Jie‐Mei Wang
YOU?
Author Swipe
View article: Proteomic and functional analysis on endothelial cell heterogeneity identifies key regulators in hyperglycemia-induced dysfunction
Proteomic and functional analysis on endothelial cell heterogeneity identifies key regulators in hyperglycemia-induced dysfunction Open
Our research highlights the functional and proteomic differences between human aortic endothelial cells (HAECs) and human dermal microvascular endothelial cells (HDMVECs). Importantly, we identified WARS1 as a novel target in HDMVECs. Toge…
View article: The RhoGDIβ-Rac1-CARD9 Signaling Module Mediates Islet β-Cell Dysfunction Under Chronic Hyperglycemia
The RhoGDIβ-Rac1-CARD9 Signaling Module Mediates Islet β-Cell Dysfunction Under Chronic Hyperglycemia Open
Small (monomeric) GTP-binding proteins (smgs; Cdc42 and Rac1) play requisite roles in islet beta cell function, including glucose-stimulated insulin secretion. In addition, emerging evidence suggests that sustained (constitutive) activatio…
View article: <b>G protein-coupled receptor 35 suppresses oxidative stress response 1 in diabetic wound healing</b>
<b>G protein-coupled receptor 35 suppresses oxidative stress response 1 in diabetic wound healing</b> Open
G protein-coupled receptor 35 (GPR35) is a poorly characterized receptor with unclear intracellular mechanisms in endothelial cells (ECs). Oxidative stress responsive 1 (OXSR1) is a serine/ threonine protein kinase that modulates cell morp…
View article: <b>G protein-coupled receptor 35 suppresses oxidative stress response 1 in diabetic wound healing</b>
<b>G protein-coupled receptor 35 suppresses oxidative stress response 1 in diabetic wound healing</b> Open
G protein-coupled receptor 35 (GPR35) is a poorly characterized receptor with unclear intracellular mechanisms in endothelial cells (ECs). Oxidative stress responsive 1 (OXSR1) is a serine/ threonine protein kinase that modulates cell morp…
View article: Inhalation exposure to airborne PM<sub>2.5</sub> attenuates hepatic metabolic pathways through <i>S</i>-nitrosylation of the primary ER stress sensor
Inhalation exposure to airborne PM<sub>2.5</sub> attenuates hepatic metabolic pathways through <i>S</i>-nitrosylation of the primary ER stress sensor Open
Exposure to fine airborne particulate matter PM 2.5 causes metabolic dysfunction-associated steatohepatitis characterized by hepatic steatosis, inflammation, and fibrosis. Here, we discovered that inhalation exposure to environmental PM 2.…
View article: The Impact of Obesity on Diabetes Onset and Neovascularization in Mouse Models of Metabolic Stress
The Impact of Obesity on Diabetes Onset and Neovascularization in Mouse Models of Metabolic Stress Open
Animal models of metabolic disorders are essential to studying pathogenic mechanisms and developing therapies for diabetes, but the induction protocols vary, and sexual dimorphism often exists. In a chronic diabetic model of diet-induced o…
View article: Reply to Doboszewska et al.: The many faces of G-protein-coupled receptor 39
Reply to Doboszewska et al.: The many faces of G-protein-coupled receptor 39 Open
The linkage between abuse to artisanal cobalt miners—including children—in the Democratic Republic of the Congo (DRC) and use of cobalt in advanced batteries has prompted global supply chain reviews, responsible sourcing initiatives, and .…
View article: Oxidative Stress and MicroRNAs in Endothelial Cells under Metabolic Disorders
Oxidative Stress and MicroRNAs in Endothelial Cells under Metabolic Disorders Open
Reactive oxygen species (ROS) are radical oxygen intermediates that serve as important second messengers in signal transduction. However, when the accumulation of these molecules exceeds the buffering capacity of antioxidant enzymes, oxida…
View article: A grading method for Kayser Fleischer ring images based on ResNet
A grading method for Kayser Fleischer ring images based on ResNet Open
The corneal K-F ring is the most common ophthalmic manifestation of WD patients. Early diagnosis and treatment have an important impact on the patient's condition. K-F ring is one of the gold standards for the diagnosis of WD disease. Ther…
View article: Quantitative Proteomics Reveals Transforming Growth Factor β Receptor Targeted by Resveratrol and Hesperetin Coformulation in Endothelial Cells
Quantitative Proteomics Reveals Transforming Growth Factor β Receptor Targeted by Resveratrol and Hesperetin Coformulation in Endothelial Cells Open
The endothelium is the frontline target of multiple metabolic stressors and pharmacological agents. As a consequence, endothelial cells (ECs) display highly dynamic and diverse proteome profiles. We describe here the culture of human aorti…
View article: Boosting UPR transcriptional activator XBP1 accelerates acute wound healing
Boosting UPR transcriptional activator XBP1 accelerates acute wound healing Open
Patients’ suffering from large or deep wounds caused by traumatic and/or thermal injuries have significantly lower chances of recapitulating lost skin function through natural healing. We tested whether enhanced unfolded protein response (…
View article: Inhibition of GPR39 restores defects in endothelial cell–mediated neovascularization under the duress of chronic hyperglycemia: Evidence for regulatory roles of the sonic hedgehog signaling axis
Inhibition of GPR39 restores defects in endothelial cell–mediated neovascularization under the duress of chronic hyperglycemia: Evidence for regulatory roles of the sonic hedgehog signaling axis Open
Impaired endothelial cell (EC)–mediated angiogenesis contributes to critical limb ischemia in diabetic patients. The sonic hedgehog (SHH) pathway participates in angiogenesis but is repressed in hyperglycemia by obscure mechanisms. We inve…
View article: Comparison of Different Drying Methods on the Volatile Components of Ginger (Zingiber officinale Roscoe) by HS-GC-MS Coupled with Fast GC E-Nose
