Jian Tu
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View article: Isolation and Genome-Based Characterization of Bacillus velezensis AN6 for Its Biocontrol Potential Against Multiple Plant Pathogens
Isolation and Genome-Based Characterization of Bacillus velezensis AN6 for Its Biocontrol Potential Against Multiple Plant Pathogens Open
Biological control is an effective and environmentally friendly strategy for managing plant diseases. In this study, a broad-spectrum antagonistic bacterium, designated strain AN6, was isolated from rice plants and exhibited potent inhibit…
View article: Allelic Variations of the Waxy Gene and Their Associations with Indica–Japonica Differentiation and Amylose Content in Yunnan Local Rice Germplasm
Allelic Variations of the Waxy Gene and Their Associations with Indica–Japonica Differentiation and Amylose Content in Yunnan Local Rice Germplasm Open
Objectives: To provide insights for breeding high-quality rice varieties, we analyzed local rice (Oryza sativa L.) germplasm from Yunnan Province, China, focusing on the relationships among Waxy gene alleles, indica–japonica differentiatio…
View article: Integrated traditional Chinese and western medicine nursing management of radiotherapy-induced skin allergy in a patient with gastric cancer and liver metastasis
Integrated traditional Chinese and western medicine nursing management of radiotherapy-induced skin allergy in a patient with gastric cancer and liver metastasis Open
This article presents the Traditional Chinese Medicine (TCM) nursing experience in managing acute skin allergic reactions and fever induced by radiotherapy in a liver-metastatic gastric cancer patient. Key nursing interventions included: P…
View article: Phosphaturic mesenchymal tumors: a report of 14 cases and literature review
Phosphaturic mesenchymal tumors: a report of 14 cases and literature review Open
View article: Identification and validation of shared biomarkers and drug repurposing in psoriasis and Crohn’s disease: integrating bioinformatics, machine learning, and experimental approaches
Identification and validation of shared biomarkers and drug repurposing in psoriasis and Crohn’s disease: integrating bioinformatics, machine learning, and experimental approaches Open
Background Psoriasis and Crohn’s disease (CD) are chronic inflammatory diseases that involve complex immune-mediated mechanisms. Despite clinical overlap and shared genetic predispositions, the molecular pathways connecting these diseases …
View article: Rapid and Effective Neuronal Conversion of Human Glioblastoma In Vitro and In Vivo Using Potent Small Molecules
Rapid and Effective Neuronal Conversion of Human Glioblastoma In Vitro and In Vivo Using Potent Small Molecules Open
Exploring effective, prompt and universally applicable approaches for inducing the differentiation of glioblastoma (GBM) into terminally differentiated cells, such as astrocytes or neurons that cease cell division, is pivotal for the succe…
View article: STUDY OF SPECIES DISTRIBUTION AND HARM CAUSED BY INVASIVE ALIEN PLANTS IN THE UPPER REACHES OF THE XIANGJIANG RIVER
STUDY OF SPECIES DISTRIBUTION AND HARM CAUSED BY INVASIVE ALIEN PLANTS IN THE UPPER REACHES OF THE XIANGJIANG RIVER Open
View article: Design and development of bridge erecting machine with small curve radius and bottom feeding beam
Design and development of bridge erecting machine with small curve radius and bottom feeding beam Open
View article: Comparison in prostate cancer diagnosis with PSA 4–10 ng/mL: radiomics-based model VS. PI-RADS v2.1
Comparison in prostate cancer diagnosis with PSA 4–10 ng/mL: radiomics-based model VS. PI-RADS v2.1 Open
View article: Targeting NAT10 inhibits osteosarcoma progression via ATF4/ASNS-mediated asparagine biosynthesis
Targeting NAT10 inhibits osteosarcoma progression via ATF4/ASNS-mediated asparagine biosynthesis Open
View article: A glimpse into the future: Integrating artificial intelligence for precision HER2‐positive breast cancer management
