J. Zhao
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View article: Correlation between Interleukin-6, C-reactive protein, and lactate dehydrogenase levels and macrolide-resistant severe mycoplasma pneumoniae infection in children
Correlation between Interleukin-6, C-reactive protein, and lactate dehydrogenase levels and macrolide-resistant severe mycoplasma pneumoniae infection in children Open
BACKGROUND : In recent years, macrolide-resistant Mycoplasma pneumoniae (MRMP) has been increasingly reported worldwide, with a macrolide resistance rate of >90% in China , leading to a rise in severe Mycoplasma pneumoniae pneumonia(MPP) i…
View article: Efficacy and Safety of Anti‐Influenza Drugs in 160 Chinese Children With Influenza A: A Retrospective Study
Efficacy and Safety of Anti‐Influenza Drugs in 160 Chinese Children With Influenza A: A Retrospective Study Open
Aim In this study, we aimed to provide a comprehensive analysis of real‐world implications for the therapeutic efficacy and safety of baloxavir marboxil, oseltamivir phosphate capsules and oseltamivir phosphate granules in the treatment of…
View article: Metabolic Reprogramming in Urological Tumors: New Perspectives from Tumor Metabolic Phenotypes to Therapeutic Targets
Metabolic Reprogramming in Urological Tumors: New Perspectives from Tumor Metabolic Phenotypes to Therapeutic Targets Open
Metabolic reprogramming is a hallmark of cancer, enabling tumor cells to sustain growth, evade immune surveillance, and resist therapy. Urological tumors, including prostate, bladder, and renal cancers, exhibit distinct metabolic phenotype…
View article: A Novel Demographic Indicator Fusion Network (DIFNet) for Dynamic Fusion of EEG and Demographic Indicators for Robust Depression Detection
A Novel Demographic Indicator Fusion Network (DIFNet) for Dynamic Fusion of EEG and Demographic Indicators for Robust Depression Detection Open
Electroencephalography (EEG) has proven to be effective for detecting major depressive disorder (MDD), with deep learning models further advancing its potential. However, the performance of these models may be limited by their neglect of d…
View article: AI‐Assisted Detection of Early Gastric Cancer via Visualization of Mucosal Acidity Compromise During Endoscopy
AI‐Assisted Detection of Early Gastric Cancer via Visualization of Mucosal Acidity Compromise During Endoscopy Open
Accurate localization of early gastric cancer (EGC) remains challenging due to its morphological resemblance to gastritis. This study presents an artificial intelligence (AI)‐assisted bedside diagnostic system to enhance EGC detection by v…
View article: Activation of USP30 Disrupts Endothelial Cell Function and Aggravates Acute Lung Injury Through Regulating the S‐Adenosylmethionine Cycle
Activation of USP30 Disrupts Endothelial Cell Function and Aggravates Acute Lung Injury Through Regulating the S‐Adenosylmethionine Cycle Open
Microvascular dysfunction is a key contributor to the development of acute inflammatory diseases, characterized by heightened vascular hyperpermeability and leukocyte infiltration into interstitial tissues. Despite substantial research eff…
View article: Intelligent substation communication network fault location method based on dynamic spatiotemporal graph association perception
Intelligent substation communication network fault location method based on dynamic spatiotemporal graph association perception Open
INTRODUCTION: Accurately locating faults in intelligent substation communication networks is crucial for power grid safety. Existing methods fail to fully capture dynamic fault characteristic evolution and complex dependencies within netwo…
View article: The association between dietary fiber intake and cognitive function: mediating role of inflammatory markers
The association between dietary fiber intake and cognitive function: mediating role of inflammatory markers Open
Aims Cognitive impairment, frequently associated with neurodegenerative diseases such as Alzheimer's disease, may be associated with multiple factors including dietary fiber intake and inflammation. We aimed to explore the associations bet…
View article: Second-order cone programming support vector machine based on generalized memory kernel
Second-order cone programming support vector machine based on generalized memory kernel Open
