Jiaqian Wang
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View article: Immunoinflammatory evidence of rheumatoid arthritis caused by COVID-19
Immunoinflammatory evidence of rheumatoid arthritis caused by COVID-19 Open
View article: Bulk RNA sequencing combined with single-cell RNA sequencing analysis revealed the ferroptosis immune target of osteoarthritis synovial fibroblasts
Bulk RNA sequencing combined with single-cell RNA sequencing analysis revealed the ferroptosis immune target of osteoarthritis synovial fibroblasts Open
View article: Similarities and differences between osteoarthritis and rheumatoid arthritis: insights from Mendelian randomization and transcriptome analysis
Similarities and differences between osteoarthritis and rheumatoid arthritis: insights from Mendelian randomization and transcriptome analysis Open
View article: Rheumatoid arthritis reduces the risk of colorectal cancer through immune inflammation mediation
Rheumatoid arthritis reduces the risk of colorectal cancer through immune inflammation mediation Open
There is a close relationship between immune‐mediated inflammation and cancer, and there is still controversy over whether rheumatoid arthritis (RA) increases the risk of malignancy. We first used Mendelian randomization (MR) analysis to e…
View article: Comprehensive single-cell analysis deciphered microenvironmental dynamics and immune regulator olfactomedin 4 in pathogenesis of gallbladder cancer
Comprehensive single-cell analysis deciphered microenvironmental dynamics and immune regulator olfactomedin 4 in pathogenesis of gallbladder cancer Open
Objective Elucidating complex ecosystems and molecular features of gallbladder cancer (GBC) and benign gallbladder diseases is pivotal to proactive cancer prevention and optimal therapeutic intervention. Design We performed single-cell tra…
View article: New Classification of Rheumatoid Arthritis Based on Immune Cells and Clinical Characteristics
New Classification of Rheumatoid Arthritis Based on Immune Cells and Clinical Characteristics Open
In this study, RA patients were divided into different immune molecular subtypes based on gene expression profile, and immune diagnostic markers were screened, which provided a new idea for the diagnosis and treatment of RA.
View article: Organelle Remodeling Enhances Mitochondrial Atp Disruption for Blocking Neuro-Pain Signaling in Bone Tumor Therapy
Organelle Remodeling Enhances Mitochondrial Atp Disruption for Blocking Neuro-Pain Signaling in Bone Tumor Therapy Open
View article: Classification of distinct osteoarthritis subtypes with different knee joint tissues by gene expression profiles
Classification of distinct osteoarthritis subtypes with different knee joint tissues by gene expression profiles Open
Aims Knee osteoarthritis (OA) involves a variety of tissues in the joint. Gene expression profiles in different tissues are of great importance in order to understand OA. Methods First, we obtained gene expression profiles of cartilage, sy…
View article: Neoantigens heterogeneity as a prognostic marker in patients with resected intrahepatic cholangiocarcinoma
Neoantigens heterogeneity as a prognostic marker in patients with resected intrahepatic cholangiocarcinoma Open
Background The prognostic significance of neoantigens and the understanding of neoantigen-associated heterogeneity in intrahepatic cholangiocarcinoma (iCCA) is still unclear. This study aims to investigate the prognostic role of neoantigen…
View article: Multi‐omics analyses reveal spatial heterogeneity in primary and metastatic oesophageal squamous cell carcinoma
Multi‐omics analyses reveal spatial heterogeneity in primary and metastatic oesophageal squamous cell carcinoma Open
Background Biopsies obtained from primary oesophageal squamous cell carcinoma (ESCC) guide diagnosis and treatment. However, spatial intra‐tumoral heterogeneity (ITH) influences biopsy‐derived information and patient responsiveness to ther…
View article: Characterization of the tumor microenvironment and identification of spatially predictive biomarkers associated with beneficial neoadjuvant chemoradiotherapy in locally advanced rectal cancer
Characterization of the tumor microenvironment and identification of spatially predictive biomarkers associated with beneficial neoadjuvant chemoradiotherapy in locally advanced rectal cancer Open
