Jiayi Zheng
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View article: Associations of Sleep, Screen Time, and Extracurricular Activities With Cognitive Development: A Longitudinal Study
Associations of Sleep, Screen Time, and Extracurricular Activities With Cognitive Development: A Longitudinal Study Open
Introduction Adolescence is a sensitive period typified by marked cognitive and neural development, during which modifiable lifestyle factors may be particularly relevant. However, longitudinal associations of modifiable lifestyle factors—…
View article: A MGMT Enhancer Variant is Associated with Glioma Susceptibility and Progression
A MGMT Enhancer Variant is Associated with Glioma Susceptibility and Progression Open
The O6-methylguanine-DNA methyltransferase (MGMT) plays a significant role in the pathogenesis and progression of glioma. Numerous enhancer variants, including those within the MGMT gene region and adjacent gene regions, have been found to…
View article: Adaptive immune responses associated with the progression of premalignant lesions to colorectal cancer
Adaptive immune responses associated with the progression of premalignant lesions to colorectal cancer Open
View article: Preserving Pomelo Quality: Sodium Alginate Coating Containing Bacillus subtilis for Sustained Antifungal Activity
Preserving Pomelo Quality: Sodium Alginate Coating Containing Bacillus subtilis for Sustained Antifungal Activity Open
Wendan pomelo (Citrus maxima), valued for its unique quality and high nutritional value, is susceptible to postharvest decay caused by mechanical damage and fungal infection. This study developed a bio-based preservation strategy by incorp…
View article: β-Cyclodextrin/Thymol Microcapsule-Embedded Starch Coatings for Synchronized Antimicrobial Release and Shelf-Life Extension in Blueberries
β-Cyclodextrin/Thymol Microcapsule-Embedded Starch Coatings for Synchronized Antimicrobial Release and Shelf-Life Extension in Blueberries Open
An eco-friendly composite coating was developed for blueberry preservation through the incorporation of thymol-loaded β-cyclodextrin microcapsules (THY@β-CD) into a potato starch (PO) matrix. Microencapsulation at an optimal wall-to-core r…
View article: Research on the Localization Digital Marketing Strategy of McDonald's in Chinese Market
Research on the Localization Digital Marketing Strategy of McDonald's in Chinese Market Open
In the current digital era, the fast food industry in China has achieved remarkable development, and marketing strategies are crucial for the success of brands. McDonald's, as a global fast food giant, this research aims to explore the str…
View article: Association between functional gastrointestinal disorders and Parkinson’s disease in a prospective cohort study
Association between functional gastrointestinal disorders and Parkinson’s disease in a prospective cohort study Open
The influence of functional gastrointestinal disorders (FGIDs) on the onset of Parkinson’s disease (PD) remains unclear. Therefore, in this study, we examined the effect of FGIDs and their subtypes on the PD onset. In Cox proportional haza…
View article: Huang-Lian-Jie-Du decoction alleviates cognitive deficits in Alzheimer’s disease model 5xFAD mice by inhibiting Trem2/Dap12 signaling pathway
Huang-Lian-Jie-Du decoction alleviates cognitive deficits in Alzheimer’s disease model 5xFAD mice by inhibiting Trem2/Dap12 signaling pathway Open
View article: A study on the Expression of Cover Illustrations of Children's Picture Books Ranked among the Top 20 Online Bestseller in the Chinese Market
A study on the Expression of Cover Illustrations of Children's Picture Books Ranked among the Top 20 Online Bestseller in the Chinese Market Open
View article: Observations of Negative Sprites and Halos Over a Coastal Thunderstorm in South China
Observations of Negative Sprites and Halos Over a Coastal Thunderstorm in South China Open
View article: Property and Leaching Toxicity Changes of Fly Ash under Thermal Treatment and the Underlying Mechanism
Property and Leaching Toxicity Changes of Fly Ash under Thermal Treatment and the Underlying Mechanism Open
Thermal treatment can achieve the solidification of heavy metals by changing the physical properties and mineral phases of municipal solid waste incineration (MSWI) fly ash. Taking the fly ash from an MSWI power plant in southern China as …
