Jidong Zhou
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View article: Melatonin attenuates Drp1-mediated excessive mitochondrial fission through SIRT1 upregulation in granulosa cells of PCOS
Melatonin attenuates Drp1-mediated excessive mitochondrial fission through SIRT1 upregulation in granulosa cells of PCOS Open
Background Mitochondrial dysfunction in granulosa cells (GCs) has been implicated in the pathogenesis of polycystic ovary syndrome (PCOS). Our previous studies showed that melatonin alleviated mitochondrial dysfunction by upregulating SIRT…
View article: Subcutaneous delivery of icariin via a gelatin methacryloyl (GelMA) hydrogel sustained-release system improves ovarian function in reproductively aged mice
Subcutaneous delivery of icariin via a gelatin methacryloyl (GelMA) hydrogel sustained-release system improves ovarian function in reproductively aged mice Open
Ovarian aging is characterized by a progressive decline in oocyte quality and quantity with age. Icariin (ICA), a flavonoid compound derived from Epimedium species, has demonstrated potential as an agent for ovarian restoration. In …
View article: Elevated levels of KLF12 impair trophoblast syncytialization via GCM1 downregulation
Elevated levels of KLF12 impair trophoblast syncytialization via GCM1 downregulation Open
Objective: Placental dysfunction is a major contributor to miscarriages in humans. We observed elevated expression of Kruppel-like factor 12 (KLF12) in placental villi of women who experienced miscarriage compared to that in women with hea…
View article: Mevalonate metabolites boost aged oocyte quality through small GTPases prenylation
Mevalonate metabolites boost aged oocyte quality through small GTPases prenylation Open
Declined oocyte quality is the major contributor to female subfertility in aged mammals. Currently, there are no effective interventions to ameliorate aged oocyte quality. We found that oocytes from aged mice exhibited lower levels of meva…
View article: Dysregulation of endometrial stromal serotonin homeostasis leading to abnormal phosphatidylcholine metabolism impairs decidualization in patients with recurrent implantation failure
Dysregulation of endometrial stromal serotonin homeostasis leading to abnormal phosphatidylcholine metabolism impairs decidualization in patients with recurrent implantation failure Open
STUDY QUESTION Does abnormal serotonin homeostasis contribute to impaired endometrial decidualization in patients with recurrent implantation failure (RIF)? SUMMARY ANSWER Abnormal serotonin homeostasis in patients with RIF, which is accom…
View article: Decreased HAT1 expression in granulosa cells disturbs oocyte meiosis during mouse ovarian aging
Decreased HAT1 expression in granulosa cells disturbs oocyte meiosis during mouse ovarian aging Open
Background With advanced maternal age, abnormalities during oocyte meiosis increase significantly. Aneuploidy is an important reason for the reduction in the quality of aged oocytes. However, the molecular mechanism of aneuploidy in aged o…
View article: Krüppel-like factor 12 regulates aging ovarian granulosa cell apoptosis by repressing SPHK1 transcription and sphingosine-1-phosphate (S1P) production
Krüppel-like factor 12 regulates aging ovarian granulosa cell apoptosis by repressing SPHK1 transcription and sphingosine-1-phosphate (S1P) production Open
View article: DNAJB7 is dispensable for male fertility in mice
DNAJB7 is dispensable for male fertility in mice Open
Background DNAJBs are highly conserved proteins that are involved in various biological processes. Although several DNAJBs are highly expressed in the testis, the function of DNAJB7 in spermatogenesis and male fertility remains unclear. Me…
View article: Downregulated INHBB in endometrial tissue of recurrent implantation failure patients impeded decidualization through the ADCY1/cAMP signalling pathway
Downregulated INHBB in endometrial tissue of recurrent implantation failure patients impeded decidualization through the ADCY1/cAMP signalling pathway Open
Purpose This study aims to identify the mechanism of Inhibin Subunit Beta B (INHBB), a member of the transforming growth factor-β (TGF-β) family involved in the regulation of human endometrial stromal cells (HESCs) decidualization in recur…
View article: Additional file 1 of DNAJB7 is dispensable for male fertility in mice
Additional file 1 of DNAJB7 is dispensable for male fertility in mice Open
Additional file 1: Supplementary figure 1. Alignment of DNAJB7 protein sequences among mammals. Highly conserved regions are shown in red. Unconserved residues are shown in blue or as asterisks in the consensus. Multiple alignments were pe…
View article: Spatial-Temporal Regulation of Follicle Development by Perifollicular Stromal Cells
Spatial-Temporal Regulation of Follicle Development by Perifollicular Stromal Cells Open
View article: Perfluorooctanoic Acid Exposure Disrupts the Mitochondrial Electron Transport Chain in Granulosa Cells, Leading to Defect in Follicular Development
Perfluorooctanoic Acid Exposure Disrupts the Mitochondrial Electron Transport Chain in Granulosa Cells, Leading to Defect in Follicular Development Open
View article: FHL1 mediates HOXA10 deacetylation via SIRT2 to enhance blastocyst-epithelial adhesion
FHL1 mediates HOXA10 deacetylation via SIRT2 to enhance blastocyst-epithelial adhesion Open
View article: MEKK4-mediated Phosphorylation of HOXA10 at Threonine 362 facilitates embryo adhesion to the endometrial epithelium
MEKK4-mediated Phosphorylation of HOXA10 at Threonine 362 facilitates embryo adhesion to the endometrial epithelium Open
View article: Endometrial stromal PRMT5 plays a crucial role in decidualization by regulating NF-κB signaling in endometriosis
Endometrial stromal PRMT5 plays a crucial role in decidualization by regulating NF-κB signaling in endometriosis Open
