Jiayi Liu
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View article: An Artificial Neural Network for Rapid Prediction of the 3D Transient Temperature Fields in Ship Hull Plate Line Heating Forming
An Artificial Neural Network for Rapid Prediction of the 3D Transient Temperature Fields in Ship Hull Plate Line Heating Forming Open
Line heating processes play a significant role in the fabrication of structural steel components, particularly in industries such as shipbuilding, aerospace, and automotive manufacturing, where dimensional accuracy and minimal defects are …
View article: The causal relationship between vitamin D deficiency and chronic hepatitis: A 2-sample Mendelian randomization approach
The causal relationship between vitamin D deficiency and chronic hepatitis: A 2-sample Mendelian randomization approach Open
Observational studies have suggested an association between vitamin D (Vit D) and chronic hepatitis (CH). However, the nature of this relationship remains uncertain. Therefore, the aim of this study is to investigate the potential causal l…
View article: Genome-wide characterization of ZmCRY genes: unveiling stress response mechanisms and the role of ZmCRYPHR2 in salinity tolerance
Genome-wide characterization of ZmCRY genes: unveiling stress response mechanisms and the role of ZmCRYPHR2 in salinity tolerance Open
These findings provide a comprehensive genomic and functional characterization of the ZmCRY gene family, with ZmCRYPHR2 identified as a pivotal regulator of salt tolerance, offering valuable genetic insights for the development of stress-r…
View article: Association between body roundness index and chronic obstructive pulmonary disease: a cross-sectional analysis
Association between body roundness index and chronic obstructive pulmonary disease: a cross-sectional analysis Open
Background Studies suggest that obesity may exacerbate the clinical symptoms of chronic obstructive pulmonary disease (COPD), and early screening is critical for improving treatment outcomes. This study aims to investigate the correlation …
View article: Isolation and growth-promoting mechanisms of phosphate-solubilizing bacteria from Qinghai-Tibet Plateau in Lespedeza bicolor Turcz
Isolation and growth-promoting mechanisms of phosphate-solubilizing bacteria from Qinghai-Tibet Plateau in Lespedeza bicolor Turcz Open
Introduction The recovery of slopes in high-altitude areas is often challenging due to insufficient nutrients in the soil, with phosphorus deficiency being a key limiting factor for plant growth. This study aimed to screen highly efficient…
View article: Mutations of schizophrenia risk gene SETD1A dysregulate synaptic function in human neurons
Mutations of schizophrenia risk gene SETD1A dysregulate synaptic function in human neurons Open
Schizophrenia (SCZ) is a complex neuropsychiatric disorder associated with both common risk variants of small effect sizes and rare risk variants of high penetrance. Rare premature open reading frame (ORF) termination variants in SETD1A (S…
View article: The pharmacy graduate global competence evaluation scale (PGGCES): a nationwide study in China
The pharmacy graduate global competence evaluation scale (PGGCES): a nationwide study in China Open
View article: The Functional Transformation of Green Belts: Research on Spatial Spillover of Recreational Services in Shanghai’s Ecological Park Belt
The Functional Transformation of Green Belts: Research on Spatial Spillover of Recreational Services in Shanghai’s Ecological Park Belt Open
The establishment of a new green space system based on the green belt has become a new trend in the world. Shanghai’s Outer Ring Ecological Park Belt (formerly the Outer Green Belt) faces challenges of spatial imbalance in recreational ser…
View article: The impact of Stromal antigen 2 (STAG2) on migration and invasion of Hepatocellular carcinoma
The impact of Stromal antigen 2 (STAG2) on migration and invasion of Hepatocellular carcinoma Open
Stromal antigen2 (STAG2) is involved in metastasis and invasion processes of various cancers, however, the functions of STAG2 in HCC remain unclear. In our study, We evaluated the global mRNA expression levels of STAG2 using the TCGA and G…
View article: Targeting Immune Checkpoints: Basic Signaling Pathways and Clinical Translation in Cancer Therapeutics
Targeting Immune Checkpoints: Basic Signaling Pathways and Clinical Translation in Cancer Therapeutics Open
Immune checkpoints, the key gatekeepers of immune homeostasis, have become the central targets of modern cancer immunotherapy. These regulatory pathways, composed of co‐suppressive and co‐stimulatory molecules, enable the immune system to …
