Jiaxiang Ding
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View article: China Precision Nutrition and Health: Knowledge, Attitude, and Practice Real-World Study (CPNAS): A Cross-Sectional Analysis of the Association Between Serum Vitamin A and Homocysteine Levels in Rural Middle-Aged and Elderly Populations in China
China Precision Nutrition and Health: Knowledge, Attitude, and Practice Real-World Study (CPNAS): A Cross-Sectional Analysis of the Association Between Serum Vitamin A and Homocysteine Levels in Rural Middle-Aged and Elderly Populations in China Open
Background Homocysteine levels are closely associated with overall health. An elevation in homocysteine can lead to a variety of health issues and is influenced by vitamins B12, B6, and folic acid. However, the dose-response relationship b…
View article: Pharmacokinetic and mass balance characterization of [ <sup>14</sup> C] RAY1216, a SARS-CoV-2 M <sup>pro</sup> inhibitor, in healthy Chinese male subjects
Pharmacokinetic and mass balance characterization of [ <sup>14</sup> C] RAY1216, a SARS-CoV-2 M <sup>pro</sup> inhibitor, in healthy Chinese male subjects Open
Background RAY1216 is an alpha-ketoamide-based peptide inhibitor of severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) major protease (M pro ). This study evaluated the absorption, distribution, metabolism and excretion of […
View article: Prophylactic proton pump inhibitor usage and new-onset acute kidney injury in critically ill patients: a retrospective analysis
Prophylactic proton pump inhibitor usage and new-onset acute kidney injury in critically ill patients: a retrospective analysis Open
Background Proton pump inhibitors (PPIs) are widely prescribed for stress ulcer prophylaxis (SUP) in intensive care unit (ICU) patients. However, the potential association between prophylactic PPIs and the development of new-onset acute ki…
View article: [Venous air embolism following removal of central venous catheters: A case report].
[Venous air embolism following removal of central venous catheters: A case report]. Open
Air embolism is a rare but dreaded complication of medical or surgical procedures with significant mortality. An abnormal air-to-blood pressure gradient and communication between the vein and atmosphere can lead to the venous air embolism.…
View article: The efficacy of cuff-shaving combined with negative pressure wound therapy in refractory exit-site and tunnel infections: a single center experience
The efficacy of cuff-shaving combined with negative pressure wound therapy in refractory exit-site and tunnel infections: a single center experience Open
View article: Relationship between effective blood flow rate and clinical outcomes in maintenance hemodialysis patients: a single-center study
Relationship between effective blood flow rate and clinical outcomes in maintenance hemodialysis patients: a single-center study Open
The association between blood flow rate (BFR) and clinical outcomes in patients undergoing maintenance hemodialysis (MHD) is inconclusive. This retrospective study included 175 patients undergoing MHD treatment between July 2015 and March …
View article: Clinical characteristics and outcomes of maintenance hemodialysis patients with COVID-19 during the Omicron wave of the pandemic in Beijing: a single center retrospective study
Clinical characteristics and outcomes of maintenance hemodialysis patients with COVID-19 during the Omicron wave of the pandemic in Beijing: a single center retrospective study Open
View article: A Novel Risk Score Model for the Differential Diagnosis of Type 2 Diabetic Nephropathy: A Multicenter Study
A Novel Risk Score Model for the Differential Diagnosis of Type 2 Diabetic Nephropathy: A Multicenter Study Open
Introduction. DN is a common complication of diabetes. However, diabetes combined with renal injury may involve DN or NDKD, with different treatment schemes. The purpose of our study was to determine the independent risk factors of DN and …
View article: The role of CSTF2 in cancer: from technology to clinical application
The role of CSTF2 in cancer: from technology to clinical application Open
A protein called cleavage-stimulating factor subunit 2 (CSTF2, additionally called CSTF-64) binds RNA and is needed for the cleavage and polyadenylation of mRNA. CSTF2 is an important component subunit of the cleavage stimulating factor (C…
View article: Conscious sedation anesthesia using different doses of remifentanil combined with dexmedetomidine for peritoneal dialysis catheter implantation
Conscious sedation anesthesia using different doses of remifentanil combined with dexmedetomidine for peritoneal dialysis catheter implantation Open
Low-dose remifentanil (0.02-0.07 μg/kg/min) combined with dexmedetomidine achieved satisfactory anesthetic effects with fewer adverse drug reactions during PD catheter implantation, indicating its potential for use in patients undergoing P…
View article: Effects of sacubitril-valsartan in patients undergoing maintenance dialysis
Effects of sacubitril-valsartan in patients undergoing maintenance dialysis Open
Data on angiotensin receptor-neprilysin inhibitor (ARNI) sacubitril-valsartan (SV) in patients undergoing maintenance dialysis is scarce. Our study aimed to investigate the effect of SV on patients undergoing dialysis. We retrospectively r…
View article: A phase I study comparing the biosimilarity of the pharmacokinetics and safety of recombinant humanized anti-vascular endothelial growth factor monoclonal antibody injection with Avastin® in healthy Chinese male subjects
A phase I study comparing the biosimilarity of the pharmacokinetics and safety of recombinant humanized anti-vascular endothelial growth factor monoclonal antibody injection with Avastin® in healthy Chinese male subjects Open
Background The biosimilar landscape for malignancies continues to grow, with several biosimilars for reference product bevacizumab currently available. Bevacizumab has been shown to be well tolerated; however, the safety of recombinant hum…
View article: Corrigendum: Association between hemoglobin glycation index and diabetic kidney disease in type 2 diabetes mellitus in China: a cross-sectional inpatient study
Corrigendum: Association between hemoglobin glycation index and diabetic kidney disease in type 2 diabetes mellitus in China: a cross-sectional inpatient study Open
[This corrects the article DOI: 10.3389/fendo.2023.1108061.].