A glimpse into the future: Integrating artificial intelligence for precision HER2‐positive breast cancer management Open
Breast cancer (BC), specifically HER2‐positives subtype, has a poor prognosis. Nevertheless, the development of anti‐HER2 therapy yielded satisfactory outcomes. Therefore, evaluating patient HER2 status and ascertaining responsiveness to a…
View article: A diagnostic signature developed based on the necroptosis-related genes and its association with immune infiltration in osteosarcoma
A diagnostic signature developed based on the necroptosis-related genes and its association with immune infiltration in osteosarcoma Open
View article: Systematic transcriptome profiling of hPSC-derived osteoblasts unveils CORIN's mastery in governing osteogenesis through CEBPD modulation
Systematic transcriptome profiling of hPSC-derived osteoblasts unveils CORIN's mastery in governing osteogenesis through CEBPD modulation Open
View article: Age-dependent molecular variations in osteosarcoma: implications for precision oncology across pediatric, adolescent, and adult patients
Age-dependent molecular variations in osteosarcoma: implications for precision oncology across pediatric, adolescent, and adult patients Open
Background Osteosarcoma is a leading subtype of bone tumor affecting adolescents and adults. Comparative molecular characterization among different age groups, especially in pediatric, adolescents and adults, is scarce. Methods We collecte…
View article: Comparison of oncological and functional outcomes in Lower-limb osteosarcoma pediatric patients: a large single-center retrospective cohort study
Comparison of oncological and functional outcomes in Lower-limb osteosarcoma pediatric patients: a large single-center retrospective cohort study Open
Objective: Treating pediatric osteosarcoma in long bones is challenging due to skeletal immaturity, which restricts the generalizability of insights derived from adult patients. Are there disparities in outcomes? How should surgical protoc…
View article: Construction of an ER stress-related prognostic signature for predicting prognosis and screening the effective anti-tumor drug in osteosarcoma
Construction of an ER stress-related prognostic signature for predicting prognosis and screening the effective anti-tumor drug in osteosarcoma Open
View article: Additional file 1 of Construction of an ER stress-related prognostic signature for predicting prognosis and screening the effective anti-tumor drug in osteosarcoma
Additional file 1 of Construction of an ER stress-related prognostic signature for predicting prognosis and screening the effective anti-tumor drug in osteosarcoma Open
Additional file 1: Table S1. Summary of 62 osteosarcoma patients clinical information.
View article: Genome-wide identification of <i>DUF506</i> gene family in <i>Oryza</i> <i>sativa</i> and expression profiling under abiotic stresses
Genome-wide identification of <i>DUF506</i> gene family in <i>Oryza</i> <i>sativa</i> and expression profiling under abiotic stresses Open
The domain of unknown function 560 (DUF560), also known as the PDDEXK_6 family, is a ubiquitous plant protein that has been confirmed to play critical roles in Arabidopsis root development as well as ABA and abiotic responses. However, gen…
View article: Rewired m6A epitranscriptomic networks link mutant p53 to neoplastic transformation
Rewired m6A epitranscriptomic networks link mutant p53 to neoplastic transformation Open
View article: METTL14-mediated epitranscriptome modification of MN1 mRNA promote tumorigenicity and all-trans-retinoic acid resistance in osteosarcoma
METTL14-mediated epitranscriptome modification of MN1 mRNA promote tumorigenicity and all-trans-retinoic acid resistance in osteosarcoma Open
View article: Construction of survival-related co-expression modules and identification of potential prognostic biomarkers of osteosarcoma using WGCNA
Construction of survival-related co-expression modules and identification of potential prognostic biomarkers of osteosarcoma using WGCNA Open
Osteosarcoma (OS); weighted gene co-expression network analysis (WGCNA); gene.