View article: Huang Lian Jie Du decoction attenuated colitis via suppressing the macrophage Csf1r/Src pathway and modulating gut microbiota
Huang Lian Jie Du decoction attenuated colitis via suppressing the macrophage Csf1r/Src pathway and modulating gut microbiota Open
Introduction Ulcerative colitis, a subtype of chronic inflammatory bowel disease (IBD), is characterized by relapsing colonic inflammation and ulcers. The traditional Chinese herbal formulation Huang Lian Jie Du (HLJD) decoction is used cl…
View article: Endophthalmitis Caused by Bacillus cereus: Clinical Characteristics, Outcomes and Antibiotic Susceptibility
Endophthalmitis Caused by Bacillus cereus: Clinical Characteristics, Outcomes and Antibiotic Susceptibility Open
Bacillus cereus endophthalmitis is a severe vision-threatening disease. This study aimed to analyze the clinical characteristics, antibiotic susceptibility, and risk factors for poor final visual acuity (VA) and enucleation or evisceration…
View article: <i>Tremella</i> polysaccharide mitigates high-fat diet-induced anxiety-like behavior through the microbiota-gut-brain axis
<i>Tremella</i> polysaccharide mitigates high-fat diet-induced anxiety-like behavior through the microbiota-gut-brain axis Open
High-fat diet (HFD) consumption induces gut microbiota dysbiosis and neuropsychiatric disorders, including anxiety. Previous research found that Tremella polysaccharide (TP) exhibited neuroprotective effects in vitro and in vivo. This stud…
View article: Differential cytokine expression in gastric tissues highlights helicobacter pylori’s role in gastritis
Differential cytokine expression in gastric tissues highlights helicobacter pylori’s role in gastritis Open
View article: Fusobacterium nucleatum promotes tumor progression in KRAS p.G12D-mutant colorectal cancer by binding to DHX15
Fusobacterium nucleatum promotes tumor progression in KRAS p.G12D-mutant colorectal cancer by binding to DHX15 Open
Fusobacterium nucleatum ( F. nucleatum ) promotes intestinal tumor growth and its relative abundance varies greatly among patients with CRC, suggesting the presence of unknown, individual-specific effectors in F. nucleatum -dependent carci…
View article: Effect of Soil Amendment of Greening Waste on Leaching Loss of Soil Nitrogen and Phosphorus
Effect of Soil Amendment of Greening Waste on Leaching Loss of Soil Nitrogen and Phosphorus Open
It is of great practical significance for comprehensively promoting the green development of agriculture to explore practical products for preventing and controlling nitrogen and phosphorus leaching. In this study, PVC soil column experime…
View article: Association between Physical Activity Pattern and Type 2 Diabetes: A Prospective Study of 89,400 UK Biobank Participants
Association between Physical Activity Pattern and Type 2 Diabetes: A Prospective Study of 89,400 UK Biobank Participants Open
View article: Targeting integrin α5 in fibroblasts potentiates colorectal cancer response to PD-L1 blockade by affecting extracellular-matrix deposition
Targeting integrin α5 in fibroblasts potentiates colorectal cancer response to PD-L1 blockade by affecting extracellular-matrix deposition Open
Background One reason patients with cancer cannot benefit from immunotherapy is the lack of immune cell infiltration in tumor tissues. Cancer-associated fibroblasts (CAFs) are emerging as central players in immune regulation that shapes tu…
View article: N-terminal-targeted anti-amyloid monoclonal antibodies illuminate the therapy for Alzheimer’s disease: a systematic review and comprehensive meta-analysis
N-terminal-targeted anti-amyloid monoclonal antibodies illuminate the therapy for Alzheimer’s disease: a systematic review and comprehensive meta-analysis Open
Summary Background Recent clinical trials of anti-amyloid-beta (Aβ) monoclonal antibodies (mAbs) have demonstrated that the removal of Aβ in symptomatic patients can slow down the progression of Alzheimer’s disease (AD) and reinforce the “…
View article: Colorectal cancer–associated T cell receptor repertoire abnormalities are linked to gut microbiome shifts and somatic cell mutations
Colorectal cancer–associated T cell receptor repertoire abnormalities are linked to gut microbiome shifts and somatic cell mutations Open
