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View article: Research on the Formation Mechanism of Low Power Metal-Fuse Additive Manufacturing In-Space
Research on the Formation Mechanism of Low Power Metal-Fuse Additive Manufacturing In-Space Open
View article: Resistive thermal fusion interface of a novel excellent balanced-performance laminated Ti-5Al-2.5Sn / Ti–6Al–2Zr–1Mo–1V dissimilar titanium alloys
Resistive thermal fusion interface of a novel excellent balanced-performance laminated Ti-5Al-2.5Sn / Ti–6Al–2Zr–1Mo–1V dissimilar titanium alloys Open
View article: Interfacial Charge Transfer and Defect Engineering in the MoTe<sub>2</sub>/Graphene Heterostructure for Tailored Carrier Kinetics and Nonlinear Absorption
Interfacial Charge Transfer and Defect Engineering in the MoTe<sub>2</sub>/Graphene Heterostructure for Tailored Carrier Kinetics and Nonlinear Absorption Open
The MoTe 2 and graphene heterostructure exhibits significant potential for ultrafast photonic switching owing to their ultrafast carrier dynamics, superior nonlinear saturable absorption (SA) properties, and scalable synthesis. Interfacial…
View article: LKB1 dictates sensitivity to immunotherapy through Skp2-mediated ubiquitination of PD-L1 protein in non-small cell lung cancer
LKB1 dictates sensitivity to immunotherapy through Skp2-mediated ubiquitination of PD-L1 protein in non-small cell lung cancer Open
Background Loss-of-function mutations of liver kinase B ( LKB1 , also termed as STK11 ( serine/threonine kinase 11 )) are frequently detected in patients with non-small cell lung cancer (NSCLC). The LKB1 mutant NSCLC was refractory to almo…
View article: Christensenellaceae minuta modulates epithelial healing via PI3K-AKT pathway and macrophage differentiation in the colitis
Christensenellaceae minuta modulates epithelial healing via PI3K-AKT pathway and macrophage differentiation in the colitis Open
Ulcerative colitis (UC) is a chronic inflammatory disorder with an unsatisfactory cure rate and mucosal healing is a key treatment objective. Christensenellaceae minuta (C. minuta) has emerged as a next-generation of probiotic for maintain…
View article: Lactobacillus helveticus attenuates alcoholic liver injury via regulation of gut microecology in mice
Lactobacillus helveticus attenuates alcoholic liver injury via regulation of gut microecology in mice Open
Previous reports have demonstrated that alcohol consumption significantly reduces the abundance of Lactobacillus in the gut. In this study, we selected five species of the genus Lactobacillus , commonly found in fermented foods, and acknow…
View article: High-output <b>∼</b>3 <b> <i>μ</i> </b>m MIR pulsed laser enabled by surface state regulation in PtTe2 optical switch
High-output <b>∼</b>3 <b> <i>μ</i> </b>m MIR pulsed laser enabled by surface state regulation in PtTe2 optical switch Open
Mid-infrared (MIR) pulsed lasers operating in the ∼3 μm region play a crucial role in various applications, including molecular spectroscopy, ultrafast molecular imaging, and laser-assisted surgery. Despite recent advancements in MIR gain …
View article: Sub-60-fs mode-locked Tm,Ho:CaYLuAlO<sub>4</sub> laser at 2.05 µm
Sub-60-fs mode-locked Tm,Ho:CaYLuAlO<sub>4</sub> laser at 2.05 µm Open
Tm,Ho:CaYLuAlO 4 (Tm,Ho:CALYLO) crystal has wide emission spectra both for π-polarization and σ-polarization, showing significant potential for the generation of ultrashort pulses. Here, a widely tunable and passively mode-locked laser ope…
View article: Efficacy of immunotherapy in patients with oncogene-driven non-small-cell lung cancer: a systematic review and meta-analysis
Efficacy of immunotherapy in patients with oncogene-driven non-small-cell lung cancer: a systematic review and meta-analysis Open
Background: Immunotherapy is an emerging antitumor therapy that can improve the survival of patients with advanced non-small-cell lung cancer (NSCLC). However, only about 20% of NSCLC patients can benefit from this treatment. At present, w…
View article: [Effect of Different Antitumor Regimens on Incidence and Severity of Corona Virus
Disease 2019 Pneumonia in Lung Cancer Patients:
A Single-center Retrospective Study].