View article: Patient-derived iPSCs link elevated mitochondrial respiratory complex I function to osteosarcoma in Rothmund-Thomson syndrome
Patient-derived iPSCs link elevated mitochondrial respiratory complex I function to osteosarcoma in Rothmund-Thomson syndrome Open
Rothmund-Thomson syndrome (RTS) is an autosomal recessive genetic disorder characterized by poikiloderma, small stature, skeletal anomalies, sparse brows/lashes, cataracts, and predisposition to cancer. Type 2 RTS patients with biallelic R…
View article: Clinical application value of Inhibin B alone or in combination with other hormone indicators in subfertile men with different spermatogenesis status: A study of 324 Chinese men
Clinical application value of Inhibin B alone or in combination with other hormone indicators in subfertile men with different spermatogenesis status: A study of 324 Chinese men Open
Background In this study, we investigated the clinical value of serum Inhibin B alone or in combination with other hormone indicators in subfertile men. Methods This is a multicenter study involving 324 men from different cities in China. …
View article: A nomogram based on PI-RADS v2.1 and clinical indicators for predicting clinically significant prostate cancer in the transition zone
A nomogram based on PI-RADS v2.1 and clinical indicators for predicting clinically significant prostate cancer in the transition zone Open
The newly constructed nomogram exhibits satisfactory predictive accuracy and consistency for TZ cs-PCa. PI-RADS v2.1 based on bp-MRI is a strong predictor in the detection of TZ cs-PCa. Adding PSAD to PI-RADS v2.1 could improve its diagnos…
View article: Tristetraprolin, a Potential Safeguard Against Carcinoma: Role in the Tumor Microenvironment
Tristetraprolin, a Potential Safeguard Against Carcinoma: Role in the Tumor Microenvironment Open
Tristetraprolin (TTP), a well-known RNA-binding protein, primarily affects the expression of inflammation-related proteins by binding to the targeted AU-rich element in the 3’ untranslated region after transcription and subsequently mediat…
View article: A Novel mRNA-miRNA Regulatory Sub-Network Associated With Prognosis of Metastatic Clear Cell Renal Cell Carcinoma
A Novel mRNA-miRNA Regulatory Sub-Network Associated With Prognosis of Metastatic Clear Cell Renal Cell Carcinoma Open
Background Clear cell renal cell carcinoma (ccRCC) is a urinary disease with high incidence. The high incidence of metastasis is the leading cause of death in patients with ccRCC. This study was aimed to identify the gene signatures during…
View article: The Role of PSA Density among PI‐RADS v2.1 Categories to Avoid an Unnecessary Transition Zone Biopsy in Patients with PSA 4‐20 ng/mL
The Role of PSA Density among PI‐RADS v2.1 Categories to Avoid an Unnecessary Transition Zone Biopsy in Patients with PSA 4‐20 ng/mL Open
Objective . To evaluate the role of prostate‐specific antigen density (PSAD) in different Prostate Imaging Reporting and Data System version 2.1 (PI‐RADS v2.1) categories to avoid an unnecessary biopsy in transition zone (TZ) patients with…
View article: Multimodal Risk-Adapted Treatment in Surgical Patients With Synovial Sarcoma: A Preoperative Nomogram-Guided Adjuvant Treatment Strategy
Multimodal Risk-Adapted Treatment in Surgical Patients With Synovial Sarcoma: A Preoperative Nomogram-Guided Adjuvant Treatment Strategy Open
Background: Synovial sarcoma is characterized by heterogeneous clinical manifestations, making it difficult to evaluate individual patients' prognoses and design personal treatment schemes. We established an effective preoperative nomogram…
View article: The circular RNA circ-ERBIN promotes growth and metastasis of colorectal cancer by miR-125a-5p and miR-138-5p/4EBP-1 mediated cap-independent HIF-1α translation
The circular RNA circ-ERBIN promotes growth and metastasis of colorectal cancer by miR-125a-5p and miR-138-5p/4EBP-1 mediated cap-independent HIF-1α translation Open
Background Circular RNA (circRNAs) and hypoxia have been found to play the key roles in the pathogenesis and progression of cancer including colorectal cancer (CRC). However, the expressions and functions of the specific circRNAs in regula…
View article: Regional lymph node involvement is associated with poorer survivorship in patients with upper extremity osteosarcoma than with lower extremity osteosarcoma: a SEER analysis
Regional lymph node involvement is associated with poorer survivorship in patients with upper extremity osteosarcoma than with lower extremity osteosarcoma: a SEER analysis Open
Upper limb osteosarcoma patients are characterized by more lymph node involvement than lower limb patients, leading to poorer OS. In addition, upper limb patients are at greater risk for both lymph node involvement and distal metastasis. O…