View article: Association between hemoglobin glycation index and diabetic kidney disease in type 2 diabetes mellitus in China: A cross- sectional inpatient study
Association between hemoglobin glycation index and diabetic kidney disease in type 2 diabetes mellitus in China: A cross- sectional inpatient study Open
Objective To investigate the association between Hemoglobin Glycation Index (HGI) and Diabetic Kidney Disease (DKD) in Chinese type 2 diabetic individuals and to construct a risk score based on HGI to predict a person’s risk of DKD. Method…
View article: Oseltamivir phosphate for suspension is bioequivalent to TAMIFLU in healthy volunteers: a randomized, open-label clinical study
Oseltamivir phosphate for suspension is bioequivalent to TAMIFLU in healthy volunteers: a randomized, open-label clinical study Open
View article: Drug-Drug Interaction Potential of SH-1028, a Third-generation EGFR-TKI: In Vitro and Clinical Trials
Drug-Drug Interaction Potential of SH-1028, a Third-generation EGFR-TKI: In Vitro and Clinical Trials Open
SH-1028 is an irreversible third-generation EGFR tyrosine kinase inhibitor (EGFR-TKI) for the treatment of locally advanced or metastatic non-small cell lung cancer (NSCLC). Considering the possibility of combination therapy in patients wi…
View article: Drug-Drug Interaction Potential of SH-1028, a Third-generation EGFR-TKI: In Vitro and Clinical Trials
Drug-Drug Interaction Potential of SH-1028, a Third-generation EGFR-TKI: In Vitro and Clinical Trials Open
SH-1028 is an irreversible third-generation EGFR tyrosine kinase inhibitor (EGFR-TKI) for the treatment of locally advanced or metastatic non-small cell lung cancer (NSCLC). Considering the possibility of combination therapy in patients wi…
View article: Research progress on microRNA in gout
Research progress on microRNA in gout Open
Gout is a common form of arthritis caused by the deposition of sodium urate crystals in the joints and tissues around them. MicroRNAs (miRNAs) are noncoding RNAs that have been shown to be involved in regulating the pathogenesis of gout th…
View article: The regulatory role of PDE4B in the progression of inflammatory function study
The regulatory role of PDE4B in the progression of inflammatory function study Open
Inflammation is a response of the body to external stimuli (eg. chemical irritants, bacteria, viruses, etc.), and when the stimuli are persistent, they tend to trigger chronic inflammation. The presence of chronic inflammation is an import…
View article: Effects of Food on the Pharmacokinetics and Bioequivalence of Oseltamivir Phosphate for Suspension and TAMIFLU® in Healthy Chinese Subjects：A randomized, open-label Clinical Trial.
Effects of Food on the Pharmacokinetics and Bioequivalence of Oseltamivir Phosphate for Suspension and TAMIFLU® in Healthy Chinese Subjects：A randomized, open-label Clinical Trial. Open
Purpose Oseltamivir is mainly used for the treatment and prevention of influenza. The study was aimed at evaluating the bioequivalence and safety of oseltamivir phosphate suspension (Oselavir®), provided by Shenzhen Beimei Pharmaceutical C…
View article: TMEM88 Modulates Lipid Synthesis and Metabolism Cytokine by Regulating Wnt/β-Catenin Signaling Pathway in Non-Alcoholic Fatty Liver Disease
TMEM88 Modulates Lipid Synthesis and Metabolism Cytokine by Regulating Wnt/β-Catenin Signaling Pathway in Non-Alcoholic Fatty Liver Disease Open
Objective: To clarify the molecular mechanism of TMEM88 regulating lipid synthesis and metabolism cytokine in NAFLD. Methods: In vivo , NAFLD model mice were fed by a Methionine and Choline-Deficient (MCD) diet. H&E staining and immuno…
View article: A rare case of malignant hypertension with splenic rupture and thrombotic microangiopathy
A rare case of malignant hypertension with splenic rupture and thrombotic microangiopathy Open
Introduction: Thrombotic microangiopathy (TMA) is characterized by endothelial injury followed by formation of multiple microthrombi in the target organs due to various causes, including malignant hypertension (MHT). Here, we reported a ra…
View article: The downregulation of SnoN expression in human renal proximal tubule epithelial cells under high-glucose conditions is mediated by an increase in Smurf2 expression through TGF-β1 signaling
The downregulation of SnoN expression in human renal proximal tubule epithelial cells under high-glucose conditions is mediated by an increase in Smurf2 expression through TGF-β1 signaling Open
Transforming growth factor (TGF)-β1 is a profibrotic cytokine that plays a critical role in the progression of diabetic nephropathy (DN). Previous studies have demonstrated that the Smad transcriptional co-repressor, Ski-related novel prot…