Jiaojiao Zheng
YOU?
Author Swipe
View article: The Role of Mitochondrial Genome Stability and Metabolic Plasticity in Thyroid Cancer
The Role of Mitochondrial Genome Stability and Metabolic Plasticity in Thyroid Cancer Open
Mitochondria play a central role in energy metabolism, redox homeostasis, and signal transduction in the thyroid cells. Increasing evidence indicates that mitochondrial DNA (mtDNA) mutations, copy number variations, and haplogroup-specific…
View article: Molecular Mechanisms of Thyroid Hormone Signaling in Thyroid Cancer: Oncogenesis, Progression, and Therapeutic Implications
Molecular Mechanisms of Thyroid Hormone Signaling in Thyroid Cancer: Oncogenesis, Progression, and Therapeutic Implications Open
Thyroid cancer, as a highly hormone-dependent malignancy, is significantly regulated by thyroid hormones (T3/T4) and thyroid-stimulating hormone (TSH) signaling in its initiation and progression. This article comprehensively reviews the ro…
View article: Can smart rural construction improve agricultural products supply chain resilience? Empirical evidence from 31 provinces in China
Can smart rural construction improve agricultural products supply chain resilience? Empirical evidence from 31 provinces in China Open
Introduction The stable and secure supply of food and important agricultural products is related to the foundation of people’s livelihoods and is a top priority for the country’s economy. The construction of a robust supply chain system fo…
View article: Clinical performance of a machine learning-based model for detecting lymph node metastasis in papillary thyroid carcinoma: A multicenter study
Clinical performance of a machine learning-based model for detecting lymph node metastasis in papillary thyroid carcinoma: A multicenter study Open
Papillary thyroid carcinoma (PTC) is a common endocrine malignancy with a generally favorable prognosis, but lymph node metastasis (LNM) complicates treatment and increases recurrence risk. Current preoperative methods like neck ultrasound…
View article: Novel derivatives of brincidofovir and (S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine inhibit orthopoxviruses and human adenoviruses more potently than brincidofovir
Novel derivatives of brincidofovir and (S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine inhibit orthopoxviruses and human adenoviruses more potently than brincidofovir Open
Brincidofovir (BCV) and tecovirimat are the only two chemical drugs that have been approved to treat smallpox and can be requested for monkeypox (Mpox) treatment through a single-patient Emergency Investigational New Drug (EIND) applicatio…
View article: Trap Assisted Dynamic Mechanoluminescence Toward Self‐Referencing and Visualized Strain Sensing
Trap Assisted Dynamic Mechanoluminescence Toward Self‐Referencing and Visualized Strain Sensing Open
Strain sensors utilizing mechanoluminescent (ML) materials have garnered significant attention and application due to their advantages, such as self‐powering, non‐contact operation, and real‐time response. However, ML‐based strain sensing …
View article: Burdens and trends of pulmonary arterial hypertension at global, regional, and national levels from 1990 to 2021 and prediction to 2040: findings from the Global Burden of Disease study 2021
Burdens and trends of pulmonary arterial hypertension at global, regional, and national levels from 1990 to 2021 and prediction to 2040: findings from the Global Burden of Disease study 2021 Open
Objective To estimate burdens and trends of pulmonary arterial hypertension(PAH) globally, in five sociodemographic index(SDI) regions, 204 countries and territories around the world from 1990 to 2021 and further predicted its changes to 2…
View article: Novel Derivatives of BCV and (S)-HPMPA Inhibit Orthopoxviruses and Human Adenoviruses More Potently Than BCV
Novel Derivatives of BCV and (S)-HPMPA Inhibit Orthopoxviruses and Human Adenoviruses More Potently Than BCV Open
BCV and tecovirimat are the only two chemical drugs that have been approved to treat smallpox and can be requested for Mpox treatment through a single-patient Emergency Investigational New Drug (EIND) application. Disappointedly, the effic…
View article: Deficiency of TET2-mediated KMT2D self-transcription confers a targetable vulnerability in hepatocellular carcinoma
Deficiency of TET2-mediated KMT2D self-transcription confers a targetable vulnerability in hepatocellular carcinoma Open
