Jiemin Liao
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View article: Extent of ctDNA Tumor Fraction Reduction as a Predictor of Chemotherapy Outcomes in Advanced Solid Tumors
Extent of ctDNA Tumor Fraction Reduction as a Predictor of Chemotherapy Outcomes in Advanced Solid Tumors Open
View article: Chemotherapy response monitoring with DNA methylation-based ctDNA tumor fraction: Evidence from a real-world cohort of patients with advanced common solid malignancies
Chemotherapy response monitoring with DNA methylation-based ctDNA tumor fraction: Evidence from a real-world cohort of patients with advanced common solid malignancies Open
On-treatment changes in methylation-based TF in chemotherapy-treated patients are associated with long-term outcomes. CtDNA monitoring offers an opportunity to rapidly evaluate therapy efficacy, potentially improving clinical decision-maki…
View article: Evaluating transient stability of power systems by stability-preserving transfer of state vectors into domain of attraction of a state-reduction model
Evaluating transient stability of power systems by stability-preserving transfer of state vectors into domain of attraction of a state-reduction model Open
View article: A bedside-to-bench translational analysis of NF1 alterations and CDK4/6 inhibitor resistance in hormone receptor-positive metastatic breast cancer
A bedside-to-bench translational analysis of NF1 alterations and CDK4/6 inhibitor resistance in hormone receptor-positive metastatic breast cancer Open
View article: A Proposed Statistical Approach for Conducting a Longitudinal Assessment of Circulating Tumor DNA
A Proposed Statistical Approach for Conducting a Longitudinal Assessment of Circulating Tumor DNA Open
As circulating tumor DNA (ctDNA) may reflect cancer progression, understanding its temporal evolution can inform clinical decision-making in precision oncology. Temporal changes in ctDNA often exhibit complex patterns, varying significantl…
View article: Clinical Impact of Sub-Clonal RAS/BRAF Alterations in Liquid Biopsies From Patients With Advanced or Metastatic CRC
Clinical Impact of Sub-Clonal RAS/BRAF Alterations in Liquid Biopsies From Patients With Advanced or Metastatic CRC Open
View article: Real-world clinical and economic outcomes for patients with advanced non–small cell lung cancer enrolled in a clinical trial following comprehensive genomic profiling via liquid biopsy
Real-world clinical and economic outcomes for patients with advanced non–small cell lung cancer enrolled in a clinical trial following comprehensive genomic profiling via liquid biopsy Open
BACKGROUND: Oncology clinical trial enrollment is strongly recommended for patients with cancer who are not eligible for established and approved therapies. Many trials are specific to biomarker-targeted therapies, which are typically mana…
View article: Longitudinal Assessment of Circulating Tumor DNA: A Proposed Statistical Framework
Longitudinal Assessment of Circulating Tumor DNA: A Proposed Statistical Framework Open
As circulating tumor DNA (ctDNA) levels can reflect disease progression, achieving a comprehensive understanding of the temporal evolution of ctDNA is key to informing clinical decision making. However, temporal changes can exhibit complex…
View article: 33 Blood-based tumor mutation burden (bTMB) predicts response to immune checkpoint blockade-based combination therapy (ICBC) in advanced non-small cell lung cancer (NSCLC): a real-world (RW) analysis
33 Blood-based tumor mutation burden (bTMB) predicts response to immune checkpoint blockade-based combination therapy (ICBC) in advanced non-small cell lung cancer (NSCLC): a real-world (RW) analysis Open
Background Studies have shown that high TMB (≥10mut/MB on tissue) across solid tumors is associated with improved overall survival (OS) in patients (pts) treated with ICBC. For a subset of pts, including those with insufficient tissue, blo…
View article: Real-World Clinical Outcomes after Genomic Profiling of Circulating Tumor DNA in Patients with Previously Treated Advanced Non-Small Cell Lung Cancer
Real-World Clinical Outcomes after Genomic Profiling of Circulating Tumor DNA in Patients with Previously Treated Advanced Non-Small Cell Lung Cancer Open
Comprehensive genomic profiling for advanced non-small cell lung cancer (NSCLC) can identify patients for molecularly targeted therapies that improve clinical outcomes. We analyzed data from 3084 patients (median age 65 years, 72.9% with a…
