Jiazhong Zhang
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View article: Simulation of near-wall bubble collapse and research on load mechanism of wall damage based on improved multi-relaxation-time lattice Boltzmann method
Simulation of near-wall bubble collapse and research on load mechanism of wall damage based on improved multi-relaxation-time lattice Boltzmann method Open
To reveal the load mechanism of wall damage induced by bubble collapse, the near-wall cavitation bubble collapse evolution is numerically simulated using an improved multi-relaxation-time lattice Boltzmann method (MRT-LBM), and the dynamic…
View article: Supplementary Tables 1 - 6, Figures 1 - 7 from Characterizing and Overriding the Structural Mechanism of the Quizartinib-Resistant FLT3 “Gatekeeper” F691L Mutation with PLX3397
Supplementary Tables 1 - 6, Figures 1 - 7 from Characterizing and Overriding the Structural Mechanism of the Quizartinib-Resistant FLT3 “Gatekeeper” F691L Mutation with PLX3397 Open
Supplementary Table 1. Crystallographic Data and Refinement statistics. Supplementary Table 2. Comparing Target Inhibition by Quizartinib and PLX3397 in Engineered Ba/F3 cells Expressing FLT3-ITD, FLT3-ITD/F691L and FLT3-ITD/D835Y. Supplem…
View article: Data from Characterizing and Overriding the Structural Mechanism of the Quizartinib-Resistant FLT3 “Gatekeeper” F691L Mutation with PLX3397
Data from Characterizing and Overriding the Structural Mechanism of the Quizartinib-Resistant FLT3 “Gatekeeper” F691L Mutation with PLX3397 Open
Tyrosine kinase domain mutations are a common cause of acquired clinical resistance to tyrosine kinase inhibitors (TKI) used to treat cancer, including the FLT3 inhibitor quizartinib. Mutation of kinase “gatekeeper” residues, which control…
View article: Supplementary Methods from BRD4 Profiling Identifies Critical Chronic Lymphocytic Leukemia Oncogenic Circuits and Reveals Sensitivity to PLX51107, a Novel Structurally Distinct BET Inhibitor
Supplementary Methods from BRD4 Profiling Identifies Critical Chronic Lymphocytic Leukemia Oncogenic Circuits and Reveals Sensitivity to PLX51107, a Novel Structurally Distinct BET Inhibitor Open
Supplementary Methods
View article: Supplementary Methods from BRD4 Profiling Identifies Critical Chronic Lymphocytic Leukemia Oncogenic Circuits and Reveals Sensitivity to PLX51107, a Novel Structurally Distinct BET Inhibitor
Supplementary Methods from BRD4 Profiling Identifies Critical Chronic Lymphocytic Leukemia Oncogenic Circuits and Reveals Sensitivity to PLX51107, a Novel Structurally Distinct BET Inhibitor Open
Supplementary Methods
View article: Data from Characterizing and Overriding the Structural Mechanism of the Quizartinib-Resistant FLT3 “Gatekeeper” F691L Mutation with PLX3397
Data from Characterizing and Overriding the Structural Mechanism of the Quizartinib-Resistant FLT3 “Gatekeeper” F691L Mutation with PLX3397 Open
Tyrosine kinase domain mutations are a common cause of acquired clinical resistance to tyrosine kinase inhibitors (TKI) used to treat cancer, including the FLT3 inhibitor quizartinib. Mutation of kinase “gatekeeper” residues, which control…
View article: Supplementary Tables 1 - 6, Figures 1 - 7 from Characterizing and Overriding the Structural Mechanism of the Quizartinib-Resistant FLT3 “Gatekeeper” F691L Mutation with PLX3397
Supplementary Tables 1 - 6, Figures 1 - 7 from Characterizing and Overriding the Structural Mechanism of the Quizartinib-Resistant FLT3 “Gatekeeper” F691L Mutation with PLX3397 Open
Supplementary Table 1. Crystallographic Data and Refinement statistics. Supplementary Table 2. Comparing Target Inhibition by Quizartinib and PLX3397 in Engineered Ba/F3 cells Expressing FLT3-ITD, FLT3-ITD/F691L and FLT3-ITD/D835Y. Supplem…