[Effect of Different Antitumor Regimens on Incidence and Severity of Corona Virus
Disease 2019 Pneumonia in Lung Cancer Patients:
A Single-center Retrospective Study]. Open
Intrapulmonary focal radiation therapy within 6 months increased the incidence of COVID-19 pneumonia, but did not increase the severity. However, there was no safety concern for chemotherapy, targeted therapy, surgery and immunotherapy.
View article: Clinical characteristics and targeted therapy of different gene fusions in non-small cell lung cancer: a narrative review
Clinical characteristics and targeted therapy of different gene fusions in non-small cell lung cancer: a narrative review Open
The present report summarizes the current state of fusion gene research and the associated therapeutic methods to improve understanding for clinicians, but how to better overcome drug resistance remains a problem that needs to be explored.
View article: Microbial metabolites indole derivatives sensitize mice to D-GalN/LPS induced-acute liver failure via the Tlr2/NF-κB pathway
Microbial metabolites indole derivatives sensitize mice to D-GalN/LPS induced-acute liver failure via the Tlr2/NF-κB pathway Open
Introduction Acute liver failure (ALF) is a clinical condition with many causes, fast progression, and a poor prognosis. Previous research has indicated that microbial factors have a role in ALF, but a clear picture has yet to emerge. Meth…
View article: Ultrasound-Guided Dynamic Needle-Tip Positioning Method Is Superior to Conventional Palpation and Ultrasound Method in Arterial Catheterization
Ultrasound-Guided Dynamic Needle-Tip Positioning Method Is Superior to Conventional Palpation and Ultrasound Method in Arterial Catheterization Open
Background: Dynamic needle-tip positioning (DNTP) was shown to improve arterial cannulation efficiency with fewer complications than conventional palpation and ultrasound methods by some studies. However, this is still controversial, and w…
View article: Multifield-Controlled Terahertz Hybrid Metasurface for Switches and Logic Operations
Multifield-Controlled Terahertz Hybrid Metasurface for Switches and Logic Operations Open
Terahertz (THz) meta-devices are considered to be a promising framework for constructing integrated photonic circuitry, which is significant for processing the upsurge of data brought about by next-generation telecommunications. However, p…
View article: Alterations of gut microbiota in cirrhotic patients with spontaneous bacterial peritonitis: A distinctive diagnostic feature
Alterations of gut microbiota in cirrhotic patients with spontaneous bacterial peritonitis: A distinctive diagnostic feature Open
Background Spontaneous bacterial peritonitis (SBP) is a severe infection in cirrhotic patients that requires early diagnosis to improve the long-term outcome. Alterations in the gut microbiota have been shown to correlate with the developm…
View article: Characteristics of the gut microbiota in Bifidobacterium catenulatum LI10 pretreated rats with lower levels of D-galactosamine-induced liver damage
Characteristics of the gut microbiota in Bifidobacterium catenulatum LI10 pretreated rats with lower levels of D-galactosamine-induced liver damage Open
Aims Liver damage has caused great illness in human beings. Bifidobacterium catenulatum LI10 has been determined with protective effect against D-galactosamine-induced liver damage. However, due to the sample limitation, the individual dif…
View article: Anticoccidial Activity of Qinghao Powder Against Eimeria tenella in Broiler Chickens
Anticoccidial Activity of Qinghao Powder Against Eimeria tenella in Broiler Chickens Open
Artemisia annua (AAH) is traditionally used as an anti-malarial, expectorant and antipyretic Chinese medicine. The aim of this study was to explore the therapeutic effect of Qinghao Powder (QHP) on chicken coccidiosis, evaluate the safe do…
View article: Graphene-Assisted Polymer Waveguide Optically Controlled Switch Using First-Order Mode
Graphene-Assisted Polymer Waveguide Optically Controlled Switch Using First-Order Mode Open
All-optical devices have a great potential in optical communication systems. As a new material, graphene has attracted great attention in the field of optics due to its unique properties. We propose a graphene-assisted polymer optically co…
View article: An unusual case of piperacillin-tazobactam-induced fever, eosinophilia, thrombocytopenia and liver damage
An unusual case of piperacillin-tazobactam-induced fever, eosinophilia, thrombocytopenia and liver damage Open
Piperacillin-tazobactam is a broad-spectrum antimicrobial agent that is commonly used in clinical practice. The development of delayed drug hypersensitivity reaction (DHR) has been reported in several cases previously. Here we describe an …
