Explanipedia

A conserved immune dysregulation is associated with infection severity, risk factors prior to infection, and treatment response Open

Ananthakrishnan Ganesan, A. R. Moore, Hong Zheng, Jiaying Toh, Michael Freedman , et al. · 2025

Older age, being male, obesity, smoking, and comorbidities (e.g., diabetes, asthma) are associated with the increased risk for severe infections. We hypothesized that there is a conserved common immune dysregulation across these risk facto…

Multi-modal analysis reveals tumor and immune features distinguishing EBV-positive and EBV-negative post-transplant lymphoproliferative disorders Open

Jiaying Toh, Andrea Reitsma, Tetsuya Tajima, Sheren F. Younes, Chimere Ezeiruaku , et al. · 2024

Systems immunology of transcriptional responses to viral infection identifies conserved antiviral pathways across macaques and humans Open

Kalani Ratnasiri, Hong Zheng, Jiaying Toh, Zhiyuan Yao, Verónica Durán , et al. · 2024

Viral pandemics and epidemics pose a significant global threat. While macaque models of viral disease are routinely used, it remains unclear how conserved antiviral responses are between macaques and humans. Therefore, we conducted a cross…

Systems immunology of transcriptional responses to viral infection identifies conserved antiviral pathways across macaques and humans Open

Kalani Ratnasiri, Hong Zheng, Jiaying Toh, Zhiyuan Yao, Verónica Durán , et al. · 2023

Viral pandemics and epidemics pose a significant global threat, with emerging and re-emerging viruses responsible for four pandemics in the 21st century alone. While macaques have been utilized as a model for understanding viral disease in…

A 6-mRNA host response classifier in whole blood predicts outcomes in COVID-19 and other acute viral infections Open

Ljubomir Buturović, Hong Zheng, Benjamin Tang, Kevin Lai, Win Sen Kuan , et al. · 2022

Predicting the severity of COVID-19 remains an unmet medical need. Our objective was to develop a blood-based host-gene-expression classifier for the severity of viral infections and validate it in independent data, including COVID-19. We …

Multi-cohort analysis of host immune response identifies conserved protective and detrimental modules associated with severity across viruses Open

Hong Zheng, Aditya Rao, Denis Đermadi, Jiaying Toh, Lara Murphy Jones , et al. · 2021

High-resolution phenotyping of early acute rejection reveals a conserved alloimmune signature Open

James T. Harden, Xi Wang, Jiaying Toh, Adam X. Sang, Ryanne A. Brown , et al. · 2021

Transcriptomic similarities and differences in host response between SARS-CoV-2 and other viral infections Open

Simone A. Thair, Yudong D. He, Yehudit Hasin-Brumshtein, Suraj Sakaram, Rushika Pandya , et al. · 2020

A 6-mRNA host response whole-blood classifier trained on pre-pandemic data accurately predicts severity in COVID-19 and other acute viral infections Open

Ljubomir Buturović, Hong Zheng, Benjamin Tang, Kevin Lai, Win Sen Kuan , et al. · 2020

Background Determining the severity of COVID-19 remains an unmet medical need. Our objective was to develop a blood-based host-gene-expression classifier for the severity of viral infections and validate it in independent data, including C…

Multi-cohort analysis of host immune response identifies conserved protective and detrimental modules associated with severity irrespective of virus Open

Hong Zheng, Aditya Rao, Denis Đermadi, Jiaying Toh, Lara Murphy Jones , et al. · 2020

SARS-CoV-2 pandemic, the fourth pandemic of the decade, has underscored gaps in global pandemic preparedness and the need for generalizable tests to avert overwhelming healthcare systems worldwide, irrespective of a virus. We integrated 4,…

521. Similarities and Differences in Transcriptomic Host Response between SARS-CoV-2 and Other Viral Infections Open

Simone A. Thair, Yudong D. He, Yehudit Hasin-Brumshtein, Suraj Sakaram, Rushika Pandya , et al. · 2020

Background COVID-19 is a pandemic caused by the SARS-CoV-2 virus that shares and differs in clinical characteristics of known viral infections. Methods We obtained RNAseq profiles of 62 prospectively enrolled COVID-19 patients and 24 healt…

Transcriptomic Similarities and Differences in Host Response between SARS-CoV-2 and Other Viral Infections Open

Simone A. Thair, Yudong D. He, Yehudit Hasin-Brumshtein, Suraj Sakaram, Rushika Pandya , et al. · 2020

COVID-19 is a pandemic that shares certain clinical characteristics with other acute viral infections. Here, we studied the whole-blood transcriptomic host response to SARS-CoV-2 and compared it with other viral infections to understand si…

Genomic variations in EBNA3C of EBV associate with posttransplant lymphoproliferative disorder Open

Eden M. Maloney, Vincent Busque, Sin Ting Hui, Jiaying Toh, Marcelo Fernández-Viña , et al. · 2020

Epstein-Barr Virus (EBV) is a ubiquitous virus linked to a variety of lymphoid and epithelial malignancies. In solid organ and hematopoietic stem cell transplant recipients, EBV is causally associated with posttransplant lymphoproliferativ…

Multi-cohort analysis of host immune response identifies conserved protective and detrimental modules associated with severity irrespective of virus Open

Hong Zheng, Aditya Rao, Denis Đermadi, Jiaying Toh, Lara Murphy Jones , et al. · 2020

SARS-CoV-2 pandemic, the fourth pandemic of the decade, has underscored gaps in global pandemic preparedness and the need for generalizable tests to avert overwhelming healthcare systems worldwide, irrespective of a virus. We integrated 4,…

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