Wenjie Zhang
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View article: Outcomes after therapeutic SBE-ERCP for choledochojejunal/hepaticojejunal anastomotic stenosis after bile duct injury
Outcomes after therapeutic SBE-ERCP for choledochojejunal/hepaticojejunal anastomotic stenosis after bile duct injury Open
Background Choledochojejunal/hepaticojejunal anastomotic stenosis (CJS/HJS) is significant clinical problem associated with decreased survival postsurgery. Endoscopic retrograde cholangiopancreatography (ERCP) using single-balloon enterosc…
View article: Long-term exposure to ambient air pollution and cardiometabolic multimorbidity in Chinese adults over 45 years
Long-term exposure to ambient air pollution and cardiometabolic multimorbidity in Chinese adults over 45 years Open
The rising prevalence of cardiometabolic multimorbidity (CMM), characterized by the coexistence of two or more cardiometabolic disorders, poses a significant public health challenge in aging populations. While ambient air pollution is a re…
View article: Mineralized Supramolecular Microspheres with Immunoregulating Functions for Transarterial Chemoembolization Immunotherapy of Hepatocellular Carcinoma
Mineralized Supramolecular Microspheres with Immunoregulating Functions for Transarterial Chemoembolization Immunotherapy of Hepatocellular Carcinoma Open
Transcatheter arterial chemoembolization (TACE) is a pivotal therapeutic option for hepatocellular carcinoma (HCC) at intermediate or advanced stage. However, conventional TACE, which primarily relies on embolic microspheres for localized …
View article: 3D-bioprinted liver cancer models derived from primary hepatocytes for simulating cancer initiation and drug screening
3D-bioprinted liver cancer models derived from primary hepatocytes for simulating cancer initiation and drug screening Open
Background: HCC remains one of the most lethal cancers globally, and accurately replicating the early events of tumor evolution remains a critical challenge. Methods: In this study, we developed early-stage liver cancer cell lines by intro…
View article: HSPA1A Can Alleviate CFA-Induced Inflammatory Pain by Modulating Macrophages
HSPA1A Can Alleviate CFA-Induced Inflammatory Pain by Modulating Macrophages Open
Current clinical approaches for managing inflammatory pain are frequently accompanied by adverse effects, significantly compromising patients’ quality of life. This study investigates the analgesic potential of Heat Shock Protein Family A …
View article: Enhancing Anti‐Tumor Effects of Engineered Extracellular Vesicles via Endocytosis Route Switching and Interferon Response Suppression
Enhancing Anti‐Tumor Effects of Engineered Extracellular Vesicles via Endocytosis Route Switching and Interferon Response Suppression Open
Engineered extracellular vesicles (EVs) represent a promising therapeutic strategy with many applications in cancer therapy. EVs derived from engineered tumor‐targeting killer cells, such as chimeric antigen receptor (CAR)‐T cells. However…
View article: Diagnostic and prognostic value of heparin-binding protein in infection and critically ill adult patients: A systematic review and meta-analysis
Diagnostic and prognostic value of heparin-binding protein in infection and critically ill adult patients: A systematic review and meta-analysis Open
Purpose: In this study, we seek to evaluate the diagnostic value of Heparin-binding protein (HBP) levels in infection and intended to investigate the prognostic value of HBP in critically ill adult patients. Methods：We searched PubMed, Web…
View article: Construction of Probiotic Escherichia coli Nissle 1917 as a Next- Generation Expression Platform and Its Application in Therapeutic Protein Production
Construction of Probiotic Escherichia coli Nissle 1917 as a Next- Generation Expression Platform and Its Application in Therapeutic Protein Production Open
Biologics produced in Escherichia coli BL21(DE3) require rigorous removal of lipopolysaccharide (LPS), also termed endotoxin, as its presence can elicit severe immune responses and life threatening complications in humans. Escherichia coli…
View article: Pathogenesis of metabolic dysfunction-associated steatotic liver disease and donor liver damage
Pathogenesis of metabolic dysfunction-associated steatotic liver disease and donor liver damage Open
View article: Dynamic response and control strategy of energy dissipation and shock absorption structure under earthquake action
Dynamic response and control strategy of energy dissipation and shock absorption structure under earthquake action Open
Aiming at the limitations of dynamic response analysis and control strategy of traditional energy dissipation and shock absorption structure under earthquake action, this paper adopts an improved energy dissipation and shock absorption des…
View article: Lidocaine-Based vs Sufentanil-Based PCIA After Pulmonary Resection Surgery: A Randomized Controlled Trial
Lidocaine-Based vs Sufentanil-Based PCIA After Pulmonary Resection Surgery: A Randomized Controlled Trial Open
This study was retrospectively registered at the Chinese Clinical Trial Registry on March 1st, 2023 (number ChiCTR2300068840).
