Jicai Huang
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View article: Cyclicity of sliding cycles with singularities of regularized piecewise smooth visible-invisible two-folds
Cyclicity of sliding cycles with singularities of regularized piecewise smooth visible-invisible two-folds Open
In this paper we study the cyclicity of sliding cycles for regularized piecewise smooth visible-invisible two-folds, in the presence of singularities of the Filippov sliding vector field located away from two-folds. We obtain a slow-fast s…
View article: Cyclicity of slow–fast cycles with one self-intersection point and two nilpotent contact points<sup>*</sup>
Cyclicity of slow–fast cycles with one self-intersection point and two nilpotent contact points<sup>*</sup> Open
In this paper, we study the cyclicity of slow–fast cycles with one self-intersection point and two nilpotent contact points in planar slow–fast systems, where the nilpotent contact point is a jump point or a slow–fast Hopf point. These slo…
View article: Bifurcations of higher codimension in a prey-predator model with generalist predator
Bifurcations of higher codimension in a prey-predator model with generalist predator Open
Consideration of generalist predators leads to relatively complex dynamics due to alternative food sources. Here, we propose and analyze a prey-predator model with a generalist predator. The availability of alternative food sources for the…
View article: Destabilization of synchronous periodic solutions for patch models: a criterion by period functions
Destabilization of synchronous periodic solutions for patch models: a criterion by period functions Open
In this paper, we study the destabilization of synchronous periodic solutions for patch models. By applying perturbation theory for matrices, we derive asymptotic expressions of the Floquet spectra and provide a destabilization criterion f…
View article: Data from NKTR-214, an Engineered Cytokine with Biased IL2 Receptor Binding, Increased Tumor Exposure, and Marked Efficacy in Mouse Tumor Models
Data from NKTR-214, an Engineered Cytokine with Biased IL2 Receptor Binding, Increased Tumor Exposure, and Marked Efficacy in Mouse Tumor Models Open
Purpose: Aldesleukin, recombinant human IL2, is an effective immunotherapy for metastatic melanoma and renal cancer, with durable responses in approximately 10% of patients; however, severe side effects limit maximal dosing and thus…
View article: Figure S2 from NKTR-214, an Engineered Cytokine with Biased IL2 Receptor Binding, Increased Tumor Exposure, and Marked Efficacy in Mouse Tumor Models
Figure S2 from NKTR-214, an Engineered Cytokine with Biased IL2 Receptor Binding, Increased Tumor Exposure, and Marked Efficacy in Mouse Tumor Models Open
Binding curves from surface plasmon resonance studies of purified active 1-PEG-IL-2 released from NKTR-214 binding to IL-2Rαβ and IL-2Rβ
View article: Figure S3 from NKTR-214, an Engineered Cytokine with Biased IL2 Receptor Binding, Increased Tumor Exposure, and Marked Efficacy in Mouse Tumor Models
Figure S3 from NKTR-214, an Engineered Cytokine with Biased IL2 Receptor Binding, Increased Tumor Exposure, and Marked Efficacy in Mouse Tumor Models Open
Antitumor immunity stimulated by NKTR-214 and anti-CTLA-4 in mouse EMT6 tumors requires innate and adaptive immune responses
View article: Supplemental Data from NKTR-214, an Engineered Cytokine with Biased IL2 Receptor Binding, Increased Tumor Exposure, and Marked Efficacy in Mouse Tumor Models
Supplemental Data from NKTR-214, an Engineered Cytokine with Biased IL2 Receptor Binding, Increased Tumor Exposure, and Marked Efficacy in Mouse Tumor Models Open
Supplemental Materials and Methods. ELISA study materials; NKTR-214 chemistry; Mapping of PEGylation sites; Identification of active released IL-2 conjugates; Binding affinity to IL-2 receptors; In vivo immune cell phenotyping, In vivo imm…
View article: Figure S3 from NKTR-214, an Engineered Cytokine with Biased IL2 Receptor Binding, Increased Tumor Exposure, and Marked Efficacy in Mouse Tumor Models
