Jiaqi Gao
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View article: YAP contributes to liver injury through mediating capillarization of liver sinusoidal endothelial cells via GATA6/eNOS signaling
YAP contributes to liver injury through mediating capillarization of liver sinusoidal endothelial cells via GATA6/eNOS signaling Open
View article: Comprehensive Transcriptomic Analysis of Brain Tissues From the Infarcted Area of MCAO Rats Revealed That Acupuncture Attenuates Brain Injury via the Complement System
Comprehensive Transcriptomic Analysis of Brain Tissues From the Infarcted Area of MCAO Rats Revealed That Acupuncture Attenuates Brain Injury via the Complement System Open
Objective This research focused on investigating acupuncture's effect on brain injury in middle cerebral artery occlusion (MCAO) rats and elucidating its potential mechanisms, with a focus on transcriptomic and protein‐level changes relate…
View article: Global burden of disease and its risk factors for adults aged 70 and older across 204 countries and territories: a comprehensive analysis of the Global Burden of Disease Study 2021
Global burden of disease and its risk factors for adults aged 70 and older across 204 countries and territories: a comprehensive analysis of the Global Burden of Disease Study 2021 Open
The global disease burden among adults aged 70 and older has shown declines in death and DALY rates, yet remains a significant challenge exacerbated by population growth, especially in less developed regions. Implementing preventive strate…
View article: Ileal FXR Knockdown Ameliorates MASLD Progression in Rats via Modulating Bile Acid Metabolism Mediated by Gut Microbiota
Ileal FXR Knockdown Ameliorates MASLD Progression in Rats via Modulating Bile Acid Metabolism Mediated by Gut Microbiota Open
Background and Aim Metabolic dysfunction associated steatotic liver disease (MASLD) is the predominant cause of chronic liver disease, with dysregulation of bile acid (BA) metabolism and intestinal microbiota being intricately associated w…
View article: Smoking impairs cognitive function through the mediating effect of periodontitis in older adults
Smoking impairs cognitive function through the mediating effect of periodontitis in older adults Open
View article: Diagnosis of massive obscure gastrointestinal bleeding from a Dieulafoy lesion identified by intraoperative enteroscopy
Diagnosis of massive obscure gastrointestinal bleeding from a Dieulafoy lesion identified by intraoperative enteroscopy Open
View article: YBX1/CD36 positive feedback loop-mediated lipid accumulation drives metabolic dysfunction-associated steatotic liver disease
YBX1/CD36 positive feedback loop-mediated lipid accumulation drives metabolic dysfunction-associated steatotic liver disease Open
Metabolic dysfunction-associated steatotic liver disease (MASLD) is a common chronic liver disorder mainly caused by an imbalance in lipid homeostasis. Y-box binding protein 1 (YBX1) participates in multiple pathophysiological processes, i…
View article: Targeting BRD4 ameliorates experimental emphysema by disrupting super-enhancer in polarized alveolar macrophage
Targeting BRD4 ameliorates experimental emphysema by disrupting super-enhancer in polarized alveolar macrophage Open
This study suggested that downregulation of BRD4 might suppress airway inflammation and emphysema through disrupting the SEs of IRF4 and alveolar macrophages polarization, which might be a potential target of therapeutic intervention in CO…
View article: Nanocrystal-Loaded Dissolving Microneedles: A Novel Transdermal Strategy for Long‑Acting Tizanidine Administration
Nanocrystal-Loaded Dissolving Microneedles: A Novel Transdermal Strategy for Long‑Acting Tizanidine Administration Open
View article: Association of Air Pollution with Memory Decline Later in Life in the United States
Association of Air Pollution with Memory Decline Later in Life in the United States Open
Background Emerging evidence suggests that air pollution exposure might diminish the cognitive health of older adults. Although many studies have reported that air pollution is associated with increased dementia risk, associations with the…
View article: Generation of a MYH6 (c.4034T > C) mutant human embryonic stem cell line via CRISPR base editing
Generation of a MYH6 (c.4034T > C) mutant human embryonic stem cell line via CRISPR base editing Open
The MYH6 gene encodes α-myosin heavy chain in the adult human heart. MYH6 c.4034T > C (p.Leu1345Pro) mutation in MYH6 gene have been reported in patients with hypertrophic cardiomyopathy (HCM), but its causal role in HCM is less certain an…
View article: Long-term air pollution exposure and incident physical disability in older US adults: a cohort study
Long-term air pollution exposure and incident physical disability in older US adults: a cohort study Open
National Institutes of Environmental Health Sciences and National Institute on Aging.