Hepatocellular carcinoma (HCC) has become a leading cause of cancer-related mortality worldwide. Conventional therapies tend to exacerbate comorbidities, liver dysfunction, and relapse, rendering an urgent demand for novel strategy for man…
View article: The SUMO Family: Mechanisms and Implications in Thyroid Cancer Pathogenesis and Therapy
The SUMO Family: Mechanisms and Implications in Thyroid Cancer Pathogenesis and Therapy Open
(1) Background: Small ubiquitin-like modifiers (SUMOs) are pivotal in post-translational modifications, influencing various cellular processes, such as protein localization, stability, and genome integrity. (2) Methods: This review explore…
View article: Novel Derivatives of BCV and (S)-HPMPA Inhibit Orthopoxviruses and Human Adenoviruses More Potently Than BCV
Novel Derivatives of BCV and (S)-HPMPA Inhibit Orthopoxviruses and Human Adenoviruses More Potently Than BCV Open
BCV and tecovirimat are the only two chemical drugs that have been approved to treat smallpox and can be requested for Mpox treatment through a single-patient Emergency Investigational New Drug (EIND) application. Disappointedly, the effic…
View article: Novel derivatives of BCV and (S)-HPMPA inhibit orthopoxviruses and human adenoviruses more potently than BCV
Novel derivatives of BCV and (S)-HPMPA inhibit orthopoxviruses and human adenoviruses more potently than BCV Open
BCV and tecovirimat are the only two chemical drugs that have been approved to treat smallpox and can be requested for Mpox treatment through a single-patient Emergency Investigational New Drug (EIND) application. Disappointedly, the effic…
View article: New evidence that vitamin D prevents headache: a bidirectional two-sample Mendelian randomization analysis
New evidence that vitamin D prevents headache: a bidirectional two-sample Mendelian randomization analysis Open
Background Previous observational clinical studies and meta-analyses have yielded inconsistent results regarding the relationship between vitamin D and headache, and the causal relationship remains unclear. The aim of this study was to inv…
View article: Analysis and risk factors of deep vein catheterization-related bloodstream infections in neonates
Analysis and risk factors of deep vein catheterization-related bloodstream infections in neonates Open
To investigate the incidence, risk factors, and pathogenic characteristics of catheter-related bloodstream infection caused by peripherally inserted central venous catheter in neonates, and to provide references for reducing the infection …
View article: Insight of novel biomarkers for papillary thyroid carcinoma through multiomics
Insight of novel biomarkers for papillary thyroid carcinoma through multiomics Open
Introduction The overdiagnosing of papillary thyroid carcinoma (PTC) in China necessitates the development of an evidence-based diagnosis and prognosis strategy in line with precision medicine. A landscape of PTC in Chinese cohorts is need…
View article: Combined preoperative plasma fibrinogen and D-Dimer concentration as a prognostic marker of endometrial cancer
Combined preoperative plasma fibrinogen and D-Dimer concentration as a prognostic marker of endometrial cancer Open
Endometrial cancer (EC) is one of the most common gynecological malignancies. The aim of this study was to evaluate the combined prognostic value of D-dimer and fibrinogen in EC patients. We evaluated the prognostic value of preoperative p…
View article: Activation of TRPV4 Induces Exocytosis and Ferroptosis in Human Melanoma Cells
Activation of TRPV4 Induces Exocytosis and Ferroptosis in Human Melanoma Cells Open
TRPV4 (transient receptor potential vanilloid 4), a calcium permeable TRP ion channel, is known to play a key role in endocytosis. However, whether it contributes to exocytosis remains unclear. Here, we report that activation of TRPV4 indu…
View article: NAT10 regulates mitotic cell fate by acetylating Eg5 to control bipolar spindle assembly and chromosome segregation
NAT10 regulates mitotic cell fate by acetylating Eg5 to control bipolar spindle assembly and chromosome segregation Open
View article: Correction: Haemoglobin A1c and serum glucose levels and risk of gastric cancer: a systematic review and meta-analysis
Correction: Haemoglobin A1c and serum glucose levels and risk of gastric cancer: a systematic review and meta-analysis Open
View article: Gut microbiome alterations and gut barrier dysfunction are associated with host immune homeostasis in COVID-19 patients
Gut microbiome alterations and gut barrier dysfunction are associated with host immune homeostasis in COVID-19 patients Open