View article: Comparison of Bacterial Community in the Jejunum, Ileum and Cecum of Suckling Lambs During Different Growth Stages
Comparison of Bacterial Community in the Jejunum, Ileum and Cecum of Suckling Lambs During Different Growth Stages Open
Given that suckling lambs with immature rumen development rely on intestinal microbiota for nutrient utilization, investigating the composition and functional characteristics of their intestinal microbiota is therefore of paramount importa…
View article: Influence of Two Types of Microcapsule Composites on the Performance of Thermochromic UV Coatings on Bleached Poplar Wood Surfaces
Influence of Two Types of Microcapsule Composites on the Performance of Thermochromic UV Coatings on Bleached Poplar Wood Surfaces Open
To meet the growing demand for intelligent surfaces in furniture and interior design, this study developed thermochromic UV coatings for bleached poplar. While conventional UV coatings are valued for their ecofriendliness and rapid curing,…
View article: Towards Microbiota‐Targeted Interventions in Acute Pancreatitis: Evidence From Meta‐Analysis and Mendelian Randomization
Towards Microbiota‐Targeted Interventions in Acute Pancreatitis: Evidence From Meta‐Analysis and Mendelian Randomization Open
Previous studies have established a causal relationship between gut microbiota and acute pancreatitis (AP) using Mendelian randomization (MR) methods, with a predominant focus on European populations. This study aimed to systematically eva…
View article: Preoperative contrast-enhanced ultrasound combined with intra-lymph node methylene blue injection for sentinel lymph node identification: a minimally invasive sentinel lymph node biopsy tracing approach
Preoperative contrast-enhanced ultrasound combined with intra-lymph node methylene blue injection for sentinel lymph node identification: a minimally invasive sentinel lymph node biopsy tracing approach Open
Objectives To investigate the significance of preoperative contrast-enhanced ultrasound (CEUS) coupled with injections of methylene blue (MB) into the lymph nodes, alongside intracutaneous injections of indocyanine green (ICG) for sentinel…
View article: Ovis2.5 Technical Report
Ovis2.5 Technical Report Open
We present Ovis2.5, a successor to Ovis2 designed for native-resolution visual perception and strong multimodal reasoning. Ovis2.5 integrates a native-resolution vision transformer that processes images at their native, variable resolution…
View article: Preparation of low-phenylalanine whey protein polypeptides using a two-step trypsin and papain hydrolysis followed by activated carbon adsorption
Preparation of low-phenylalanine whey protein polypeptides using a two-step trypsin and papain hydrolysis followed by activated carbon adsorption Open
View article: Usefulness of the internal-to-external circle area ratio in contrast-enhanced CT to differentiate small (< 3 cm) fat-poor angiomyolipoma from renal cell carcinoma
Usefulness of the internal-to-external circle area ratio in contrast-enhanced CT to differentiate small (< 3 cm) fat-poor angiomyolipoma from renal cell carcinoma Open
View article: Connexin43 hemichannel blockade turns microglia neuroprotective and mitigates cognitive deficits in a mouse model of amyloidosis
Connexin43 hemichannel blockade turns microglia neuroprotective and mitigates cognitive deficits in a mouse model of amyloidosis Open
Alzheimer's disease (AD), the leading cause of senile dementia, lacks effective therapies. While microglia are central to AD pathology, key therapeutic targets remain unclear. Here we identify microglial connexin43 (Cx43) hemichannels as a…
View article: Wernicke’s encephalopathy following radical gastrectomy and prolonged parenteral nutrition: a case report of pyloric obstruction and undisclosed psychiatric comorbidity