Comparison of Different Drying Methods on the Volatile Components of Ginger (Zingiber officinale Roscoe) by HS-GC-MS Coupled with Fast GC E-Nose Open
Ginger (Zingiber officinale Roscoe) is one of the most popular spices in the world, with its unique odor. Due to its health benefits, ginger is also widely used as a dietary supplement and herbal medicine. In this study, the main flavor co…
View article: Association of Dietary Calcium Intake With Bone Health and Chronic Diseases: Two Prospective Cohort Studies in China
Association of Dietary Calcium Intake With Bone Health and Chronic Diseases: Two Prospective Cohort Studies in China Open
Background: Calcium is an essential element in our diet and the most abundant mineral in the body. A high proportion of Chinese residents are not meeting dietary calcium recommendations. The purpose of this study was to investigate the rel…
View article: Novel Role of GPR35 (G-Protein–Coupled Receptor 35) in the Regulation of Endothelial Cell Function and Blood Pressure
Novel Role of GPR35 (G-Protein–Coupled Receptor 35) in the Regulation of Endothelial Cell Function and Blood Pressure Open
GPR35 (G-protein–coupled receptor 35) is a poorly characterized receptor that has garnered increased interest as a therapeutic target through its implications in a range of inflammatory and cardiovascular diseases, but its biological funct…
View article: A novel imidazolinone metformin‐methylglyoxal metabolite promotes endothelial cell angiogenesis via the eNOS/HIF‐1α pathway
A novel imidazolinone metformin‐methylglyoxal metabolite promotes endothelial cell angiogenesis via the eNOS/HIF‐1α pathway Open
Peripheral arterial disease (PAD) is one of the major complications of diabetes due to an impairment in angiogenesis. Since there is currently no drug with satisfactory efficacy to enhance blood vessel formation, discovering therapies to i…
View article: Extent reflecting overall dietary amino acids composition adherence to the human requirement amino acids pattern is associated with the development of type 2 diabetes
Extent reflecting overall dietary amino acids composition adherence to the human requirement amino acids pattern is associated with the development of type 2 diabetes Open
This study aimed to elucidate whether dietary amino acids (AAs) composition is associated with type 2 diabetes mellitus (T2DM) and to investigate how serum AAs profiles mediated this association. Two prospective cohorts of 1750 and 4024 ad…
View article: The associations of circulating common and uncommon polyunsaturated fatty acids and modification effects on dietary quality with all-cause and disease-specific mortality in NHANES 2003–2004 and 2011–2012
The associations of circulating common and uncommon polyunsaturated fatty acids and modification effects on dietary quality with all-cause and disease-specific mortality in NHANES 2003–2004 and 2011–2012 Open
Our results support the recent dietary recommendations to increase the intake of plant-derived and marine-derived n-6 and n-3 to improve the ability of primary and secondary prevention.
View article: Extent Reflecting Overall Dietary Amino Acids Composition Adherence to the Human Requirement Amino Acids Pattern is Associated with the Development of type 2 Diabetes
Extent Reflecting Overall Dietary Amino Acids Composition Adherence to the Human Requirement Amino Acids Pattern is Associated with the Development of type 2 Diabetes Open
Background: This study aimed to elucidate whether dietary amino acids (AAs) composition is associated with type 2 diabetes mellitus (T2DM), and to investigate whether and how serum AAs profiles mediated this association.Methods: Two prospe…
View article: Insulin Signal Transduction is Impaired in the Type 2 Diabetic Retina
Insulin Signal Transduction is Impaired in the Type 2 Diabetic Retina Open
Rates of type 2 diabetes are reaching epidemic levels. Yet, the tissue specific alterations due to insulin resistance are only recently being investigated. The goal of the present study was to evaluate retinal insulin signal transduction i…
View article: Insulin signal transduction is impaired in the type 2 diabetic retina
Insulin signal transduction is impaired in the type 2 diabetic retina Open
Rates of type 2 diabetes are reaching epidemic levels. Yet, the tissue specific alterations due to insulin resistance are only recently being investigated. The goal of the present study was to evaluate retinal insulin signal transduction i…
View article: 100 m/500 Mbps underwater optical wireless communication using an NRZ-OOK modulated 520 nm laser diode
100 m/500 Mbps underwater optical wireless communication using an NRZ-OOK modulated 520 nm laser diode Open
In this paper, we proposed and experimentally demonstrated a long-distance high-speed underwater optical wireless communication (UOWC) system in a laboratory environment by using a low-cost green laser diode (LD) and power-efficient non-re…
View article: Methylglyoxal triggers human aortic endothelial cell dysfunction via modulation of the K<sub>ATP</sub>/MAPK pathway
Methylglyoxal triggers human aortic endothelial cell dysfunction via modulation of the K<sub>ATP</sub>/MAPK pathway Open
Endothelial dysfunction is a key risk factor in diabetes-related multiorgan damage. Methylglyoxal (MGO), a highly reactive dicarbonyl generated primarily as a by-product of glycolysis, is increased in both type 1 and type 2 diabetic patien…
View article: Ameliorating Methylglyoxal-Induced Progenitor Cell Dysfunction for Tissue Repair in Diabetes
Ameliorating Methylglyoxal-Induced Progenitor Cell Dysfunction for Tissue Repair in Diabetes Open
Patient-derived progenitor cell (PC) dysfunction is severely impaired in diabetes, but the molecular triggers that contribute to mechanisms of PC dysfunction are not fully understood. Methylglyoxal (MGO) is one of the highly reactive dicar…