View article: Comprehensive Genomic Profiling of Circulating Tumor DNA in Patients with Previously Treated Metastatic Colorectal Cancer: Analysis of a Real-World Healthcare Claims Database
Comprehensive Genomic Profiling of Circulating Tumor DNA in Patients with Previously Treated Metastatic Colorectal Cancer: Analysis of a Real-World Healthcare Claims Database Open
We used a real-world database (GuardantINFORMTM) to analyze the treatment choices for patients with mCRC who underwent next-generation sequencing of circulating tumor DNA (ctDNA) using a commercially available test (Guardant360®) after fir…
View article: Risk of Guillain-Barré Syndrome Following Recombinant Zoster Vaccine in Medicare Beneficiaries
Risk of Guillain-Barré Syndrome Following Recombinant Zoster Vaccine in Medicare Beneficiaries Open
Findings of this case series cohort study indicate a slightly increased risk of Guillain-Barré syndrome during the 42 days following RZV vaccination in the Medicare population, with approximately 3 excess Guillain-Barré syndrome cases per …
View article: Babesiosis Occurrence Among United States Medicare Beneficiaries, Ages 65 and Older, During 2006–2017: Overall and by State and County of Residence
Babesiosis Occurrence Among United States Medicare Beneficiaries, Ages 65 and Older, During 2006–2017: Overall and by State and County of Residence Open
Background Human babesiosis is a mild-to-severe parasitic infection that poses health concerns especially in older and other at-risk populations. The study objective was to assess babesiosis occurrence among US Medicare beneficiaries, ages…
View article: Common variants in SOX-2 and congenital cataract genes contribute to age-related nuclear cataract
Common variants in SOX-2 and congenital cataract genes contribute to age-related nuclear cataract Open
View article: Risk of serious spinal adverse events associated with epidural corticosteroid injections in the Medicare population
Risk of serious spinal adverse events associated with epidural corticosteroid injections in the Medicare population Open
Background Epidural corticosteroid injections (ESIs) are widely performed and have an unquantified risk of serious spinal adverse events (SSAEs). We sought to determine the rate of SSAEs following ESI and to compare the rates by spinal lev…
View article: Multi-Ethnic Genome-Wide Association Study of Cerebral White Matter Hyperintensities on MRI
Multi-Ethnic Genome-Wide Association Study of Cerebral White Matter Hyperintensities on MRI Open
The burden of cerebral white matter hyperintensities (WMH) is associated with an increased risk of stroke, dementia, and death. WMH are highly heritable, but their genetic underpinnings are incompletely characterized. To identify novel gen…
View article: Guillain-Barré Syndrome After High-Dose Influenza Vaccine Administration in the United States, 2018–2019 Season
Guillain-Barré Syndrome After High-Dose Influenza Vaccine Administration in the United States, 2018–2019 Season Open
Background The Vaccine Safety Datalink (VSD) identified a statistical signal for an increased risk of Guillain-Barré syndrome (GBS) in days 1–42 after 2018–2019 high-dose influenza vaccine (IIV3-HD) administration. We evaluated the signal …
View article: Novel genetic loci underlying human intracranial volume identified through genome-wide association
Novel genetic loci underlying human intracranial volume identified through genome-wide association Open
Intracranial volume reflects the maximally attained brain size during development, and remains stable with loss of tissue in late life. It is highly heritable, but the underlying genes remain largely undetermined. In a genome-wide associat…
View article: Genetic and lifestyle risk factors for MRI-defined brain infarcts in a population-based setting
Genetic and lifestyle risk factors for MRI-defined brain infarcts in a population-based setting Open
In this multiethnic GWAS meta-analysis, including over 20,000 population-based participants, we identified genetic risk loci for BI requiring validation once additional large datasets become available. High BP, including genetically determ…
View article: New insights into the genetics of primary open-angle glaucoma based on meta-analyses of intraocular pressure and optic disc characteristics.
