Dan Zhu
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View article: Ngn2 and Isl1-mediated astrocyte-to-neuron conversion in vivo promotes functional recovery after spinal cord injury
Ngn2 and Isl1-mediated astrocyte-to-neuron conversion in vivo promotes functional recovery after spinal cord injury Open
Adult neurogenesis plays a crucial role in maintaining brain homeostasis and can respond to neurogenic injuries. However, the adult mammalian spinal cord has extremely limited intrinsic neurogenic ability. Here, we show that in vivo astroc…
View article: Neuro-lymphaphotonics opens new horizons of the future technologies for the therapy of brain diseases
Neuro-lymphaphotonics opens new horizons of the future technologies for the therapy of brain diseases Open
View article: Left atrial appendage closure versus oral anticoagulants in atrial fibrillation: A systematic review and meta-analysis
Left atrial appendage closure versus oral anticoagulants in atrial fibrillation: A systematic review and meta-analysis Open
View article: Real-time self-supervised denoising for high-speed fluorescence neural imaging
Real-time self-supervised denoising for high-speed fluorescence neural imaging Open
View article: Second-level high-speed 3D isotropic imaging of whole mouse brain using deep-learning spinning-disk light-sheet microscopy
Second-level high-speed 3D isotropic imaging of whole mouse brain using deep-learning spinning-disk light-sheet microscopy Open
Axially-swept light-sheet microscopy (ASLM) has emerged as a distinguished tool for 3D imaging owing to its excellent spatial resolution. However, the acquisition time is significantly elongated due to the extra time consumed in axial scan…
View article: 1275‐nm Photobiomodulation Alleviates Brain Drainage Impairment as a Promising Therapeutic Strategy for Aging‐Related Neurological Decline
1275‐nm Photobiomodulation Alleviates Brain Drainage Impairment as a Promising Therapeutic Strategy for Aging‐Related Neurological Decline Open
Aging imposes a significant socioeconomic and healthcare burden worldwide, while effective therapy is still lacking. Impaired brain drainage and excessive accumulation of metabolites and toxins such as advanced glycation end products (AGEs…
View article: FedEve: On Bridging the Client Drift and Period Drift for Cross-device Federated Learning
FedEve: On Bridging the Client Drift and Period Drift for Cross-device Federated Learning Open
Federated learning (FL) is a machine learning paradigm that allows multiple clients to collaboratively train a shared model without exposing their private data. Data heterogeneity is a fundamental challenge in FL, which can result in poor …
View article: Multi-scale information fusion of well-logging data-based deep learning 3D modeling method
Multi-scale information fusion of well-logging data-based deep learning 3D modeling method Open
Reservoir modeling based on interpolation and extrapolation of well-logging data provides initial model for seismic inversion. However, the conventional Kriging-based interpolation algorithm relies on the spatial correlation between differ…
View article: Advances in tissue optical clearing for 3D imaging in large animal
Advances in tissue optical clearing for 3D imaging in large animal Open
Three-dimensional reconstruction of tissue architecture is crucial for biomedical research. Tissue optical clearing technology overcomes light scattering limitations in biological tissues, providing an essential tool for high-resolution th…
View article: Real-time self-supervised denoising for high-speed fluorescence neural imaging
Real-time self-supervised denoising for high-speed fluorescence neural imaging Open
Self-supervised denoising methods significantly enhance the signal-to-noise ratio in fluorescence neural imaging, yet real-time solutions remain scarce in high-speed applications. Here, we present the FrAme-multiplexed SpatioTemporal learn…
View article: Panzerina lanata accelerates methicillin-resistant Staphylococcus aureus eradication by promoting migration and activation of neutrophils
Panzerina lanata accelerates methicillin-resistant Staphylococcus aureus eradication by promoting migration and activation of neutrophils Open
Background Panzerina lanata (Lanata) is generally used to treat pustule infection in Inner Mongolia folk medicine and is called “the holy medicine for pustule.” However, the pharmacological mechanism of Lanata in treating pustule infection…
View article: Obtusifolin ameliorates dry eye model in rats by reducing inflammation and blocking MAPK/NF-κB pathways.
Obtusifolin ameliorates dry eye model in rats by reducing inflammation and blocking MAPK/NF-κB pathways. Open
Obtusifolin ameliorates DED in rats possibly by alleviating inflammation via the inactivation of MAPK/NF-κB signaling.