Figure S3 from NKTR-214, an Engineered Cytokine with Biased IL2 Receptor Binding, Increased Tumor Exposure, and Marked Efficacy in Mouse Tumor Models Open
Antitumor immunity stimulated by NKTR-214 and anti-CTLA-4 in mouse EMT6 tumors requires innate and adaptive immune responses
View article: Figure S1 from NKTR-214, an Engineered Cytokine with Biased IL2 Receptor Binding, Increased Tumor Exposure, and Marked Efficacy in Mouse Tumor Models
Figure S1 from NKTR-214, an Engineered Cytokine with Biased IL2 Receptor Binding, Increased Tumor Exposure, and Marked Efficacy in Mouse Tumor Models Open
In vitro hydrolysis of NKTR-214 under physiological conditions generating NKTR-214 released IL-2 conjugates
View article: Figure S4 from NKTR-214, an Engineered Cytokine with Biased IL2 Receptor Binding, Increased Tumor Exposure, and Marked Efficacy in Mouse Tumor Models
Figure S4 from NKTR-214, an Engineered Cytokine with Biased IL2 Receptor Binding, Increased Tumor Exposure, and Marked Efficacy in Mouse Tumor Models Open
NKTR-214 produces potent immune activation in cynomolgus monkeys and is well tolerated
View article: Supplemental Data from NKTR-214, an Engineered Cytokine with Biased IL2 Receptor Binding, Increased Tumor Exposure, and Marked Efficacy in Mouse Tumor Models
Supplemental Data from NKTR-214, an Engineered Cytokine with Biased IL2 Receptor Binding, Increased Tumor Exposure, and Marked Efficacy in Mouse Tumor Models Open
Supplemental Materials and Methods. ELISA study materials; NKTR-214 chemistry; Mapping of PEGylation sites; Identification of active released IL-2 conjugates; Binding affinity to IL-2 receptors; In vivo immune cell phenotyping, In vivo imm…
View article: Figure S2 from NKTR-214, an Engineered Cytokine with Biased IL2 Receptor Binding, Increased Tumor Exposure, and Marked Efficacy in Mouse Tumor Models
Figure S2 from NKTR-214, an Engineered Cytokine with Biased IL2 Receptor Binding, Increased Tumor Exposure, and Marked Efficacy in Mouse Tumor Models Open
Binding curves from surface plasmon resonance studies of purified active 1-PEG-IL-2 released from NKTR-214 binding to IL-2Rαβ and IL-2Rβ
View article: Figure S4 from NKTR-214, an Engineered Cytokine with Biased IL2 Receptor Binding, Increased Tumor Exposure, and Marked Efficacy in Mouse Tumor Models
Figure S4 from NKTR-214, an Engineered Cytokine with Biased IL2 Receptor Binding, Increased Tumor Exposure, and Marked Efficacy in Mouse Tumor Models Open
NKTR-214 produces potent immune activation in cynomolgus monkeys and is well tolerated
View article: Data from NKTR-214, an Engineered Cytokine with Biased IL2 Receptor Binding, Increased Tumor Exposure, and Marked Efficacy in Mouse Tumor Models
Data from NKTR-214, an Engineered Cytokine with Biased IL2 Receptor Binding, Increased Tumor Exposure, and Marked Efficacy in Mouse Tumor Models Open
Purpose: Aldesleukin, recombinant human IL2, is an effective immunotherapy for metastatic melanoma and renal cancer, with durable responses in approximately 10% of patients; however, severe side effects limit maximal dosing and thus…
View article: Figure S1 from NKTR-214, an Engineered Cytokine with Biased IL2 Receptor Binding, Increased Tumor Exposure, and Marked Efficacy in Mouse Tumor Models
Figure S1 from NKTR-214, an Engineered Cytokine with Biased IL2 Receptor Binding, Increased Tumor Exposure, and Marked Efficacy in Mouse Tumor Models Open
In vitro hydrolysis of NKTR-214 under physiological conditions generating NKTR-214 released IL-2 conjugates
View article: Relative prevalence-based dispersal in an epidemic patch model
Relative prevalence-based dispersal in an epidemic patch model Open
View article: Correction: An SIRS model with nonmonotone incidence and saturated treatment in a changing environment
Correction: An SIRS model with nonmonotone incidence and saturated treatment in a changing environment Open
View article: Cyclicity of Slow-Fast Cycles with Two Canard Mechanisms
