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View article: #230 INShore: phase III, multicentre, randomised, open-label study of efficacy and safety of obinutuzumab vs MMF in patients with childhood-onset idiopathic nephrotic syndrome
#230 INShore: phase III, multicentre, randomised, open-label study of efficacy and safety of obinutuzumab vs MMF in patients with childhood-onset idiopathic nephrotic syndrome Open
Background and Aims Patients with childhood-onset frequently relapsing nephrotic syndrome (FRNS) or steroid-dependent nephrotic syndrome (SDNS) need approved therapies that sustain clinical remission and minimise glucocorticoid burden. Ove…
View article: Tacrolimus or Mycophenolate Mofetil for Frequently Relapsing or Steroid-Dependent Nephrotic Syndrome
Tacrolimus or Mycophenolate Mofetil for Frequently Relapsing or Steroid-Dependent Nephrotic Syndrome Open
Importance Both tacrolimus (TAC) and mycophenolate mofetil (MMF) are recommended for children with frequently relapsing nephrotic syndrome (FRNS) or steroid-dependent nephrotic syndrome (SDNS). However, their comparative effectiveness and …
View article: Prognosis prediction in non‐Hodgkin lymphoma by assessing lymphoid organs uptake patterns using baseline <scp><sup>18</sup>F</scp>‐<scp>FDG PET</scp>/<scp>CT</scp>
Prognosis prediction in non‐Hodgkin lymphoma by assessing lymphoid organs uptake patterns using baseline <span><sup>18</sup>F</span>‐<span>FDG PET</span>/<span>CT</span> Open
The prognostic implications of lymphoid organs (LOs) involvement in untreated non‐Hodgkin lymphoma (NHL) patients remain underexplored. This study aims to explore the significance of LOs metabolic activity, assessed via 18 F‐FDG PET/CT, in…
View article: Nanomaterials for acute myeloid leukemia therapy: Current progress and future perspectives
Nanomaterials for acute myeloid leukemia therapy: Current progress and future perspectives Open
Acute myeloid leukemia (AML) is a highly aggressive hematologic malignancy characterized by poor prognosis, high relapse rates, and resistance to conventional chemotherapy. The limitations of standard treatments, including systemic toxicit…
View article: A Matrigel-Free 3D Chondrocytic Spheroid Model for Rheumatoid Arthritis-Associated Synoviocytes Invasion Studies
A Matrigel-Free 3D Chondrocytic Spheroid Model for Rheumatoid Arthritis-Associated Synoviocytes Invasion Studies Open
This matrigel-free 3D chondrocytic spheroid model offers an ideal platform for innovative drug screening and pathogenesis studies focused on synoviocytes invasion of cartilage.
View article: Metagenomic analysis identifying a polymicrobial pulmonary infection in a non-HIV immunocompromised patient: a case report
Metagenomic analysis identifying a polymicrobial pulmonary infection in a non-HIV immunocompromised patient: a case report Open
For immunocompromised patients with multiple infections and atypical symptoms, mNGS emerged as a reliable approach to pathogen detection and guiding antibiotic therapy.
View article: Metagenomic Analysis Identifying a Polymicrobial Pulmonary Infection in a Non-HIV Immunocompromised Patient: A Case Report
Metagenomic Analysis Identifying a Polymicrobial Pulmonary Infection in a Non-HIV Immunocompromised Patient: A Case Report Open
Background Polymicrobial pulmonary infections, common in immunocompromised patients, often manifest more severe symptoms than monomicrobial infections. Clinical diagnosis delays may lead to mortality, emphasizing the importance of fast and…
View article: Reform of Salary System in Universities and the Strategy of Strengthening Schools with Talents
Reform of Salary System in Universities and the Strategy of Strengthening Schools with Talents Open
The reform of the salary system is a significant change faced by colleges and universities under modern historical conditions. This article summarizes the relationship between the reform of the salary system in universities and the strateg…
View article: Are children with IgA nephropathy different from adult patients?
