Jing Han
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View article: Efficacy of acupuncture for chronic migraine: a protocol for a multicenter randomized controlled trial
Efficacy of acupuncture for chronic migraine: a protocol for a multicenter randomized controlled trial Open
Introduction Chronic migraine (CM) is a prevalent neurovascular disorder that significantly affects quality of life. Research has shown promising results for the efficacy of acupuncture in the treatment of chronic migraine. This study aims…
View article: Identification of antimalarial drugs and bradykinin as ligands of the Plasmodium membrane protein PfSR10
Identification of antimalarial drugs and bradykinin as ligands of the Plasmodium membrane protein PfSR10 Open
Malaria caused by Plasmodium falciparum remains a public health issue, yet direct targets of antimalarial drugs remain elusive. Membrane proteins in Plasmodium are potential drug targets and may contribute to pathophysiological processes i…
View article: Case Report: A rare RUNX1 rearrangement resulting from t(8;21)(p12;q22) in acute myeloid leukemia with plasmacytoid dendritic cell expansion
Case Report: A rare RUNX1 rearrangement resulting from t(8;21)(p12;q22) in acute myeloid leukemia with plasmacytoid dendritic cell expansion Open
In recent years, acute myeloid leukemia with plasmacytoid dendritic cell expansion (pDC-AML) has been recognized as a rare provisional subtype of AML, comprising approximately 3–5% of all reported cases and associated with a poorer clinica…
View article: Abnormal Adsorption Characteristics of Copper, Zinc, and Manganese Ions on Natural Diatomite in a Liquid/Solid Heterogeneous System
Abnormal Adsorption Characteristics of Copper, Zinc, and Manganese Ions on Natural Diatomite in a Liquid/Solid Heterogeneous System Open
In order to investigate the adsorption characteristics of Cu2+, Zn2+, and Mn2+ on natural diatomite in liquid/solid systems and to provide reliable theoretical support for the application of these materials, we conducted a series of adsorp…
View article: Study on the Characteristics of Sea-Air Flux Variations in the Xisha Region of the South China Sea During Winter and Summer
Study on the Characteristics of Sea-Air Flux Variations in the Xisha Region of the South China Sea During Winter and Summer Open
Based on observational data collected during clear-sky conditions in the Xisha region during winter and summer of 2024, this study systematically analyzes the variability characteristics and driving mechanisms of key air-sea interface flux…
Do ethnic disparities exist in disease burden and healthcare utilization of male breast cancer? A 9-year cohort study of 9.08 million adults in China Open
This study revealed a moderate disease burden and relatively lower healthcare utilization for male breast cancer in Inner Mongolia, China. No significant ethnic disparities existed in disease burden and healthcare utilization. However, inc…
View article: Enhanced Stress Tolerance in Rice Through Overexpression of a Chimeric Glycerol-3-Phosphate Dehydrogenase (OEGD)
Enhanced Stress Tolerance in Rice Through Overexpression of a Chimeric Glycerol-3-Phosphate Dehydrogenase (OEGD) Open
Crop productivity is severely constrained by abiotic and biotic stresses, necessitating innovative strategies to enhance stress resilience. Glycerol-3-phosphate (G3P) is a central metabolite in carbohydrate and lipid metabolism, playing cr…
Single-cell RNA sequencing revealed cell landscape of tongue dorsal mucosa in rats with gastric intestinal metaplasia Open
The formation of tongue coating is closely related with the differentiation of the lingual dorsal mucosa, and a great deal of evidence shows that the variation of tongue coating reflects the pathological and physiological state of the gast…
View article: Prediction of Pharmacokinetics for CYP3A4-Metabolized Drugs in Pediatrics and Geriatrics Using Dynamic Age-Dependent Physiologically Based Pharmacokinetic Models
Prediction of Pharmacokinetics for CYP3A4-Metabolized Drugs in Pediatrics and Geriatrics Using Dynamic Age-Dependent Physiologically Based Pharmacokinetic Models Open
Background/Objectives: The use of medicines in pediatrics and geriatrics is widespread. However, information on pharmacokinetics of therapeutic drugs mainly comes from healthy adults, and the pharmacokinetic parameters of therapeutic drugs…
View article: A TRAILR2/CDH3 bispecific antibody demonstrates selective apoptosis and tumor regression in CDH3-positive pancreatic cancer
A TRAILR2/CDH3 bispecific antibody demonstrates selective apoptosis and tumor regression in CDH3-positive pancreatic cancer Open
Exploitation of extrinsic apoptosis signaling via TRAILR2 activation represents a promising therapeutic concept in cancer treatment. The limited clinical success of previous TRAILR2 agonistic agents, to date, has been ascribed to either po…
View article: Long-Term Variation Patterns of Precipitations Driven by Climate Change in China from 1901 to 2022
Long-Term Variation Patterns of Precipitations Driven by Climate Change in China from 1901 to 2022 Open
Studying long-term precipitation trends is crucial for sustainable development, as the proper utilization of water resources is essential for maintaining a sustainable water supply. The objective and novelty of this paper was to reveal the…
View article: Dynamic immune status analysis of peripheral blood mononuclear cells in patients with Klebsiella pneumoniae bloodstream infection sepsis using single-cell RNA sequencing
Dynamic immune status analysis of peripheral blood mononuclear cells in patients with Klebsiella pneumoniae bloodstream infection sepsis using single-cell RNA sequencing Open
Background Klebsiella pneumoniae is a common Gram-negative bacterium. Blood infection caused by K. pneumoniae is one of the most common causes of human sepsis, which seriously threatens the life of patients. The immune status of peripheral…
