Jinfang Yu
YOU?
Author Swipe
View article: Comparative efficacy of balloon dilatation duration on patients with choledocholithiasis: a Bayesian network meta-analysis and systematic review
Comparative efficacy of balloon dilatation duration on patients with choledocholithiasis: a Bayesian network meta-analysis and systematic review Open
View article: An optimized Langendorff-free isolating method and electrophysiology studies for adult mouse atrioventricular node cells
An optimized Langendorff-free isolating method and electrophysiology studies for adult mouse atrioventricular node cells Open
View article: Bone-brain interaction: mechanisms and potential intervention strategies of biomaterials
Bone-brain interaction: mechanisms and potential intervention strategies of biomaterials Open
Following the discovery of bone as an endocrine organ with systemic influence, bone-brain interaction has emerged as a research hotspot, unveiling complex bidirectional communication between bone and brain. Studies indicate that bone and b…
View article: Inactivated vaccine-elicited potent antibodies can broadly neutralize SARS-CoV-2 circulating variants
Inactivated vaccine-elicited potent antibodies can broadly neutralize SARS-CoV-2 circulating variants Open
View article: Structural basis of a two-antibody cocktail exhibiting highly potent and broadly neutralizing activities against SARS-CoV-2 variants including diverse Omicron sublineages
Structural basis of a two-antibody cocktail exhibiting highly potent and broadly neutralizing activities against SARS-CoV-2 variants including diverse Omicron sublineages Open
View article: Structural basis of a two-antibody cocktail exhibiting highly potent and broadly neutralizing activities against SARS-CoV-2 variants including diverse Omicron sublineages
Structural basis of a two-antibody cocktail exhibiting highly potent and broadly neutralizing activities against SARS-CoV-2 variants including diverse Omicron sublineages Open
SARS-CoV-2 variants of concern (VOCs), especially the latest Omicron, have exhibited severe antibody evasion. Broadly neutralizing antibodies with high potency against Omicron are urgently needed for understanding working mechanisms and de…
View article: A Potent and Protective Human Neutralizing Antibody Against SARS-CoV-2 Variants
A Potent and Protective Human Neutralizing Antibody Against SARS-CoV-2 Variants Open
As severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants continue to emerge and spread around the world, antibodies and vaccines to confer broad and potent neutralizing activity are urgently needed. Through the isolation an…
View article: A potent and protective human neutralizing antibody targeting a novel vulnerable site of Epstein-Barr virus
A potent and protective human neutralizing antibody targeting a novel vulnerable site of Epstein-Barr virus Open
View article: Structural basis of tetanus toxin neutralization by native human monoclonal antibodies
Structural basis of tetanus toxin neutralization by native human monoclonal antibodies Open
Four potent native human monoclonal antibodies (mAbs) targeting distinct epitopes on tetanus toxin (TeNT) are isolated with neutralization potency ranging from approximately 17 mg to 6 mg each that are equivalent to 250 IU of human anti-Te…
View article: Structural basis for bivalent binding and inhibition of SARS-CoV-2 infection by human potent neutralizing antibodies
Structural basis for bivalent binding and inhibition of SARS-CoV-2 infection by human potent neutralizing antibodies Open
Neutralizing monoclonal antibodies (nAbs) to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) represent promising candidates for clinical intervention against coronavirus disease 2019 (COVID-19). We isolated a large number of n…
View article: Bat and pangolin coronavirus spike glycoprotein structures provide insights into SARS-CoV-2 evolution
Bat and pangolin coronavirus spike glycoprotein structures provide insights into SARS-CoV-2 evolution Open
View article: A potent and protective human neutralizing antibody targeting a key vulnerable site of Epstein-Barr Virus
A potent and protective human neutralizing antibody targeting a key vulnerable site of Epstein-Barr Virus Open
Epstein-Barr virus (EBV) is associated with a range of epithelial and B cell malignancies as well as autoimmune disorders, for which there are still no specific treatments or effective vaccines. Here, we isolated EBV gH/gL-specific antibod…
View article: High Selectivity of an α-Conotoxin LvIA Analogue for α3β2 Nicotinic Acetylcholine Receptors Is Mediated by β2 Functionally Important Residues
High Selectivity of an α-Conotoxin LvIA Analogue for α3β2 Nicotinic Acetylcholine Receptors Is Mediated by β2 Functionally Important Residues Open