Wernicke’s encephalopathy following radical gastrectomy and prolonged parenteral nutrition: a case report of pyloric obstruction and undisclosed psychiatric comorbidity Open
Wernicke’s encephalopathy (WE), a neuropsychiatric emergency caused by thiamine deficiency, is increasingly recognized in nonalcoholic populations. We present a 64-year-old male with pyloric obstruction from gastric cancer (stage IIIA) who…
View article: Analysis of immune status and prognostic model incorporating lactate metabolism and immune-related genes in clear cell renal cell carcinoma
Analysis of immune status and prognostic model incorporating lactate metabolism and immune-related genes in clear cell renal cell carcinoma Open
View article: Nanoparticle-enabled molecular imaging diagnosis of osteoarthritis
Nanoparticle-enabled molecular imaging diagnosis of osteoarthritis Open
Osteoarthritis (OA) is the most common type of arthritis and affects patients with chronic pain, while imposing a heavy burden on public health systems worldwide. Current imaging technologies such as X-ray, MRI, and CT assist the diagnosis…
View article: Development and validation of a CT algorithm based on intratumoral necrosis and tumor morphology to predict the nuclear grade of small (2–4 cm) solid clear cell renal cell carcinoma
Development and validation of a CT algorithm based on intratumoral necrosis and tumor morphology to predict the nuclear grade of small (2–4 cm) solid clear cell renal cell carcinoma Open
View article: FSformer: Sparsely and effectively learning key features for multi-channel speech enhancement
FSformer: Sparsely and effectively learning key features for multi-channel speech enhancement Open
View article: Percutaneous transhepatic insertion of guide wire combined with ERCP for treatment of biliary anastomotic stenosis after liver transplantation: Report of three cases
Percutaneous transhepatic insertion of guide wire combined with ERCP for treatment of biliary anastomotic stenosis after liver transplantation: Report of three cases Open
View article: Cell-free extracts from human fat tissue attenuate ischemic injury in cardiomyocytes in a murine model
Cell-free extracts from human fat tissue attenuate ischemic injury in cardiomyocytes in a murine model Open
BACKGROUND Ischemic heart disease ranks among the foremost contributors to mortality worldwide. Myocardial infarction injury poses a prevalent challenge in current therapies. Studies have shown that mesenchymal stem cell transplantation in…
View article: Establishment of a prognostic model based on ER stress-related cell death genes and proposing a novel combination therapy in acute myeloid leukemia
Establishment of a prognostic model based on ER stress-related cell death genes and proposing a novel combination therapy in acute myeloid leukemia Open
View article: Controlled preparation of fish oil powders via complex coacervation and genipin crosslinking
Controlled preparation of fish oil powders via complex coacervation and genipin crosslinking Open
View article: Clinical diagnosis and treatment of a patient with hypertension, hypokalemia, and bilateral adrenal adenomas
Clinical diagnosis and treatment of a patient with hypertension, hypokalemia, and bilateral adrenal adenomas Open
Aldosterone-producing adenoma (APA) is one of the main types of primary aldosteronism (PA). APAs are predominantly unilateral, whereas bilateral APAs are rare. Currently, clinical experience in the diagnosis and treatment of bilateral APAs…
View article: PDGF-BB overexpressing dental pulp stem cells improve angiogenesis in dental pulp regeneration
PDGF-BB overexpressing dental pulp stem cells improve angiogenesis in dental pulp regeneration Open
Introduction Angiogenesis represents a critical challenge in dental pulp regeneration due to the tissue’s restricted nutrient supply through a 0.5-mm apical foramen. While dental pulp stem cells (DPSCs) hold regenerative potential, their l…