Cyclicity of Slow-Fast Cycles with Two Canard Mechanisms Open
View article: An SIRS model with nonmonotone incidence and saturated treatment in a changing environment
An SIRS model with nonmonotone incidence and saturated treatment in a changing environment Open
View article: Global dynamics and bifurcations in a SIRS epidemic model with a nonmonotone incidence rate and a piecewise-smooth treatment rate
Global dynamics and bifurcations in a SIRS epidemic model with a nonmonotone incidence rate and a piecewise-smooth treatment rate Open
In this paper, we analyze a SIRS epidemic model with a nonmonotone incidence rate and a piecewise-smooth treatment rate. The nonmonotone incidence rate describes the "psychological effect": when the number of the infected individuals (deno…
View article: NKTR-255, a novel polymer-conjugated rhIL-15 with potent antitumor efficacy
NKTR-255, a novel polymer-conjugated rhIL-15 with potent antitumor efficacy Open
Background NKTR-255 is a novel polyethylene glycol-conjugate of recombinant human interleukin-15 (rhIL-15), which was designed to retain all known receptor binding interactions of the IL-15 molecule. We explored the biologic and pharmacolo…
View article: Modelling homosexual and heterosexual transmissions of hepatitis B virus in China
Modelling homosexual and heterosexual transmissions of hepatitis B virus in China Open
Studies have shown that sexual transmission, both heterosexually and homosexually, is one of the main ways of HBV infection. Based on this fact, we propose a mathematical model to study the sexual transmission of HBV among adults by classi…
View article: The impact of toxins on competition dynamics of three species in a polluted aquatic environment
The impact of toxins on competition dynamics of three species in a polluted aquatic environment Open
Accurately assessing the risks of toxins in polluted ecosystems and finding factors that determine population persistence and extirpation are important from both environmental and conservation perspectives. In this paper, we develop and st…
View article: Global Dynamics of a Susceptible-Infectious-Recovered Epidemic Model with a Generalized Nonmonotone Incidence Rate
Global Dynamics of a Susceptible-Infectious-Recovered Epidemic Model with a Generalized Nonmonotone Incidence Rate Open
View article: Global dynamics in a tumor-immune model with an immune checkpoint inhibitor
Global dynamics in a tumor-immune model with an immune checkpoint inhibitor Open
In this paper, we fill several key gaps in the study of the global dynamics of a highly nonlinear tumor-immune model with an immune checkpoint inhibitor proposed by Nikolopoulou et al. (Letters in Biomathematics, 5 (2018), S137-S159). For …
View article: Bifurcation analysis of an SIRS epidemic model with a generalized nonmonotone and saturated incidence rate
Bifurcation analysis of an SIRS epidemic model with a generalized nonmonotone and saturated incidence rate Open
View article: Mathematical modeling the dynamics of Clonorchiasis in Guangzhou City of China
Mathematical modeling the dynamics of Clonorchiasis in Guangzhou City of China Open
In this paper, we have set up a mathematical model on the basic life cycle of clonorchiasis to fit the data of human clonorchiasis infection ratios of Guangzhou City of Guangdong Province in China from 2006-2012. By this model, we have pro…
View article: Bifurcation analysis of a mosquito population model for proportional releasing sterile mosquitoes
Bifurcation analysis of a mosquito population model for proportional releasing sterile mosquitoes Open
To reduce or eradicate mosquito-borne diseases, one of effective methods is to control the wild mosquito populations by using the sterile insect technique. Dynamical models with different releasing strategies of sterile mosquitoes have bee…
View article: Modeling the Transmission Dynamics of Clonorchiasis in Foshan, China
Modeling the Transmission Dynamics of Clonorchiasis in Foshan, China Open