View article: The pro-cancer and immunosuppressive activity of macrophage-transformed cancer-associated fibroblasts in oral squamous cell carcinoma
The pro-cancer and immunosuppressive activity of macrophage-transformed cancer-associated fibroblasts in oral squamous cell carcinoma Open
These results imply that macrophages can transform into CAFs via the activated smad3 pathway by TGFβ1 derived from tumor cells in OSCC, and MMT exerts protumoral and immunosuppressive functions in OSCC through the CXCL10 pathway. MMT may b…
View article: A Study on Urban Vegetation and Pollen Allergy in Beijing
A Study on Urban Vegetation and Pollen Allergy in Beijing Open
Beijing, as an ecological city with a forest coverage rate reaching 44.95%, significantly benefits from its abundant vegetation resources which improve the urban environmental quality. However, the dense distribution of numerous anemophilo…
View article: LPAR4-targeted dual-loaded liposome for synergistic lung cancer therapy
LPAR4-targeted dual-loaded liposome for synergistic lung cancer therapy Open
Lung cancer continues to be the primary contributor to global cancer deaths, with metastasis posing a major challenge to effective treatment. Although chemotherapy is a primary first-line intervention, its efficacy in preventing tumor diss…
View article: A subset of evolutionarily conserved centriolar satellite core components is crucial for sperm flagellum biogenesis
A subset of evolutionarily conserved centriolar satellite core components is crucial for sperm flagellum biogenesis Open
Rationale: Centriolar satellites are non-membranous cytoplasmic granules that cluster around centrosomes, with pericentriolar material 1 (PCM1) serving as the molecular marker for these structures. Although significant progress has …
View article: Antimicrobial resistance and molecular characteristics of bovine mastitis-associated methicillin-resistant <i>Staphylococcus aureus</i> : potential for cross-species transmission of ST59-MRSA
Antimicrobial resistance and molecular characteristics of bovine mastitis-associated methicillin-resistant <i>Staphylococcus aureus</i> : potential for cross-species transmission of ST59-MRSA Open
Mastitis caused by methicillin-resistant Staphylococcus aureus (MRSA) is a common issue in dairy farming, with sequence types (STs) related to cows mainly including ST9 and ST97. ST59, the predominant community-acquired clone, is still les…
View article: Identification and characterization of antibacterial metal complexes in ZiHua DiDing (<i>Viola philippica</i>) aqueous extract
Identification and characterization of antibacterial metal complexes in ZiHua DiDing (<i>Viola philippica</i>) aqueous extract Open
The excessive use of antibiotics leading to bacterial resistance poses a significant threat to global public health, particularly the serious problem of resistance in Staphylococcus aureus , which requires the development of new antibiotic…
View article: Associations of Mucus Plugging, Small Airway Dysfunction, and Airway Wall Thickening in Cough-Variant Versus Classic Asthma
Associations of Mucus Plugging, Small Airway Dysfunction, and Airway Wall Thickening in Cough-Variant Versus Classic Asthma Open
Background Mucus plugs have been implicated in airflow obstruction in asthma and chronic obstructive pulmonary disease (COPD). However, the role of mucus plugs in cough-variant asthma (CVA) remains understudied, and their associations with…
View article: Quercetin induces keratinocytes apoptosis via triple inhibition of Notch, PI3K/AKT signaling and Glut1 in the treatment of psoriasis
Quercetin induces keratinocytes apoptosis via triple inhibition of Notch, PI3K/AKT signaling and Glut1 in the treatment of psoriasis Open
This study provides the first evidence that quercetin induces keratinocyte apoptosis and promotes keratinocyte differentiation to treat psoriasis through the triple inhibition of the Notch and PI3K/AKT signaling pathways, as well as Glut1.…
View article: Development and Application of Foam Drainage System Optimization Software
Development and Application of Foam Drainage System Optimization Software Open
This study proposes an intelligent decision-making method based on the combination of time series prediction and multi-dimensional evaluation, aiming at the key issues of foam drainage agent dosage control and injection system optimization…
View article: Macrophage-centered therapy strategies: A promising weapon in cancer immunotherapy
Macrophage-centered therapy strategies: A promising weapon in cancer immunotherapy Open