New insights into the genetics of primary open-angle glaucoma based on meta-analyses of intraocular pressure and optic disc characteristics. Open
Primary open-angle glaucoma (POAG), the most common optic neuropathy, is a heritable disease. Siblings of POAG cases have a ten-fold increased risk of developing the disease. Intraocular pressure (IOP) and optic nerve head characteristics …
View article: Novel genetic loci underlying human intracranial volume identified through genome-wide association
Novel genetic loci underlying human intracranial volume identified through genome-wide association Open
View article: Childhood gene-environment interactions and age-dependent effects of genetic variants associated with refractive error and myopia: The CREAM Consortium
Childhood gene-environment interactions and age-dependent effects of genetic variants associated with refractive error and myopia: The CREAM Consortium Open
View article: Assessing the Causality between Blood Pressure and Retinal Vascular Caliber through Mendelian Randomisation
Assessing the Causality between Blood Pressure and Retinal Vascular Caliber through Mendelian Randomisation Open
View article: Evaluation of transethnic fine mapping with population-specific and cosmopolitan imputation reference panels in diverse Asian populations
Evaluation of transethnic fine mapping with population-specific and cosmopolitan imputation reference panels in diverse Asian populations Open
View article: Correction: Corrigendum: New loci and coding variants confer risk for age-related macular degeneration in East Asians
Correction: Corrigendum: New loci and coding variants confer risk for age-related macular degeneration in East Asians Open
Nature Communications 6: Article number: 6063 (2015); Published 28 January 2015; Updated 30 March 2015. The financial support for this Article was not fully acknowledged. The Acknowledgements should have included the following: This study …
View article: Lens Status Influences the Association between CFH Polymorphisms and Age-Related Macular Degeneration: Findings from Two Population-Based Studies in Singapore
Lens Status Influences the Association between CFH Polymorphisms and Age-Related Macular Degeneration: Findings from Two Population-Based Studies in Singapore Open
CFH genetic polymorphism and pseudophakic/aphakic status may have a potential synergistic effect on early AMD, suggesting roles for the complement system and related pathways in the pathogenesis of AMD in eyes after cataract surgery.
View article: Multiethnic Genome-Wide Association Study of Cerebral White Matter Hyperintensities on MRI
Multiethnic Genome-Wide Association Study of Cerebral White Matter Hyperintensities on MRI Open
Background— The burden of cerebral white matter hyperintensities (WMH) is associated with an increased risk of stroke, dementia, and death. WMH are highly heritable, but their genetic underpinnings are incompletely characterized. To identi…
View article: Low-frequency and rare exome chip variants associate with fasting glucose and type 2 diabetes susceptibility
Low-frequency and rare exome chip variants associate with fasting glucose and type 2 diabetes susceptibility Open
\n\t\t\t\t\tFasting glucose and insulin are intermediate traits for type 2 diabetes. Here we explore the role of coding variation on these traits by analysis of variants on the HumanExome BeadChip in 60,564 non-diabetic individuals and in …
View article: Low-frequency and rare exome chip variants associate with fasting glucose and type 2 diabetes susceptibility
Low-frequency and rare exome chip variants associate with fasting glucose and type 2 diabetes susceptibility Open
View article: New loci and coding variants confer risk for age-related macular degeneration in East Asians
New loci and coding variants confer risk for age-related macular degeneration in East Asians Open
Age-related macular degeneration (AMD) is a major cause of blindness, but presents differently in Europeans and Asians. Here, we perform a genome-wide and exome-wide association study on 2,119 patients with exudative AMD and 5,691 controls…