View article: Strongly absorbing molecules make tissue transparent: a new insight for understanding tissue optical clearing
Strongly absorbing molecules make tissue transparent: a new insight for understanding tissue optical clearing Open
Optical imaging plays a central role in the field of biomedicine, but it suffers from the light scattering of tissues. The research group from Stanford University has reported a counterintuitive observation that strongly absorbing molecule…
View article: UPLC-Q-TOF/MS-based Spectrum-effect Correlation Combined with Chemometrics and Molecular Docking for Quality Assessment and Screening of Bioactive Components with Hemostatic, Antinociceptive, and Anti-Inflammatory Activities in Liparis nervosa
UPLC-Q-TOF/MS-based Spectrum-effect Correlation Combined with Chemometrics and Molecular Docking for Quality Assessment and Screening of Bioactive Components with Hemostatic, Antinociceptive, and Anti-Inflammatory Activities in Liparis nervosa Open
View article: Ecological Stoichiometry of Carbon, Nitrogen and Phosphorus in Coffee Leaves and Soil from Different Origins in Yunnan Province
Ecological Stoichiometry of Carbon, Nitrogen and Phosphorus in Coffee Leaves and Soil from Different Origins in Yunnan Province Open
This study examines the ecological stoichiometry of carbon(C), nitrogen(N) and phosphorus(P) in coffee from Baoshan, Pu’er, and Xishuangbanna in Yunnan. The results show that there are significant differences in soil carbon (C) content and…
View article: Molecular mechanism of culinary herb Artemisia argyi in promoting lifespan and stress tolerance
Molecular mechanism of culinary herb Artemisia argyi in promoting lifespan and stress tolerance Open
Artemisia argyi Lévl. et Vant. (A. argyi) leaf possesses various health promoting functions contributed by its main bioactive flavonoids. In this study, the anti-aging effect and mechanism of Artemisia argyi leaf extract (AALE) were identi…
View article: Genotype-independent transformation technique development and application in maize
Genotype-independent transformation technique development and application in maize Open
View article: SOLID: minimizing tissue distortion for brain-wide profiling of diverse architectures
SOLID: minimizing tissue distortion for brain-wide profiling of diverse architectures Open
Brain-wide profiling of diverse biological components is fundamental for understanding complex brain pathology. Despite the availability in whole-brain imaging, it is still challenging to conduct multiplexed, brain-wide analysis with curre…
View article: Integrating GWAS and transcriptomics to identify candidate genes conferring relative growth rate trait in white-feathered broiler
Integrating GWAS and transcriptomics to identify candidate genes conferring relative growth rate trait in white-feathered broiler Open
View article: Preface — Introduction to the Special Issue for Chinese-Russian Workshop on Biophotonics and Biomedical Optics
Preface — Introduction to the Special Issue for Chinese-Russian Workshop on Biophotonics and Biomedical Optics Open
View article: Two-beam Interference Microscopy: high-resolution multi-scale light-sheet imaging from subcellular structures to whole organs
Two-beam Interference Microscopy: high-resolution multi-scale light-sheet imaging from subcellular structures to whole organs Open
Despite offering rapid and gentle 3D imaging of biological samples, the revolution by light-sheet fluorescence microscopy faces challenges due to optical constraints and limited geometry flexibility, hindering its widespread application. H…
View article: Editorial on the special issue on neuro-sleep as a complex system
Editorial on the special issue on neuro-sleep as a complex system Open
View article: Dynamic Light Scattering in Biomedical Applications: feature issue introduction
Dynamic Light Scattering in Biomedical Applications: feature issue introduction Open
The feature Issue on “Dynamic Light Scattering in Biomedical Applications” presents a compilation of research breakthroughs and technological advancements that have shaped the field of biophotonics, particularly in the non-invasive explora…
View article: New insights into the genetic loci related to egg weight and age at first egg traits in broiler breeder
New insights into the genetic loci related to egg weight and age at first egg traits in broiler breeder Open
Egg weight (EW) and age at first egg (AFE) are economically important traits in breeder chicken production. The genetic basis of these traits, however, is far from understood, especially for broiler breeders. In this study, genetic paramet…
View article: Tau induces inflammasome activation and microgliosis through acetylating NLRP3
Tau induces inflammasome activation and microgliosis through acetylating NLRP3 Open
Background Alzheimer's disease (AD) and related Tauopathies are characterised by the pathologically hyperphosphorylated and aggregated microtubule‐associated protein Tau, which is accompanied by neuroinflammation mediated by activated micr…
View article: Transcranial photobiomodulation for brain diseases: review of animal and human studies including mechanisms and emerging trends
Transcranial photobiomodulation for brain diseases: review of animal and human studies including mechanisms and emerging trends Open
The brain diseases account for 30% of all known diseases. Pharmacological treatment is hampered by the blood-brain barrier, limiting drug delivery to the central nervous system (CNS). Transcranial photobiomodulation (tPBM) is a promising t…
View article: Tissue Optical Clearing Imaging from Ex vivo toward In vivo
Tissue Optical Clearing Imaging from Ex vivo toward In vivo Open
View article: Photostimulation of lymphatic clearance of β-amyloid from mouse brain: a new strategy for the therapy of Alzheimer’s disease
Photostimulation of lymphatic clearance of β-amyloid from mouse brain: a new strategy for the therapy of Alzheimer’s disease Open
Alzheimer’s disease (AD) is an age-related neurodegenerative disorder that poses a significant burden on socio-economic and healthcare systems worldwide. However, the currently available therapy of AD is limited, and new strategies are nee…
View article: Transcranial photobiomodulation improves insulin therapy in diabetic microglial reactivity and the brain drainage system
Transcranial photobiomodulation improves insulin therapy in diabetic microglial reactivity and the brain drainage system Open
The dysfunction of microglia in the development of diabetes is associated with various diabetic complications, while traditional insulin therapy is insufficient to rapidly restore the function of microglia. Therefore, the search for new al…
View article: Multifocal fluorescence video-rate imaging of centimetre-wide arbitrarily shaped brain surfaces at micrometric resolution
Multifocal fluorescence video-rate imaging of centimetre-wide arbitrarily shaped brain surfaces at micrometric resolution Open