View article: Machine learning-based phenogroups and prediction model in patients with functional gastrointestinal disorders to reveal distinct disease subsets associated with gas production
Machine learning-based phenogroups and prediction model in patients with functional gastrointestinal disorders to reveal distinct disease subsets associated with gas production Open
Background and Objectives Symptom-based subtyping for functional gastrointestinal disorders (FGIDs) has limited value in identifying underlying mechanisms and guiding therapeutic strategies. Small intestinal dysbiosis is implicated in the …
View article: Association of Source-specific PM2.5 with Memory Decline Later in Life in the United States
Association of Source-specific PM2.5 with Memory Decline Later in Life in the United States Open
View article: Source-specific Air Pollution and Lost Independence in Late Life
Source-specific Air Pollution and Lost Independence in Late Life Open
View article: Long-term Air Pollution and Physical Disability in Older U.S. Adults: A Multi-State Modeling Evaluation from the EPOCH Study
Long-term Air Pollution and Physical Disability in Older U.S. Adults: A Multi-State Modeling Evaluation from the EPOCH Study Open
View article: Reservoir-type intranasal implants for sustained release of risperidone: A potential alternative for long-term treatment of schizophrenia
Reservoir-type intranasal implants for sustained release of risperidone: A potential alternative for long-term treatment of schizophrenia Open
To overcome the challenges of the blood-brain barrier for drug delivery to the central nervous system (CNS), intranasal implants were developed to improve the management of CNS conditions, such as schizophrenia. In the present work, we dev…
View article: Establishment of human embryonic stem cell lines carrying LQT1 mutations by CRISPR base editing
Establishment of human embryonic stem cell lines carrying LQT1 mutations by CRISPR base editing Open
The KCNQ1 gene encodes a voltage-gated potassium channel required for cardiac action potentials. Mutations in this gene have been associated with hereditary long QT syndrome 1, Jervell and Lange-Nielsen syndromes, and familial atrial fibri…
View article: The Impact of Green Finance on Agricultural Pollution and Carbon Reduction: The Case of China
The Impact of Green Finance on Agricultural Pollution and Carbon Reduction: The Case of China Open
Based on the double-carbon target, the agricultural sector has implemented the concept of being green and synergistically promoted pollution and carbon reduction. Positioned as a novel financial paradigm, green finance places greater empha…
View article: Source-Specific Air Pollution and Loss of Independence in Older Adults Across the US
Source-Specific Air Pollution and Loss of Independence in Older Adults Across the US Open
Importance Air pollution is a recognized risk factor associated with chronic diseases, including respiratory and cardiovascular conditions, which can lead to physical and cognitive impairments in later life. Although these losses of functi…
View article: Association between vitamin D status and thyroid cancer: a meta-analysis
Association between vitamin D status and thyroid cancer: a meta-analysis Open
Background Cumulative evidence has suggested that vitamin D deficiency is related with an increased susceptibility to various types of cancers. However, the association between vitamin D and thyroid cancer (TC) has remained to be unknown. …
View article: PD-1/PD-L1 inhibitors for early and middle stage microsatellite high-instability and stable colorectal cancer: a review
PD-1/PD-L1 inhibitors for early and middle stage microsatellite high-instability and stable colorectal cancer: a review Open
Background Programmed cell death receptor 1 (PD-1) and programmed cell death ligand 1 (PD-L1) are important immune checkpoint molecules that contribute to tumor immune evasion. However, the main treatment modalities for patients with early…
View article: Generation of a KCNQ1 (c.1032 + 2 T > C) mutant human embryonic stem cell line via CRISPR base editing
Generation of a KCNQ1 (c.1032 + 2 T > C) mutant human embryonic stem cell line via CRISPR base editing Open
The KCNQ1 gene encodes a voltage-gated potassium channel, which plays an important role in the repolarization of myocardial action potentials. Mutations in this gene often result in type 1 long QT syndrome (LQT1). Here, we generated a KCNQ…
View article: Targeting BRD4 Ameliorates Experimental Emphysema by Disrupting Super-Enhancer in Polarized Alveolar Macrophage
Targeting BRD4 Ameliorates Experimental Emphysema by Disrupting Super-Enhancer in Polarized Alveolar Macrophage Open
Background Chronic obstructive pulmonary disease (COPD) is a progressive chronic lung disease characterized by chronic airway inflammation and emphysema. Macrophage polarization plays an important role in COPD pathogenesis by secreting inf…
View article: Identification and Expression Analysis of Suppressors of Cytokine Signaling from Spotted Seabass (<i>Lateolabrax maculatus</i>)
Identification and Expression Analysis of Suppressors of Cytokine Signaling from Spotted Seabass (<i>Lateolabrax maculatus</i>) Open
The suppressor of cytokine signaling (SOCS) plays a negative role in the cytokine signaling pathway, preventing excessive signaling from interfering with the metabolic homeostasis of the body. By regulating the Janus kinase‐signal transduc…
View article: The Associations of Long-term Ambient Air Pollution, Physical Disability, and Accelerated Aging in Later Life
The Associations of Long-term Ambient Air Pollution, Physical Disability, and Accelerated Aging in Later Life Open
Physical function disability is one of the most prevalent outcomes among older adults in the U.S. with considerable burdens. The process of physical disability starts when healthy people experience physical function limitations that then p…
View article: Effects of cerium oxide nanoparticles on adenine‐induced chronic kidney disease model rats
Effects of cerium oxide nanoparticles on adenine‐induced chronic kidney disease model rats Open
Aim Cerium oxide, particularly in nanoparticle form (nanoceria), has been investigated for biomedical applications as a promising new agent for treating several pathologies. The aim of the present study was to characterize the pharmacologi…
View article: Natural compounds efficacy in complicated diabetes: A new twist impacting ferroptosis
Natural compounds efficacy in complicated diabetes: A new twist impacting ferroptosis Open
Ferroptosis, as a way of cell death, participates in the body's normal physiological and pathological regulation. Recent studies have shown that ferroptosis may damage glucose-stimulated islets β Insulin secretion and programmed cell death…
View article: Comparison of Particulate Air Pollution From Different Emission Sources and Incident Dementia in the US
Comparison of Particulate Air Pollution From Different Emission Sources and Incident Dementia in the US Open
Importance Emerging evidence indicates that exposure to fine particulate matter (PM 2.5 ) air pollution may increase dementia risk in older adults. Although this evidence suggests opportunities for intervention, little is known about the r…
View article: The analysis and solution for intercity travel behaviors during holidays in the post-epidemic era based on big data
The analysis and solution for intercity travel behaviors during holidays in the post-epidemic era based on big data Open
The COVID-19 had a huge impact on the transportation industry. In the post-epidemic stage, intercity transportation will face great challenges as places are unsealed, tourism and other service industries begin to recover, and residents’ tr…