Neoadjuvant chemoradiotherapy (nCRT) has become the standard treatment for patients with locally advanced rectal cancer (LARC). However, 20-40% of patients with LARC show little to no response to nCRT. Thus, comprehensively understanding t…
View article: Screening diagnostic markers of osteoporosis based on ferroptosis of osteoblast and osteoclast
Screening diagnostic markers of osteoporosis based on ferroptosis of osteoblast and osteoclast Open
Ferroptosis may inhibit bone formation and promote bone absorption through oxidative stress, thus leading to osteoporosis. The study of ferroptosis on osteoblasts and osteoclasts provides a new idea for the diagnosis and treatment of osteo…
View article: Stem Cell-Associated Signatures Help to Predict Diagnosis and Prognosis in Ovarian Serous Cystadenocarcinoma
Stem Cell-Associated Signatures Help to Predict Diagnosis and Prognosis in Ovarian Serous Cystadenocarcinoma Open
Ovarian serous cystadenocarcinoma (OV) is a fatal gynecologic cancer with a five-year survival rate of only 46%. Resistance to platinum-based chemotherapy is a prevalent factor in OV patients, leading to increased mortality. The platinum r…
View article: The Mutational, Prognostic, and Therapeutic Landscape of Neuroendocrine Neoplasms
The Mutational, Prognostic, and Therapeutic Landscape of Neuroendocrine Neoplasms Open
Background Neuroendocrine neoplasms (NENs) represent clinically and genetically heterogeneous malignancies, thus a comprehensive understanding of underlying molecular characteristics, prognostic signatures, and potential therapeutic target…
View article: Supplementary Dataset 1 from Distinct Subtypes of Gastric Cancer Defined by Molecular Characterization Include Novel Mutational Signatures with Prognostic Capability
Supplementary Dataset 1 from Distinct Subtypes of Gastric Cancer Defined by Molecular Characterization Include Novel Mutational Signatures with Prognostic Capability Open
Clinical data of gastric cancer patients whose genomic data was aggregrated for integrated analysis.
View article: Supplementary Figure 2 from Distinct Subtypes of Gastric Cancer Defined by Molecular Characterization Include Novel Mutational Signatures with Prognostic Capability
Supplementary Figure 2 from Distinct Subtypes of Gastric Cancer Defined by Molecular Characterization Include Novel Mutational Signatures with Prognostic Capability Open
Fig. S2: Prognostic significance of C1/2.
View article: Supplementary Figure Legends from Distinct Subtypes of Gastric Cancer Defined by Molecular Characterization Include Novel Mutational Signatures with Prognostic Capability
Supplementary Figure Legends from Distinct Subtypes of Gastric Cancer Defined by Molecular Characterization Include Novel Mutational Signatures with Prognostic Capability Open
Supplementary Figure Legends
View article: Data from Distinct Subtypes of Gastric Cancer Defined by Molecular Characterization Include Novel Mutational Signatures with Prognostic Capability
Data from Distinct Subtypes of Gastric Cancer Defined by Molecular Characterization Include Novel Mutational Signatures with Prognostic Capability Open
Gastric cancer is not a single disease, and its subtype classification is still evolving. Next-generation sequencing studies have identified novel genetic drivers of gastric cancer, but their use as molecular classifiers or prognostic mark…
View article: Supplementary Dataset 1 from Distinct Subtypes of Gastric Cancer Defined by Molecular Characterization Include Novel Mutational Signatures with Prognostic Capability
Supplementary Dataset 1 from Distinct Subtypes of Gastric Cancer Defined by Molecular Characterization Include Novel Mutational Signatures with Prognostic Capability Open
Clinical data of gastric cancer patients whose genomic data was aggregrated for integrated analysis.
View article: Supplementary Figure 1 from Distinct Subtypes of Gastric Cancer Defined by Molecular Characterization Include Novel Mutational Signatures with Prognostic Capability
Supplementary Figure 1 from Distinct Subtypes of Gastric Cancer Defined by Molecular Characterization Include Novel Mutational Signatures with Prognostic Capability Open
Fig. S1: Optimization of number of molecular subtypes and assessment of batch effects.
