Jide Jin
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View article: Traditional Chinese Medicine Properties and Microcalorimetry: BioScience Evaluation
Traditional Chinese Medicine Properties and Microcalorimetry: BioScience Evaluation Open
The properties theory of traditional Chinese medicine (TCM), characterized by cold, hot, warm, and cool four properties, is fundamental to its development, distinguishing it from natural, botanical, and chemical medicines. However, despite…
View article: Human Pituitary Organoids: Transcriptional Landscape Deciphered by scRNA‐Seq and Stereo‐Seq, with Insights into SOX3's Role in Pituitary Development
Human Pituitary Organoids: Transcriptional Landscape Deciphered by scRNA‐Seq and Stereo‐Seq, with Insights into SOX3's Role in Pituitary Development Open
The 3D human pituitary organoid represents a promising laboratory model for investigating human pituitary diseases. Nonetheless, this technology is still in its nascent stage, with uncertainties regarding the cellular composition, intercel…
View article: Safety, Tolerability, Pharmacodynamics, and Pharmacokinetics of Recombinant Neorudin, a New Anticoagulant Drug in Patients With Acute Coronary Syndrome
Safety, Tolerability, Pharmacodynamics, and Pharmacokinetics of Recombinant Neorudin, a New Anticoagulant Drug in Patients With Acute Coronary Syndrome Open
This study evaluated the safety, tolerability, pharmacodynamics, and pharmacokinetics of recombinant neorudin (EPR‐hirudin [EH]) in patients with acute coronary syndrome (ACS), providing a basis for further therapeutic research. This open‐…
View article: Recombinant neorudin and its active metabolite hirudin: the fate in vivo of a novel anticoagulant drug
Recombinant neorudin and its active metabolite hirudin: the fate in vivo of a novel anticoagulant drug Open
Thrombosis, a prevalent condition, can provoke severe health issues like acute coronary syndrome (ACS), deep vein thrombosis (DVT), and pulmonary embolism (PE). The rising incidence of these diseases annually significantly impacts patient …
View article: A Phase I, single and continuous administration study of Safety, tolerability and pharmacokinetics of neorudin, a noval recombinant anticoagulant protein, in healthy subjects
A Phase I, single and continuous administration study of Safety, tolerability and pharmacokinetics of neorudin, a noval recombinant anticoagulant protein, in healthy subjects Open
AIMS: The aims of the study were to evaluate the tolerability, safety and pharmacokinetics of single and continuous administration of recombinant neorudin (EPR-hirudin, EH) by intravenous injection in healthy subjects, and to provide a saf…
View article: CHARACTERIZATION OF SLUDGE FROM FIVE SEWAGE PLANTS IN LINZHI CITY, QINGHAI-TIBET PLATEAU
CHARACTERIZATION OF SLUDGE FROM FIVE SEWAGE PLANTS IN LINZHI CITY, QINGHAI-TIBET PLATEAU Open
Sludge from five wastewater treatment plants (WWTPs) in Tibet was investigated for microplastic content, microplastic morphology, major pollutant indicators of sludge and physicomechanical indicators of sludge.The results showed that the u…
View article: Recombinant Neorudin for the Prevention of Deep-Vein Thrombosis After Spinal-Cord Injury
Recombinant Neorudin for the Prevention of Deep-Vein Thrombosis After Spinal-Cord Injury Open
EH can reduce thrombus formation in a rat model of SCI, and bleeding is decreased significantly compared with that using LMWH. EH may prevent thrombosis after SCI or spinal surgery.
