Jiaqian Chen
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View article: Ceritinib inhibits growth and ACTH production of PitNETs: Insights from patient-derived organoids
Ceritinib inhibits growth and ACTH production of PitNETs: Insights from patient-derived organoids Open
ACTH-secreting pituitary neuroendocrine tumors (PitNETs), also known as Cushing's disease (CD), are a rare condition lacking effective pharmacological treatments. Drug development for CD has been limited by the absence of suitable preclini…
View article: Research on the mechanism of effective remelted layer removal in micro-hole electrical discharge machining with ultrasonic vibration drilling
Research on the mechanism of effective remelted layer removal in micro-hole electrical discharge machining with ultrasonic vibration drilling Open
This study addresses the issue of remelted layer removal in the composite machining of micro-holes using electrical discharge machining (EDM) combined with ultrasonic vibration drilling. The effects of machining deviations caused by limite…
View article: Total Saponins from Siraitiae Fructus Alleviate Lung and Intestinal Injuries in Rats with Acute Lung Injury and Mice Infected with the Influenza Virus by Regulating Cytokines and Enhancing the Mucosal Barrier
Total Saponins from Siraitiae Fructus Alleviate Lung and Intestinal Injuries in Rats with Acute Lung Injury and Mice Infected with the Influenza Virus by Regulating Cytokines and Enhancing the Mucosal Barrier Open
View article: Soybean fermentation drives the production of native neuroprotective peptides based on a peptidomics strategy
Soybean fermentation drives the production of native neuroprotective peptides based on a peptidomics strategy Open
Fermentation is applied to improve bioactive components (e.g., native peptides and amino acids) responsible for health benefits. The native peptide identification is vital for precisely delineating fermented food properties. However…
View article: Evidence of Lung-Gut Co-Treatment: Total Saponins of Siraitiae Fructus Alleviate Lung and Intestinal Injuries in Acute Lung-Injured Rats and Influenza Virus-Infected Mice by Regulating Cytokines and Enhancing Mucosal Barrier
Evidence of Lung-Gut Co-Treatment: Total Saponins of Siraitiae Fructus Alleviate Lung and Intestinal Injuries in Acute Lung-Injured Rats and Influenza Virus-Infected Mice by Regulating Cytokines and Enhancing Mucosal Barrier Open
View article: Isolation, Bioactivity, and Molecular Docking of a Rare Gastrodin Isocitrate and Diverse Parishin Derivatives from <i>Gastrodia elata</i> Blume
Isolation, Bioactivity, and Molecular Docking of a Rare Gastrodin Isocitrate and Diverse Parishin Derivatives from <i>Gastrodia elata</i> Blume Open
Gastrodia elata Blume (G. elata) is a well-known medicine food homology plant widely used in treating neurological disorders such as Alzheimer's disease (AD). Here, undiscovered gastrodin derivatives were systematically studi…
View article: An “off-on” fluorescent nanosensor for the detection of cadmium ions based on APDC-etched CdTe/CdS/SiO2 quantum dots
An “off-on” fluorescent nanosensor for the detection of cadmium ions based on APDC-etched CdTe/CdS/SiO2 quantum dots Open
In this study, we have developed a novel fluorescent "OFF-ON" quantum dots (QDs) sensor based on CdTe/CdS/SiO2 cores. Ammonium pyrrolidine dithiocarbamate (APDC), ethylenediamine tetraacetic acid (EDTA), and 1,10-phenanthroline …
View article: Ferroptotic alveolar epithelial type II cells drive TH2 and TH17 mixed asthma triggered by birch pollen allergen Bet v 1
Ferroptotic alveolar epithelial type II cells drive TH2 and TH17 mixed asthma triggered by birch pollen allergen Bet v 1 Open
View article: Simulation research on the thermal phase transition of EDM and the formation mechanism of remelted layer in single pulse spark discharge crater
Simulation research on the thermal phase transition of EDM and the formation mechanism of remelted layer in single pulse spark discharge crater Open
The remelted layer formed by the Electrical Discharge Machine(EDM)impacts surface quality of small hole and significantly reduces the fatigue life of workpieces. Based on Comsol Multiphysics ,this paperusessimulates the formation process o…
View article: A Primer on Bitcoin Cross-Border Flows: Measurement and Drivers
A Primer on Bitcoin Cross-Border Flows: Measurement and Drivers Open
View article: Study on optimal allocation of energy storage in multi-regional integrated energy system considering stepped carbon trading
Study on optimal allocation of energy storage in multi-regional integrated energy system considering stepped carbon trading Open
In this study, an energy storage configuration optimization model of multi regional integrated energy system based on integrated scheduling and stepped Carbon emission trading is proposed. By analyzing the steady-state, dynamic, and variab…
View article: A 36-Nucleus Silver-Thiolate Cluster Encapsulating Double Sulfates and Co-Protected by Cyclen
A 36-Nucleus Silver-Thiolate Cluster Encapsulating Double Sulfates and Co-Protected by Cyclen Open
View article: Can Fiscal Consolidation help Central Banks Fight Inflation?