View article: FHL1 mediates HOXA10 deacetylation via SIRT2 to enhance blastocyst-epithelial adhesion
FHL1 mediates HOXA10 deacetylation via SIRT2 to enhance blastocyst-epithelial adhesion Open
Recurrent implantation failure (RIF) is a rather thorny problem in the clinical practice of assisted reproductive technology. Due to the complex aetiology of RIF, its pathogenesis is far from fully understood, and there is no effective tre…
View article: A novel lncRNA lncSAMD11-1: 1 interacts with PIP4K2A to promote endometrial decidualization by stabilizing FoxO1 nuclear localization
A novel lncRNA lncSAMD11-1: 1 interacts with PIP4K2A to promote endometrial decidualization by stabilizing FoxO1 nuclear localization Open
Decidualization is essential for a successful pregnancy and determines embryo implantation and pregnancy maintenance. Abnormal decidualization is one of the main causes of recurrent implantation failure (RIF). Studies have shown that large…
View article: MEKK4-mediated Phosphorylation of HOXA10 at Threonine 362 facilitates embryo adhesion to the endometrial epithelium
MEKK4-mediated Phosphorylation of HOXA10 at Threonine 362 facilitates embryo adhesion to the endometrial epithelium Open
Embryo adhesion is a very important step in the embryo implantation process. Homeobox A10 (HOXA10), a key transcriptional factor of endometrial receptivity, is indispensable for embryo adhesion. However, how to control the activation statu…
View article: Endometrial stromal PRMT5 plays a crucial role in decidualization by regulating NF-κB signaling in endometriosis
Endometrial stromal PRMT5 plays a crucial role in decidualization by regulating NF-κB signaling in endometriosis Open
Decidualization is a prerequisite for successful embryo implantation, in which elongated fibroblast-like endometrial stromal cells differentiate into more rounded decidual cells. Accumulating evidence has stressed the important role of the…
View article: Decreased Krüppel-like factor 4 in adenomyosis impairs decidualization by repressing autophagy in human endometrial stromal cells
Decreased Krüppel-like factor 4 in adenomyosis impairs decidualization by repressing autophagy in human endometrial stromal cells Open
View article: Homeodomain protein HOMEZ is dispensable for male fertility in mice
Homeodomain protein HOMEZ is dispensable for male fertility in mice Open
Homez knockout mice are fertile and are not essential for germ cell development. These findings could prevent unnecessary duplicative work by other groups.
View article: Sequential functional differentiation of luminal epithelial cells regulated by maternal and embryonic signaling in the mouse endometrium
Sequential functional differentiation of luminal epithelial cells regulated by maternal and embryonic signaling in the mouse endometrium Open
Summary Embryo implantation requires temporospatial maternal-embryo dialog to regulate the interactions between an activated blastocyst and a receptive endometrium; however, the details of the related cell-specific coordination is largely …
View article: Temporal and spatial dynamics mapping reveals follicle development regulated by different stromal cell populations
Temporal and spatial dynamics mapping reveals follicle development regulated by different stromal cell populations Open
Follicle development is a complex dynamic process. The follicles are encapsulated in the stroma, and once the follicle develops, the follicle moves from the cortex to the medulla and finally to the cortex to ovulate in the process of conti…
View article: Association between gestational trophoblastic disease (GTD) history and clinical outcomes in in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) cycles
Association between gestational trophoblastic disease (GTD) history and clinical outcomes in in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) cycles Open
View article: Functional Differentiation of Luminal Epithelial Cells Regulated by Maternal and Embryonic Signaling and Its Relationship With Receptivity Establishment
Functional Differentiation of Luminal Epithelial Cells Regulated by Maternal and Embryonic Signaling and Its Relationship With Receptivity Establishment Open
View article: The mitochondrial protease LONP1 maintains oocyte development and survival by suppressing nuclear translocation of AIFM1 in mammals
The mitochondrial protease LONP1 maintains oocyte development and survival by suppressing nuclear translocation of AIFM1 in mammals Open
View article: Calpain7 Negatively Regulates Human Endometrial Stromal Cell Decidualization in Endometriosis by Promoting FoxO1’s Phosphorylation and Nuclear Exclusion via Hydrolyzing AKT1
Calpain7 Negatively Regulates Human Endometrial Stromal Cell Decidualization in Endometriosis by Promoting FoxO1’s Phosphorylation and Nuclear Exclusion via Hydrolyzing AKT1 Open
Background Endometrial receptivity damage caused by impaired decidualization may be one of the mechanisms of infertility in endometriosis (EMs). Our previous study demonstrated that Calpain-7 (CAPN7) is abnormally overexpressed in EMs. Whe…
View article: ATF3 deficiency impairs the proliferative–secretory phase transition and decidualization in RIF patients
ATF3 deficiency impairs the proliferative–secretory phase transition and decidualization in RIF patients Open
View article: Calpain7 Negatively Regulates Human Endometrial Stromal Cell Decidualization in EMS by Promoting Foxo1 Nuclear Exclusion by Increasing the Phosphorylation of AKT1
Calpain7 Negatively Regulates Human Endometrial Stromal Cell Decidualization in EMS by Promoting Foxo1 Nuclear Exclusion by Increasing the Phosphorylation of AKT1 Open
View article: The Mitochondrial Protease Lonp1 Maintains Oocyte Development and Survival by Suppressing Nuclear Translocation of AIFM1 in Mammals
The Mitochondrial Protease Lonp1 Maintains Oocyte Development and Survival by Suppressing Nuclear Translocation of AIFM1 in Mammals Open