This paper proposes a new robust support vector machine framework based on generalized memory kernel and second-order cone programming. Aiming at the generalization limitations and insufficient memory ability (i.e., fitting ability) of tra…
View article: Effect of respiratory syncytial virus on the global burden of lower respiratory infections: lessons from the Global Burden of Disease Study 1990-2021
Effect of respiratory syncytial virus on the global burden of lower respiratory infections: lessons from the Global Burden of Disease Study 1990-2021 Open
View article: Rational design of respiratory syncytial virus dimeric F-subunit vaccines in protein and mRNA forms
Rational design of respiratory syncytial virus dimeric F-subunit vaccines in protein and mRNA forms Open
View article: Review on mechanisms and therapeutic advances in inorganic arsenic-induced reproductive system disorders
Review on mechanisms and therapeutic advances in inorganic arsenic-induced reproductive system disorders Open
Inorganic arsenic (iAs), a toxic metalloid and recognized carcinogen, is widely distributed in the natural environment. Human exposure to iAs occurs via multiple pathways, leading to its accumulation and adverse effects on the human body. …
View article: Clinical uremic syndrome scores and mortality in peritoneal dialysis: a multi-center retrospective study
Clinical uremic syndrome scores and mortality in peritoneal dialysis: a multi-center retrospective study Open
No study has comprehensively investigated the association between comorbidities, uremic-specific complications (collectively defined as clinical uremic syndrome [CUS]), and mortality in peritoneal dialysis (PD) patients. We conducted a ret…
View article: Deep learning model enables the discovery of a novel BET inhibitor YD-851
Deep learning model enables the discovery of a novel BET inhibitor YD-851 Open
BET inhibitor is a novel strategy in tumor therapy based on targeting epigenetic mechanism. In recent decades, dozens of clinical trials have been conducted to validate the potential efficacy of the first-generation BET inhibitors in refra…
View article: Semi-inclusive deep inelastic scattering off a tensor-polarized spin-1 target
Semi-inclusive deep inelastic scattering off a tensor-polarized spin-1 target Open
We investigate the semi-inclusive deep inelastic scattering off a tensor-polarized spin-1 target, focusing on the production of an unpolarized hadron. The complete differential cross section is expressed in terms of 23 structure functions,…
View article: MemOS: A Memory OS for AI System
MemOS: A Memory OS for AI System Open
Large Language Models (LLMs) have become an essential infrastructure for Artificial General Intelligence (AGI), yet their lack of well-defined memory management systems hinders the development of long-context reasoning, continual personali…
View article: Effect of respiratory syncytial virus on the global burden of lower respiratory infections: lessons from the Global Burden of Disease Study 1990-2021
Effect of respiratory syncytial virus on the global burden of lower respiratory infections: lessons from the Global Burden of Disease Study 1990-2021 Open
View article: A comprehensive life cycle cost model for high-temperature pipe insulation: balancing heat dissipation, temperature resistance and economic benefits
A comprehensive life cycle cost model for high-temperature pipe insulation: balancing heat dissipation, temperature resistance and economic benefits Open
Efficient insulation technologies are essential for enhancing energy utilization and maximizing economic benefits. High-temperature pipelines typically use composite insulation, which combine high-temperature resistant materials with conve…
View article: Real-world survival analysis of elderly patients with acute myeloid leukemia
Real-world survival analysis of elderly patients with acute myeloid leukemia Open
Acute myeloid leukemia (AML) predominantly affects the elderly, who often have a poor prognosis due to age-related comorbidities, adverse genetic features, and limited tolerance to standard therapies. This study aimed to evaluate real-worl…
View article: Inside Front Cover: Hierarchically Self‐Assembled Anion‐Coordination‐Driven Gels for Guest Segregation and Electrical Sensing (Angew. Chem. Int. Ed. 28/2025)