Can Fiscal Consolidation help Central Banks Fight Inflation? Open
View article: A Simplified and Environmental Friendly Processing Procedure for Preserving Gastrodia elata with No Significant Change on the Contents of Gastrodin Derivatives and Anti-Oxidation Activity
A Simplified and Environmental Friendly Processing Procedure for Preserving Gastrodia elata with No Significant Change on the Contents of Gastrodin Derivatives and Anti-Oxidation Activity Open
Gastrodia elata Bl., one of the well-known edible plants in China, belongs to the family of Orchidaceae. In recent years, the consumption rate of this plant as food supplements or health products is gradually rising in China. However, the …
View article: External Sector Report, 2023
External Sector Report, 2023 Open
Global current account balances—the overall size of headline current account deficits and surpluses—widened for a third consecutive year in 2022. Main drivers were Russia's invasion of Ukraine, the uneven recovery from the pandemic, and th…
View article: Fragmentation in Global Trade: Accounting for Commodities
Fragmentation in Global Trade: Accounting for Commodities Open
We construct a new database which covers production and trade in 136 primary commodities and 24 manufacturing and service sectors for 145 countries. Using this new more granular data, we estimate spillover effects from plausible trade frag…
View article: Geo-Economic Fragmentation and the Future of Multilateralism
Geo-Economic Fragmentation and the Future of Multilateralism Open
After several decades of increasing global economic integration, the world is facing the risk of policy-driven geoeconomic fragmentation (GEF). This note explores the ramifications. It identifies multiple channels through which the benefit…
View article: CCDC 2192633: Experimental Crystal Structure Determination
CCDC 2192633: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2192590: Experimental Crystal Structure Determination
CCDC 2192590: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2171563: Experimental Crystal Structure Determination
CCDC 2171563: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Integrated dose–response metabolomics with therapeutic effects and adverse reactions may demystify the dosage of traditional Chinese medicine
Integrated dose–response metabolomics with therapeutic effects and adverse reactions may demystify the dosage of traditional Chinese medicine Open
Background Traditional Chinese medicine (TCM) has been used to treat various diseases for thousands of years. However, the uncertainty of dosage as well as the lack of systemic evaluation of pharmacology and toxicology is one major reason …
View article: Biases in Survey Inflation Expectations: Evidence from the Euro Area
Biases in Survey Inflation Expectations: Evidence from the Euro Area Open
This paper documents five facts about inflation expectations in the euro area.First, individual inflation forecasts overreact to individual news.Second, the cross-section average of individual forecasts of inflation underreact to shocks in…
View article: Effective Fiscal-Monetary Interactions in Severe Recessions
Effective Fiscal-Monetary Interactions in Severe Recessions Open
The COVID-19 pandemic and the subsequent need for policy support have called the traditional separation between fiscal and monetary policies into question.Based on simulations of an open economy DSGE model calibrated to emerging and advanc…
View article: Selective eosinophil necroptosis contributes to airway inflammation and remodeling in asthma
Selective eosinophil necroptosis contributes to airway inflammation and remodeling in asthma Open
Asthma is a widespread inflammatory disease characterized by airway inflammation, remodeling, and hyperresponsiveness (AHR),1, 2 that eosinophils are assumed to play essential roles in the development of asthma and are associated with asth…
View article: Comprehensive Evaluation of Low Temperature and Salt Tolerance in Grafted and Rootstock Seedlings Combined with Yield and Quality of Grafted Tomato
Comprehensive Evaluation of Low Temperature and Salt Tolerance in Grafted and Rootstock Seedlings Combined with Yield and Quality of Grafted Tomato Open
Environmental stress, especially in the form of low temperatures and salinity, has becomethe main limiting factor affecting the yield and quality of tomatoes in greenhouse production in China. Grafting, as an effective and sustainable stra…
View article: Nitric Oxide-Induced Calcineurin A Mediates Antimicrobial Peptide Production Through the IMD Pathway
Nitric Oxide-Induced Calcineurin A Mediates Antimicrobial Peptide Production Through the IMD Pathway Open
Nitric oxide (NO) at a high concentration is an effector to kill pathogens during insect immune responses, it also functions as a second messenger at a low concentration to regulate antimicrobial peptide (AMP) production in insects. Drosop…
View article: Fuzzy identification of bioactive components for different efficacies of rhubarb by the back propagation neural network association analysis of UPLC-Q-TOF/MSE and integrated effects
Fuzzy identification of bioactive components for different efficacies of rhubarb by the back propagation neural network association analysis of UPLC-Q-TOF/MSE and integrated effects Open
Background Rhei Radix et Rhizoma (rhubarb), as one of the typical representatives of multi-effect traditional Chinese medicines (TCMs), has been utilized in the treatment of various diseases due to its multicomponent nature. However, there…
View article: P. ae induced necroptosis signaling and NLRP3 inflammasome cross-talking in epithelium facilitates acute lung injury
P. ae induced necroptosis signaling and NLRP3 inflammasome cross-talking in epithelium facilitates acute lung injury Open
Pseudomonas aeruginosa induced acute lung injury is such a serious risk to public health throughout the world, but the pathological regulation remains unclear. Here, we reported that P. ae mediated epithelial necroptosis leads to subsequen…
View article: Fuzzy identification of bioactive components for different efficacies of a medicinal herb by BP neural network association analysis of UPLC-Q-TOF/MSE and integrated effects
Fuzzy identification of bioactive components for different efficacies of a medicinal herb by BP neural network association analysis of UPLC-Q-TOF/MSE and integrated effects Open
Background: The multicomponent nature of a medicinal herb leads to multiple efficacies via numerous metabolic byproducts, potential molecular interactions and targets, which makes a network-oriented approach preferable in the preliminary s…
View article: Enlightenment of German Energy Decarbonization to Power System
Enlightenment of German Energy Decarbonization to Power System Open
With the proposal of carbon neutralization and carbon peak strategy, power system decarbonization has become an important path to realize the strategy.This paper combs the experience of Germany in energy decarbonization and deconstructs th…