Jiuping Ding
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View article: Fast inactivation of Nav current in rat adrenal chromaffin cells involves two independent inactivation pathways
Fast inactivation of Nav current in rat adrenal chromaffin cells involves two independent inactivation pathways Open
Voltage-dependent sodium (Nav) current in adrenal chromaffin cells (CCs) is rapidly inactivating and tetrodotoxin (TTX)–sensitive. The fractional availability of CC Nav current has been implicated in regulation of action potential (AP) fre…
View article: Fast inactivation of Na<sup>+</sup>current in rat adrenal chromaffin cells involves two independent inactivation pathways
Fast inactivation of Na<sup>+</sup>current in rat adrenal chromaffin cells involves two independent inactivation pathways Open
Voltage-dependent sodium (Nav) current in adrenal chromaffin cells (CCs) is rapidly inactivating and TTX-sensitive. The fractional availability of CC Nav current has been implicated in regulation of action potential (AP) frequency and the …
View article: A conserved arginine/lysine-based motif promotes ER export of KCNE1 and KCNE2 to regulate KCNQ1 channel activity
A conserved arginine/lysine-based motif promotes ER export of KCNE1 and KCNE2 to regulate KCNQ1 channel activity Open
KCNE β-subunits play critical roles in modulating cardiac voltage-gated potassium channels. Among them, KCNE1 associates with KCNQ1 channel to confer a slow-activated IKs current, while KCNE2 functions as a dominant negative modulator to s…
View article: Rectification ratio based determination of disulfide bonds of β2 extracellular loop of BK channel
Rectification ratio based determination of disulfide bonds of β2 extracellular loop of BK channel Open
Large-conductance Ca2+-activated K+ (BK) channels are composed of a pore-forming α and a variable number of auxiliary β subunits and play important roles in regulating excitability, action potential waveforms and firing patterns, particula…
View article: Solution structure of extracellular loop of human β4 subunit of BK channel and its biological implication on ChTX sensitivity
Solution structure of extracellular loop of human β4 subunit of BK channel and its biological implication on ChTX sensitivity Open
Large-conductance Ca 2+ - and voltage-dependent K + (BK) channels display diverse biological functions while their pore-forming α subunit is coded by a single Slo1 gene. The variety of BK channels is correlated with the effects of BKα coex…
View article: Distinct Effects of Ca<sup>2+ </sup>Sparks on Cerebral Artery and Airway Smooth Muscle Cell Tone in Mice and Humans
Distinct Effects of Ca<sup>2+ </sup>Sparks on Cerebral Artery and Airway Smooth Muscle Cell Tone in Mice and Humans Open
The effects of Ca2+ sparks on cerebral artery smooth muscle cells (CASMCs) and airway smooth muscle cells (ASMCs) tone, as well as the underlying mechanisms, are not clear. In this investigation, we elucidated the underlying mechanisms of …
View article: Single Channel Recordings Reveal Differential β2 Subunit Modulations Between Mammalian and Drosophila BKCa(β2) Channels
Single Channel Recordings Reveal Differential β2 Subunit Modulations Between Mammalian and Drosophila BKCa(β2) Channels Open
Large-conductance Ca2+- and voltage-activated potassium (BK) channels are widely expressed in tissues. As a voltage and calcium sensor, BK channels play significant roles in regulating the action potential frequency, neurotransmitter relea…
View article: Extrapolating microdomain Ca2+ dynamics using BK channels as a Ca2+ sensor
Extrapolating microdomain Ca2+ dynamics using BK channels as a Ca2+ sensor Open
Ca 2+ ions play crucial roles in mediating physiological and pathophysiological processes, yet Ca 2+ dynamics local to the Ca 2+ source, either from influx via calcium permeable ion channels on plasmic membrane or release from internal Ca …
View article: Crystallographic analysis of NosA, which catalyzes terminal amide formation in the biosynthesis of nosiheptide
Crystallographic analysis of NosA, which catalyzes terminal amide formation in the biosynthesis of nosiheptide Open
Nosiheptide is a member of the thiopeptide family of antibiotics which demonstrates potent activities against various bacterial pathogens. The formation of its C-terminal amide is catalysed by NosA in an unusual strategy for maturating cer…
View article: Cytotoxic effect of Quinidine on testicular tissues, sperm parameters and Ca2+ level in mice sperms; as an option of male contraception
Cytotoxic effect of Quinidine on testicular tissues, sperm parameters and Ca2+ level in mice sperms; as an option of male contraception Open
Recently, there is developing of a new approach push of male contraception, based on targeting specific processes in sperm development, maturation, and function by using quinidine as a one of calcium channel blocker.The ef…
View article: Fluorescence Technique Description for Measuring Ca&lt;sup&gt;2+&lt;/sup&gt; in Mice Sperm
Fluorescence Technique Description for Measuring Ca<sup>2+</sup> in Mice Sperm Open
Recently, fluorescence technique becomes very useful. It can allow for addressing a fundamental problem of cellular mechanism besides characterizing the species inside the cell to facilitate the diagnostic and prognostic value. Manipulatio…