Inside Front Cover: Hierarchically Self‐Assembled Anion‐Coordination‐Driven Gels for Guest Segregation and Electrical Sensing (Angew. Chem. Int. Ed. 28/2025) Open
View article: Fusion-Attention Diagnosis Network (FADNet): An end-to-end framework for optic disc segmentation and ocular disease classification
Fusion-Attention Diagnosis Network (FADNet): An end-to-end framework for optic disc segmentation and ocular disease classification Open
View article: Measurement of IBD-like background with plastic scintillator detector array at surface level
Measurement of IBD-like background with plastic scintillator detector array at surface level Open
View article: Scrub-and-Learn: Category-Aware Weight Modification for Machine Unlearning
Scrub-and-Learn: Category-Aware Weight Modification for Machine Unlearning Open
(1) Background: Machine unlearning plays a crucial role in privacy protection and model optimization, particularly in forgetting entire categories of data in classification tasks. However, existing methods often struggle with high computat…
View article: Molecular Alchemy: Converting Stress into Resilience via Secondary Metabolites and Calcium Signaling in Rice
Molecular Alchemy: Converting Stress into Resilience via Secondary Metabolites and Calcium Signaling in Rice Open
Salt stress impairs plant growth by disrupting osmotic regulation, ion homeostasis, and oxidative stress management. Plants respond by activating defense mechanisms, including the biosynthesis of secondary metabolites (SMs) such as alkaloi…
View article: Invoke Interfaces Only When Needed: Adaptive Invocation for Large Language Models in Question Answering
Invoke Interfaces Only When Needed: Adaptive Invocation for Large Language Models in Question Answering Open
The collaborative paradigm of large and small language models (LMs) effectively balances performance and cost, yet its pivotal challenge lies in precisely pinpointing the moment of invocation when hallucinations arise in small LMs. Previou…
View article: Systematic evaluation of patient-reported outcomes in clinical trials of digital health in cardiovascular diseases
Systematic evaluation of patient-reported outcomes in clinical trials of digital health in cardiovascular diseases Open
The integration of patient-reported outcomes (PROs) in digital health (DH) trials for cardiovascular diseases (CVDs) remains unknown. We searched ClinicalTrials.gov for randomized trials that tested DH interventions in CVDs from 2004 to 20…
View article: Analysis of the clinical characteristics of five patients with Kawasaki disease complicated with macrophage activation syndrome in Baoding Hospital of Beijing Children’s Hospital, Capital Medical University
Analysis of the clinical characteristics of five patients with Kawasaki disease complicated with macrophage activation syndrome in Baoding Hospital of Beijing Children’s Hospital, Capital Medical University Open
Objective: To investigate clinical characteristics of Kawasaki disease (KD) complicated with macrophage activation syndrome (MAS) and to identify possible indicators for early diagnosis. Method: Clinical data, laboratory indexes, treatment…
View article: Effect of respiratory syncytial virus on the global burden of lower respiratory infections: lessons from the Global Burden of Disease Study 1990-2021
Effect of respiratory syncytial virus on the global burden of lower respiratory infections: lessons from the Global Burden of Disease Study 1990-2021 Open
View article: A novel quantitative evaluation strategy of polysaccharides from Lycium barbarum L. fruits based on simultaneous quantification of total polysaccharides and polysaccharides with active structure characteristics
A novel quantitative evaluation strategy of polysaccharides from Lycium barbarum L. fruits based on simultaneous quantification of total polysaccharides and polysaccharides with active structure characteristics Open
View article: A diagnostic model for non-invasive urothelial cancer early detection based on methylation of urinary tumor DNA
A diagnostic model for non-invasive urothelial cancer early detection based on methylation of urinary tumor DNA Open
Background Diagnostic methods for urothelial cancer (UC) are often invasive, while urinary cytology, a non-invasive alternative, suffers from limited sensitivity. This study aimed to identify differentially methylated markers in urinary tu…