Jing Wen
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View article: Isoginkgetin antagonizes ALS pathologies in its animal and patient iPSC models via PINK1-Parkin-dependent mitophagy
Isoginkgetin antagonizes ALS pathologies in its animal and patient iPSC models via PINK1-Parkin-dependent mitophagy Open
Damaged mitochondria initiate mitochondrial dysfunction-associated senescence, which is considered to be a critical cause for amyotrophic lateral sclerosis (ALS). Thus, mitophagic elimination of damaged mitochondria provides a promising st…
View article: Effects of Glycerol Monooleate on Improving Quality Characteristics and Baking Performance of Frozen Dough Breads
Effects of Glycerol Monooleate on Improving Quality Characteristics and Baking Performance of Frozen Dough Breads Open
This study investigated the impact of glycerol monooleate (MO) at varying levels (0.3%, 0.6%, 0.9%, and 1.2%) on the quality and baking properties of frozen dough. Low-field NMR and MRI were used to analyze the moisture distribution, water…
View article: 326 - Piezo1 promotes MMT aggravated Neurogenic bladder fibrosis via the PKM2/ITGB6/TGFB pathway
326 - Piezo1 promotes MMT aggravated Neurogenic bladder fibrosis via the PKM2/ITGB6/TGFB pathway Open
View article: Cytokine polarized, alternatively activated bone marrow neutrophils drive axon regeneration
Cytokine polarized, alternatively activated bone marrow neutrophils drive axon regeneration Open
View article: Evolution of <i>FLOWERING LOCUS T-like</i> genes in angiosperms: a core <i>Lamiales</i>-specific diversification
Evolution of <i>FLOWERING LOCUS T-like</i> genes in angiosperms: a core <i>Lamiales</i>-specific diversification Open
Plant life history is determined by two transitions, germination and flowering time, in which the phosphatidylethanolamine-binding proteins (PEBPs) FLOWERING LOCUS T (FT) and TERMINAL FLOWER1 (TFL1) play key regulatory roles. Compared with…
View article: Prediction Evaluation of the Tp-Te Interval in Patients with Vasovagal Syncope
Prediction Evaluation of the Tp-Te Interval in Patients with Vasovagal Syncope Open
View article: Deep-learning-augmented microscopy for super-resolution imaging of nanoparticles
Deep-learning-augmented microscopy for super-resolution imaging of nanoparticles Open
Conventional optical microscopes generally provide blurry and indistinguishable images for subwavelength nanostructures. However, a wealth of intensity and phase information is hidden in the corresponding diffraction-limited optical patter…
View article: Cholinergic α7 nAChR signaling suppresses SARS-CoV-2 infection and inflammation in lung epithelial cells
Cholinergic α7 nAChR signaling suppresses SARS-CoV-2 infection and inflammation in lung epithelial cells Open
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-induced coronavirus disease 2019 (COVID-19) has caused more than 6 million deaths and poses a huge threat to the global economy and public health.SARS-CoV-2 enters lung epith…
View article: Vagal-mAChR4 signaling promotes Friend virus complex (FV)-induced acute erythroleukemia
Vagal-mAChR4 signaling promotes Friend virus complex (FV)-induced acute erythroleukemia Open
Erythroleukemia belongs to acute myeloid leukemia (AML) type 6 (M6), and treatment remains difficult due to the poor prognosis of the disease. Friend virus (FV) is a complex of two viruses: Friend murine leukemia virus (F-MuLV) strain alon…
View article: EVA2.0: Investigating Open-domain Chinese Dialogue Systems with Large-scale Pre-training
EVA2.0: Investigating Open-domain Chinese Dialogue Systems with Large-scale Pre-training Open
View article: Thromboxane-induced contractile response of mesenteric arterioles is diminished in the older rats and the older hypertensive rats
Thromboxane-induced contractile response of mesenteric arterioles is diminished in the older rats and the older hypertensive rats Open
Nearly all physiological processes are controlled at some level by G-protein-coupled receptor (GPCR) signaling activity. The thromboxane A2 (TXA2) receptor (TP) is a member of the GPCR family. The ultimate effect of TP receptor activation …
View article: Tang-Ping-San Decoction Remodel Intestinal Flora and Barrier to Ameliorate Type 2 Diabetes Mellitus in Rodent Model