Macrophages are critical phagocytes in the immune system, and tumor-infiltrating macrophages can substantially influence the efficacy and prognosis of immunotherapy. Therefore, macrophages may serve as therapeutic targets for modulating th…
View article: Excitation Spectral Phasor Microscopy (ExSPM) unveils spatiotemporal heterogeneities in polarity of intracellular lipid droplets
Excitation Spectral Phasor Microscopy (ExSPM) unveils spatiotemporal heterogeneities in polarity of intracellular lipid droplets Open
Spatiotemporal heterogeneities in the polarity of intracellular LDs play essential roles in cellular function but remain largely unexplored. Here, we introduce excitation spectral phasor microscopy (ExSPM), which combines high-throughput e…
View article: Targeting of Lysosomes as a Therapeutic Target in Cancer
Targeting of Lysosomes as a Therapeutic Target in Cancer Open
Lysosomes are important intracellular organelles involved in degradation metabolism, maintenance of homeostasis, cell survival and programmed death regulation, and play an important role in immunity. Some studies have shown that lysosomes…
View article: 3-Fucosyllactose alleviates DSS-induced mouse colitis through modulation of the PI3K-Akt signaling pathway: An integrated multi-omics analysis
3-Fucosyllactose alleviates DSS-induced mouse colitis through modulation of the PI3K-Akt signaling pathway: An integrated multi-omics analysis Open
Ulcerative colitis (UC) is a chronic inflammatory bowel disease, characterized by colonic inflammation, intestinal barrier disruption, and dysbiosis of gut microbiota. This study investigates the beneficial effects of 3-fucosyllactose (3-F…
View article: Exercise antagonizes cadmium-caused liver and intestinal injury in mice via Nrf2 and TLR2/NF-κB signalling pathway
Exercise antagonizes cadmium-caused liver and intestinal injury in mice via Nrf2 and TLR2/NF-κB signalling pathway Open
Cadmium (Cd) causes a health risk to humans and animals. Exercise can prevent and treat a variety of diseases, but the effect and mechanism of exercise on cadmium poisoning are still unclear. The present research aims to investigate the an…
View article: Artesunate Inhibits Neointimal Hyperplasia by Promoting IRF4 Associated Macrophage Polarization
Artesunate Inhibits Neointimal Hyperplasia by Promoting IRF4 Associated Macrophage Polarization Open
Vascular restenosis is a serious clinical issue initiated and aggravated by macrophage inflammation, with no effective treatments available, in cardiovascular and autoimmune diseases. However, the untapped mechanisms and new targets that c…
View article: Study on the Mechanism of Immunoglobulin-Based Targeted Therapy in Tumor Immune Escape
Study on the Mechanism of Immunoglobulin-Based Targeted Therapy in Tumor Immune Escape Open
This article aims to explore the targeted therapy strategy based on immunoglobulin and its application and prospect in tumor immunotherapy. By reviewing the basic structure and classification of immunoglobulin, its role in immune system an…
View article: TBS as a complementary tool for assessing vertebral fractures and spinal deformity in children and adolescents with osteogenesis imperfecta
TBS as a complementary tool for assessing vertebral fractures and spinal deformity in children and adolescents with osteogenesis imperfecta Open
View article: Exosomes: a double‐edged sword in cancer immunotherapy
Exosomes: a double‐edged sword in cancer immunotherapy Open
Over the past few decades, immunotherapy has emerged as a powerful strategy to overcome the limitations of conventional cancer treatments. The use of extracellular vesicles, particularly exosomes, which carry cargoes capable of modulating …
View article: Inhibiting NLRP3 enhances cellular autophagy induced by outer membrane vesicles from <i>Pseudomonas aeruginosa</i>
Inhibiting NLRP3 enhances cellular autophagy induced by outer membrane vesicles from <i>Pseudomonas aeruginosa</i> Open
The bacterium Pseudomonas aeruginosa is able to invade lung epithelial cells and survive intracellularly. During this process, it secretes outer membrane vesicles (OMVs), however, it is currently unclear how OMVs from P. aeruginosa (PA-OMV…
View article: Helicobacter pylori reduces METTL14-mediated VAMP3 m6A modification and promotes the development of gastric cancer by regulating LC3C-mediated c-Met recycling
Helicobacter pylori reduces METTL14-mediated VAMP3 m6A modification and promotes the development of gastric cancer by regulating LC3C-mediated c-Met recycling Open
Helicobacter pylori ( H. pylori ) plays an important role in the malignant transformation of the gastric mucosa from chronic inflammation to cancer. However, the mechanisms underlying the epigenetic regulation of gastric carcinogenesis med…