Jiaqi Lan
YOU?
Author Swipe
View article: TIMP1 inhibits Rac1-mediated ROS production to ameliorate blood–spinal cord barrier disruption in amyotrophic lateral sclerosis
TIMP1 inhibits Rac1-mediated ROS production to ameliorate blood–spinal cord barrier disruption in amyotrophic lateral sclerosis Open
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by the progressive degeneration of motor neurons, for which therapeutic strategies and pharmacological interventions remain limited. Disruption of the blood-…
View article: H13N8 and H16N3 AIV Isolated From Shorebirds Can Replicate in the Rectum of Mice
H13N8 and H16N3 AIV Isolated From Shorebirds Can Replicate in the Rectum of Mice Open
To investigate the pathogenicity and cross‐species transmission potential of H13 and H16‐subtype of low pathogenic avian influenza viruses (LPAIVs), two strains of H13N8 and H16N3 isolated from shorebirds were used to infect mice. Clinical…
View article: Discovery of 4-(Arylethynyl)piperidine Derivatives as Potent Nonsaccharide <i>O</i>-GlcNAcase Inhibitors for the Treatment of Alzheimer’s Disease
Discovery of 4-(Arylethynyl)piperidine Derivatives as Potent Nonsaccharide <i>O</i>-GlcNAcase Inhibitors for the Treatment of Alzheimer’s Disease Open
Inhibiting O-GlcNAcase and thereby up-regulation of the O-GlcNAc levels of tau was a potential approach for discovering AD treatments. Herein, a series of novel highly potent OGA inhibitors embracing a 4-(arylethynyl)piperidine moiety was …
View article: Quantitative assessment of runoff change and its drivers in a multi-scale framework
Quantitative assessment of runoff change and its drivers in a multi-scale framework Open
Identifying runoff changes and quantifying the impacts of climate change and human activities are important for water resources planning and management in river basins. The impacts of climate change and human activities on runoff can be mo…
View article: Quantitative evaluation of runoff drivers based on the MLLR-Budyko framework
Quantitative evaluation of runoff drivers based on the MLLR-Budyko framework Open
At the request of the authors, the article ‘Quantitative evaluation of runoff drivers based on the MLLR-Budyko framework’ has been withdrawn from Water Supply.
View article: Mitophagy protects against silver nanoparticle–induced hepatotoxicity by inhibiting mitochondrial ROS and the NLRP3 inflammasome
Mitophagy protects against silver nanoparticle–induced hepatotoxicity by inhibiting mitochondrial ROS and the NLRP3 inflammasome Open
Silver nanoparticles (AgNPs) have wide clinical applications because of their excellent antibacterial properties; however, they can cause liver inflammation in animals. Macrophages are among the main cells mediating inflammation and are al…
View article: TIMP2 ameliorates blood-brain barrier disruption in traumatic brain injury by inhibiting Src-dependent VE-cadherin internalization
TIMP2 ameliorates blood-brain barrier disruption in traumatic brain injury by inhibiting Src-dependent VE-cadherin internalization Open
Blood-brain barrier (BBB) disruption is a serious pathological consequence of traumatic brain injury (TBI), for which there are limited therapeutic strategies. Tissue inhibitor of metalloproteinase-2 (TIMP2), a molecule with dual functions…
View article: Umbilical cord mesenchymal stem cell-conditioned medium inhibits microglial activation to ameliorate neuroinflammation in amyotrophic lateral sclerosis mice and cell models
Umbilical cord mesenchymal stem cell-conditioned medium inhibits microglial activation to ameliorate neuroinflammation in amyotrophic lateral sclerosis mice and cell models Open
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease for which few effective therapeutic strategies are available. Increasing evidence indicates that neuroinflammation plays a significant role in ALS pathogenesis. Mesen…
View article: Antidepressant effect of 4-Butyl-alpha-agarofuran via HPA axis and serotonin system
Antidepressant effect of 4-Butyl-alpha-agarofuran via HPA axis and serotonin system Open
Depression is a leading cause of disability worldwide and the psychiatric diagnosis most commonly associated with suicide. 4-Butyl-alpha-agarofuran (AF-5), a derivative of agarwood furan, is currently in phase III clinical trials for gener…
View article: Performance of LIBs with Nanostructured Silicon as Anode Materials
Performance of LIBs with Nanostructured Silicon as Anode Materials Open
With the development of electronic equipment and new energy transportation vehicles, the demand for lithium-ion batteries (LIBs) is increasing, and LIBs with better performance are also required. Due to its theoretically higher energy dens…
View article: Short-term exposure to dimethyl fumarate (DMF) inhibits LPS-induced IκBζ expression in macrophages
Short-term exposure to dimethyl fumarate (DMF) inhibits LPS-induced IκBζ expression in macrophages Open
Background: The pharmacological activity of dimethyl fumarate (DMF) in treating psoriasis and multiple sclerosis (MS) is not fully understood. DMF is hydrolysed to monomethyl fumarate (MMF) in vivo , which is believed to account for the th…
View article: Protective effect of human umbilical cord mesenchymal stem cell derived conditioned medium in a mutant TDP-43 induced motoneuron-like cellular model of ALS
Protective effect of human umbilical cord mesenchymal stem cell derived conditioned medium in a mutant TDP-43 induced motoneuron-like cellular model of ALS Open
