Jia‐Wen Mo
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View article: Brain‐Wide Spatiotemporally Distinct Traveling Waves Drive Anxiety‐Like Behaviors in Mice
Brain‐Wide Spatiotemporally Distinct Traveling Waves Drive Anxiety‐Like Behaviors in Mice Open
Cortical traveling waves coordinate communication among distributed neural ensembles to modulate brain function and dysfunction through distinct spatiotemporal propagation patterns. However, the brain‐wide propagation dynamics of traveling…
View article: Lysosomal TFEB‐TRPML1 Axis in Astrocytes Modulates Depressive‐like Behaviors
Lysosomal TFEB‐TRPML1 Axis in Astrocytes Modulates Depressive‐like Behaviors Open
Lysosomes are important cellular structures for human health as centers for recycling, signaling, metabolism and stress adaptation. However, the potential role of lysosomes in stress‐related emotions has long been overlooked. Here, it is f…
View article: O-GlcNAc transferase in astrocytes modulates depression-related stress susceptibility through glutamatergic synaptic transmission
O-GlcNAc transferase in astrocytes modulates depression-related stress susceptibility through glutamatergic synaptic transmission Open
Major depressive disorder is a common and devastating psychiatric disease, and the prevalence and burden are substantially increasing worldwide. Multiple studies of depression patients have implicated glucose metabolic dysfunction in the p…
View article: Astrocyte dysfunction drives abnormal resting-state functional connectivity in depression
Astrocyte dysfunction drives abnormal resting-state functional connectivity in depression Open
Major depressive disorder (MDD) is a devastating mental disorder that affects up to 17% of the population worldwide. Although brain-wide network-level abnormalities in MDD patients via resting-state functional magnetic resonance imaging (r…
View article: Proteomic Profiling of Astrocytic O-GlcNAc Transferase-Related Proteins in the Medial Prefrontal Cortex
Proteomic Profiling of Astrocytic O-GlcNAc Transferase-Related Proteins in the Medial Prefrontal Cortex Open
The medial prefrontal cortex (mPFC), a key part of the brain networks that are closely related to the regulation of behavior, acts as a key regulator in emotion, social cognition, and decision making. Astrocytes are the majority cell type …
View article: [<i>Chaihu Guizhi</i> decoction produces antidepressant-like effects <i>via</i> sirt1-p53 signaling pathway].
[<i>Chaihu Guizhi</i> decoction produces antidepressant-like effects <i>via</i> sirt1-p53 signaling pathway]. Open
CGD produces antidepressant-like effects in mice possibly through the sirt1-p53 signaling pathway and synaptic plasticity.