View article: Supplementary Figures & Tables from BRD4 Profiling Identifies Critical Chronic Lymphocytic Leukemia Oncogenic Circuits and Reveals Sensitivity to PLX51107, a Novel Structurally Distinct BET Inhibitor
Supplementary Figures & Tables from BRD4 Profiling Identifies Critical Chronic Lymphocytic Leukemia Oncogenic Circuits and Reveals Sensitivity to PLX51107, a Novel Structurally Distinct BET Inhibitor Open
Supplementary Figures S1-S7 with captions and Supplementary Tables
View article: Data from BRD4 Profiling Identifies Critical Chronic Lymphocytic Leukemia Oncogenic Circuits and Reveals Sensitivity to PLX51107, a Novel Structurally Distinct BET Inhibitor
Data from BRD4 Profiling Identifies Critical Chronic Lymphocytic Leukemia Oncogenic Circuits and Reveals Sensitivity to PLX51107, a Novel Structurally Distinct BET Inhibitor Open
Bromodomain and extra-terminal (BET) family proteins are key regulators of gene expression in cancer. Herein, we utilize BRD4 profiling to identify critical pathways involved in pathogenesis of chronic lymphocytic leukemia (CLL). BRD4 is o…
View article: Data from BRD4 Profiling Identifies Critical Chronic Lymphocytic Leukemia Oncogenic Circuits and Reveals Sensitivity to PLX51107, a Novel Structurally Distinct BET Inhibitor
Data from BRD4 Profiling Identifies Critical Chronic Lymphocytic Leukemia Oncogenic Circuits and Reveals Sensitivity to PLX51107, a Novel Structurally Distinct BET Inhibitor Open
Bromodomain and extra-terminal (BET) family proteins are key regulators of gene expression in cancer. Herein, we utilize BRD4 profiling to identify critical pathways involved in pathogenesis of chronic lymphocytic leukemia (CLL). BRD4 is o…
View article: Supplementary Figures & Tables from BRD4 Profiling Identifies Critical Chronic Lymphocytic Leukemia Oncogenic Circuits and Reveals Sensitivity to PLX51107, a Novel Structurally Distinct BET Inhibitor
Supplementary Figures & Tables from BRD4 Profiling Identifies Critical Chronic Lymphocytic Leukemia Oncogenic Circuits and Reveals Sensitivity to PLX51107, a Novel Structurally Distinct BET Inhibitor Open
Supplementary Figures S1-S7 with captions and Supplementary Tables
View article: Bifurcation Characteristics of Airfoil-NESs coupled System
Bifurcation Characteristics of Airfoil-NESs coupled System Open
Aeroelastic instability has become a hot research topic. It has increasingly high-lighted its importance in the aircraft and fluid machinery industry and brings challenges to the safe flight of various aircraft and the safe operation of fl…
View article: Analysis of Transport and Mixing Phenomenon to Invariant Manifolds Using LCS and KAM Theory Approach in Unsteady Dynamical Systems
Analysis of Transport and Mixing Phenomenon to Invariant Manifolds Using LCS and KAM Theory Approach in Unsteady Dynamical Systems Open
The Lagrangian approach for the two-dimensional incompressible fluid flows has been studied with the help of dynamical systems techniques: Kolmogorov-Arnold-Moser (KAM) theory, stable, unstable manifold structures, and Lagrangian coherent …
View article: Sustained microglial depletion with CSF1R inhibitor impairs parenchymal plaque development in an Alzheimer’s disease model
Sustained microglial depletion with CSF1R inhibitor impairs parenchymal plaque development in an Alzheimer’s disease model Open
Many risk genes for the development of Alzheimer’s disease (AD) are exclusively or highly expressed in myeloid cells. Microglia are dependent on colony-stimulating factor 1 receptor (CSF1R) signaling for their survival. We designed and syn…
View article: Similarity and vortex-acoustic lock-on behavior in thermoacoustic oscillation involving vortex shedding
Similarity and vortex-acoustic lock-on behavior in thermoacoustic oscillation involving vortex shedding Open