Amyotrophic lateral sclerosis (ALS) is a multi-factor neurodegenerative disease, characterized by the loss of motor neurons. TAR DNA-binding protein 43 (TDP-43) mutation, accumulation and aggregation, as well as oxidative stress are recogn…
View article: Short-term exposure to dimethyl fumarate (DMF) inhibits LPS-induced IκBζ expression in macrophages: implications for the pharmacological activity of DMF
Short-term exposure to dimethyl fumarate (DMF) inhibits LPS-induced IκBζ expression in macrophages: implications for the pharmacological activity of DMF Open
Background The pharmacological activity of dimethyl fumarate (DMF) in treating psoriasis and multiple sclerosis (MS) is not fully understood. DMF is hydrolysed to monomethyl fumarate (MMF) in vivo , which is believed to account for the the…
View article: Honokiol alleviated neurodegeneration by reducing oxidative stress and improving mitochondrial function in mutant SOD1 cellular and mouse models of amyotrophic lateral sclerosis
Honokiol alleviated neurodegeneration by reducing oxidative stress and improving mitochondrial function in mutant SOD1 cellular and mouse models of amyotrophic lateral sclerosis Open
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease affecting both upper and lower motor neurons (MNs) with large unmet medical needs. Multiple pathological mechanisms are considered to contribute to the progress…
View article: The Variation of Duck RIG-I-Mediated Innate Immune Response Induced by Different Virulence Avian Influenza Viruses
The Variation of Duck RIG-I-Mediated Innate Immune Response Induced by Different Virulence Avian Influenza Viruses Open
In recent years, the emerging highly pathogenic avian influenza (HPAI) A(H5N8) virus has been reported with features of widely spread, an expanding host range, and cross-species transmission, attracting wide attention. The domestic duck pl…
View article: Design and Experimental Analysis of Charge Recovery for Piezoelectric Fan
Design and Experimental Analysis of Charge Recovery for Piezoelectric Fan Open
The piezoelectric (PE) fan is widely adopted in the field of microelectronics cooling due to its advantages of high reliability and good heat dissipation characteristics. However, PE fans driven by conventional circuits suffer from plenty …
View article: Dependence of Graphene Oxide (GO) Toxicity on Oxidation Level, Elemental Composition, and Size
Dependence of Graphene Oxide (GO) Toxicity on Oxidation Level, Elemental Composition, and Size Open
The mass production of graphene oxide (GO) unavoidably elevates the chance of human exposure, as well as the possibility of release into the environment with high stability, raising public concern as to its potential toxicological risks an…
View article: Machine Learning-based Biomarkers Identification and Validation from Toxicogenomics - Bridging to Regulatory Relevant Phenotypic Endpoints
Machine Learning-based Biomarkers Identification and Validation from Toxicogenomics - Bridging to Regulatory Relevant Phenotypic Endpoints Open
High-throughput in vitro assays and AOP-based approach is promising for the assessment of health and ecotoxicological risks from exposure to pollutants and their mixtures. However, one of the major challenges in realization and implementat…
View article: Toxicity of single-walled carbon nanotubes (SWCNTs): effect of lengths, functional groups and electronic structures revealed by a quantitative toxicogenomics assay
Toxicity of single-walled carbon nanotubes (SWCNTs): effect of lengths, functional groups and electronic structures revealed by a quantitative toxicogenomics assay Open
Single-walled carbon nanotubes (SWCNTs) have caused increasing public concerns associated with their potential toxicological effects. This study demonstrated that the physicochemical properties of SWCNTs have impacts on their toxicological…
View article: Genotoxicity Assessment of Drinking Water Disinfection Byproducts by DNA Damage and Repair Pathway Profiling Analysis
Genotoxicity Assessment of Drinking Water Disinfection Byproducts by DNA Damage and Repair Pathway Profiling Analysis Open
Genotoxicity is considered a major concern for drinking water disinfection byproducts (DBPs). Of over 700 DBPs identified to date, only a small number has been assessed with limited information for DBP genotoxicity mechanism(s). In this st…
View article: Toxicity Assessment of 4-Methyl-1-cyclohexanemethanol and Its Metabolites in Response to a Recent Chemical Spill in West Virginia, USA
Toxicity Assessment of 4-Methyl-1-cyclohexanemethanol and Its Metabolites in Response to a Recent Chemical Spill in West Virginia, USA Open
The large-scale chemical spill on January 9, 2014 from coal processing and cleaning storage tanks of Freedom Industries in Charleston affected the drinking water supply to 300,000 people in Charleston, West Virginia metropolitan, while the…
View article: Toxicity Mechanisms Identification via Gene Set Enrichment Analysis of Time-Series Toxicogenomics Data: Impact of Time and Concentration
Toxicity Mechanisms Identification via Gene Set Enrichment Analysis of Time-Series Toxicogenomics Data: Impact of Time and Concentration Open
The advance in high-throughput "toxicogenomics" technologies, which allows for concurrent monitoring of cellular responses globally upon exposure to chemical toxicants, presents promises for next-generation toxicity assessment. It is recog…