Are children with IgA nephropathy different from adult patients? Open
Background Previously, several studies have indicated that pediatric IgA nephropathy (IgAN) might be different from adult IgAN, and treatment strategies might be also different between pediatric IgAN and adult IgAN. Methods We analyzed two…
View article: Activation of RIG-I signaling in the early stage of Paragonimus proliferus infection causes lung injury via type I immune response in rat
Activation of RIG-I signaling in the early stage of Paragonimus proliferus infection causes lung injury via type I immune response in rat Open
Paragonimiasis is a common zoonotic parasitic disease. The retinoic acid-inducible gene I (RIG-I) signaling is very important for the host to recognize invading pathogens (especially viruses and bacteria). However, the role of RIG-I signal…
View article: Development and validation of a model for predicting the risk of cardiovascular events in maintenance hemodialysis patients
Development and validation of a model for predicting the risk of cardiovascular events in maintenance hemodialysis patients Open
The mortality rates for patients undergoing hemodialysis (HD) remain unacceptably high compared to the general population, and more specific information about the causes of death is not known. The study aimed to develop and validate a risk…
View article: Clinical features and outcomes of patients with acute myeloid leukemia: the single-center experience of 668 patients in China
Clinical features and outcomes of patients with acute myeloid leukemia: the single-center experience of 668 patients in China Open
In the treatment of adult AML patients, IA regimen is associated with a high CR rate and ORR rate and does not increase treatment-related toxicity. IA regimen prolongs OS and PFS in AML patients and reduces the likelihood of leukemia cells…
View article: Regulation of T cells in the tumor microenvironment by histone methylation: LSD1 inhibition—a new direction for enhancing immunotherapy
Regulation of T cells in the tumor microenvironment by histone methylation: LSD1 inhibition—a new direction for enhancing immunotherapy Open
Although immune checkpoint blockade (ICB) has been shown to achieve durable therapeutic responses in various types of tumors, only 20-40 % of patients benefit from this therapy. A growing body of research suggests that epigenetic modulatio…
View article: LSD1 regulates the FOXF2-mediated Wnt/β-catenin signaling pathway by interacting with Ku80 to promote colon cancer progression.
LSD1 regulates the FOXF2-mediated Wnt/β-catenin signaling pathway by interacting with Ku80 to promote colon cancer progression. Open
Lysine-specific demethylase 1 (LSD1) is widely involved in the proliferation, invasion, and metastasis of cancers. However, it is uncertain whether LSD1 plays a role in facilitating colon cancer progression. Here, we have clarified the mol…
View article: Pediatric Acute Kidney Injury to the Subsequent CKD Transition
Pediatric Acute Kidney Injury to the Subsequent CKD Transition Open
Background: Both acute kidney injury (AKI) and CKD are complex syndromes caused by multiple etiologies and presented with various degrees of severity. Studies on adults provide strong evidence that AKI is an independent risk factor for bot…
View article: Development and validation of an immune-related gene prognostic model for stomach adenocarcinoma
Development and validation of an immune-related gene prognostic model for stomach adenocarcinoma Open
Purpose: Stomach adenocarcinoma (STAD) is one of the most common malignant tumors, and its occurrence and prognosis are closely related to inflammation. The aim of the present study was to identify gene signatures and construct an immune-r…
View article: Genomic analysis and clinical implications of immune cell infiltration in gastric cancer
Genomic analysis and clinical implications of immune cell infiltration in gastric cancer Open
The immune infiltration of patients with gastric cancer (GC) is closely associated with clinical prognosis. However, previous studies failed to explain the different subsets of immune cells involved in immune responses and diverse function…
View article: Knocking down LSD1 inhibits the stemness features of colorectal cancer stem cells
Knocking down LSD1 inhibits the stemness features of colorectal cancer stem cells Open
As a top leading cause of cancer death in many countries, colorectal cancer (CRC) has drawn increasing attention to the study of the pathological mechanism. According to the "cancer stem cell hypothesis", malignancies originate from a smal…
View article: Supplementary Material for: Glycyrrhizin, a High-Mobility Group Box 1 Inhibitor, Improves Lipid Metabolism and Suppresses Vascular Inflammation in Apolipoprotein E Knockout Mice
Supplementary Material for: Glycyrrhizin, a High-Mobility Group Box 1 Inhibitor, Improves Lipid Metabolism and Suppresses Vascular Inflammation in Apolipoprotein E Knockout Mice Open
Background: High-mobility group box protein 1 (HMGB1) is known to have proinflammatory properties; however, the mechanisms by which HMGB1 influences immune responses during atherosclerosis (AS) development are not well understood. Thus, th…
View article: What is the impact of human leukocyte antigen mismatching on graft survival and mortality in renal transplantation? A meta-analysis of 23 cohort studies involving 486,608 recipients
What is the impact of human leukocyte antigen mismatching on graft survival and mortality in renal transplantation? A meta-analysis of 23 cohort studies involving 486,608 recipients Open
HLA mismatching was still a critical prognostic factor that affects graft and recipient survival. HLA-DR mismatching has a substantial impact on recipient's graft survival. HLA-A mismatching has minor but insignificant impact on graft surv…
View article: Identification of downstream metastasis-associated target genes regulated by LSD1 in colon cancer cells
Identification of downstream metastasis-associated target genes regulated by LSD1 in colon cancer cells Open
LSD1- depletion contributed to the upregulation of CABYR and CDH1 through enhancing the dimethylation of H3K4 at the LSD1-target genes promoter. LSD1- overexpression mediated the downregulation of CABYR and CDH1expression through decreasin…
View article: The Expression Profile of Complement Components in Podocytes
The Expression Profile of Complement Components in Podocytes Open
Podocytes are critical for maintaining the glomerular filtration barrier and are injured in many renal diseases, especially proteinuric kidney diseases. Recently, reports suggested that podocytes are among the renal cells that synthesize c…