View article: Supplementary Fig. S1 from Therapeutic targeting of human hepatocyte growth factor with a single neutralizing monoclonal antibody reduces lung tumorigenesis
Supplementary Fig. S1 from Therapeutic targeting of human hepatocyte growth factor with a single neutralizing monoclonal antibody reduces lung tumorigenesis Open
Supplementary Fig. S1 from Therapeutic targeting of human hepatocyte growth factor with a single neutralizing monoclonal antibody reduces lung tumorigenesis
View article: Data from Therapeutic targeting of human hepatocyte growth factor with a single neutralizing monoclonal antibody reduces lung tumorigenesis
Data from Therapeutic targeting of human hepatocyte growth factor with a single neutralizing monoclonal antibody reduces lung tumorigenesis Open
The hepatocyte growth factor (HGF)/c-Met signaling pathway is involved in lung tumor growth and progression, and agents that target this pathway have clinical potential for lung cancer treatment. L2G7, a single potent anti-human HGF neutra…
View article: Supplementary Fig. S1 from Therapeutic targeting of human hepatocyte growth factor with a single neutralizing monoclonal antibody reduces lung tumorigenesis
Supplementary Fig. S1 from Therapeutic targeting of human hepatocyte growth factor with a single neutralizing monoclonal antibody reduces lung tumorigenesis Open
Supplementary Fig. S1 from Therapeutic targeting of human hepatocyte growth factor with a single neutralizing monoclonal antibody reduces lung tumorigenesis
View article: Data from Therapeutic targeting of human hepatocyte growth factor with a single neutralizing monoclonal antibody reduces lung tumorigenesis
Data from Therapeutic targeting of human hepatocyte growth factor with a single neutralizing monoclonal antibody reduces lung tumorigenesis Open
The hepatocyte growth factor (HGF)/c-Met signaling pathway is involved in lung tumor growth and progression, and agents that target this pathway have clinical potential for lung cancer treatment. L2G7, a single potent anti-human HGF neutra…
View article: The toxicity assessment of neorudin in cynomolgus monkeys
The toxicity assessment of neorudin in cynomolgus monkeys Open
In this study, the toxicity effects on circulatory system and respiratory system, and the acute toxicity test of recombinant neorudin (EPR-hirudin, EH) in cynomolgus monkeys were evaluated to provide reference information for clinical stud…
View article: Recent advances in the therapeutic efficacy of hepatocyte growth factor <scp>gene‐modified</scp> mesenchymal stem cells in multiple disease settings
Recent advances in the therapeutic efficacy of hepatocyte growth factor <span>gene‐modified</span> mesenchymal stem cells in multiple disease settings Open
Mesenchymal stem cell (MSC) therapy is considered a new treatment for a wide range of diseases and injuries, but challenges remain, such as poor survival, homing and engraftment rates, thus limiting the therapeutic efficacy of the transpla…
View article: The Antithrombotic Effect of Recombinant Neorudin on Thrombi
The Antithrombotic Effect of Recombinant Neorudin on Thrombi Open
The findings from the preclinical animal models used in this study showed that EH could not only effectively inhibit thrombus formation but also reduce the risk of bleeding.
View article: Inhibitory role of recombinant neorudin on canine coronary artery thrombosis
Inhibitory role of recombinant neorudin on canine coronary artery thrombosis Open
The anticoagulant application is an effective treatment modality for cardiovascular diseases such as coronary heart disease, unstable angina pectoris, and myocardial infarction. In this study, the antithrombotic effect of recombinant neoru…
View article: A phase I, single and continuous dose administration study on the safety, tolerability, and pharmacokinetics of neorudin, a novel recombinant anticoagulant protein, in healthy subjects
A phase I, single and continuous dose administration study on the safety, tolerability, and pharmacokinetics of neorudin, a novel recombinant anticoagulant protein, in healthy subjects Open
The aim of this study was to evaluate the tolerability, safety, and pharmacokinetics of single and continuous dose administration of recombinant neorudin (EPR‐hirudin, EH) by intravenous administration in healthy subjects, and to provide a…
View article: Overexpression of Hepatocyte growth factor in dental pulp stem cells ameliorates the severity of psoriasis by downregulating Th1 and Th17 cells and upregulating Treg cells
Overexpression of Hepatocyte growth factor in dental pulp stem cells ameliorates the severity of psoriasis by downregulating Th1 and Th17 cells and upregulating Treg cells Open
Background Psoriasis is a kind of autoimmune disease still lacking standard treatment. Recently, it was demonstrated that mesenchymal stem cells (MSCs) are capable of immunoregulation. The underlying mechanism might involve the secretion o…