Background COVID-19 is an infectious disease characterized by multiple respiratory and extrapulmonary manifestations, including gastrointestinal symptoms. Although recent studies have linked gut microbiota to infectious diseases such as in…
View article: Haemoglobin A1c and serum glucose levels and risk of gastric cancer: a systematic review and meta-analysis
Haemoglobin A1c and serum glucose levels and risk of gastric cancer: a systematic review and meta-analysis Open
Background This systematic review and meta-analysis examined associations between serum levels of haemoglobin A1c (HbA1c) and glucose and the risk of gastric cancer. Methods MEDLINE, Embase, and Cochrane Library were searched for studies e…
View article: Coronaviruses in wild animals sampled in and around Wuhan at the beginning of COVID-19 emergence
Coronaviruses in wild animals sampled in and around Wuhan at the beginning of COVID-19 emergence Open
Over the last several decades, no emerging virus has had a profound impact on the world as the SARS-CoV-2 that emerged at the end of 2019 has done. To know where severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) originated from …
View article: Additional file 2 of Gut microbiome alterations and gut barrier dysfunction are associated with host immune homeostasis in COVID-19 patients
Additional file 2 of Gut microbiome alterations and gut barrier dysfunction are associated with host immune homeostasis in COVID-19 patients Open
Additional file 2: Table S1. The basic information of COVID-19 patients. Table S2. The basic information of fecal samples collected from COVID-19 patients. Table S3. The microbial species identified from all participants. Table S4. The ass…
View article: Effect of pH on Photosynthesis of Euglena mutabilis Schmitz, an Acidophilic Benthic Flagellate
Effect of pH on Photosynthesis of Euglena mutabilis Schmitz, an Acidophilic Benthic Flagellate Open
The dependence of the photosynthetic rate of Euglena mutabilis Schmitz on pH across a range of 2.0–10.0 was investigated. Populations of E. mutabilis isolated from sediments of acidic mine drainage in Sensui (pH = 3.95) and a volcanic cold…
View article: Diabetes, metformin and gastric adenocarcinoma
Diabetes, metformin and gastric adenocarcinoma Open
Diabetes may increase the risk and mortality of certain cancers, but its association with gastric adenocarcinoma is not clear. On the other hand, metformin, a first-line treatment for diabetes, may reduce cancer risks and improve cancer-re…
View article: Improved prognosis in gastric adenocarcinoma among metformin users in a population-based study
Improved prognosis in gastric adenocarcinoma among metformin users in a population-based study Open
View article: A Systematic Screening of Traditional Chinese Medicine Identifies Two Novel Inhibitors Against the Cytotoxic Aggregation of Amyloid Beta
A Systematic Screening of Traditional Chinese Medicine Identifies Two Novel Inhibitors Against the Cytotoxic Aggregation of Amyloid Beta Open
The toxic aggregates of amyloid beta (Aβ) disrupt the cell membrane, induce oxidative stress and mitochondrial dysfunction, and eventually lead to Alzheimer’s disease (AD). Intervening with this cytotoxic aggregation process has been sugge…
View article: PEGylated and Acylated Elabela Analogues Show Enhanced Receptor Binding, Prolonged Stability, and Remedy of Acute Kidney Injury
PEGylated and Acylated Elabela Analogues Show Enhanced Receptor Binding, Prolonged Stability, and Remedy of Acute Kidney Injury Open
Acute kidney injury (AKI), mostly caused by renal ischemia-reperfusion (I/R) injury and nephrotoxins, is characterized by rapid deterioration in renal-functions without effective drug treatment available. Through activation of a G protein-…
View article: Author Correction: A new coronavirus associated with human respiratory disease in China
Author Correction: A new coronavirus associated with human respiratory disease in China Open
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
View article: Complete genome characterisation of a novel coronavirus associated with severe human respiratory disease in Wuhan, China
Complete genome characterisation of a novel coronavirus associated with severe human respiratory disease in Wuhan, China Open
Emerging and re-emerging infectious diseases, such as SARS, MERS, Zika and highly pathogenic influenza present a major threat to public health 1–3 . Despite intense research effort, how, when and where novel diseases appear are still the s…