基于Matveev和Culick提出的涡脱落引起的热声不稳定性一维简化模型, 对涡脱落引起的热声振荡中的典型非线性现象进行研究, 着重研究了系统的初值敏感性、关键参数对热声振荡的影响规律及涡声锁频现象. 首先, 采用Galerkin方法将控制方程中压力和速度波动在基函数下展开, 使偏微分方程组转化为一簇常微分方程; 然后, 数值求解得到了不同系统参数下声场的压力和速度波动, 并详细分析了系统在不同初始条件下的热声不稳定性, 同时研究了不同稳态流动速度对系统热声振荡的影响规律…
View article: Steady flow of a power law fluid through a tapered non-symmetric stenotic tube
Steady flow of a power law fluid through a tapered non-symmetric stenotic tube Open
A steady flow of a power law fluid through an artery with a stenosis has been analyzed. The equation governing the flow is derived under the assumption of mild stenosis. An exact solution of the governing equation is obtained, which is the…
View article: Stability switching behavior of thermoacoustic oscillation in Rijke tube
Stability switching behavior of thermoacoustic oscillation in Rijke tube Open
Large-amplitude self-excited thermoacoustic oscillations arising due to the interaction between unsteady heat release and acoustic pressure fluctuations have been encountered in many thermal devices. These oscillations may lead to unwanted…
View article: Non-orthogonal multiple-relaxation-time lattice Boltzmann method for axisymmetric thermal flows
Non-orthogonal multiple-relaxation-time lattice Boltzmann method for axisymmetric thermal flows Open
Axisymmetric thermal flows in cylindrical systems are widely encountered in engineering practices. Typically, axisymmetric thermal flows belong in three-dimensional (3D) problems. However, taking advantage of the axisymmetric condition, th…
View article: Space-time spectral element method solution for the acoustic wave equation and its dispersion analysis
Space-time spectral element method solution for the acoustic wave equation and its dispersion analysis Open
This paper presents the solution for the continuous space-time spectral element method (CSTSEM) based on Chebyshev polynomials for the acoustic wave equation.Acoustic wave propagation in various dimensions is simulated using quadrilateral,…
View article: Simulation of micro flow in the transition regime using effective-viscosity-based multi-relaxation-time lattice Boltzmann model
Simulation of micro flow in the transition regime using effective-viscosity-based multi-relaxation-time lattice Boltzmann model Open
With the rapid development of micro-electro-mechanical systems (MEMS), microscale rarefied gas flows have received considerable attention in the past decades. Recently, the lattice Boltzmann method (LBM) emerges as a promising way to study…
View article: Characterizing and Overriding the Structural Mechanism of the Quizartinib-Resistant FLT3 “Gatekeeper” F691L Mutation with PLX3397
Characterizing and Overriding the Structural Mechanism of the Quizartinib-Resistant FLT3 “Gatekeeper” F691L Mutation with PLX3397 Open
Tyrosine kinase domain mutations are a common cause of acquired clinical resistance to tyrosine kinase inhibitors (TKI) used to treat cancer, including the FLT3 inhibitor quizartinib. Mutation of kinase “gatekeeper” residues, which control…
View article: Modeling of the Propulsion Hydrodynamics for the Water Strider Locomotion on Water Surface
Modeling of the Propulsion Hydrodynamics for the Water Strider Locomotion on Water Surface Open
Modeling of the propulsion hydrodynamics of water striders, which was rare performed in previous studies, was developed in this paper. First, kinematical mechanism of the production of dipolar vortex in the wake of striders was illustrated…
View article: Business Process-aware ERP Development and Evolution
Business Process-aware ERP Development and Evolution Open
with the rapid development of the Internet and its wide application, the management of enterprises is gradually shifting from a closed environment to a dynamic and open one.So, how to improve the flexibility of ERP software under the Inter…