The α3β2 and α3β4 nicotinic acetylcholine receptors (nAChRs) are widely expressed in the central and peripheral nervous systems, playing critical roles in various physiological processes and in such pathologies as addiction to nicotine and…
View article: Structural basis for bivalent binding and inhibition of SARS-CoV-2 infection by human potent neutralizing antibodies
Structural basis for bivalent binding and inhibition of SARS-CoV-2 infection by human potent neutralizing antibodies Open
Neutralizing monoclonal antibodies (nAbs) to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) represent promising candidates for clinical intervention against coronavirus virus diseases 2019 (COVID-19). We isolated a large numb…
View article: Bat and pangolin coronavirus spike glycoprotein structures provide insights into SARS-CoV-2 evolution
Bat and pangolin coronavirus spike glycoprotein structures provide insights into SARS-CoV-2 evolution Open
In recognizing the host cellular receptor and mediating fusion of virus and cell membranes, the spike (S) glycoprotein of coronaviruses is the most critical viral protein for cross-species transmission and infection. Here we determined the…
View article: Cryo-EM structures of HKU2 and SADS-CoV spike glycoproteins provide insights into coronavirus evolution
Cryo-EM structures of HKU2 and SADS-CoV spike glycoproteins provide insights into coronavirus evolution Open
Porcine coronavirus SADS-CoV has been identified from suckling piglets with severe diarrhea in southern China in 2017. The SADS-CoV genome shares ~95% identity to that of bat α-coronavirus HKU2, suggesting that SADS-CoV may have emerged fr…
View article: Human neutralizing antibodies elicited by SARS-CoV-2 infection
Human neutralizing antibodies elicited by SARS-CoV-2 infection Open
View article: Structure of the SARS-CoV-2 spike receptor-binding domain bound to the ACE2 receptor
Structure of the SARS-CoV-2 spike receptor-binding domain bound to the ACE2 receptor Open
View article: Potent human neutralizing antibodies elicited by SARS-CoV-2 infection
Potent human neutralizing antibodies elicited by SARS-CoV-2 infection Open
The pandemic caused by emerging coronavirus SARS-CoV-2 presents a serious global public health emergency in urgent need of prophylactic and therapeutic interventions. SARS-CoV-2 cellular entry depends on binding between the viral Spike pro…
View article: Cryo-EM structures of HKU2 and SADS-CoV spike glycoproteins and insights into coronavirus evolution
Cryo-EM structures of HKU2 and SADS-CoV spike glycoproteins and insights into coronavirus evolution Open
A new porcine coronavirus SADS-CoV was recently identified from suckling piglets with severe diarrhea in southern China and its genome sequence is most identical (~95% identity) to that of bat α-coronavirus HKU2. It again indicates bats ar…
View article: Crystal structure of the 2019-nCoV spike receptor-binding domain bound with the ACE2 receptor
Crystal structure of the 2019-nCoV spike receptor-binding domain bound with the ACE2 receptor Open
A novel and highly pathogenic coronavirus (2019-nCoV) has caused an outbreak in Wuhan city, Hubei province of China since December 2019, and soon spread nationwide and spilled over to other countries around the world. To better understand …
View article: Potent Neutralizing Native Human Monoclonal Antibody that Recognizes the Ganglioside Receptor-Binding Pocket of Tetanus Toxin
Potent Neutralizing Native Human Monoclonal Antibody that Recognizes the Ganglioside Receptor-Binding Pocket of Tetanus Toxin Open
View article: Erratum to: The crystal structure of Ac-AChBP in complex with α-conotoxin LvIA reveals the mechanism of its selectivity towards different nAChR subtypes
Erratum to: The crystal structure of Ac-AChBP in complex with α-conotoxin LvIA reveals the mechanism of its selectivity towards different nAChR subtypes Open
In the original publication of the article the keywords are incorrectly online published. The correct keywords should read as α-Conotoxin; Nicotinc acetylcholine receptor; Acetylcholine binding protein; X-ray crystallography”.
View article: The crystal structure of Ac-AChBP in complex with α-conotoxin LvIA reveals the mechanism of its selectivity towards different nAChR subtypes
The crystal structure of Ac-AChBP in complex with α-conotoxin LvIA reveals the mechanism of its selectivity towards different nAChR subtypes Open
The α3* nAChRs, which are considered to be promising drug targets for problems such as pain, addiction, cardiovascular function, cognitive disorders etc., are found throughout the central and peripheral nervous system. The α-conotoxin (α-C…