Tang-Ping-San Decoction Remodel Intestinal Flora and Barrier to Ameliorate Type 2 Diabetes Mellitus in Rodent Model Open
TPS decoction improves T2DM and liver function and reduces the risk of hyperglycemia, hyperlipidemia, insulin resistance, pathological organ changes, and inflammatory reactions. The mechanism of TPS decoction in T2DM can be correlated with…
View article: Inhibiting effect of miR-18a on expression of extracellular matrix-related genes of NIH-3T3 by targeting Notch2
Inhibiting effect of miR-18a on expression of extracellular matrix-related genes of NIH-3T3 by targeting Notch2 Open
BackgroundThe main pathological feature of silicosis is pulmonary fibrosis. Multiple miRNAs regulate the development of silicosis.ObjectiveUsing a fibroblast cell line, to explore the effect of miR-18a on the expression of extracellular ma…
View article: Activation of α7 nicotinic acetylcholine receptor promotes HIV-1 transcription
Activation of α7 nicotinic acetylcholine receptor promotes HIV-1 transcription Open
View article: Pharmacological suppression of glycogen synthase kinase-3 reactivates HIV-1 from latency via activating Wnt/β-catenin/TCF1 axis in CD4 <sup>+</sup> T cells
Pharmacological suppression of glycogen synthase kinase-3 reactivates HIV-1 from latency via activating Wnt/β-catenin/TCF1 axis in CD4 <sup>+</sup> T cells Open
ABSTRACTHIV-1 latency posts a major obstacle for HIV-1 eradication. Currently, no desirable latency reversing agents (LRAs) have been implicated in the "Shock and Kill" strategy to mobilize the latently infected cells to be suscepti…
View article: Pharmacological suppression of glycogen synthase kinase-3 reactivates HIV-1 from latency via activating Wnt/β-catenin/TCF1 axis in CD4<sup>+</sup> T cells
Pharmacological suppression of glycogen synthase kinase-3 reactivates HIV-1 from latency via activating Wnt/β-catenin/TCF1 axis in CD4<sup>+</sup> T cells Open
HIV-1 latency posts a major obstacle for HIV-1 eradication. Currently, no desirable latency reversing agents (LRAs) have been implicated in the “Shock and Kill” strategy to mobilize the latently infected cells to be susceptible for clearan…
View article: Decrease of MYPT1 Is Critical for Impairment of NO-mediated Vasodilation in Mesenteric Artery of the Older Spontaneously Hypertensive Rats
Decrease of MYPT1 Is Critical for Impairment of NO-mediated Vasodilation in Mesenteric Artery of the Older Spontaneously Hypertensive Rats Open
Nitric oxide (NO)-mediated vasodilatation is a fundamental response of vasculature, however, regulation of NO signaling pathway on resistance vessels in the older adult with hypertension is still unclear. The 16-week-spontaneously hyperten…
View article: Analysis of Lung Ground-glass Nodules From the Perspective of Inflammation-to-cancer Transition Based on Il-6 Level and Clinical Features
Analysis of Lung Ground-glass Nodules From the Perspective of Inflammation-to-cancer Transition Based on Il-6 Level and Clinical Features Open
Objective：To explore the potential impact of interleukin-6 (IL-6) in promoting the development and progression of lung ground-glass nodules (GGN) based on multiple clinical features using multi-dimensional analysis (MDA). Methods: Sample c…
View article: TSC1 Suppresses Macrophage Necroptosis for the Control of Infection by Fungal Pathogen <i>Candida albicans</i>
TSC1 Suppresses Macrophage Necroptosis for the Control of Infection by Fungal Pathogen <i>Candida albicans</i> Open
Candida albicans is the most common, opportunistic human fungal pathogen whose complex interplay with the host innate immune system remains incompletely understood. In this study, we revealed that infection macrophages with C. albicans tri…
View article: SOX1 Is Required for the Specification of Rostral Hindbrain Neural Progenitor Cells from Human Embryonic Stem Cells
SOX1 Is Required for the Specification of Rostral Hindbrain Neural Progenitor Cells from Human Embryonic Stem Cells Open
Region-specific neural progenitor cells (NPCs) can be generated from human embryonic stem cells (hESCs) by modulating signaling pathways. However, how intrinsic transcriptional factors contribute to the neural regionalization is not well c…
View article: <p>Tumor Necrosis Factor-α Regulates the TRPA1 Expression in Human Odontoblast-Like Cells</p>