View article: The relationship between social support and erectile dysfunction in middle-aged and older males
The relationship between social support and erectile dysfunction in middle-aged and older males Open
Background Erectile dysfunction (ED) is a prevalent condition that affects middle-aged and older men, impacting their sexual health and overall wellbeing. We aimed to investigate the relationship between social support and ED among this sp…
View article: Beyond the Burden: A Qualitative Inquiry into the Experiences of Chinese Informal Caregivers for People Living with HIV or AIDS
Beyond the Burden: A Qualitative Inquiry into the Experiences of Chinese Informal Caregivers for People Living with HIV or AIDS Open
This qualitative study provides a comprehensive exploration of the experiences faced by informal caregivers of PLWHA in China, uncovering the complex spectrum of psychological, physical, social, and economic challenges inherent in their ca…
View article: Prevalence and factors associated with fertility desires among HIV-positive MSM
Prevalence and factors associated with fertility desires among HIV-positive MSM Open
The National surveillance data showed that homosexual transmission played a considerable role in new HIV infections in China. The emphasis on antiretroviral therapy and prevention of mother-to-child transmission provided chances for reprod…
View article: Do ethnic disparities exist in disease burden and healthcare utilization of male breast cancer: a 9-year cohort study of 18.19 million adults in China
Do ethnic disparities exist in disease burden and healthcare utilization of male breast cancer: a 9-year cohort study of 18.19 million adults in China Open
Background As a rare disease, male breast cancer (MBC) is of increasing concern in China. Whether health inequalities of disease burden and healthcare utilization exist by ethnicity in male breast cancer remains unclear. We aim to measure …
View article: Comparing the Evolution of Land Surface Temperature and Driving Factors between Three Different Urban Agglomerations in China
Comparing the Evolution of Land Surface Temperature and Driving Factors between Three Different Urban Agglomerations in China Open
Increases in land surface temperature (LST) and the urban heat island effect have become major challenges in the process of urban development. However, few studies have examined variations in LST between different urban agglomerations (UAs…
View article: Knowledge, Attitude, and Practice Towards Mpox and Associated Factors Among HIV-Infected Individuals — Beijing Municipality, China, 2023
Knowledge, Attitude, and Practice Towards Mpox and Associated Factors Among HIV-Infected Individuals — Beijing Municipality, China, 2023 Open
This study is the first to investigate the KAP of mpox among individuals living with HIV. The findings suggest that mpox health education should prioritize individuals with co-existing sexually transmitted diseases (STDs) and a high viral …
View article: <i>GlMPC</i> activated by GCN4 regulates secondary metabolism under nitrogen limitation conditions in <i>Ganoderma lucidum</i>
<i>GlMPC</i> activated by GCN4 regulates secondary metabolism under nitrogen limitation conditions in <i>Ganoderma lucidum</i> Open
Fungi actively alter their metabolic and synthetic pathways to cope with changing environmental conditions. The mitochondrial pyruvate carrier (MPC) plays a vital role in transporting pyruvate into mitochondria and regulating carbon metabo…
View article: T-Fiber, A Highland Barley Fiber-Rich Powder, Alleviates Hyperglycemia and Improves Kidney Pathology in Db/db Mice
T-Fiber, A Highland Barley Fiber-Rich Powder, Alleviates Hyperglycemia and Improves Kidney Pathology in Db/db Mice Open
The role of dietary fiber in highland barley in lowering blood lipids has been continuously studied in recent years. However, its effects on diabetes and diabetic nephropathy are rarely studied. Considering that highland barley bran is ric…
View article: Efficient Synthesis and In Vitro Hypoglycemic Activity of Rare Apigenin Glycosylation Derivatives
Efficient Synthesis and In Vitro Hypoglycemic Activity of Rare Apigenin Glycosylation Derivatives Open
Apigenin is a natural flavonoid with significant biological activity, but poor solubility in water and low bioavailability limits its use in the food and pharmaceutical industries. In this paper, apigenin-7-O-β-(6″-O)-d-glucoside (AG) and …
View article: A GLP‐1/glucagon (GCG)/CCK<sub>2</sub> receptors tri‐agonist provides new therapy for obesity and diabetes
A GLP‐1/glucagon (GCG)/CCK<sub>2</sub> receptors tri‐agonist provides new therapy for obesity and diabetes Open
Background and Purpose Glucagon‐like peptide‐1 (GLP‐1) and glucagon (GCG) receptor dual agonist have promising therapeutic effects in the treatment of obesity and diabetes. Moreover, GLP‐1 and cholecystokinin 2 (CCK 2 ) dual agonists have …
View article: A Novel Formononetin Derivative Promotes Anti-ischemic Effects on Acute Ischemic Injury in Mice
A Novel Formononetin Derivative Promotes Anti-ischemic Effects on Acute Ischemic Injury in Mice Open
Natural flavonoids, formononetin and ononin, possess antioxidant, antibacterial, anti-inflammatory and neuroprotective effects. Many complications caused by SARS-CoV-2 make patients difficult to recover. Flavonoids, especially formononetin…
View article: Iron nanoparticles green-formulated by Coriandrum sativum leaf aqueous extract: Investigation of its anti-liver cancer effects
Iron nanoparticles green-formulated by Coriandrum sativum leaf aqueous extract: Investigation of its anti-liver cancer effects Open
Introduction Recently, scientists have understood that metallic nanoparticles especially iron nanoparticles have excellent anticancer properties. A green, productive, and environmentally method was developed for the valuable study and t…