As with many diseases, tumor formation in colorectal cancer (CRC) is multifactorial and involves immune, environmental factors and various genetics that contribute to disease development. Accumulating evidence suggests that the gut microbi…
View article: A Comparative Study of Medical Practitioner Examination and Civil Service Examination
A Comparative Study of Medical Practitioner Examination and Civil Service Examination Open
The health professional technical qualification examination and the civil service examination belong to the national examination, the similarities and differences between them in terms of function, purpose, value orientation and question t…
View article: To Bleed or Not to Bleed
To Bleed or Not to Bleed Open
The location of gastrointestinal (GI) bleeding can be characterized based on the characteristics of the bowel movements these patients present with. Bright red blood per rectum is usually associated with a lower bleed; if brisk and signifi…
View article: SIRT2/HSF1/PERK pathway is essential for melatonin-alleviated endoplasmic reticulum stress in cerebral ischemic/reperfusion injury
SIRT2/HSF1/PERK pathway is essential for melatonin-alleviated endoplasmic reticulum stress in cerebral ischemic/reperfusion injury Open
Background: Targeting endoplasmic reticulum (ER) stress with melatonin has been proven helpful for cerebral ischemic/reperfusion (CI/R) damage, while the mechanism remains unclear. In current study, we investigated whether melatonin could …
View article: Table S3 from <i>Fusobacterium Nucleatum</i> Promotes the Development of Colorectal Cancer by Activating a Cytochrome P450/Epoxyoctadecenoic Acid Axis via TLR4/Keap1/NRF2 Signaling
Table S3 from <i>Fusobacterium Nucleatum</i> Promotes the Development of Colorectal Cancer by Activating a Cytochrome P450/Epoxyoctadecenoic Acid Axis via TLR4/Keap1/NRF2 Signaling Open
Table S3 shows the details of generated metagenomic reads in the stool from control subjects and CRC patients.
View article: Supplementary Materials from <i>Fusobacterium Nucleatum</i> Promotes the Development of Colorectal Cancer by Activating a Cytochrome P450/Epoxyoctadecenoic Acid Axis via TLR4/Keap1/NRF2 Signaling
Supplementary Materials from <i>Fusobacterium Nucleatum</i> Promotes the Development of Colorectal Cancer by Activating a Cytochrome P450/Epoxyoctadecenoic Acid Axis via TLR4/Keap1/NRF2 Signaling Open
Supplemental methods, Figure legends, and Figure S1-S5
View article: Table S9 from <i>Fusobacterium Nucleatum</i> Promotes the Development of Colorectal Cancer by Activating a Cytochrome P450/Epoxyoctadecenoic Acid Axis via TLR4/Keap1/NRF2 Signaling
Table S9 from <i>Fusobacterium Nucleatum</i> Promotes the Development of Colorectal Cancer by Activating a Cytochrome P450/Epoxyoctadecenoic Acid Axis via TLR4/Keap1/NRF2 Signaling Open
Table S9 shows all primer sequences used in this study.
View article: Table S2 from <i>Fusobacterium Nucleatum</i> Promotes the Development of Colorectal Cancer by Activating a Cytochrome P450/Epoxyoctadecenoic Acid Axis via TLR4/Keap1/NRF2 Signaling
Table S2 from <i>Fusobacterium Nucleatum</i> Promotes the Development of Colorectal Cancer by Activating a Cytochrome P450/Epoxyoctadecenoic Acid Axis via TLR4/Keap1/NRF2 Signaling Open
Table S2 shows the concentrations of lipid mediators in the serum from control subjects and CRC patients.
View article: Table S7 from <i>Fusobacterium Nucleatum</i> Promotes the Development of Colorectal Cancer by Activating a Cytochrome P450/Epoxyoctadecenoic Acid Axis via TLR4/Keap1/NRF2 Signaling
Table S7 from <i>Fusobacterium Nucleatum</i> Promotes the Development of Colorectal Cancer by Activating a Cytochrome P450/Epoxyoctadecenoic Acid Axis via TLR4/Keap1/NRF2 Signaling Open
Table S7 shows representative differentially expressed mRNA between Fusobacterium nucleatum treated and untreated HCT116 cells.
View article: Data from <i>Fusobacterium Nucleatum</i> Promotes the Development of Colorectal Cancer by Activating a Cytochrome P450/Epoxyoctadecenoic Acid Axis via TLR4/Keap1/NRF2 Signaling
Data from <i>Fusobacterium Nucleatum</i> Promotes the Development of Colorectal Cancer by Activating a Cytochrome P450/Epoxyoctadecenoic Acid Axis via TLR4/Keap1/NRF2 Signaling Open
Emerging research has revealed regulation of colorectal cancer metabolism by bacteria. Fusobacterium nucleatum (Fn) plays a crucial role in the development of colorectal cancer, however, whether Fn infection modifies m…