View article: Au Nanoparticles-Doped Polymer All-Optical Switches Based on Photothermal Effects
Au Nanoparticles-Doped Polymer All-Optical Switches Based on Photothermal Effects Open
This article demonstrated the Au nanoparticles-doped polymer all-optical switches based on photothermal effects. The Au nanoparticles have a strong photothermal effect, which would generate the inhomogeneous thermal field distributions in …
View article: Low Power Consumption 3D-Inverted Ridge Thermal Optical Switch of Graphene-Coated Polymer/Silica Hybrid Waveguide
Low Power Consumption 3D-Inverted Ridge Thermal Optical Switch of Graphene-Coated Polymer/Silica Hybrid Waveguide Open
An inverted ridge 3D thermal optical (TO) switch of a graphene-coated polymer/silica hybrid waveguide is proposed. The side electrode structure is designed to reduce the mode loss induced by the graphene film and by heating the electrode. …
View article: Low Power Consumption Mode Switch Based on Three-Dimensional Polymer Mach-Zehnder Interferometer
Low Power Consumption Mode Switch Based on Three-Dimensional Polymer Mach-Zehnder Interferometer Open
We present a polymer thermo-optic mode switch based on the structure of two vertical Mach-Zehnder interferometers (MZIs). It can achieve a rapid switch between , , and with the different heaters turning on. In our simulation, we compare …
View article: Dispersed-Monolayer Graphene-Doped Polymer/Silica Hybrid Mach-Zehnder interferometer (MZI) Thermal Optical Switch with Low-Power Consumption and Fast Response
Dispersed-Monolayer Graphene-Doped Polymer/Silica Hybrid Mach-Zehnder interferometer (MZI) Thermal Optical Switch with Low-Power Consumption and Fast Response Open
This article demonstrates a dispersed-monolayer graphene-doped polymer/silica hybrid Mach–Zehnder interferometer (MZI) thermal optical switch with low-power consumption and fast response. The polymer/silica hybrid MZI structure reduces the…
View article: MicroRNA-25-3p regulates osteoclasts through nuclear factor I X
MicroRNA-25-3p regulates osteoclasts through nuclear factor I X Open
Osteoporosis is a bone metabolic disease, characterized by loss of bone density leading to fractures. Its incidence increases with age and affects patient quality of life. Although osteoclasts play a significant role in osteoporosis, their…
View article: A Polymer Asymmetric Mach–Zehnder Interferometer Sensor Model Based on Electrode Thermal Writing Waveguide Technology
A Polymer Asymmetric Mach–Zehnder Interferometer Sensor Model Based on Electrode Thermal Writing Waveguide Technology Open
This paper presents a novel electrode thermal writing waveguide based on a heating-induced refractive index change mechanism. The mode condition and the electrode thermal writing parameters were optimized, and the output patterns of the op…
View article: Polymer M-Z Thermal Optical Switch at 532-nm Based on Wet Etching and UV-Writing Waveguide
Polymer M-Z Thermal Optical Switch at 532-nm Based on Wet Etching and UV-Writing Waveguide Open
Polymer thermal optical switches have low power consumption and 532 nm is the communication window of polymer fiber. Polymer thermal optical switches at 532 nm are rarely reported, because of switching extinction ratio properties that are …
View article: Could cell division cycle protein 42 be a target for lung cancer treatment?
Could cell division cycle protein 42 be a target for lung cancer treatment? Open
Cell division cycle protein 42 (Cdc42), a member of the Rho GTPase family, which is part of the Ras superfamily, plays important roles in multiple fundamental cellular processes. Deregulation of Cdc42 may cause cellular defects that are re…
View article: Could cell division cycle protein 42 be a target for lung cancer treatment
Could cell division cycle protein 42 be a target for lung cancer treatment Open
Cell division cycle protein 42 (Cdc42), a member of the Rho GTPase family, which is part of the Ras superfamily, plays important roles in multiple fundamental cellular processes. Deregulation of Cdc42 may cause cellular defects that are re…
View article: Vascular endothelial Cdc42 deficiency delays skin wound-healing processes by increasing IL-1β and TNF-α expression.
Vascular endothelial Cdc42 deficiency delays skin wound-healing processes by increasing IL-1β and TNF-α expression. Open
Angiogenesis is an important step in skin wound repair. Angiogenesis is affected by the functions of many types of cells, especially endothelial cells. Cdc42 plays a vital role in endothelial cell function and vascular development; however…
View article: Endothelial Cdc42 deficiency impairs endothelial regeneration and vascular repair after inflammatory vascular injury
Endothelial Cdc42 deficiency impairs endothelial regeneration and vascular repair after inflammatory vascular injury Open