Tumor Necrosis Factor-α Regulates the TRPA1 Expression in Human Odontoblast-Like Cells Open
Our study demonstrated that TRPA1 expression in HOD-like cells was evidently upregulated by TNF-α, presumably via TNFR1. TNF-α induced significant increasement in the intracellular distributions of TRPA1 proteins, with increases in the cyt…
View article: Caffeic Acid Phenethyl Ester Prevents Colitis-Associated Cancer by Inhibiting NLRP3 Inflammasome
Caffeic Acid Phenethyl Ester Prevents Colitis-Associated Cancer by Inhibiting NLRP3 Inflammasome Open
Long-lasting inflammation in the intestinal tract renders individuals susceptible to colitis-associated cancer (CAC). The NOD-like receptor protein 3 (NLRP3) inflammasome plays a key role in the progression of inflammatory bowel disease an…
View article: ECM1 is an essential factor for the determination of M1 macrophage polarization in IBD in response to LPS stimulation
ECM1 is an essential factor for the determination of M1 macrophage polarization in IBD in response to LPS stimulation Open
Inflammatory bowel disease (IBD) comprises chronic relapsing disorders of the gastrointestinal tract characterized pathologically by intestinal inflammation and epithelial injury. Here, we uncover a function of extracellular matrix protein…
View article: Bifidobacterium pseudolongum reduces triglycerides by modulating gut microbiota in mice fed high-fat food
Bifidobacterium pseudolongum reduces triglycerides by modulating gut microbiota in mice fed high-fat food Open
Obesity has become a growing concern around the world. The purpose of this study was to investigate the potential benefit of Bifidobacterium pseudolongum (B. pseudolongum) on obesity, gut microbiota, and its physiological mechanism. The ob…
View article: SOX21 Ensures Rostral Forebrain Identity by Suppression of WNT8B during Neural Regionalization of Human Embryonic Stem Cells
SOX21 Ensures Rostral Forebrain Identity by Suppression of WNT8B during Neural Regionalization of Human Embryonic Stem Cells Open
View article: <i>Mahuang-Fuzi-Xixin</i>Decoction Reverses Depression-Like Behavior in LPS-Induced Mice by Regulating NLRP3 Inflammasome and Neurogenesis
<i>Mahuang-Fuzi-Xixin</i>Decoction Reverses Depression-Like Behavior in LPS-Induced Mice by Regulating NLRP3 Inflammasome and Neurogenesis Open
Evidence suggests that inflammation and neurogenesis play an important role in major depressive disorder (MDD). Mahuang-Fuzi-Xixin decoction (MFX), as the traditional Chinese prescription, has been widely applied for asthma, migraine, and …
View article: Amino Acids License Kinase mTORC1 Activity and Treg Cell Function via Small G Proteins Rag and Rheb
Amino Acids License Kinase mTORC1 Activity and Treg Cell Function via Small G Proteins Rag and Rheb Open
View article: The expression and function of KCNQ potassium channels in human chorionic plate arteries from women with normal pregnancies and pre-eclampsia
The expression and function of KCNQ potassium channels in human chorionic plate arteries from women with normal pregnancies and pre-eclampsia Open
Pre-eclampsia is associated with altered maternal and placental vascular reactivity. Kv7 channels (encoded by KCNQ 1-5 genes) are a potential contributor to the regulation of vascular tone in CPAs (chorionic plate arteries) during normal p…
View article: Sodium Tanshinone II-A Sulfonate (DS-201) Induces Vasorelaxation of Rat Mesenteric Arteries via Inhibition of L-Type Ca2+ Channel
Sodium Tanshinone II-A Sulfonate (DS-201) Induces Vasorelaxation of Rat Mesenteric Arteries via Inhibition of L-Type Ca2+ Channel Open
Background: We previously have proved that sodium tanshinone II-A sulfonate (DS-201), a derivative of traditional Chinese medicinal herb Danshen (Salvia miltiorrhiza), is an opener and vasodilator of BKCa channel in the v…
View article: Single-cell analysis reveals lineage segregation in early post-implantation mouse embryos
Single-cell analysis reveals lineage segregation in early post-implantation mouse embryos Open
The mammalian post-implantation embryo has been extensively investigated at the tissue level. However, to unravel the molecular basis for the cell-fate plasticity and determination, it is essential to study the characteristics of individua…