View article: Supplementary Figure 1 from Distinct Subtypes of Gastric Cancer Defined by Molecular Characterization Include Novel Mutational Signatures with Prognostic Capability
Supplementary Figure 1 from Distinct Subtypes of Gastric Cancer Defined by Molecular Characterization Include Novel Mutational Signatures with Prognostic Capability Open
Fig. S1: Optimization of number of molecular subtypes and assessment of batch effects.
View article: Supplementary Table 1 from Distinct Subtypes of Gastric Cancer Defined by Molecular Characterization Include Novel Mutational Signatures with Prognostic Capability
Supplementary Table 1 from Distinct Subtypes of Gastric Cancer Defined by Molecular Characterization Include Novel Mutational Signatures with Prognostic Capability Open
Supplementary Table 1: Published publications and cohorts
View article: Supplementary Figure 2 from Distinct Subtypes of Gastric Cancer Defined by Molecular Characterization Include Novel Mutational Signatures with Prognostic Capability
Supplementary Figure 2 from Distinct Subtypes of Gastric Cancer Defined by Molecular Characterization Include Novel Mutational Signatures with Prognostic Capability Open
Fig. S2: Prognostic significance of C1/2.
View article: Supplementary Figure Legends from Distinct Subtypes of Gastric Cancer Defined by Molecular Characterization Include Novel Mutational Signatures with Prognostic Capability
Supplementary Figure Legends from Distinct Subtypes of Gastric Cancer Defined by Molecular Characterization Include Novel Mutational Signatures with Prognostic Capability Open
Supplementary Figure Legends
View article: Supplementary Dataset 2 from Distinct Subtypes of Gastric Cancer Defined by Molecular Characterization Include Novel Mutational Signatures with Prognostic Capability
Supplementary Dataset 2 from Distinct Subtypes of Gastric Cancer Defined by Molecular Characterization Include Novel Mutational Signatures with Prognostic Capability Open
DNA repair gene mutations, SMGs, and hotspot mutations in RGC and HGC.
View article: Supplementary Dataset 2 from Distinct Subtypes of Gastric Cancer Defined by Molecular Characterization Include Novel Mutational Signatures with Prognostic Capability
Supplementary Dataset 2 from Distinct Subtypes of Gastric Cancer Defined by Molecular Characterization Include Novel Mutational Signatures with Prognostic Capability Open
DNA repair gene mutations, SMGs, and hotspot mutations in RGC and HGC.
View article: Data from Distinct Subtypes of Gastric Cancer Defined by Molecular Characterization Include Novel Mutational Signatures with Prognostic Capability
Data from Distinct Subtypes of Gastric Cancer Defined by Molecular Characterization Include Novel Mutational Signatures with Prognostic Capability Open
Gastric cancer is not a single disease, and its subtype classification is still evolving. Next-generation sequencing studies have identified novel genetic drivers of gastric cancer, but their use as molecular classifiers or prognostic mark…
View article: Supplementary Table 1 from Distinct Subtypes of Gastric Cancer Defined by Molecular Characterization Include Novel Mutational Signatures with Prognostic Capability
Supplementary Table 1 from Distinct Subtypes of Gastric Cancer Defined by Molecular Characterization Include Novel Mutational Signatures with Prognostic Capability Open
Supplementary Table 1: Published publications and cohorts
View article: Comparison of current treatment strategy for osteonecrosis of the femoral head from the perspective of cell therapy
Comparison of current treatment strategy for osteonecrosis of the femoral head from the perspective of cell therapy Open
Aims: The purpose of our study is to compare the effects of core decompression (CD) and bone grafting (BG) on osteonecrosis of the femoral head (ONFH). And evaluate the efficacy of CD based on cell therapy to provide guidance for the dose …
View article: New classification of rheumatoid arthritis based on immune cells and clinical characteristics
New classification of rheumatoid arthritis based on immune cells and clinical characteristics Open
Background Rheumatoid arthritis (RA) is a chronic systemic immune disease characterized by joint synovitis, but the specific etiology is unknown, and the characteristic serum diagnostic markers are also lacking. Methods First, we obtained …