing CBS in NPC patients after radiotherapy. Future research should focus on refining patient selection criteria and optimizing long-term outc…
View article: Weight‐Adjusted Waist Index May Predict Hypertension Plus Hyperuricemia
Weight‐Adjusted Waist Index May Predict Hypertension Plus Hyperuricemia Open
The weight‐adjusted waist index (WWI) is a novel indicator that could estimate body fat and muscle mass. This study aimed to investigate the relationship between WWI and hypertension plus hyperuricemia (HTN‐HUA). The data were obtained fro…
View article: SUGP1 loss is the sole driver of SF3B1 hotspot mutant missplicing in cancer
SUGP1 loss is the sole driver of SF3B1 hotspot mutant missplicing in cancer Open
SF3B1 is the most frequently mutated splicing factor in cancer. Mechanistically, such mutations cause missplicing by promoting aberrant 3’ splice site usage; however, how this occurs remains controversial. To address this issue, we employe…
View article: Research on predicting radiographic exposure time in imaging based on neural network prediction models
Research on predicting radiographic exposure time in imaging based on neural network prediction models Open
Age, hypertension, double curvature of the subclavian and innominate arteries, proximal left common carotid artery loop, diameter of the aortic arch, width and length of the innominate artery, and angle between the innominate artery and ao…
View article: Artificial intelligence in cardiac metabolism: the next frontier in cardiovascular health
Artificial intelligence in cardiac metabolism: the next frontier in cardiovascular health Open
In this article, we aim to explore the rapidly developing role of artificial intelligence (AI) in cardiac metabolism research, highlighting its impact on biomarker discovery, precision medicine, and patient stratification. Cardiac metaboli…
View article: Prognostic Value of Plasma Big Endothelin-1 in Patients Hospitalized for Heart Failure
Prognostic Value of Plasma Big Endothelin-1 in Patients Hospitalized for Heart Failure Open
Elevated big ET-1 was independently associated with cardiovascular death in patients with HF. Big ET-1 may be a promising indicator of HF prognosis. In combination with NT-proBNP, big ET-1 may provide incremental predictive information.
View article: Diffusion-Weighted Imaging–Based Radiomics Features and Machine Learning Method to Predict the 90-Day Prognosis in Patients With Acute Ischemic Stroke
Diffusion-Weighted Imaging–Based Radiomics Features and Machine Learning Method to Predict the 90-Day Prognosis in Patients With Acute Ischemic Stroke Open
Objectives: The evaluation of the prognosis of patients with acute ischemic stroke (AIS) is of great significance in clinical practice. We aim to evaluate the feasibility and effectiveness of diffusion-weighted imaging (DWI) image-based ra…
View article: Association between RDW-SD and prognosis across glycemic status in patients with dilated cardiomyopathy
Association between RDW-SD and prognosis across glycemic status in patients with dilated cardiomyopathy Open
Introduction The prognostic significance of red cell distribution width-SD (RDW-SD) as a promising inflammatory biomarker in individuals with non-ischemic dilated cardiomyopathy (DCM) and varying glycemic status remains unexplored. Researc…
View article: Low Aortic Pulsatility Index and Pulmonary Artery Pulsatility Index Are Associated With Increased Mortality in Patients With Dilated Cardiomyopathy Awaiting Heart Transplantation
Low Aortic Pulsatility Index and Pulmonary Artery Pulsatility Index Are Associated With Increased Mortality in Patients With Dilated Cardiomyopathy Awaiting Heart Transplantation Open
ClinicalTrials.gov Identifier: NCT02664818.
View article: Oncofetal MCB1 Is a Functional Biomarker for HCC Personalized Therapy
Oncofetal MCB1 Is a Functional Biomarker for HCC Personalized Therapy Open
Hepatocellular carcinoma (HCC) is one of the leading causes of cancer‐related death worldwide and lacks biomarkers for personalized therapy. Herein, it is reported that MCB1 could be a novel oncofetal protein that is upregulated in the pre…
View article: Mechanisms of tamoxifen resistance: insight from long non-coding RNAs
Mechanisms of tamoxifen resistance: insight from long non-coding RNAs Open
Breast cancer(BC) is the second most prevalent tumor in the world and one of the most lethal tumors in women. Patients with estrogen receptor-positive breast cancer can obtain significant advantages from endocrine therapies including tamox…
View article: Construction of a metabolism-malnutrition-inflammation prognostic risk score in patients with heart failure with preserved ejection fraction: a machine learning based Lasso-Cox model
Construction of a metabolism-malnutrition-inflammation prognostic risk score in patients with heart failure with preserved ejection fraction: a machine learning based Lasso-Cox model Open
View article: LACTB suppresses liver cancer progression through regulation of ferroptosis
LACTB suppresses liver cancer progression through regulation of ferroptosis Open
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View article: Calorie Restriction Induces Degeneration of Neurons with Mitochondrial DNA Depletion by Altering ER-Mitochondria Calcium Transfer
Calorie Restriction Induces Degeneration of Neurons with Mitochondrial DNA Depletion by Altering ER-Mitochondria Calcium Transfer Open
Mitochondrial DNA (mtDNA) mutations and/or depletion are implicated in epilepsy and many neurodegenerative diseases. However, systematic investigation into how mtDNA alterations relate to epilepsy and neural degeneration is needed. Here, w…